No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Primary Small-Bowel Malignancy and Celiac Disease

QJM, May 1, 2003; 96(5): 345 - 353

Celiac.com 05/29/2003 – A survey was recently conducted by Professor P.D. Howdle, St. Jamess University Hospital (UK), et al, to estimate the frequency in the UK of small bowel malignancy, and its relationship to celiac disease. Data were collected from 1,327 clinicians on a monthly basis between June 1998 and May 2000. The clinicians were asked to report all cases of newly diagnosed primary small bowel malignancy, and whether or not the patients reported also had celiac disease. Normally malignancies of the small intestine are rare, and they only account for less than 2% of all gastrointestinal cancers.

Ads by Google:

Results: "Clinico-pathological data were ascertained for 395 cases, including 175 adenocarcinomas, 107 lymphomas and 79 carcinoid tumors. In 13% of adenocarcinoma cases and in 39% of lymphomas, there was a diagnosis of celiac disease. Survival rates at 30 months for adenocarcinomas, lymphomas and carcinoid tumors were 58%, 45% and 78%, respectively. Prognosis of all tumors was inversely related to stage at presentation, and lymphomas associated with celiac disease were associated with a poorer prognosis."

This study provides more evidence that those with celiac disease run a greater risk of getting adenocarcinoma of the small bowel, as well as lymphoma. Because of the high rate of metastatic disease in the patients studied, there appears to be a long time from the onset of symptoms to diagnosis, which is a concern.

Unfortunately this study does not address when celiac disease was diagnosed in these patients, and whether or not they were treating it with a gluten-free diet. Other studies have shown that cancer risk decreases to that of the normal population in patients who are on a gluten-free diet for at least five years.

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Thanks kareng. Yoga is something I've always really loved and I'm pretty sure I'll feel better doing it. I like the flowy kind too, it's almost like a meditation. Slowly sounds good to me. I could put on some quiet music too or do a guided one. Light weights is a nice idea too tessa. It's l...

Is Non-Celiac Gluten Sensitivity and/or Celiac disease really Pellagra in disguise in the 21st Century? Whether to supplement or to not supplement by the Posterboy What to say? What not to Say? So many things to cover. . . yet so little time/room for it in only one post. Let me b...

I would be happy to email you all of my recipes that I've collected over the last 5 years for Thanksgiving (and my Christmas recipes if needed). I have some super easy (i.e make ahead and crockpot friendly) and tasty recipes for everything: turkey, stuffing, mashed potatoes, sweet potatoes, etc. ...

Wise words Hobbes. I heard something recently talking about how not to let constant demanding events consume you and stop you from moving towards your dreams. Celiac can definitely take a big chunk and time out of your life but it's not my purpose for being here on the planet. Focus is an excelle...

Yeah if I was there I would totally play board games!! You are the most helpful person ever. I've read and used so much of what you've written on here. I don't feel in a place to help much though I could play the forum games or chat in the non celiac area. I never think to. I do help out on some ...