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Intestinal Permeability in Patients with Celiac Disease on a Gluten-free Diet

Dig Dis Sci. 2005 Apr;50(4):785-90.

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Celiac.com 05/09/2005 – To determine the effect a long-term gluten-free diet has on intestinal permeability in those with celiac disease, Canadian researchers divided celiac disease patients into three groups based on the length of time on a gluten-free diet: Group A less than 1 month; Group B, 1 month-1 year; Group C more than 1 year. Groups B and C were tested three times over the course of 12 weeks for lactulose/mannitol intestinal permeability, endomysial antibody, and 3-day food record. These results were compared to that of Group A and control subjects. The researchers found that intestinal permeability was elevated in those newly diagnosed with celiac disease and in those who were on a gluten-free diet for less than one year. They also found that it increased in those on a gluten-free diet for more than one year in those whose diets were contaminated with gluten. The researchers conclude that intestinal permeability normalizes in most people with celiac disease on a gluten-free diet, and gluten ingestion as determined by a 3 day food record correlates with intestinal permeability measurements. Further studies need to be done on the role of intestinal permeability testing in the follow-up care of those with celiac disease.

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1 Response:

 
Gloria Brown
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said this on
02 Nov 2007 3:11:32 PM PDT
The study did not include intestinal permeability findings for longterm celiacs.

Even on what one would hope is a strict gluten-free diet, as celiacs age I have reason to suspect injury to the intestine from the minutest of gluten--from ingestion to exposure to non-celiacs--contributes to intestinal permeability and increased malabsorption.




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...ON a side note this is quite easy, you can make your own out of any gluten-free Bread mix, I recently started using a coconut flour blend for this.......Most often people associate caraway with Rye Bread so you just add caraway seeds to the dough and a bit more vinegar to sour it a tad and BAM gluten-free Rye Bread knock off. I think Authentic Foods even has a additive to put in bread mixes to make it taste like Rye Bread....Or you can buy it preamade, I have issues with all the other ingredients but as for one of the best gluten-free Breads out the Canyon House makes a Rye like bread https://canyonglutenfree.com/buy-gluten-free-bread-products/Gluten-Free-Rye-Deli-Sandwich-Bread.html

Took me less than a minute, although why did they need our addy and phone?

As mentioned before you said she had rashes, have they checked if that is DH? That is a positive sign of celiac and those with the DH manifestation can have problems getting a postive with the gut biopsy. Here are some links. https://celiac.org/celiac-disease/understanding-celiac-disease-2/dermatitis-herpetiformis/ https://www.gluten.org/resources/getting-started/dermatitus-herpetiformis/ Please read up on this. She can get the rash tested for the disease if it is DH.

Thanks for your reply. I will get her retested. She hasn't had any gluten for a year and is very good at not eating it, but had some cake that night. It's so hard because the Dr who did the biopsy said there wasn't any damage so she can't be classed as Coeliacs. She had ten samples taken, but yes, like you say the intestines are huge.

Thank you for your informative reply. Yes I think you are right in that she is still getting dome cross contamination exposure through chopping boards, condiments etc. I will get her bloods redone to see if her levels have dropped and do a gluten challenge again. We all are on a whole foods diet, buy not all Gluten-Free. I find extended family difficult as because she had a negative biopsy they don't believe she could still possibly have it and aren't so careful with her. Thank you for the links, all very helpful.