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Down Syndrome: Celiac Disease Prevalent in Children With Down Syndrome

Am J Med Gen 2001;98:70-74.

Celiac.com 02/15/2001 - Dr. Susan L. Neuhausen and associates at the University of Utah School of Medicine in Salt Lake City studied 97 Caucasian children with Down Syndrome, ages 2 to 18 years. Their results, which were published in the January issue of the American Journal of Medical Genetics, show that 10 of the children tested positive for celiac disease (IgA anti-endomysial antibody). This is a rate that is about 25 times the general population.

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According to the results of genetic testing on these children, their genetic predisposition is the same as in the general population, which leads the researchers to believe that a gene on chromosome 21 may be involved in the pathogenesis of celiac disease.. The only symptom exhibited by the children was bloating. Six of the children who were found to have celiac disease are now on a gluten-free diet and have experienced significant improvement of their symptoms.

Conclusion: Children with Down Syndrome should be screened for celiac disease because there is a 10% incidence of the autoimmune disorder in this population. Screening for and treating celiac disease can improve the quality of life for children with Down Syndrome.

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1 Response:

 
Chris Wellington
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said this on
29 Oct 2007 8:34:57 PM PDT
My 3 y/o Daughter has Downs Syndrome and has digestion problems. We were recently informed of the possibility of celiac disease and she has been tested for it. It would explain a lot of the symptoms she is having and her trouble 'thriving'. I am glad I came across this article. It really helps knowing that there are easier solutions to some of the obstacles we face




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I'm on my first business trip since being diagnosed. I brought all kinds of food with me, as I'm in a Hilton hotel and I have a fridge and microwave in my room. I brought yogurt, cheese, eggs, fruit, bread, peanut butter, Terra sweet potato chips, Popcorn Indiana popcorn, snow peas. Does anyone have tips for me? Ideas for what I can eat, aside the things I mentioned? I made some hard boiled eggs before I left home but the fridge in my room isn't great and I don't know how cold they've been overnight so I'm not sure I'll eat them. I don't know how cold eggs need to stay. I'm in a small town but there are supermarkets. I'm just limited because I don't have a stove or much cooking space.

Weird, I tried to copy and paste it, and it thinks it's a celiac.com link?

You should be fine as long as you were eating it prior to that 10 days.

Yes, endoscopy is needed. The gliadin tests can be false positive with liver issues, connective tissue disease and other autoimmune disorders. Best to rule out or in celiac before going gluten free. Have you considered the genetic test?

The first test is used to verify that a low on an IGA test is valid. In your case it is valid. A high on any one of the other 4 tests should lead to an endoscopy to confirm celiac.