Celiac.com 05/20/2021 - Celiac disease is the result of complex interactions of environmental, genetic, and immunological factors. Celiac disease is now considered a prototype of T-cell-mediated disease marked by gluten intolerance, and the targeted destruction of enterocytes by T-cell receptor αβ intraepithelial lymphocytes. 
However, the latest research indicates that innate immune system activation is necessary to trigger a gluten-specific T helper-1 response. Mast cells play a key role in innate immune response, and contribute to the pathogenesis of numerous diseases. A team of researchers recently set out to examine the role of mast cells in celiac disease.
The research team included Barbara Frossi, Marco De Carli, and Antonino Calabrò. They are variously affiliated with t...

Celiac.com 09/06/2021 - Antibodies specific for peptides bound to human leukocyte antigen (HLA) molecules are valuable tools for studies of antigen presentation, and may have therapeutic potential. Human T cell receptor (TCR)–like antibodies that block immunodominant epitope recognition have potential as personalized medicine treatments for blunting gluten-activated T cell responses without compromising effector functions provided by other T cells.
A team of researchers recently set out to generate human T cell receptor (TCR)–like antibodies toward the immunodominant signature gluten epitope DQ2.5-glia-α2 in celiac disease (CeD). 
Consuming gluten in food triggers the gastrointestinal symptoms of celiac disease in patients with CD4+ T cells specific for deamidated gluten peptid...

Celiac.com 08/14/2023 - Celiac disease is an autoimmune condition in which dietary gluten triggers inflammation in the intestine, which can result in damage to the intestinal lining. Researchers conducted a study to understand how gluten-specific CD4+ T cell activation causes intestinal damage through single-cell analysis of patients in different celiac disease states and healthy individuals.
The study revealed distinctive immune cell signatures in patients with untreated celiac disease, including elevated CD4+ follicular T-helper cells, regulatory T cells, and natural CD8+ αβ and γδ intraepithelial T cells (T-IELs). The presence of these activated intestinal T cell populations was associated with untreated, active, and potential celiac disease.
In response to gluten consumption, a ...

Celiac.com 09/11/2023 - Researchers recently carried out multiplexed-single cell analysis of intestinal and peripheral blood T cells from patients with celiac disease in different disease states as well as healthy controls. 
The research team included Adam Kornberg; Theo Botella; Christine S. Moon; Samhita Rao; Jared Gelbs; Liang Cheng; Jonathan Mille; Alyssa M. Bacarella; Javier A. García-Vilas; Justin Vargas; Xuechen Yu; Izabela Krupska; Erin Bush; Reuben Garcia-Carrasquillo; Benjamin Lebwohl; Suneeta Krishnareddy; Suzanne Lewis; Peter H. R. Green; Govind Bhagat; Kelley S. Yan; and Arnold Han.
Analysis of T Cells from Celiac Disease Patients at Different Stages
Celiac disease is an autoimmune disorder characterized by intestinal inflammation triggered by dietary g...