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Refractory Celiac Disease & Collagenous Sprue

This category contains summaries of research articles that deal with refractory celiac disease and collagenous sprue and their association with celiac disease. Most of the articles are research summaries that include the original source of the summary.

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    New study on cladribine treatment for Type II Refractory celiac disease.
    A new study indicates that cladribine shows excellent clinical and histological response rates, and probably less frequent transition into EATL, it looks like a promising treatment for refractory celiac disease II.


    New research indicates that refractory celiac disease may be on the rise.
    Researchers recently presented information at the American College of Gastroenterology that indicates that more people with celiac disease might stop responding to gluten-free diets.


    New study on Mesalamine and Refractory Celiac Disease.
    A recent evaluation of the safety and efficacy of small intestinal release mesalamine (SIRM) for symptom relief in refractory celiac disease (RCD) shows that SIRM seems to be a safe and effective treatment option, though larger tests are needed to know for certain.


    Steroids and a GFD to Treat Collagenous Sprue
    A recent study shows that most patients with collagenous sprue show a positive clinical response to a combination of gluten-free diet and steroids.

    Patients with collagenous sprue typically show a severe to variably severe "flattened" mucosal biopsy lesion with distinctive sub-epithelial deposits in the lamina propria region. These deposits contain collagens, as demonstrated by both histochemical stains and ultra-structural studies.

    A team of researchers recently set out to compare continual monitoring of intraepithelial lymphocyte immunophenotype and clonality against snapshot analysis in the surveillance of refractory celiac disease.


    Collagenous sprue is associated with high morbidity, but the etiology of this condition is poorly understood. There is little data concerning the pathological and clinical manifestations of patients with collagenous sprue. The research team set out shed some light on the etiology, disease manifestations and outcomes of collagenous sprue.

    A recent study used lactulose hydrogen-breath assays to show that small intestine bacterial overgrowth (SIBO) is likely a routine cause of non-responsive celiac disease.

    Doctors from the Mayo clinic are proposing a new staging system for patients with refractory celiac disease after results of a recent study showed that their system offered greater accuracy and improved survival rates over the existing staging system. The new system will rely on the cumulative effect of 5 prognostic factors evaluated at the time of the refractory state diagnosis.

    Am J Gastroenterol. 2002 Aug;97(8):2016-21 Celiac.com 01/29/2004 - According to researchers at the

    Aliment Pharmacol Ther 18(5):487-494, 2003. M. S. Goerres*, J. W. R. Meijer, P. J. Wahab*, J. A. M

    This article originally appeared in the Spring 2003 edition of Celiac.com's Scott-Free Newsletter.

    The following post is from Dr. Joseph Murray, one of the leading USA physicians in the diagnosis

    Collagenous Sprue is a distinctive lesion of the intestinal mucosa associated with progressi

    Celiac that do not remain on a gluten-free diet can develop Refractory Sprue. Refractory Spr

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