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Antibodies to Oat Prolamines Found in Children with Celiac Disease

Scand J Gastroenterol. 2003 Jul;38(7):742-6

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Celiac.com 08/25/2003 – A recent study published in the July edition of the Scandinavian Journal of Gastroenterology demonstrates that avenin oat prolamines can be detected at higher levels in children with celiac disease compared to those without CD. The researchers prepared a crude avenin extract using an ethanol and salt solution, and used it as an antigen in a three step ELISA test. The blood of 81 children, including 34 with celiac disease, were analyzed for both IgA and IgG antibodies to avenin and gliadin. The researchers found that: Children with coeliac disease on a normal diet had significantly higher levels of antibodies to avenin, both IgG and IgA, than reference children (P < 0.001) and the levels correlated positively with gliadin antibodies, especially of IgA-type (r = 0.798). Both anti-avenin and anti-gliadin antibodies were only absorbed by the corresponding protein.

The researchers conclude: Children with coeliac disease have antibodies to oat proteins at significantly higher levels than reference children. The absorption test did not indicate a cross-reactivity between the prolamines of wheat and oats. The method will be employed for repeated sampling of anti-avenin antibodies during a prospective interventional study with a gluten-free diet supplemented with oats. An emphasis should be added to the last sentence, as it appears that they will now perform a study on celiac children who actually eat oats, and most other major studies of this type have shown no intestinal damage caused by the avenin oat prolamines in people with celiac disease. It is interesting that this study shows a different response to oats in those with celiac disease, but it remains to be seen if this response is actually harmful to celiacs.

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4 Responses:

 
Kathie Bauer
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said this on
14 Mar 2008 2:15:38 AM PDT
If my celiac 13 year old daughter eats oats daily she has bad stomach aches but if eaten just once a week, she has no symptoms.

 
sandy p
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said this on
22 Jul 2008 11:56:08 AM PDT
My daughter can also eat oatmeal without any problems though seldom does except for homemade granola.

 
judy
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said this on
01 Sep 2008 3:25:03 PM PDT
I miss oatmeal ? Is there anyway to be tested for the prolamines mentioned in this article . I stopped eating oatmeal in 1990 - as I finally realized my face and feet were reacting to the oatmeal - my feet and sometimes my face were swollen each morning after consuming oatmeal in the past week . I have celiac and Dermatitis Herpetiformis. The swelling was so bad I couldn't get my shoes on and as far as my face it could be so bad that my neighbors didn't recognize me.

 
marilyn mcmahon
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said this on
25 May 2010 2:05:28 PM PDT
I have the same problem. I would love to try the assorted oatmeal they have out, but just getting cleared up by my great doctor after three years.




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Make sure that you ask the doctor how long she has to stop the supplements before you have her levels tested and be sure to take them all with you when you have the appointment so the doctor knows what she is taking.

Talk to your doctor. With your family history and symptoms he/she may be able to diagnose based on resolution of your symptoms and family history. Also check with your local hospital if it has it's own lab. Mine covered any labs at a greatly reduced cost based on a sliding fee scale. Did you have an MRI before they did the spinal? Celiacs with neuro impact will have white spots on an MRI that resemble the lesions found with MS. Many neuro doctors don't know this. I went through what you did and they did a spinal on me also based on the MRI results. If my doctor had know what the UBOs (unidentified bright objects) were I would have been diagnosed a couple years sooner than I was. Make sure if you supplement that you ask your doctor which ones you need to stop taking and for how long before they do a blood test to check levels. Sublingual B12 is a good idea when we have nervous system issues, but needs to be stopped for at least a week for an accurate blood level on testing. I hope you get some answers and feel better soon.

Thanks for that. Will get her tested for deficiencies. I did take her to a naturopath and get her on a bunch of vitamins, but she never was tested via bloods, so will get on to that, thanks

Hi Could a mod please move this post: and my reply below to a new thread when they get a chance? Thanks! Matt

Hello and welcome Firstly, don't worry about it but for ease your post (and hopefully my reply) will probably be moved to its own thread. That will make it easier for others to see it and reply and also help Galaxy's own thread here on track and making sense. The antibodies that the celiac tests look for can drop very quickly, so... maybe? Celiac is difficult to test for, there are different tests and sometimes someone doesnt test on one but does on the other. If you can get a copy of the tests and post it here the community may be able to help explain the results. It may have shown damage to the villi, the little tendrils in your intestine that help you extract nutrients from your food. Celiac is one, but not the only, way in which they can get damaged leading to a vast number of potential symptoms and further making diagnosis a tricky proposition. Definitely, there's a connection. Here's a page that explains it in detail: https://stomachachefree.wordpress.com/2012/03/21/liver-disease-in-celiacs/ Fantastic It sounds as if your doctors were happy to diagnose you on the basis of the endoscopy? It may be then that you've found your answer. I hope so, you've clearly had a rotten and very scary time. I'm sure with the positive reaction to the diet you want to go on and get healthy, but I would only add that you should discuss this with your doctors, because they may want to exclude other potential causes if they've not confirmed celiac at this point. Check out the advice for newly diagnosed here: To your family I'd simply say that celiac is a disease of the autoimmune system, the part of our body that fights diseases and keeps us safe. In celiac people the autoimmune system see's the gluten protein found in wheat, barley, or rye grains as a threat to the system and it produces antibodies to attack it and in doing so attacks it's own body as well. It's genetic in component so close family members should consider a test if they have any of the many symptoms. There's roughly 1 person in 100 with celiac but most of them don't know it and are risking getting or staying sick by not finding out. There's further info for them and you here: https://www.celiac.com/gluten-free/announcement/3-frequently-asked-questions-about-celiac-disease/ I'm going to ask a mod to move your post and my reply to a new thread, but wanted to give you an answer first The good news is you've found a great site and there will be lots of support for you here. You've also got 'lucky' in that if you're going to have an autoimmune condition, celiac is a good one Most react really well to the gluten free diet and you will hopefully have much more healing to come! Best wishes Matt