No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Tissue Transglutaminase Antibody Screening May Replace the Biopsy in the Diagnosis of Celiac Disease

Pediatrics 2005;115:1341-1346.

Celiac.com 05/31/2005 – According to Canadian researchers, the use of Tissue Transglutaminase Antibody (tTG) Screening may soon replace the use of the small bowel biopsy to diagnose celiac disease in children. The researchers reviewed the charts of 103 children who were screened for celiac disease using both small bowel biopsy and tTG. Fifty-eight of the children were found to have positive biopsy results, and out of these, 48 had very high tTG levels (over 100 U), 7 had middle tTG levels (20-100 U), and 3 had low levels (less than 20 U). Out of the 49 children with the highest tTG levels, all but one of them had a positive biopsy result. There were 3 biopsy-positive children who had low tTG levels, two who were found to be IgA negative, and one who had a duodenal ulcer.

Ads by Google:

According to the researchers, using tTG values of greater than 100 U and less than 20 U, and knowing the patients IgA status, tTG testing was "98% sensitive and 97% specific in detecting celiac disease." The researchers also point out that the cost of diagnosis could be cut by 30% by utilizing tTG screening. The researchers conclude that children with high tTG titers can proceed straight to a gluten-free diet--if they respond well then their diagnosis is confirmed—if not they can proceed to a biopsy.

Although the authors dont address this issue specifically, this method would likely lead to an increase in the diagnosis rate of celiac disease, as many people are unwilling to undergo a biopsy--or have their children undergo one.

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



3 Responses:

 
Kerri Harrell
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
27 Oct 2007 9:45:47 PM PST
I had a ttg level of 57, symptoms for almost 10 years, genetic link with my father and after being on the gluten-free diet for two weeks, my sacral-iliac joint pain that I had for 4 years vanished. My biopsy was negative! Since the diet, I have tested the waters by eating pizza or donuts and have been sick for weeks with just a little exposure. No doubt in my case, the biopsy was not necessary and actually complicated what was already a sure thing.

 
khalaf
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
30 May 2008 12:26:51 PM PST
Really this is very interesting and may help a lot of people.

 
Norm
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
18 Jun 2009 11:51:56 AM PST
I agree that screening is helpful this way and certainly less costly and more convenient. What needs to happen however it to have a test that confirms the screen since you can still have falsely positive screen and subsequently you may be relegated to a lifetime of a gluten free diet that is not always easy to do. Celiac sprue can present in the small bowel as patchy areas therefore biopsies should be plentiful and more rigorous.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


It sounds like your hives resolved. I had a six month bout with them. Antihistamines really helped. My doctors are not sure if Mast Cell or autoimmune is the root cause.

My kid has Raynauds. It freaks her classmates out. She wears shoes and wool socks all year round and we live in a warm state. It is autoimmune. She manages it by layering, turning up the heat, use lots of blanket throws. I have Hashimoto?s and celiac disease. So, having multiple autoi...

Well, you do need to replace some things because they are too porous or damaged to remove gluten. Things like old wooden spoons, scratched non-stick pans, toaster, colander, sponges, etc. Honestly, the list is long, so try getting a few celiac books at the library or Amazon. Consider reading t...

When I woke up from my Endoscopy and was told I definitely had celiac disease the first thing I asked my doctor was do I need to get all new kitchen stuff? He assured me that I did not, and as long as my pots and pans and everything else was washed after being used to cook gluten I would have no ...

They have all given you good advice. Like Ennis_Tx said this is not medical advice. Just some observations. Ennis_Tx mentioned already a good B-complex. But people who have Perncious Anemia low B-12 have "Pens and Needles' feeling in their extremities. Mine was much more ...