No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Dutch Research Team Identifies Specific Genes Responsible for Celiac Disease

Gastroenterology, Oct 2003, Vol 125, No 4, p1032-41

Celiac.com 10/30/2003 – A Dutch research team has identified the specific regions of chromosome 19 that contribute to celiac disease. Despite its well-known association with human leukocyte antigen (HLA)-DQ2 and DQ8, the pathogenesis of celiac disease has remained largely unknown. The team studied 82 Dutch families who met strict diagnostic criteria which included biopsies that presented Marsh III lesions. The 216 independent celiac disease patients were compared to 216 age and sex-matched controls.

Ads by Google:

As expected the study found significant linkage to the suspected HLA region, but more importantly found additional, previously unknown and significant linkages at 19p13.1 (with a peak at marker D19S899), and at 6q21-22, which is ~70 cm downstream from the HLA region in question. The researchers conclude: "Significant linkage of celiac disease to chromosome region 19p13.1 was detected in our genome-wide screen. These results were confirmed by the association of D19S899 to celiac disease in an independent case-control cohort. Furthermore, we identified a possible second celiac disease locus on chromosome region 6q21-22."

The study was dedicated to the memory of Lodewijk Sandkuijl (1953-2002), who died shortly after its completion. He was an inspiration to the researchers and was a world expert on biostatistics.

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Hi, I?m new to this forum. I?m not a native English speaker so sorry if my English is not perfect :-) For the past 2,5 years (at least) I?ve had typical symptoms of celiac disease.* When I realized this (too late I guess) I went gluten free immediately. So I?ve been gluten-free for approx. ...

I do not have any answers for you but wanted to provide a virtual hug. H. Pylori can cause villi blunting too which i know you said she had. There are also immune deficiency disorders as well. But two copies of the gene... People are offering good advice about the time it can tak...

I just re-read your original post and I am more convinced than ever that it's Candida. The rashes and feeling like something is stuck in her throat are both things I have been very familiar with! Look in her throat with a light and see if you can see any white patches of any kind. Candida has ...

If I thought celiac was what I had, it would be easier for me to get myself into ketosis. Just by saying hey there's a reason you should do this. Gluten intolerance is one thing, knowing what's wrong with me would be another. For people with fears like mine, therapy doesn't work. I have tri...

It can but they have shown time and time again that the liver bounces right back after the medication is stopped. I had some severe abdominal pain, cramping, bloating and major pain that went away after 2-3 days on Fluconazole! I showed visible signs of liver damage in the form of mild jaundice...