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Refractory Celiac Disease & Collagenous Sprue

This category contains summaries of research articles that deal with refractory celiac disease and collagenous sprue and their association with celiac disease. Most of the articles are research summaries that include the original source of the summary.

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    Photo: CC--Mark Morgan

    Refractory celiac disease, and other types of complicated celiac disease are down over the last 25 years.

    Photo: CC--Frederic Rubensson

    New research shows that high Smad7 sustains inflammatory cytokine response in refractory celiac disease.

    Photo: CC--Susan

    Splenic volume is the key difference between complicated and non-complicated celiac disease.

    Should histological response guide treatment in refractory celiac disease? Photo: CC--Bruce Tuten

    Should histological response guide treatment in refractory celiac disease?

    Can a new predictive survival model help Refractory Celiac patients? Photo: CC--Jurgen Appelo

    Can a new prognostic model for predicting 5-year mortality among patients with refractory celiac disease help to clinicians provide better treatment and follow-up?

    celiac sprue successfully treated with thioguanine. Photo: CC--Rob Ellis

    Collagenous sprue is a rare form of small bowel enteropathy characterized by a thickened basement membrane and is considered to be directly related to celiac disease.

    For the first time, stem cells have been used to successfully treat refractory celiac disease. Photo: CC--Reza Ahmed

    For the first time, doctors have successfully treated refractory celiac disease using stem cell infusions.

    Walking Man; Alberto Giocometti. Photo: Wikimedia Commons

    Refractory celiac disease type II (RCDII) and EATL (Enteropathy Associated T-cell Lymphoma) are pre-malignant complications of celiac disease. However, there is scant medical literature and data what role malnutrition and intestinal absorption may play in these conditions.

    Photo: Wikimedia Commons

    Villous atrophy with intraepithelial lymphocytosis is the classic confirmation of of celiac disease. However, data show varying rates of mucosal recovery among individuals.

    Photo: CC--Remko van Dokkum

    Biopsy is currently the only way to monitor patients with non-responsive celiac disease. Looking for better options, a team of researchers set out to identify antibody biomarkers for celiac disease patients that do not respond to traditional therapy.

    Photo: Wikimedia Commons--Oona Raisanen

    Researchers and clinicians consider refractory celiac disease (RCD) to be rare, but they don't actually have solid, reliable information about how common the condition actually is.

    Photo: CC--vvracer

    Complicated celiac disease is uncommon, but patients have high death rates, say a team of researchers, who recently set out to better understand the epidemiology of complications in patients with celiac disease.

    Photo: CC--tjmwatson

    Doctors use capsule endoscopy to assess the small bowel in a number of intestinal diseases, including celiac disease. The main advantage of capsule endoscopy is that it allows for complete visualization of the intestinal mucosal surface.

    Photo: CC--W. D. Vanlue

    Abnormal intraepithelial lymphocytes (IELs) are the main feature of refractory celiac disease type II (RCDII). However, researchers still don't know exactly how these abnormal IELs originate. A pair of researchers recently commented on efforts to learn how these abnormal IELs might come about.

    Photo: CC--RDECOM

    About 40% of patients with RCDII lymphocytes develop a dangerous and invasive lymphoma. A team of researchers recently sought to identify possible origins of abnormal intraepithelial lymphocytes in refractory celiac disease type II.


    A recent, very small study indicates that tioguanine, a thiopurine derivative, offers easy, efficient treatment for refractory celiac disease, compared with current treatment regimens.

    Photo: CC--return the sun

    Non-responsive celiac disease is very much what it sounds like: celiac disease where symptoms seem to resist treatment and continue even in the face of a gluten-free diet. A team of researchers recently set out to look for the most likely causes of persistent symptoms in celiac disease patients on a gluten-free diet.

    Photo: CC--audreyjm529

    Aberrant intra-epithelial lymphocytes (IELs) are one of the major features of refractory celiac disease type II RCDII. They are categorized as pre-malignant cells, which can give rise to aggressive enteropathy-associated T cell lymphoma (EATL).

    Photo: CC--kinshuksunil

    A team of researchers recently set out to assess diagnostic yield of Vβ and Vγ clonality in refractory celiac disease (RCD). The team set out to verify whether analyzing both TCRβ and TCRγ clonality in duodenal biopsies from RCD patients improves diagnostic accuracy.

    The more severe form of Refractory Celiac Disease, RCDII, might be more common in Europe than in the US.

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