Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Record is Archived

    This article is now archived and is closed to further replies.

    Jefferson Adams
    Jefferson Adams

    Is There A Connection Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease?

    Reviewed and edited by a celiac disease expert.

    Celiac.com 05/16/2016 - A number of epidemiological and clinical studies suggest a connection between inflammation and Alzheimer disease, their relationship is not well understood and may have implications for treatment and prevention strategies.

    A research team recently set out to figure out if a subset of genes involved with increased risk of inflammation are also associated with increased risk for Alzheimer disease. The research team included JS Yokoyama, Y Wang, AJ Schork, WK Thompson, CM Karch, C Cruchaga, LK McEvoy, A Witoelar, CH Chen, D Holland, JB Brewer, A Franke, WP Dillon, DM Wilson, P Mukherjee, CP Hess, Z Miller, LW Bonham, J Shen, GD Rabinovici, HJ Rosen, BL Miller, BT Hyman, GD Schellenberg, TH Karlsen, OA Andreassen, AM Dale, RS Desikan; and the Alzheimer’s Disease Neuroimaging Initiative.

    Celiac.com Sponsor (A12):
    They are variously affiliated with the Departments of Neurosciences, Cognitive Sciences, Psychiatry, and Radiology at the University of California, San Diego, La Jolla, the Departments of Neurology, Radiology and Biomedical Imaging at the University of California, San Francisco, the Department of Psychiatry, Washington University, St Louis, Missouri, the Division of Mental Health and Addiction, Oslo University Hospital, the Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, the Division of Gastroenterology, and the Norwegian PSC Research Center and KG Jebsen Inflammation Research Centre, Research Institute of Internal Medicine, Division of Cancer Medicine, Surgery and Transplantation at Oslo University Hospital Rikshospitalet, Oslo, Norway, the Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany, the Department of Neurology, Massachusetts General Hospital, Boston, and the Department of Pathology and Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine, Philadelphia.

    Using data from numerous genome-wide association studies from several clinical research centers, the team conducted a genetic epidemiology study in July 2015, in which they systematically investigated genetic overlap between Alzheimer disease (International Genomics of Alzheimer's Project stage 1) and Crohn's disease, ulcerative colitis, rheumatoid arthritis, type 1 diabetes, celiac disease, and psoriasis.

    The team assessed P values and odds ratios from genome-wide association studies of more than 100, 000 individuals from previous comparisons of patients vs respective control groups. They used consensus criteria to confirm diagnosis for each disorder previously made in the parent study. The main outcome was the pleiotropic (conjunction) false discovery rate P value.

    Follow-up for candidate variants included neuritic plaque and neurofibrillary tangle pathology; longitudinal Alzheimer's Disease Assessment Scale cognitive subscale scores as a measure of cognitive dysfunction (Alzheimer's Disease Neuroimaging Initiative); and gene expression in Alzheimer disease vs control brains (Gene Expression Omnibus data).

    These findings confirm genetic overlap between Alzheimer disease and immune-mediated diseases, and suggest that immune system processes influence Alzheimer disease pathogenesis and progression.

    For more detail, and exact data results, see Open Original Shared Link



    User Feedback

    Recommended Comments

    Guest Ryan

    Posted

    The diagnosis of Alzheimer's disease did not exist before the introduction of RoundUp in our American wheat crops (aka GMO crops, aka Monsanto). I have wondered for years if gluten was the reason my celiacs had me so deathly ill for so long, or if it could be this pesticide/herbicide used in our crops. I have my answer now: As it turns out my girlfriend and i have been eating a wheat product from Europe once a month for two years with no reaction. Couple that with the fact that i actually taste a Raid like taste in my mouth when i do eat gluten/American wheat. This RoundUp is the cause of inflammation in our bodies, leading to autism, migraines, and Alzheimer's. If you have celiac to boot, you are basically the opposite of an 'iron stomach' and you have auto immune issues. The constant toll of ingesting a poison like RoundUp wears down the immune system and can have devastating effects, as studies have already linked "gluten" to cancer. Knowledge is power. Eat healthy, live healthy.

    Link to comment
    Share on other sites
    Guest Sarah

    Posted

    The diagnosis of Alzheimer's disease did not exist before the introduction of RoundUp in our American wheat crops (aka GMO crops, aka Monsanto). I have wondered for years if gluten was the reason my celiacs had me so deathly ill for so long, or if it could be this pesticide/herbicide used in our crops. I have my answer now: As it turns out my girlfriend and i have been eating a wheat product from Europe once a month for two years with no reaction. Couple that with the fact that i actually taste a Raid like taste in my mouth when i do eat gluten/American wheat. This RoundUp is the cause of inflammation in our bodies, leading to autism, migraines, and Alzheimer's. If you have celiac to boot, you are basically the opposite of an 'iron stomach' and you have auto immune issues. The constant toll of ingesting a poison like RoundUp wears down the immune system and can have devastating effects, as studies have already linked "gluten" to cancer. Knowledge is power. Eat healthy, live healthy.

    Please stop spreading misinformation. You have no scientific evidence for these statements. If you do, please provide them. Peer reviewed if possible.

    Link to comment
    Share on other sites
    Guest admin

    Posted

    Please stop spreading misinformation. You have no scientific evidence for these statements. If you do, please provide them. Peer reviewed if possible.

    Hmmm...we are simply summarizing a scientific study here that was published in a peer reviewed scientific journal (JAMA). If you have a problem with their results, I recommend that you contact JAMA and asked the scientists who published it why they accepted it for publication: JAMA Neurol. 2016 Apr 18. doi: 10.1001/jamaneurol.2016.0150.

    Link to comment
    Share on other sites
    Guest Sarah

    Posted

    Hmmm...we are simply summarizing a scientific study here that was published in a peer reviewed scientific journal (JAMA). If you have a problem with their results, I recommend that you contact JAMA and asked the scientists who published it why they accepted it for publication: JAMA Neurol. 2016 Apr 18. doi: 10.1001/jamaneurol.2016.0150.

    I thought your article was a fine summary of the JAMA article.

    Link to comment
    Share on other sites
    Guest Linda

    Posted

    Hmmm, maybe Sarah was responding to Ryan's statements.....

    Link to comment
    Share on other sites
    Guest Sarah

    Posted

    Hmmm, maybe Sarah was responding to Ryan's statements.....

    It's true! I was!

    Link to comment
    Share on other sites
    Guest Annie

    Posted

    Please do not listen to Ryan!

     

    Celiac disease is just as common in many European countries as in US. The prevalence is between 1-2%. I am a European celiac and I got sick from eating European grain products. Round up is used in European Union as well.

     

    Besides, if Ryan really has celiac he's harming himself every time he ingests gluten no matter the origin. He may not get symptoms but the damage to his intestines is real.

    Link to comment
    Share on other sites


    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Are People with Celiac Disease At Risk for Dementia?
    People with celiac disease frequently report cognitive symptoms when they are exposed to gluten, and clinicians have documented cognitive deficits in some patients with newly diagnosed celiac disease. A team of researchers recently set out to determine whether patients with celiac disease have an increased risk of dementia.
    The research team included Benjamin Lebwohl, José A. Luchsinger, Daniel E. Freedberg, Peter H.R. Green, and Jonas F. Ludvigsson. They are variously affiliated with the Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA; the Department of Medical Epidemiology and Biostatistics, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; the Department of Medicine, Columbia University ...


    Jefferson Adams
    Celiac.com 02/01/2016 - Among celiac researchers, there's been a good deal of professional curiosity about the clinical and immunological relevance of anti-neuronal antibodies in celiac disease with neurological manifestations. At present, doctors don't know very much about the clinical and immunological features in celiac disease patients with neurological problems, and many of them want to know more.
    Researchers estimate that about 10% of celiac disease patients have neurological issues, with the majority of those suffering from anti-neuronal antibodies (NA) to central nervous system (CNS) and/or anti-neuronal antibodies to the enteric nervous system (ENS). With that in mind, the question of the importance of such antibodies in celiac patients with neurological problems becomes important...


    Jefferson Adams
    Celiac.com 02/08/2016 - When doctors talk about non-celiac gluten sensitivity (NCGS), they are usually talking about people who have gastrointestinal symptoms without enteropathy, and for whom a gluten-free diet (GFD) provides some relief of symptoms.
    However, doctors don't currently know very much about the pathophysiology of NCGS, its connection to neurological manifestations, or if it is in any way different from the manifestations seen in patients celiac disease. To address this issue, a team of researchers recently set out to take a closer look at the clinical and immunological characteristics of patients presenting with neurological manifestations with celiac disease and those with NCGS.
    The research team included Marios Hadjivassiliou, Dasappaiah G Rao, Richard A Grìnewald,...


  • Recent Activity

    1. - Scott Adams replied to Jack Common's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      How many grams is there in one slice of wheat bread?

    2. - Jack Common replied to Jack Common's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      How many grams is there in one slice of wheat bread?

    3. - Scott Adams replied to Barcino's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      2

      Antibodies went up

    4. - Scott Adams replied to Jack Common's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      How many grams is there in one slice of wheat bread?

    5. - Scott Adams replied to Kathleen JJ's topic in Traveling with Celiac Disease
      1

      Ski trip with Celiac son - preparation advice please


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      126,378
    • Most Online (within 30 mins)
      7,748

    Kelvin Chola
    Newest Member
    Kelvin Chola
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.4k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • disneyfamilyfive
      4
    • BoiseNic
      10
    • Jtestani
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...