No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Gene Therapy for Celiac Disease?

Gene Ther 2003 May;10(10):835-43
Londei M, Quaratino S, Maiuri L.
Institute of Child Health, University College London, London, UK.

Celiac.com 05/29/2003 - This highly technical and hopeful article covers the possibility of using gene therapy to one day cure celiac disease. Here are the introduction and final words:

Ads by Google:

"Gene therapy (GT) is still at the experimental stage and some recent setbacks have cooled the potential use of this therapeutic tool even in life-threatening conditions. However, this therapeutic approach has a potential, which is not limited to disease for which we have not other option. There are increasing evidence that GT will be soon used in diseases that are not life threatening. One group of diseases that can benefit from GT is the autoimmune one. Several experimental animal models have indicated the efficacy (proof of principle) of GT. In the present review, we have addressed the possibility that even extremely benign autoimmune-like diseases such as Celiac Disease (CD) might one day profit from this type of therapy. We further point that in conditions such as CD, where the trigger is well known and the pathogenic cascade is relatively well defined, a situation not common in autoimmunity, we can even have a better situation where to explore and use GT to control disease initiation and progression. Once the risks that are still intrinsic to GT will have been reduced the therapeutic options we outline in the present review might not appear too far from reality."

"CD is the prototype of diseases in which a clear role of antigen-specific T cells has been demonstrated and where their inhibition results in disease amelioration. The present therapeutic approach is the removal of the antigenic challenge: the gluten-free diet, which is effective if there is a strict compliance to the diet. It is, however, not always easy to follow such strict restrictions for all life and alternative approaches have to be considered. The use of GT is at the moment a remote hypothesis as celiac disease is a relatively benign condition, with a valid therapeutic approach and GT has intrinsic risks that have been highlighted recently. The scope of this review is, however, to indicate a future application of GT when, as they will, the present limitations and intrinsic risks of GT will be overcome."

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
Karen Batzel
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
25 May 2013 4:05:39 PM PDT
Very relevant for me because I also have celiac disease. These kinds of websites are beautiful and life saving devices. I'm on your list for emails.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I'm sorry you're feeling poorly. As I read the good advice you already got and your message, I was wondering a couple of things. 1. You mention your very strict schedule that keeps you on track but it says eating decently well but it doesn't say cooking. If you are eating out a lot, that is ...

Thank you everyone for your replies. ravenwoodglass: Your advice was helpful I?ll try to avoid items like this which have so many unnecessary and artificial ingredients ? they make me feel out of control. A food and symptom diary is a great idea - especially when trying out new brands of fo...

Hi, I?m sorry you?re not feeling well and sympathize with the lack of answers. It?s not usually normal to have reduced WBC, no. If I had reduced WBC I would want to make sure it?s not a rheumatoid autoimmune condition, so I might get an ANA and a urinalysis. Are you taking any medicatio...

One of my daughters is milk intolerant. She had a history of mucus and phlegm and I didn't connect it right away. One day while drinking kefir she got a weird sensation in her throat and almost threw up. That happened twice. We cut milk and it has never happened again. The mucus is gone as well a...

Interesting- thank you for sharing. I saw my ND yesterday and she also suggested that after having been completely cleaned out for my procedures, my body could be trying to adjust. She is having me take a rest from the strong probiotics I was taking, and I'm focusing on eating foods that are more...