No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Myosin IXB Gene Linked to Intestinal Barrier Defect and Celiac Disease Risk

Nat Genet. 2005 Nov 13

Ads by Google:

Celiac.com 11/29/2005 - The following is an abstract of a study by Dutch researchers which demonstrates a new level of understanding with regard to the role that specific genes play in the cause of celiac disease. These findings may eventually lead to a treatment that lies beyond the gluten-free diet:

Celiac disease is probably the best-understood immune-related disorder. The disease presents in the small intestine and results from the interplay between multiple genes and gluten, the triggering environmental factor. Although HLA class II genes explain 40% of the heritable risk, non-HLA genes accounting for most of the familial clustering have not yet been identified. Here we report significant and replicable association (P = 2.1 x 10(-6)) to a common variant located in intron 28 of the gene myosin IXB (MYO9B), which encodes an unconventional myosin molecule that has a role in actin remodeling of epithelial enterocytes. Individuals homozygous with respect to the at-risk allele have a 2.3-times higher risk of celiac disease (P = 1.55 x 10(-5)). This result is suggestive of a primary impairment of the intestinal barrier in the etiology of celiac disease, which may explain why immunogenic gluten peptides are able to pass through the epithelial barrier.

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Ennis_Tx, I am just now seeing your blog post. Look into Vitamin K and Boron both are important for Calcium levels. Vitamin D gets all the press but bone density has shown to improve with Vitamin K levels. Here is a quick google search about born from the Livestrong site. ...

Yes I'd love that! How do I send you my email address so the whole world Doesn't have it. Not that it really matters no one knows me lol.

i luv tea and coffee!! if we lived close together the 3 of us would make great friends

hi yes yes n yes! its kinda silly but like u said there?s nothing to focus on! are u on east coast?? im always looking for new friends! but anyway its like im in a funk! i had a heart procedure in may then i was diagnosed w celiacs along w my father! so my fam is supportive as well as my physical...

This year I have to go easy. So I'm cooking a turkey thigh (assuming they sell those at the store), zucchini cooked with olive oil and salt, and homemade gravy. Etalia artisan style bread (boule), and pumpkin pie. Will space these things throughout the day as I can only eat small amounts at a tim...