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Celiac Disease & Gluten Intolerance Research

This category contains summaries of research articles that deal strictly with scientific research publications on celiac disease. Most of these research summaries contain the original source of the publication.

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    Is Treg cell dysfunction a key factor in celiac disease development? Photo: Zappys Technology Solutions

    Circulating gluten-specific FOXP3+CD39+ regulatory T cells have impaired suppressive function in patients with celiac disease. What does that mean?

    Although researchers understand the effector T-cell response in patients with celiac disease pretty well, they really don’t know very much about the role played by regulatory T cells (Treg cells) in the loss of tolerance to gluten. To get a better picture, a team of researchers recently set out to define whether patients with celiac disease have a dysfunction or lack of gluten-specific forkhead box protein 3 (FOXP3)+ Treg cells.



    Image: CC--zooey

    Researchers understand pretty well that celiac disease is driven in part by an accumulation of immune cells in the duodenal mucosa as a consequence of both adaptive and innate immune responses to undigested gliadin peptides.

    Mast cells are innate immune cells that produce a majority of co-stimulatory signals and inflammatory mediators in the intestinal mucosa. A team of researchers recently set out to evaluate the role of mast cells in the development of celiac disease.



    Photo: CC--Owwe

    For all the talk of studies touting evidence for non-celiac gluten sensitivity, the actual data don't stack up very well, according to an recent assessment by two researchers, whose results appear in Clinical Gastroenterology and Hepatology.

    In an effort to determine the accuracy of using a double-blind, placebo-controlled study to confirm diagnosis of non-celiac gluten sensitivity in patients who respond to a gluten-free diet, researchers Javier Molina-Infante, and Antonio Carroccio recently set out to assess data on a series of such studies. Both researchers are affiliated with the Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara in Caceres, Spain.



    Some celiac patients experience villous atrophy, even on a gluten-free diet. Why? Photo: CC-- Jon Bunting

    Despite sticking to a gluten-free diet, some celiac patients endure persistent duodenal damage; a condition associated with adverse outcomes.

    A team of researchers recently set out to determine the prevalence and clinical risk factors for persistent villus atrophy among symptomatic celiac disease patients.

    The team conducted a nested cross-sectional analysis on coeliac disease patients with self-reported moderate or severe symptoms, who were all following a gluten-free diet, and who underwent protocol-mandated duodenal biopsy upon enrollment in the CeliAction clinical trial.



    Photo: CC--Nicholas A. Tonelli

    A new study shows that people living in the southern United States have less celiac disease than their Northern counterparts, regardless of race or ethnicity, socioeconomic status, or body mass index.

    Rates of celiac disease vary by region, with a sharp variation between Americans living in the northern United States and Americans living in the southern part of the country. A team of researchers recently examined geographic, demographic, and clinical factors associated with prevalence of celiac disease and gluten-free diet in the United States.



    What factors are most important in helping young men with celiac disease to remain gluten-free? Photo: CC--katieg93

    Previous studies have shown us that men are generally less troubled living with celiac disease than are women, but most studies of men with celiac disease have been mostly quantitative, and have a bio-medical emphasis. A team of researchers recently set out to explore the social experience of young men with screening-detected celiac disease and to highlight daily life situations five years after diagnosis.  Self-assurance, authority, and confidence are key factors to a successful gluten-free diet for young adult men.



    Photo: CC--Marcin Wichary

    Microwave-based treatments of wheat can trick R5-antibody ELISA tests into registering under 20ppm gluten, and thus seeming gluten-free, but the actual gluten content remains unchanged. In recent tests, researchers found that microwave treatment (MWT) of wet wheat kernels caused a striking reduction in R5-antibody-based ELISA gluten readings, reducing the readings to under 20 ppm, so that wheat could theoretically be labeled as gluten-free.



    Image: CC--dion gillard

    Celiac disease is a chronic autoimmune-mediated enteropathy, triggered by exposure to dietary gluten in genetically prone individuals. Celiac disease is also one of many gastrointestinal diseases that can have dental manifestations. In fact, distinct dental enamel defects are strong indicators of celiac disease, and may lead to a role for dentists in better celiac screening.



    Photo: CC--Garland Cannon

    Not having a serum marker for gluten intake makes it hard for doctors to tell if celiac patients are following their diets properly.



    Photo: CC--Julian Fong

    Nearly one in five children with celiac disease in one study population had persistent enteropathy, despite maintaining a gluten free diet.



    Photo: CC--Theilr

    New research clarifies the mechanics driving crypt hyperplasia in celiac disease, and suggests that PRC2-dependent fostering of epithelial stemness is a common aspect of intestinal diseases marked by epithelial hyperplasia or neoplasia.



    Photo: CC--sleepyclaus

    A type of wheat proteins called ATIs may cause inflammation to spread beyond the gut.



    Can your doctor do more to monitor your gluten-free diet? Photo: CC--Wellness PC

    Fecal gluten peptides show limits of monitoring gluten-free diet in celiac disease patients



    How long does it take for serology to normalize in celiac children on a gluten-free diet? Photo: CC--Hannenah710

    If kids with celiac disease go on a gluten-free diet, how quickly does their serology return to normal?



    Photo: US Army Materiel Command

    New research shows that most patients with SNVA, especially non-white patients, do not have celiac disease.



    Photo: CC--Aini

    Transglutaminase 2-specific celiac disease autoantibodies cause morphological changes and inflammation in the small-bowel mucosa of mice.



    Image: CC--nicole danielson

    Could the amount of gluten matter more than breast-feeding or the timing of the introduction of gluten as a trigger for celiac disease?



    Researchers discover aberrant epigenetic regulation behind the intestinal symptoms in celiac disease. Photo: CC--EveryCarListed P

    Celiac disease is an autoimmune disease in genetically susceptible individuals and is triggered by adverse immune reactions to gluten, a protein found in wheat and other grains.



    Image: CC--Swallowtail Garden Seeds
    Researchers say carnivorous plant enzymes could help celiacs digest gluten, could work like Beano.


    Older people can show atypical signs of celiac disease. Photo: CC--Paul L. Dineen

    Older people often show clinically atypical symptoms of celiac disease, which can delay diagnosis.


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