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Malignancy and Mortality in People with Celiac Disease: Population Based Cohort Study
BMJ. 2004 Jul 21
Celiac.com 08/09/2004 – In a study designed to quantify the malignancy and mortality risks associated with celiac disease, British researchers examined 4,732 celiac disease patients and compared them to 23,620 matched controls. The researchers found that 134 (2.8%) of those with celiac disease had at least one malignancy, and 237 (5.0%) had died. In the general population, the overall hazard ratios were as follows: for any malignancy 1.29 (95% confidence interval 1.06 to 1.55), for mortality 1.31 (1.13 to 1.51), for gastrointestinal cancer 1.85 (1.22 to 2.81), for breast cancer 0.35 (0.17 to 0.72), for lung cancer 0.34 (0.13 to 0.95), and for lymphoproliferative disease 4.80 (2.71 to 8.50).
The researchers conclude that there is a modest increase in the rates of malignancy and mortality during the first year following a diagnosis of celiac disease. After one year, however, most of that increase quickly diminishes to a level that is only slightly higher than that of the normal population, presumably due to the effects of a gluten-free diet. In an unexpected finding the researchers also found a significant reduction in incidence of breast cancer in those with celiac disease, which warrants further study, as it could provide insight into the cause of the disease.
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Small Intestinal Intraepithelial Gamma/Delta T-Lymphocytes Occur Inversely to Lymphomas in Refractory Celiac Disease
Refractory celiac disease is a serious condition that occurs when celiac symptoms and intestinal damage continue even when the patient consumes a gluten-free diet.... [READ MORE]
Celiac Disease and Paraproteinemia (Serum Monoclonal Proteins)
A study published in the Leukemia Research Journal (Volume 30, issue 12, Pages 1585-1586 - December 2006) looked at samples of serum from multiple myeloma patients.... [READ MORE]
Celiac Disease Malignancy Risk Higher Despite Gluten-free Diet
Am J Med.... [READ MORE]
Malignancy in Celiac Disease -- Effect of a Gluten-Free Diet
Holmes GK, Prior P, Lane MR,
Pope D, Allan RN
Gut 1989 Mar;30(3):333-8
Gastroenterology Unit, General Hospital, Birmingham.... [READ MORE]
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I foundedÂ The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.View all articles by Scott Adams
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