Celiac.com 12/03/2018 - Biomarkers in blood samples are not effective indicators for diagnosis or monitoring of celiac disease. A team of researchers recently set out to assess biomarkers of celiac disease derived from neoepitopes of deamidated gliadin peptides (DGP) and tTG fragments, and to assess their usefulness in identifying patients with celiac disease with mucosal healing.
The research team included RS Choung, SK Rostamkolaei, JM Ju, EV Marietta, CT Van Dyke, JJ Rajasekaran, V Jayaraman, T Wang, K Bei, KE Rajasekaran, K Krishna, HK Krishnamurthy, and JA Murray. They are variously affiliated with the Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA; Vibrant Sciences LLC, San Carlos, CA, USA; and with the Division of Gastroenterology and Hepatology,...

Celiac.com 12/09/2019 - When humans eat food, we also introduce bacteria, fungi, and viruses into our gut. Here on Earth, the epithelial cells that line the gut usually work to prevent these microorganisms from crossing into our blood stream. However, little is known about how microgravity effects epithelial barrier function.
Some previous studies have shown that microgravity weakens the human immune system and increases entero-pathogen virulence. To get a better understanding of the problem, a team of researchers set out to see if microgravity changes intestinal epithelial permeability, and susceptibility, to barrier-disrupting agents.
A research team led by a biomedical scientist at the University of California, Riverside, has found that simulated microgravity, such as that...

Celiac.com 06/16/2021 - Weeks after SARS-CoV-2 infection or exposure, some children develop a severe, life-threatening illness called Multisystem Inflammatory Syndrome in Children (MIS-C). A new study offers hope for diagnosis, treatment and prevention of MIS-C. Gastrointestinal symptoms are common in MIS-C patients and severe hyperinflammatory response ensues with potential for cardiac complications. The cause of MIS-C has not previously been identified. A team of researchers recently set out to learn more about diagnosing, treating, and preventing MIS-C.
The research team analyzed specimens from 19 children with MIS-C, 26 with acute COVID-19, and 55 control subjects and assessed stool samples for SARS-CoV-2 by RT-PCR, and plasma samples for markers of breakdown of mucosal barrier ...

12/25/2023 - For those navigating the intricate landscape of celiac disease, early detection is often the key to managing the condition effectively. A recent study delves into the fascinating realm of zonulin, offering insights that could revolutionize how we identify the onset of celiac disease autoimmunity in at-risk children.
The research, spanning the years 2014 to 2022 and involving 102 children from the CDGEMM study, aimed to unravel the mystery of whether changes in intestinal permeability, specifically marked by zonulin, precede the development of celiac disease. The study included 51 cases of celiac disease autoimmunity and matched controls, all of whom consumed gluten for a minimum of 12 months.
The findings were striking. Children who eventually developed celiac...