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Future Enzyme Treatment Possible for People with Celiac Disease
J Pharmacol Exp Ther. 2004 May 13
Piper JL, Gray GM, Khosla C. Stanford University.
Celiac.com 11/28/2004 - A study by researchers at Stanford University looked at the ability of Prolyl endopeptidase (PEP)--a specific type of enzyme--to break down gliadin peptides in a living organism--rats. In an effort to determine whether a resistance to the break down of proteins by proteases enzymesgastric and pancreatic protease digestion--but can be broken down by intestinal brush border peptidases. The researchers determined that supplementation of PEP substantially reduced the concentrations of these peptides, and they determined a pharmacologically useful PEP dosage. According to the researchers: "This data verifies and extends our earlier proposal that gliadin peptides, while resistant to proteolysis, can be processed efficiently by PEP supplementation. Indeed, PEP may be able to treat Celiac Sprue by reducing or eliminating such peptides from the intestine."
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Mucosal Recovery and Mortality in Adults With Celiac Disease After Treatment With a Gluten-Free Diet
In most adults with celiac disease, clinical symptoms disappear with a gluten-free diet.... [READ MORE]
Prolyl Endoprotease Enzyme May Allow Patients with Celiac Disease to Safely Eat Gluten on Occasion
Enzyme Quickly Breaks Down Wheat Protein
Celiac.... [READ MORE]
Small Drug Firm Announces Completion of First Human Trial for AT-1001 and FDA 'Fast Track' Designation for Possible Future Celiac Disease Treatment
Alba Therapeutics Corporation
(Alba) today announced successful completion of its first
Phase I trial for the drug candidate AT-1001, and that the FDA has granted
Fast Track designation to AT-1001 for treatment of celiac
disease.... [READ MORE]
Histologic Follow-up of People With Celiac Disease on a Gluten-free Diet: Slow and Incomplete Recovery
Wahab PJ, Meijer JW, Mulder CJ.... [READ MORE]
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I foundedÂ The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.View all articles by Scott Adams
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