Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Jefferson Adams
    Jefferson Adams

    Can a New Drug Eliminate a Gluten-Free Diet for Celiac Disease Patients?

    Reviewed and edited by a celiac disease expert.

    A new oral drug for treating celiac disease could allow people with celiac disease to safely consume wheat, eliminating the need for a gluten-free diet. The drug was recently granted status as a new investigational drug (IND) by the FDA.

    Can a New Drug Eliminate a Gluten-Free Diet for Celiac Disease Patients? - Image: CC BY-SA 4.0--Bastet78
    Caption: Image: CC BY-SA 4.0--Bastet78

    Celiac.com 09/09/2019 - A new oral drug for treating celiac disease could allow people with the disease to safely consume wheat, eliminating the need for a gluten-free diet. Capsules of ActoBiotics AG017 from ActoBio Therapeutics were recently granted new investigational drug (IND) status by the US Food and Drug Administration (FDA). 

    The drug contains a customized version of the bacterium Lacotococcus lactic, designed to express a gliadin peptide, coupled with an immunomodulating cytokine. The drug can be administered orally or topically, and so requires no injections.

    Celiac.com Sponsor (A12):
    According to the company, ActoBiotics therapies promote antigen-specific immune tolerance that can prevent or reverse certain autoimmune and allergic diseases. AG017 is an antigen-specific celiac therapy with the potential to reverse gluten sensitivity that is aimed at the over 90% of celiac patients with the HLA-DQ2.5 genotype that responds to its immunomodulating cytokine.

    The drug will begin a Phase Ib/IIa study in patients with celiac disease in the US and Europe later in 2019.

    What do you think? Promising? Or likely more hype? Over the years, the celiac disease community has heard much about the promise of new drugs and treatments touting their ability to eliminate the need for a gluten-free diet, but nothing has come of it. We'll be keeping an eye on this drug to see how it pans out, so stay tuned.



    User Feedback

    Recommended Comments



    Guest Mila S

    ?

    Link to comment
    Share on other sites
    Guest Dante Fishell

    Posted

    I’m really hoping, my 16 yr old daughter has had celiac disease since she was 18mo and although we’re doing great there have been and still times it  mentally affects her. So I hope for her and other kids they can solve this!

    Link to comment
    Share on other sites
    Guest Guest Larry

    Posted

    I don’t know what is worse. My celiac disease was triggered by an operation  when I was 63 years old. So the transition from gluten food to gluten free was horrible for me. I am a taste and texture person. I don’t think I would have rather had it from my early years but it is so horrible for me. I am now 71 years old and I still can’t get use to gluten free. If this new med works the first 3 things I can’t wait to eat again are pizza, bagels, and a hamburger with a regular roll.

    Link to comment
    Share on other sites
    KimOh

    Very exciting news! I was diagnosed with celiac disease in 2013 when I was 57 years old. I am also allergic to dairy and have to eat low FODMAP because of IBS. While I have to be skeptical that this would help me, it does give me a little hope that maybe I can eat more normally again! Thank you for alerting us to this development.

    Link to comment
    Share on other sites
    Guest Made in Finland

    Posted

    9 hours ago, Guest Guest Larry said:

    I don’t know what is worse. My celiac disease was triggered by an operation  when I was 63 years old. So the transition from gluten food to gluten free was horrible for me. I am a taste Wand texture person. I don’t think I would have rather had it from my early years but it is so horrible for me. I am now 71 years old and I still can’t get use to gluten free. If this new med works the first 3 things I can’t wait to eat again are pizza, bagels, and a hamburger with a regular roll.

    Well, all I can recommend to you, Sir, is to move to Finland! They have the BEST gluten-free products I have EVER tasted anywhere! Hands down! And I'm not saying this because I'm a Finn living in the U.S., but because I've lived in many countries before moving here, and tasted gluten-free products in all of them, yet nothing has come even close to what you can find in Finland. Already 30 years ago when I was diagnosed with the celiac myself, there were a lot of tasty products I could buy - and they've even had gluten-free hamburgers at every single hamburger joint 20 years back already, do they have it here? Nope, not a single hamburger place has them, not a single one, I've tried, only in restaurants do they offer, and they're a far cry from the authentic ones - so, in short, if you ever think of traveling for a vacation somewhere in Europe, I suggest you visit Finland! You won't get disappointed! Anything that you can buy normal, you can get gluten-free also! Even in gas station bars - sandwiches and all, gluten-free versions are handmade for you, all you need to do is ask ? and of course, hygiene standards are superior, the national health organization wouldn't give a permit for anyone to prepare gluten-free foods, unless the working environment was completely free from gluten allergens. So dont despair, Sir, not everything is lost yet! ✌?

    Link to comment
    Share on other sites
    Guest Shirley spain

    Posted

    I am hoping for a drug like this ,I have been super sentive to gluten since I was in my 20s ,it's painful when I eat out as lots of people don't know what gluten does to coeliacs, so I'm limited to eating out ,it would be wonderful to go and eat anything I like made with gravy without the worry of the pain when I go to sleep if it contained even the slightest bit of gluten ,last time they said they had a drug ,I was so disappointed,as it never came true I would like to trial the drugs ,if it was possible I'm 62 years of age now been on this diet for around 45 years now be nice to have a break please keep on with your great work .

    Link to comment
    Share on other sites
    Guest Angel 1967

    Posted

    19 hours ago, Guest Dante Fishell said:

    I’m really hoping, my 16 yr old daughter has had celiac disease since she was 18mo and although we’re doing great there have been and still times it  mentally affects her. So I hope for her and other kids they can solve this!

    I am in your same position with my 14yo son. He was diagnosed late (8yo) because he wasn't thriving. He weighed just 68 pounds. Now, while he has gotten used to the diet, mentally  it does take a toll on him. Something has got to work. Praying!

    Link to comment
    Share on other sites
    Guest Pat
    11 hours ago, Guest Guest Larry said:

    I don’t know what is worse. My celiac disease was triggered by an operation  when I was 63 years old. So the transition from gluten food to gluten free was horrible for me. I am a taste and texture person. I don’t think I would have rather had it from my early years but it is so horrible for me. I am now 71 years old and I still can’t get use to gluten free. If this new med works the first 3 things I can’t wait to eat again are pizza, bagels, and a hamburger with a regular roll.

    I can relate to Larry.  I'm 69 and have only been gluten-free for 4 years, but I miss pizza and regular hamburg/hotdot rolls, too.  The gluten-free ones just aren't the same!  LiveG Free bagels are pretty good.   

    Link to comment
    Share on other sites
    Itchyscratchy

    If it does work I wonder if it would help with DH?

    Link to comment
    Share on other sites
    Guest Laura
    22 hours ago, Guest Dante Fishell said:

    I’m really hoping, my 16 yr old daughter has had celiac disease since she was 18mo and although we’re doing great there have been and still times it  mentally affects her. So I hope for her and other kids they can solve this! 

    No matter the age the stigma and social isolation continues. Food commercials make me angry!  Many gluten-free processed foods contain gluten cross-reactors or sulfites and toxic heat processed oils.  Even if there were a pill that magically made gluten tolerable, would you still want to consume the proteins in wheat (gluten & gliaden) that produce inflammatory effects in the body?

    Link to comment
    Share on other sites
    Guest Julie
    10 hours ago, Guest Guest Larry said:

    I don’t know what is worse. My celiac disease was triggered by an operation  when I was 63 years old. So the transition from gluten food to gluten free was horrible for me. I am a taste and texture person. I don’t think I would have rather had it from my early years but it is so horrible for me. I am now 71 years old and I still can’t get use to gluten free. If this new med works the first 3 things I can’t wait to eat again are pizza, bagels, and a hamburger with a regular roll.

    I was diagnosed  when I was 60. That was 3years ago. I still have anger issues about it. I really hope this new drug works out. I'm going to eat the same things you are.?

    Link to comment
    Share on other sites
    Guest gina bonine

    Posted

    On 9/10/2019 at 12:49 AM, Guest Mila S said:

    ?

    I have been diagnosed done 2001 with celiac disease  this would really be awsome to eat normal food again fingers crossed

    Link to comment
    Share on other sites



    Create an account or sign in to comment

    You need to be a member in order to leave a comment

    Create an account

    Sign up for a new account in our community. It's easy!

    Register a new account

    Sign in

    Already have an account? Sign in here.

    Sign In Now

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Tina Turbin
    Celiac.com 11/30/2011 - Researchers have been talking about it for some time, raising the hopes of the celiac community: a drug to help relieve us from the harmful effects of gluten exposure. Celiac patients are closer than ever to having such a drug on the market, as Alvine Pharmaceuticals has announced that their drug ALV003 has shown promise in a clinical trial by reducing gluten-triggered harm in people with celiac disease.
    Celiac disease is an autoimmune reaction triggered by exposure to gluten, a protein found in wheat, barley, and rye, that causes the immune system to attack the small intestine, interfering with the absorption of nutrients and leading to malnutrition and a variety of other symptoms. The disease currently has only one treatment, which is non-drug: the gluten...


    Dr. Vikki Petersen D.C, C.C.N
    Does New Drug Promise Cure for Celiac Disease?
    Celiac.com 06/23/2017 - Dr. Alessio Fasano from the University of Maryland's Celiac Research Center published a paper in Clinical and Developmental Immunology last month. It focused on a new drug developed by Dr. Fasano that has shown promising results in both animal and human trials. But is this the 'magic pill' that will cure celiac disease and gluten sensitivity? Let's take a look.
    The new drug, formerly called AT1001 but now renamed Larazotide Acetate, is a zonulin inhibitor. For those who have never heard the word 'zonulin', you might think it's a term from a science fiction movie. But zonulin is the protein that causes the 'gates' or openings between the cells making up the lining of the small intestine to open and close. These openings are called tight junctions and when zonulin...


    Jefferson Adams
    Can a New Drug Ease Gluten Effects in Celiac Patients on Gluten-free Diet
    Celiac.com 05/25/2018 - People with celiac disease need to follow a lifelong gluten-free diet. However, once their guts have healed, they can still be sensitive to gluten. Sometimes even more sensitive than they were before they went gluten-free. Accidental ingestion of gluten can trigger symptoms in celiac patients, such as pain in the gut and diarrhea, and can also cause intestinal damage. 
    A new drug being developed by a company called Amgen eases the effects of people with celiac disease on a gluten-free diet. Researchers working on the drug have announced that their proof-of-concept study shows AMG 714, an anti-IL-15 monoclonal antibody, potentially protects celiac patients from inadvertent gluten exposure by blocking interleukin 15, an important mediator of celiac disease, ...


    Jefferson Adams
    Can a New Drug Reduce Symptoms of Accidental Gluten Exposure in Celiac Patients?
    Celiac.com 08/07/2018 - A new drug designed to reduce symptoms of accidental gluten ingestion in celiac disease sufferers has yielded some encouraging data. The drug in question is a monoclonal antibody designed to reduce adverse reactions in celiacs who are accidentally exposed to gluten. The results, presented at Digestive Disease Week, held in Washington DC from 2–5 June 2018, suggest that monoclonal antibodies could provide protection for people with celiac disease.
    Celiac patients on a gluten-free diet who randomly received six injections of a monoclonal antibody, called AMG 714, over a ten-week period, enjoyed a substantial reduction in intestinal inflammation. Over a ten week study period, celiac patients on a gluten-free diet received six randomly assigned injections of eit...


  • Recent Activity

    1. - Whyz replied to Whyz's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      Feeling ill

    2. - Scott Adams replied to PixieSticks's topic in Super Sensitive People
      1

      Working in a kitchen with gluten?

    3. - PixieSticks posted a topic in Super Sensitive People
      1

      Working in a kitchen with gluten?

    4. - Art Maltman replied to Art Maltman's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      My 5 months of Struggle


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      126,519
    • Most Online (within 30 mins)
      7,748

    Aunty KK
    Newest Member
    Aunty KK
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.5k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Whyz
      5
    • Art Maltman
      5
    • JA917
      13
    • Dana Gilcrease
      5
    • marion wheaton
      6
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...