No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Wheat Protein-fed Mice Show Higher Incidence of Diabetes and Intestinal Damage Than Those on Gluten-Free Diet

Diabetologia. 2005 Apr 14

Ads by Google:

Celiac.com 04/29/2005 – According to Italian researchers an improper immune response to wheat may play an important role in the pathogenesis of Type 1 diabetes. The researchers fed one group of female non-obese diabetic (NOD) mice a standard gluten-free diet, while another group of NOD mice was fed a standard gluten-free diet that also included wheat proteins. The researchers then evaluated the small intestinal architecture of the mice and found that the wheat-protein group "showed reduced villous height, increased intraepithelial infiltration by CD3(+) cells and enhanced expression of H2-IA and IFN-gamma mRNA when compared with mice on the gluten-free diet." After 43 weeks the cumulative incidence of diabetes was 65% in the gluten-free group, and 97% in the wheat-protein group. The researchers conclude that the mice that ate wheat proteins had a much higher incidence of diabetes and small intestinal enteropathy that included higher mucosal levels of pro-inflammatory cytokines.

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I have eaten the Southwest chicken salad at McDonald's many times, with the grilled chicken and no chips. I have celiac disease, and have no problems with this salad. It's a stand by for me when traveling.

That sense of your thoughts being in a non productive loop is a classic depression symptom I can certainly recognise! The good news is that those patterns you can fall into you can also train yourself to get out of. Some of the best results come from Cognitive Behavioural Therapy or CB...

Hi Lex, First step would be to eliminate celiac. Gluten is well established as the cause of celiac. If you eliminate celiac but still react to gluten foods then it becomes trickier. Non Celiac Gluten sensitivity NCGS is still not universally accepted and there are differing views on whe...

I have corn and gluten issue this former post by bartfull helped me locate bc aspirin for my son (same issues) after he had ortho work I have not tried it personally As I still avoiding most things good luck

Hi everyone. I was just wondering if anyone knew of an easy way to determine whether one's gastrointestinal reaction is to gluten or to fructan. Cheers, Lex