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Cancer, Lymphoma and Celiac Disease

This category contains summaries of research articles that deal with cancer and lymphoma and their association with celiac disease. Most of the articles are research summaries that include the original source of the summary.

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    A microscopic compound commonly found in plant-based foods reduces inflammation and prevents the formation of cancerous lesions in the colon. The tiny molecule, called quercetin, is easily absorbed when people eat fruits and vegetables, and so requires no specialized supplements or drugs.

    An extensive recent survey of the Swedish cancer registry reveals that people with celiac disease face a 5-fold increased risk of developing non-Hodgkin lymphoma, but that the risk has decreased by more than 50% over the last 40 years.

    Refractory celiac disease is a serious condition that occurs when symptoms and intestinal damage continue even when the patient consumes a gluten-free diet.

    For decades now, doctors have known that people with celiac disease face a significantly greater risk of developing non-Hodgkin's lymphoma (NHL). Recently though, doctors discovered that siblings of celiac patients also face an increased risk of developing NHL.

    One of the important ways doctors distinguish between the two types of refractory celiac disease is by looking at differences in intra-epithelial T lymphocytes (IELs) in intestinal biopsies.

    One of the particularly aggressive and deadly types of cancer associated with celiac disease in adults is known as Enteropathy-associated T-cell lymphoma (EATL), which is a T-cell non-Hodgkin lymphoma that develops in the small bowel. So, if you haven’t heard of EATLs, you should know that while current estimates indicate that even though EATLs are rare overall, they are one of the most common causes of death in people with celiac disease.

    A couple of research articles by other researchers are discussed, with emphasis on the significance to both the celiac and paraprotein patient populations. A proposal is made that celiac patients be routinely tested for paraproteinemia, and patients with pararproteinemia also be tested for celiac disease. In addition there is a call for more intensified research into this link between celiac disease and paraproteinemia.

    Celiac disease is closely associated with the presence of HLA-DQ2 and HLA-DQ8, and has also been tied to variations in the MY09B gene on the 19th chromosome. A team of Dutch doctors recently set out to determine if the presence of the MY09B gene carries an elevated risk of refractory celiac disease type II, and enteropathy-associated T-cell lymphoma. 08/14/2007 - It has long been documented that there is a connection between celiac dis

    Eur J Gastroenterol Hepatol 2006;18:187-194. 04/10/2006 - According to findings by Du

    Gut 2005;54:54-59. 01/20/2005 - A link between untreated celiac disease and a rare e

    BMJ. 2004 Jul 21 08/09/2004 – In a study designed to quantify the malignancy

    Scand J Gastroenterol. 2003 Aug;38(8):831-3. 09/29/2003 - In the following abstract t

    Am J Med. 2003 Aug 15;115(3):191-5 09/03/2003 - The results of a study conducted by D

    QJM, May 1, 2003; 96(5): 345 - 353 05/29/2003 – A survey was recently conducted b 11/07/2002 - The results of a recent study conducted by researchers in Sweden indicate

    JAMA 2002;287:1413-1419. 04/12/2002 - According to a report published in the March

    Eur J Gastroenterol Hepatol 2000;12:645-648. 08/13/2000 - According to Drs. Simon D.

    Holmes GK, Prior P, Lane MR, Pope D, Allan RN Gut 1989 Mar;30(3):333-8 Gastroenterology Unit,

    The following piece was written by Ronald Hoggan who is a teacher at Queen Elizabeth High School

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