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Celiac Disease & Gluten Intolerance Research
Microwave-based treatments of wheat can trick R5-antibody ELISA tests into registering under 20ppm gluten, and thus seeming gluten-free, but the actual gluten content remains unchanged. In recent tests, researchers found that microwave treatment (MWT) of wet wheat kernels caused a striking reduction in R5-antibody-based ELISA gluten readings, reducing the readings to under 20 ppm, so that wheat could theoretically be labeled as gluten-free.
Celiac disease is a chronic autoimmune-mediated enteropathy, triggered by exposure to dietary gluten in genetically prone individuals. Celiac disease is also one of many gastrointestinal diseases that can have dental manifestations. In fact, distinct dental enamel defects are strong indicators of celiac disease, and may lead to a role for dentists in better celiac screening.
Not having a serum marker for gluten intake makes it hard for doctors to tell if celiac patients are following their diets properly.
Nearly one in five children with celiac disease in one study population had persistent enteropathy, despite maintaining a gluten free diet.
New research clarifies the mechanics driving crypt hyperplasia in celiac disease, and suggests that PRC2-dependent fostering of epithelial stemness is a common aspect of intestinal diseases marked by epithelial hyperplasia or neoplasia.
Fecal gluten peptides show limits of monitoring gluten-free diet in celiac disease patients
If kids with celiac disease go on a gluten-free diet, how quickly does their serology return to normal?
New research shows that most patients with SNVA, especially non-white patients, do not have celiac disease.
Transglutaminase 2-specific celiac disease autoantibodies cause morphological changes and inflammation in the small-bowel mucosa of mice.
Could the amount of gluten matter more than breast-feeding or the timing of the introduction of gluten as a trigger for celiac disease?
Celiac disease is an autoimmune disease in genetically susceptible individuals and is triggered by adverse immune reactions to gluten, a protein found in wheat and other grains.
Older people often show clinically atypical symptoms of celiac disease, which can delay diagnosis.
Sufferers of clostridium difficile infection have new hope in fecal transplants. Doctors understand better why they work.
A new study looks at intestinal cell damage and systemic immune activation in individuals reporting wheat sensitivity, but no celiac disease.
Does the season or region of birth influence celiac disease risk? New science says yes.
Although serological tests are useful for identifying celiac disease, it is well known that a small minority of celiacs are seronegative, and show no blood markers for celiac disease. A team of researchers wanted to define the prevalence and features of seronegative compared to seropositive celiac disease, and to establish whether celiac disease is a common cause of seronegative villous atrophy.
Many doctors hear from celiac patients who suffer from persistent symptoms despite a long-term gluten-free diet. A research team recently set out to investigate the prevalence and severity of these symptoms in patients with variable duration of a gluten-free diet.
Study shows previously unappreciated diversity and plasticity of innate IEL compartment, along with loss of differentiation potential in patients with RCDII.