No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Specific Serological Tests Can Now Reliably Detect All Cases of Celiac Disease

V. Kumar,* M. Jarzabek-Chorzelska, J. Sulej, Krystyna Karnewska,** T.
Farrell,* and S. Jablonska

*IMMCO Diagnostics, Inc., Buffalo, New York 14228; Departments of Microbiology and Dermatology, State University of New York at Buffalo, Buffalo, New York 14214; and Department of Dermatology, Warsaw School of Medicine, Warsaw, Poland; ** Department of Gastroenterology and Pediatrics, Selesian School of Medicine, Warsaw, Poland

Clinical Diagnostic Immunology 9:1295-1300, 2002.

Celiac.com 12/31/2002 - Background: Immunoglobulin A (IgA) deficiency is 10-15 times more common in patients with Celiac Disease (CD) than in normal subjects. Serological tests have become the preferred methods of detecting both symptomatic and asymptomatic patients with CD. However, commercially available serological methods are limited in that they detect only the IgA isotype of antibodies (with the exception of IgG gliadin assays); hence, IgA deficient celiac disease patients may yield false negative serology.

Ads by Google:

Methods: Fifteen celiac disease and ten non-CD IgA deficient pediatric cases were examined for IgA and IgG antibodies to endomysium, gliadin and tissue
transglutaminase.

Results: Twenty five specimens with IgA deficiency were examined. Fifteen were celiac disease cases and ten were non-CD cases. All fifteen IgA deficient celiac disease cases were positive for endomysium antibodies of the IgG isotype and for IgG gliadin antibodies. All but one of the IgA deficient celiac disease cases were also positive for IgG tissue transglutaminase antibodies. None of the non-CD IgA deficient cases were positive for any of the antibody markers. All the specimens examined were also negative for IgA specific antibodies to endomysium, gliadin, and tissue transglutaminase.

Conclusions: IgG specific antibody tests for endomysium, gliadin and tissue transglutaminase are useful for the identification of IgA deficient celiac disease patients. IgG antibody tests along with tests routinely being used in clinical laboratories can reliably detect all active celiac disease patients. In addition, the levels of these CD-specific IgG antibodies could be used to monitor patient dietary compliance.

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Yep. Initially I had the full panel. DGP was the only positive and it's the only one my doctor orders now.

Well I wish mine was dia. earlier, I got all kinds of other food issues, and other auto immune disease that came up as complications. If you deal with and change over now you can prevent a even more limited diet. I was running a bucket list thinking I was going to die before my dia. I had slight ...

So, do they just test your DGP like they just test my TTG?

The only test I have had done is the TTG because that's what I had done initially after taking matters into my own hands and going to my local health fair. Celiac is so common they do that screening at our health fair. My number was so high that my doctor didn't order other labs and went straight...

Celiac used to be considered a children's disease - so, by the old standards, you are a bit old to be diagnosed. We now know that Celiac can start at any age. I don't know if you are a male or a female, but untreated Celiac can lead to miscarriages and infertility. And all the other stuff...