Celiac.com 02/26/2025 - Celiac disease, an autoimmune disorder triggered by gluten consumption, affects millions worldwide. Gluten proteins, particularly gliadin, are central to the inflammation and intestinal damage associated with the condition. Recent research explores innovative methods to make gluten safer, including transamidation—a chemical modification that alters gluten’s structure to reduce its toxic effects. This study investigates the impact of transamidated gliadin on celiac-related gluten sensitivity, analyzing its effects on cellular models, animal models, and intestinal health. The findings offer promising insights into developing functional gluten-based foods that may benefit individuals with celiac disease or gluten sensitivity.
The Role of Gliadin in Celiac Dis...

Celiac.com 03/17/2025 - For millions of people with celiac disease, consuming gluten can trigger severe digestive distress, long-term intestinal damage, and an increased risk of serious health conditions. The only current treatment is a strict gluten-free diet, which can be challenging and stressful to maintain. However, scientists at Penn’s Institute for RNA Innovation are exploring a groundbreaking approach using messenger RNA (mRNA) technology to develop a vaccine that could revolutionize the management of celiac disease. This research aims to retrain the immune system to tolerate gluten, potentially offering new hope for those affected by this autoimmune condition.
Understanding Celiac Disease
Celiac disease is an autoimmune disorder where the ingestion of gluten—a pro...

Celiac.com 04/07/2025 - A recent review explores the potential of enzyme therapies to help individuals with celiac disease manage gluten exposure. The study focuses on the challenges of developing effective enzyme treatments and highlights the importance of exopeptidases, a type of enzyme that could play a key role in breaking down gluten peptides.
The Problem with Gluten and Celiac Disease
Celiac disease is an autoimmune condition triggered by gluten, a protein found in wheat, barley, and rye. When people with celiac disease consume gluten, their immune system attacks the small intestine, causing inflammation and damage. Gluten is particularly hard to digest because it contains high levels of proline and glutamine, two amino acids that resist breakdown by typical digestive ...

Celiac.com 04/28/2025 - For people with celiac disease, the only current treatment is a strict, lifelong gluten-free diet—which can be expensive, restrictive, and difficult to maintain. But what if there was another way to manage the condition? A recent study explores an experimental therapy using specially modified immune cells to help control the body’s harmful reaction to gluten. While still in early stages, this research could pave the way for future treatments that reduce—or even eliminate—the need for dietary restrictions.
Understanding Celiac Disease and the Immune System
Celiac disease is an autoimmune disorder where the immune system mistakenly attacks the small intestine when gluten is consumed. Most people with celiac disease carry a specific genetic marker called ...