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Celiac Disease Diagnosis, Testing & Treatment

This category contains a comprehensive overview that covers the information on diagnosing and treating celiac disease, including the latest research on the various new tests/screening techniques.
Note: The only medically acceptable treatment for celiac disease is a 100% gluten-free diet for life.


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    Can a vaccine work against celiac disease? Photo: MilitaryHealth

    Currently, a gluten-free diet is the only way to manage celiac disease. Can a celiac vaccine change that? One company thinks so. ImmusanT corporation has developed a therapeutic vaccine, Nexvax2, that is specifically designed to treat celiac disease. The vaccine is an adjuvant-free mix of three peptides that include immunodominant epitopes for gluten-specific CD4-positive T cells. The vaccine is designed to neutralize gluten-specific CD4-positive T cells to further antigenic stimulation.



    Photo: CC--Quinn Dombrowski

    A recent issue of JAMA, the US Preventive Services Task Force (USPSTF) critically examines screening for celiac disease in asymptomatic adults, adolescents, and children.

    Celiac disease exhibits a broad spectrum of symptoms, from subtle or no symptoms to severe malabsorption. Celiac diagnoses have increased significantly over the past few decades, in part because of greater awareness, but possibly because of an actual increase in disease rates. Researchers estimate current rates of celiac disease at 0.71% among US adults, and 0.76% among US children.



    Photo: CC--JFCherry

    From 2009 to 2014, the number of people with celiac disease in the United States held steady, while the number of undiagnosed individuals fell by about half.

    Mayo Clinic researchers, reviewing information from National Health and Nutrition Examination Surveys, say the increase in diagnosis likely stems from better detection, better celiac disease awareness, and/or possibly from the rising popularity of gluten-free diets.



    Photo: CC--Mike

    A number of researchers are looking to provide alternative or adjunct treatments to the gluten-free diet in celiac disease. Meanwhile, a number of companies are currently developing a wide variety of such options, ranging from various kinds of enzyme therapies, to treatments that eliminate celiac disease reactions, even to vaccines to inoculate celiac sufferers against their condition, perhaps allowing for full recovery and a return to non-gluten-free eating habits, as desired. At least, that is one dream.



    Photo: CC--Thomas Haynie

    Recent studies of adult celiacs have suggested that complete, not just partial, mucosal recovery and healing is possible, but, in many cases, may take longer than is currently understood.Recently Dr. Hugh James Freeman of the Department of Medicine, Gastroenterology, University of British Columbia, Vancouver, BC, Canada, conducted a study to assess healing time in celiac patients.



    Is detailed grading of villous atrophy required to diagnose enteropathy? Photo: CC--Barry Stock

    Some researchers have criticized the usefulness of the 7 level Marsh-Oberhuber classification of mucosal damage in patients with celiac disease.



    Can certain bacteria strains help treat celiac disease? Photo: CC--D26B73

    Researchers have documented a reduction of gastrointestinal symptoms in untreated celiac disease patients after oral administration of Bifidobacterium infantis Natren Life Start super strain (NLS-SS).



    Image: CC--frederic glorieux

    Could gluten-degrading enzymes offer a better future for celiac patients? Researchers identify food-grade subtilisins as gluten-degrading enzymes that might help treat celiac disease.



    What can we learn from 30 years of diagnosing adult celiac disease with biopsy? Photo: CC--Hey Paul Studios

    Study evaluates thirty years of diagnosing adult celiac disease using duodenal screening biopsies.



    Hookworms might yield treatments for celiac disease and asthma. Photo: Wiki Media Commons.

    Hookworms have shown promise in treating celiac disease, and now research shows they might help treat asthma.



    Photo: CC--Ethan Prater

    It's clear from research data that what was once thought to be a childhood disease can affect people well into adulthood and old age.



    Photo: CC--Fredrik Rubensson

    Do enzymes from our mouths offer the best next treatment celiac disease?



    How early can you diagnose celiac disease? This is a most challenging question for everyone: children, parents, pediatricians, gastroenterologists and many other health professionals. This is because, like so many other diseases, celiac disease is a progressive condition that slowly creeps up on you. In addition, there is disagreement about what constitutes a definitive diagnosis of celiac disease.



    Doctors are causing delays in diagnosing women with celiac disease. Photo: CC--Erik Wilde

    A new study says doctors, not patients, are responsible for most delays in diagnosing celiac disease in women.



    Task force says more evidence needed to support open screening for celiac disease. Photo: CC--Justin Watt

    Government task force says more evidence needed to adequately weigh the benefits and harms of celiac disease screening in asymptomatic patients.



    Photo: CC--Brett Jordan

    Are there options for treating celiac disease besides a gluten-free diet?



    New understanding about celiac disease could lead to drug breakthroughs. Photo: CC--Tom Hart

    A rapidly expanding knowledge of the celiac disease regulatory pathway could soon lead to new breakthroughs.



    Celiac disease vaccine trials will start in Australia in late 2016. Photo: CC--Corey Leopold

    The world’s first vaccine aimed at curing celiac disease is slated to begin full trials in Australia later this year.



    Task force will make recommendations for celiac screening after public comments period closes. Photo: CC--Hakan Dahlstrom

    The U.S. Preventive Services Task Force will make screening recommendations regarding celiac disease screening after taking public comments.



    Teenagers can follow simple steps to manage their celiac disease. Image: CC--d3inotes

    A few simple steps can help teens take control of their own celiac disease treatments, and manage their own gluten-free diets.


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