Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Jefferson Adams
    Jefferson Adams

    How Close Are New Celiac Disease Treatments?

    Reviewed and edited by a celiac disease expert.
    How Close Are New Celiac Disease Treatments? - Photo: CC--Andres Nieto Porros
    Caption: Photo: CC--Andres Nieto Porros

    Celiac.com 04/10/2015 - Of course, a strict gluten free diet is still the only safe and effective treatment for celiac disease. However, new drugs in development, some of which are currently being tested on humans, might allow people with celiac disease to safely eat gluten again, at least in small amounts.

    To be fair, even if all goes smoothly, it will be a few years at least before we see such treatments on the market. Moreover, even though many early results have been encouraging, none have yet entered safety trials, the final step before Food and Drug Administration approval and commercial availability.

    Celiac.com Sponsor (A12):
    Drugs currently under trial include an enzyme that splits the protein in wheat that triggers adverse reactions, into smaller harmless products, and another which promises to make the gut less leaky, and thus block potentially toxic substances from triggering inflammation.

    There are several other drugs in earlier stages of development aimed at suppressing the immune response to gluten and preventing intestinal inflammation:

    • ALV003, which will protect people with celiac disease against gut damage from small amounts of gluten.
    • BL-7010 is a novel co-polymer for the treatment of celiac disease, which significantly reduces the immune response triggered by gluten.
    • ImmusanT’s therapeutic vaccine Nexvax2 combines three proprietary peptides that elicit an immune response in celiac disease patients who carry the immune recognition gene HLA-DQ2.
    • Larazotide acetate (AT-1001) is Alba Therapeutics Corporation’s investigational product, a first-in-class tight junction regulator, intended for the treatment of patients with celiac disease.
    • AVX176, from Avaxia Biologics, is an investigational oral antibody drug that is the subject of U.S. composition of matter patent 8,071,101, “Antibody Therapy for Treatment of Diseases Associated with Gluten Intolerance.” The patent, which expires on May 27 2029, provides broad coverage for treating celiac disease using orally administered antibodies produced by Avaxia’s proprietary platform technology [32].
    • ActoGenX is carrying out discovery research in celiac disease with its range of ActoBiotics™, which use Lactococcus lactis as an expression system to locally secrete bio-therapeutics such as cytokines, antibodies, hormones, etc.
    • Chemocentryx’s CCR9, is also known as Traficet-EN, or CCX282B), and was originally intended for patients with moderate-to-severe Crohn’s disease. It has completed one Phase 2 trial in 67 patients with celiac disease.

    Meanwhile, in Europe, Dr. Falk Pharma and Zedira recently announced the start of phase I clinical trials for the drug candidate ZED1227, a direct acting inhibitor of tissue transglutaminase. The small molecule targets the dysregulated transglutaminase within the small intestine in order to dampen the immune response to gluten which drives the disease process.

    Some of these drugs may be taken right before eating gluten, while others might be more effective when taken on a regular schedule. If approved for use as intended, these drugs will likely allow people with celiac disease to eat gluten in small amounts. To my knowledge, there is no drug in current trial phases that is designed to permit unrestricted gluten consumption.

    So, the good news is that the next few years may see commercially available treatments that might actual help people manage celiac disease. The downside for people with celiac disease, at least for now, is that there is no treatment on the horizon that will allow safe, unlimited gluten-consumption. Moreover, there is no hint that a cure is coming anytime soon.

    Still, it’s good to know that researchers are working on providing helpful tools for treating celiac disease.

    Are you looking forward to seeing new treatment options for celiac disease? What kind of benefits should such treatments offer?

    Source:

    • Open Original Shared Link


    User Feedback

    Recommended Comments



    Guest Don

    It would be fabulous if attending a party would not be a total flop because of fear of intake of gluten.

    Link to comment
    Share on other sites
    Guest bucky

    Posted

    With every action there is a reaction. So it remains to be seen what the after effects of the drugs are and whether they are worth taking or just continuing to avoid gluten continues to be the best MO. We can always remain hopeful. It is a shame however, that one never knows until many years later the devastating effects of some drugs on the body.

    Link to comment
    Share on other sites
    Guest kwix

    I'm happy enough to give up bread, pasta, cake etc. entirely. (I'm middle-aged, so can't really eat starches anyway.) Just to be able to eat out with friends without having to go into long explanations and negotiations with servers about the history and provenance of every 20 parts per million would be great!

    Link to comment
    Share on other sites
    Guest Magister Mundi

    Posted

    Nexvax2 would allow normal consumption of gluten, as the whole point of the treatment is to retroactively correct the body's immune response. In fact, one of the stated objectives on their website is to help people with celiac disease enjoy normal diets again.

     

    You are correct that the rest of them are not intended to allow large amounts of gluten consumption, though. Instead, they would be useful in eliminating the need to worry about cross-contamination - and that's a pretty exciting prospect on its own!

    Link to comment
    Share on other sites
    Guest D. Johnson

    Posted

    I would be very cautious about taking any of these until it was proven absolutely to have no side effects. There always are some and history has shown some to be deadly.

    Link to comment
    Share on other sites
    Guest Pam

    Do you have any info where I can sign up to be in studies for celiac DX in the OKC OK area? I have biopsy proven Celiac and greatly dislike the restrictions on my lifestyle due to it. I would be interested in participating in some studies.

    Link to comment
    Share on other sites
    Guest Adele

    Posted

    These treatments would be wonderful for my daughter. We have had such a hard time getting her blood levels to normal, despite having a gluten-free household and carefully reading all labels. So this would give me some peace of mind in that regard. Also, with these drugs, we could eat out and order something that's "supposed to be" gluten-free and not have to worry that there might be some cross contamination. It would really make life so much easier!

    Link to comment
    Share on other sites
    Guest JZ

    Thanks so much for the update. I attempted to participate in the ALV003 enzyme study but my endoscopy showed my small intestine was too healthy for the study.

    Link to comment
    Share on other sites
    Guest Gillian

    Posted

    Why on Earth would I want to go back to eating gluten, I feel so much better since giving it up I have also given up most other cereals, and I certainly don't want to be dosing myself up on drugs to be able to eat bagels and cakes again.

    Link to comment
    Share on other sites
    Guest Cazzy55

    Posted

    I live in UK & was diagnosed with coeliac disease 22 years ago. Initially the Coeliac Society just produced a black ink A5 sheet as a seasonal newsletter - now Coeliac UK produces an impressive full colour 70 page quarterly magazine full of articles, recipes, and advertisements. Ever since I can remember, there was talk of a cure being on the horizon but I fear it's now unlikely to happen. I think the science is there, but a cure will probably be blocked.

    While I am grateful for more awareness & product choice than I could have imagined, there are now so many people with a vested interest in selling us expensive gluten-free alternatives that they are likely to protect their livelihood.

    I also think that while the NHS can fob us off with a diet that largely manages the condition, why would they waste their cash strapped resources paying out for expensive drugs or vaccines when there are so many more pressing needs for their money?

    Link to comment
    Share on other sites
    Guest Rick M.

    Posted

    Thanks so much for the update. I attempted to participate in the ALV003 enzyme study but my endoscopy showed my small intestine was too healthy for the study.

    You can add me to that same list, even though I was actively sick during the stages of the testing I was I was part of. Go figure?

     

    Hopefully these drugs will not cause other problems, because I'd sure like to get back to my job and not have to worry about eating out and someone in the kitchen not using proper precautions with my meal!

    Link to comment
    Share on other sites
    Guest Vickie

    Posted

    Once being on a gluten-free diet it's not worth going for the drugs just to be able to eat gluten again. I was also diagnosed with microscopic colotitis which means no seeds or nuts. I'm healthy now and almost in my mid 60's so staying on my gluten-free diet. No sense in changing now. there are plenty of good cookbooks that have just as good of recipes in them for the cakes and cookies that I use toake for my family. My children are grown and gone. My husband has gotten use to eating gluten-free. I do make him regular cakes with wheat flour. here is gluten-free cake mixes I can buy. There is starting to be more and more gluten-free products in the grocery stores.

    Link to comment
    Share on other sites



    Create an account or sign in to comment

    You need to be a member in order to leave a comment

    Create an account

    Sign up for a new account in our community. It's easy!

    Register a new account

    Sign in

    Already have an account? Sign in here.

    Sign In Now

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Scott Adams
    Celiac.com 03/19/2002 - The following excerpts were taken from The New England Journal of Medicines January 17, 2002 (Vol. 346, No. 30) article on recovery from celiac disease:
    In addition to a gluten-free diet, all patients with newly diagnosed celiac sprue who have clinically evident malabsorption should initially receive a multi-vitamin preparation and appropriate supplements to correct any iron or folate deficiency. Patients with steatorrhea, hypocalcemia, or osteopenic bone disease should receive oral calcium and vitamin D supplementation.
    Approximately 70 percent of patients have symptomatic improvement within two weeks after starting a gluten-free diet. The speed and eventual degree of histologic improvement are unpredictable but invariably lag behind the clinical...


    Scott Adams
    Bardella MT, Minoli G, Radaelli F, Quatrini M, Bianchi PA, Conte D Gastrointest Endosc. 2000 Jun;51(6):714-716
    Background: Loss or reduction of duodenal folds, scalloping of Kerkring folds and a micronodular or mosaic duodenal mucosal pattern have been described in celiac disease (celiac disease), endoscopic findings that are considered reliable in the diagnosis of this disorder. However, most data have been obtained in patients with suspected or certain disease. We assessed the accuracy of the above markers in diagnosing celiac disease in patients with non-ulcer dyspepsia. Methods: In this prospective study, in 705 consecutive dyspeptic patients (284 men, 421 women, mean age 51 +/- SD 15.8 years) duodenal biopsies were obtained only in the presence of typical endoscopic markers...


    Scott Adams
    Celiac.com 11/08/2005 - York Nutritional Laboratories has introduced to the US a simple, unique and revolutionary finger-stick rapid test kit designed to detect the antibodies associated with Celiac Disease and gluten intolerance.
    Celiac disease is a gluten intolerance enteropathy caused by a permanent intolerance to gluten and specifically to its protein fragment known as gliadin. The ingestion of this protein in people with genetic predisposition induces a severe compromise to the intestinal mucosa that is historically characterized by one hyperplasia of cryptas with total or subtotal atrophy of the intestinal microvilli.
    Though the definitive diagnosis of the celiac disease is based in characteristic histological changes observed in intestinal biopsies, the serological...


    Jefferson Adams
    What Are the Most Common Vitamin Deficiencies in Celiac Disease Patients?
    Celiac.com 05/11/2015 - Many people with celiac disease know that gluten exposure can cause gut damage and trouble absorbing some vitamins and minerals, which can lead to serious deficiencies. However, even celiac who follow gluten-free diets may experience similar issues, including impaired vitamin and mineral absorption.
    The most common vitamin and mineral deficiencies in celiac patients include the following vitamins and minerals:
    B vitamins, especially B12 Vitamin A Vitamin D Vitamin E Vitamin K Iron Calcium Carotene Copper Folic acid Magnesium Selenium Zinc As a result, patients with celiac disease can develop iron-deficiency anemia, including a type that resists oral iron supplementation...


  • Recent Activity

    1. - sh00148 replied to sh00148's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      21

      Vomiting - celiac or constipation

    2. - Wheatwacked replied to sh00148's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      21

      Vomiting - celiac or constipation

    3. - Scott Adams replied to Jack Common's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      How many grams is there in one slice of wheat bread?

    4. - Jack Common replied to Jack Common's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      How many grams is there in one slice of wheat bread?

    5. - Scott Adams replied to Barcino's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      2

      Antibodies went up


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      126,399
    • Most Online (within 30 mins)
      7,748

    amiamoramiaint
    Newest Member
    amiamoramiaint
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.4k

  • Celiac.com Sponsor (A22):




  • Who's Online (See full list)

    • There are no registered users currently online

  • Celiac.com Sponsor (A21):



  • Popular Now

    • disneyfamilyfive
      4
    • Jtestani
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...