Posterboy's Blog

FPIES Model for Celiac disease and or NCGS triggered by Low and or NO Stomach Acid in Children and Adults by the Posterboy of Low and No Stomach acid

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I started a thread about this topic Low and No Stomach Acid as trigger for food alelrgies…….

but it was part of a larger more general topic

Here it is if you want some background

But this topic about FPIES is important enough…..it needs to be explained some more and deserves it own blog post on this topic and/or

an article about it on the journal of gluten sensitivity…..

Maybe Scott will consider editing this blog post and making an article out of it someday….

Here is the link to the Autumn Issue

https://www.celiac.com/celiac-disease/journal-of-gluten-sensitivity/autumn-2022-issue/

I woke up tossing and turning thinking about this topic…..and I knew I needed to write one more Posterboy blog post….

explaining the FPIES Model for Celiac disease……

Mainly because Nobody else could or would write it….

To those who might read the rest of this blog post…..KNOW this will probably be another WTL: DR……(Note: this is only about 1/3 as long as normal) because

I choose to focus on the food allergy trigger of Low/NO Stomach instead of trying to bite off more than I can chew in one blog post.....

(See what I did there) and I left appropriate and proper supplemention to help support your Celiac symtpom's triggered, in large part (IMO) by being low in

stomach in the first place etc....in the rambling eclectic Posterboy style…..I am infamous for….for another blog post (If I have the time and

decide it is worth exploring some more)......Scott already has a nice thread on Supplementing to help your Celiac recovery.....

This builds on my other Posterboy blog posts……(for those who have not read the other ones)……they go something like this LOW Stomach

and/or NO Stomach is the trigger for your food allergies!

I can’t make it any simpler than this….

This blog posts is based on this article about this topic….

Entitled “Anti-acid medication as a risk factor for food allergy” I have subtitled the FPIES Model for Celiac disease…..

because it elegantly explains what is happening…

Here is the Abstract link…..

https://pubmed.ncbi.nlm.nih.gov/21121928/

For those who like to do more thorough reading/research on this topic…..it is a “Gold Mine” of information about Low/NO Stomach Acid

and why Antiacid medicines can trigger a food allergy….

Here is the full citation….

https://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2010.02511.x

Which makes it approx…12 years old now……and most people and doctor’s don’t have a clue…..

low stomach acid is the trigger for their food allergies….

As I like to say……why isn’t this information on the front page of every “newspaper” in the country…..

Recently Celiac.com did a nice summary on this topic…..confirming this very fact IMO!

And it was very widely read and popular article and why I knew I needed to write another Posterboy blog post on this topic….

Entitled “Acid Suppression Drugs and Antibiotics Given to Infants Strongly Associated with Celiac Disease”

And can be read at this link…

The Mounting Evidence is overwhelming in IMHO when you know and are aware that the stomach is the “Gate Keeper”

for the Small Intestine and what triggers someone to develop food allergens…..in the first place.

When you consider that 35+ years ago Low and NO stomach was found to be common in Celiac’s and predictable of DH in Celiacs!

See this research about it entitled “Gastric morphology and function in dermatitis herpetiformis and in coeliac disease (aka Celiac disease) .”

https://www.ncbi.nlm.nih.gov/pubmed/3992169

And this article as summarized on Celiac.com entitled “Do Proton Pump Inhibitors (aka PPIs) Increase Risk of Celiac Disease”

Add to that the recent article on PPIs in Children and you have a “Trifecta” of sorts…..

Or three strikes and your out (affect)……however you would like to look at it/think abou it????

So what does FPIES have to do with Celiac disease and or NCGS….

Because FPIES also happen when we as children are low in Stomach acid…..and why children will often outgrow their

food allergies as their stomach acid strengthens enough (as they age)….and it (stomach acid) become strong enough

to cut up food proteins in their diets….

One of the main and primary differences of FPIES of Celiac disease and NCGS in children is the level of Vomiting….

IE if you vomit as a kid (like I did)…..then it is a FPIES allergy like Lactose Intolerance etc.…..and Not NCGS and /or Celiac disease etc…..

But the trigger is the same…..Low and /or NO stomach acid.

How do we know this or can we? And why???

Now, I want to quote from the “Anti acid medication (and or Low/NO Stomach Acid) as a risk factor for food allergy” article…..

To scientifically establish this point and why this matters….. in Celiac disease and or NCGS….

Quoting…

“Adult values of gastric pH, as well as the full digestive capacity and the complete mucosal barrier function,

are reached at an age of approximately 2 years only….”

Not surprisingly the age when babies begin to outgrow a FPIE allergy…..

The keyword here is “Begins to outgrow” their food allergies…..Not when it stops being a problem…

It is not to/till age 5 or 6 often that children completely outgrows their childhood food allergies….

This is because or Longer Term Immune System Memory is about 2 years…..from the last time the food allergen triggered

the immune system and why it can take another 2 or 3 years to fully outgrow a babies (childhood) allergy…..and important

to note this is why many Vaccines A La, like the COVID-19 vaccine etc.....need "Boosters" to retrain the immune systme to fight this virus....

Because after a few years......it will forget it ever saw this virus before etc...

And this it should be noted…..is only present in full term infants……with delayed stomach acid production lasting even longer in Pre-term babies….

Quoting again…

“Similarly, the mean acid output in 21-month-old children after histamine stimulation was found to be only 50% of that

observed in adults and is roughly similar to adult levels only by the end of the second year of life (54, 55). Therefore, peptic digestion

may not be complete during early life, and protein remnants of the diet could act as allergens. Together, these facts may

contribute to the higher incidences of food allergies in children.”

And what is what noting and very interesting to say the least……antibodies to food allergens have been shown

to be passed off to their off spring in mammals….

See again quoting.

“When we fed pregnant mice with fish protein in context with anti-ulcer medication, we observed not only

allergy induced in the mother animal but also a Th2 bias in the offspring (91).”

And why Celiac disease can be inherited from mother to child without a genetic bias being involved….

.it is just our immune system has been preprogramed to avoid gluten, lactose etc…..by our mothers existing food allergy……

and High Stomach acid explains exactly how, why and when a child will outgrow a FPIE allergy.

And it is worth noting from the article (paragraph) “Impaired digestion lowers threshold levels of food allergens”.

Quoting again…

“Moreover, in histamine release test, the dose of native allergen eliciting positive reactivity was 10,000x times lower

than with predigested allergen (77). This implies that in settings of impaired digestion, lower levels of allergens may be

able to induce hypersensitivity reactions. These data might finally also explain why some food-allergic patients develop symptoms

of different intensity at different time points: their actual symptom intensity may depend on the current functional capacity

of the digestive system.” IE whether your stomach acid is low at the time of the gluten consumption!

To read more about this topic and it’s relation to a gluten allergy read this excellent work by Eva Untersmayr.

Entitled "New Study Shows that Antacid Use Leads to More Allergies: Q&A with Eva Untersmayr MD, PhD"

https://asthmaallergieschildren.com/new-study-shows-that-antacid-use-leads-to-more-allergies-qa-with-eva-untersmayr-md-phd/

Anybody that has a child with a food allergy should really read these two very authoritative articles…..one as an interview and

one as a full citation of the original work on food allergens as a trigger for FPIES (IMO) explaining the childhood diagnosis of NCGS

and or Celiac disease in Children. Or any adult still struggling from a food allery ESPECIALLY if they are/were or continue taking PPIs

and are still suffering from food allergies!

I am not surprised by this anymore……and by now….neither should you be either….

Acts 28:24 "And some believed the things which were spoken, and some believed not."

I can only tell you it helped me to treat my co-existing, comorbid Low/NO stomach in helping my many GI symptoms!

2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.

I hope this is helpful but it is not medical advice......but I sometimes with the mounting evidence of Low/NO stomach acid being widespread and common

in Celiac disease and/or NCGS and IBS etc. I honestly wonder whether it should be or not???

IBS, IBD, GERD aka Heartburn, UC etc. has a Biderectional Link via the Low/NO Stomach connection/trigger for/ too Celiac disease and this too was recently proven

to be true!!!

Now it will just take another 15 to 20 years before Medical Science integrates this into their model for NCGS and/or Celiac disease etc.... IMHO or at least

I have found this to be true....in my life!

To Whomever who read this too the end.....Good luck and God speed on your continue journey(s) in Life!

And I wish us all good health soon!

Posterboy by the grace of God,