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Oxford Research May Lead to a Cure for Celiac Disease
March 2000 Volume 6 Number 3 pp 337 - 342
Robert P. Anderson, Pilar Degano, Andrew J. Godkin, Derek P. Jewell & Adrian V.S. Hill
Celiac.com 06/25/2001 - Researchers from the Institute of Molecular Medicine and the Nuffield Department of Gastroenterology at Oxford University lead by Dr Robert Anderson have published a study regarding the toxic fraction of gluten, and the specific immune response to this fraction. To date scientists basic understanding of the mechanism that causes celiac disease has been linked to a broad immune response to a variety of gluten peptides, but researchers lacked specifics about both processes. This general understanding has now become very specific based on this new research. By subjecting 12 people with celiac disease to a gluten challenge and monitoring 51 fragments of the A-gliadin gluten protein in their bodies, researchers have determined the specific celiac disease antigen responsible for damage caused by the disorder, and the specific immune response that is caused by the antigen. The results of the study indicate that initial immune reaction to gluten was caused by only two adjacent fragments of the protein, which actually represented a single A-gliadin sequence. The immune response to this single fragment was identical in 11 out of 12 test subjects with celiac disease, and the immune response was not seen in the control subjects who did not have celiac disease. Researchers in Norway have also replicated these results.
These findings may lead to better diagnostic tests and treatment for celiac disease, including the possibility of a vaccine or a genetically-modified version of wheat that excludes the harmful A-gliadin sequence, thus making it harmless to celiacs. Dr. Robert Anderson believes that a vaccine for celiac disease would likely involve using the toxic peptide itself, or a variation of it, to desensitize a person with the disease to the A-gliadin sequence. Further research in the area is now underway by the team.
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Short Wheat Challenge Offers an Easy, Reproducible Method for Detecting Immune Response to Gluten
Research has indicated that giving small amounts of wheat-rich food to people with celiac disease, who are on a gluten-free diet, will trigger interferon (IFN)-γ-secreting T cells in the bloodstream.... [READ MORE]
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Diagnosing celiac disease can be challenging for doctors if a patient has already started a gluten-free diet, and/or when test results are inconsistent.... [READ MORE]
Simple Saliva Test Offers Promise for Monitoring Celiac Disease
Blood testing for radioimmunoassay (RIA) tissue transglutaminase auto-antibodies (tTG-Abs) has proven to be a sensitive test for celiac disease follow-up.... [READ MORE]
Lesser Degrees of Villous Atrophy Correspond to a Greater Frequency of Seronegative Celiac Disease
A recent study published in
the journal Digestive Diseases and Sciences indicates that lesser degrees
of villous atrophy correspond to seronegative celiac disease.... [READ MORE]
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I foundedÂ The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.View all articles by Scott Adams
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