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Future Enzyme Treatment Possible for People with Celiac Disease

J Pharmacol Exp Ther. 2004 May 13
Piper JL, Gray GM, Khosla C. Stanford University.

Celiac.com 11/28/2004 - A study by researchers at Stanford University looked at the ability of Prolyl endopeptidase (PEP)--a specific type of enzyme--to break down gliadin peptides in a living organism--rats. In an effort to determine whether a resistance to the break down of proteins by proteases enzymes

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is the cause of toxicity of the Pro- and Gln-rich peptides, the scientists analyzed the digestive resistance of a panel of alpha and gamma-gliadin peptides that are believed to induce gluten toxicity--all of which happen to be very resistant to gastric and pancreatic protease digestion--but can be broken down by intestinal brush border peptidases. The researchers determined that supplementation of PEP substantially reduced the concentrations of these peptides, and they determined a pharmacologically useful PEP dosage. According to the researchers: "This data verifies and extends our earlier proposal that gliadin peptides, while resistant to proteolysis, can be processed efficiently by PEP supplementation. Indeed, PEP may be able to treat Celiac Sprue by reducing or eliminating such peptides from the intestine."

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1 Response:

 
Jessica
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
31 Dec 2009 9:33:26 AM PST
I've been taking a special formula of these enzymes designed for gluten and caisein digestion, I found it at the grocery store by accident.
I started taking them and I have noticed a significant decrease in painful attacks if I accidentally get something with wheat in it.
I've only been taking it for a few weeks and only sporadically mostly if I go out to eat just in case, it is leading me think there is hope and I won't be condemned to only eating from my kitchen for the rest of my life.
This morning my husband made pancakes and I took them before eating and I wasn't keeled over in pain it may be a miracle!?
I will be looking for more research on this.
thank you




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