0
jhol

Any Uk People Joined Celiac Uk

Rate this topic

Recommended Posts

joined about 2 weeks ago,

 

 it took me abt 3 weeks to figure out how to join- i am a bit crap on computers though!) only joined for the food directory that you get. im finding it a bit odd. there doesnt seem to be a designated forum like on here and the "meeting room" they have( that doesnt belong to celiac uk) just seems to be questions about food. is that it - or have i just not found the correct place???

 

the other thing is - in the book it said that tesco,s own brand crunchy nut cornflakes are ok to eat. but it says contains barley malt in the indredients. ive had them twice now for breakfast and an hour later had to go to the loo!!  is barley malt considered safe - i thought it wasnt- but i could be wrong!

 

now i dont know if i should be using the book or not , any opinions welcome thanks :)  

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


Hi jhol, Ive joined but like you find its difficult to use and its in need of a forum. The only thing Ive used it for is to try and find a local group so Ill be attending a first meeting at the weekend. They seem pretty friendly on the phone and well organised but really need a forum ..but maybe its me whos not used it properly !

Sorry I have no idea about the barley malt...I assumed it was a no-no but its still all new to me.

Share this post


Link to post
Share on other sites

Similar experience here. I got the directory, which is good, but discovered I needed a whole food diet anyway so eating naturally gluten-free. I like the magazine for research info. I agree they need an accessible forum. The helpline was useful at the start.

I do find them to be accepting of some things I have found different advice on elsewhere, I struggle with the 20ppm thing. It is a shame they get funded by food companies so much, but maybe the need for advertising makes that inevitable.

I kind of think of my subscription as more of a charity donation.

Share this post


Link to post
Share on other sites

when i joined it was free - till may i think . i,ll probably pay for the first year and see how it goes. not sure about this barley malt thing- not happy with it, so back to my very expensive small pack of organic cornflakes lol.

Share this post


Link to post
Share on other sites
Ads by Google:


Hi VeggieGal,

Yes, I'm a member of Coeliac UK too. I joined approx. 2 years ago. I wondered why they don't have a forum like on here. It seems odd for them not to have one, perhaps we should suggest it(?)

You are right about barley not being suitable for Coeliacs. Is it just their own 'regular' cornflakes? Or is it in the 'free from' isle? I only buy cereal if it's marked as gluten & wheat free, it's far safer as it won't be produced in an area where wheat & gluten produce are present.

joined about 2 weeks ago,

 

 it took me abt 3 weeks to figure out how to join- i am a bit crap on computers though!) only joined for the food directory that you get. im finding it a bit odd. there doesnt seem to be a designated forum like on here and the "meeting room" they have( that doesnt belong to celiac uk) just seems to be questions about food. is that it - or have i just not found the correct place???

 

the other thing is - in the book it said that tesco,s own brand crunchy nut cornflakes are ok to eat. but it says contains barley malt in the indredients. ive had them twice now for breakfast and an hour later had to go to the loo!!  is barley malt considered safe - i thought it wasnt- but i could be wrong!

 

now i dont know if i should be using the book or not , any opinions welcome thanks :)  

Share this post


Link to post
Share on other sites

By the way folks, membership for Coeliac UK is only free for the first six months and you need to have been diagnosed with Coeliacs disease in order to be a member. After that you need to pay per year. I think it's worth it though as you get to access other areas of the website that non-members can't, you also get up-to-date lists of gluten free foods in UK. Also, the money will also help with research.

Share this post


Link to post
Share on other sites

Hi flowerqueen,

Although I'm a free member (think i only got 4 months free) I can't say Ive used them apart from getting in touch with the local sheffield group. Ive found this site so good, quick and supportive so maybe i've just not given coeliac uk a chance yet.

Share this post


Link to post
Share on other sites

hi, 

 

there is a forum of sorts kind of connected to the site. i only found it by googling celiac uk forum - one of the sites that came up said useful links celiac uk. it brings up a page ,scroll down til u find the message board. dont know why they,ve made it so difficult to find. ive found though its mainly food based with people telling you that theyve found a bargain in aldi and such like!!!! very occasionally will someone ask a personal question!!- but thats british people for you lol god knows what they,d make of some of the threads on here ha!

 

hi flower queen. the book says most of the supermarkets own brand cereals are ok to eat even though they all contain barley malt- ive gone back to the cereal in the free from aisle.

i joined and im not celiac - i put on the questionnaire that i was gluten intolerant. having said that i was told that someone from the nearest group would be in touch - they havent. so dont know if its because im not diagnosed or if its coz im a "free member" up to yet .maybe im being a softie and should just contact them..

Share this post


Link to post
Share on other sites

Hi! Coeliac Uk is definitely good for some things. I like this forum though, as there always seems to be someone that knows something extra and usually there's someone around to reply to your questions.

Hi flowerqueen,

Although I'm a free member (think i only got 4 months free) I can't say Ive used them apart from getting in touch with the local sheffield group. Ive found this site so good, quick and supportive so maybe i've just not given coeliac uk a chance yet.

Share this post


Link to post
Share on other sites


Ads by Google:


I'm very surprised that it says it's suitable if it contains barley. If you look in the front of the directory it tells you that you must not eat it. I certainly wouldn't be prepared to risk it.

I don't think the website is manned as often as other websites. I sent them an email about something and they didn't get back to me and I'm a full member :(

Thanks for info. I will scroll down next time I visit the site to see where the forum is. I do like this one though!

hi, 

 

there is a forum of sorts kind of connected to the site. i only found it by googling celiac uk forum - one of the sites that came up said useful links celiac uk. it brings up a page ,scroll down til u find the message board. dont know why they,ve made it so difficult to find. ive found though its mainly food based with people telling you that theyve found a bargain in aldi and such like!!!! very occasionally will someone ask a personal question!!- but thats british people for you lol god knows what they,d make of some of the threads on here ha!

 

hi flower queen. the book says most of the supermarkets own brand cereals are ok to eat even though they all contain barley malt- ive gone back to the cereal in the free from aisle.

i joined and im not celiac - i put on the questionnaire that i was gluten intolerant. having said that i was told that someone from the nearest group would be in touch - they havent. so dont know if its because im not diagnosed or if its coz im a "free member" up to yet .maybe im being a softie and should just contact them..

Share this post


Link to post
Share on other sites

Yes, I joined Coeliac UK a few weeks ago.  I was so chuffed to receive the Welcome pack, I didn't really read the details of signing up as I wanted to access a part of the site only available to members.  So as I said I was chuffed to receive the Food & Drink Directory.  They sent me a Crossed Grain magazine this week, too.  Which has been a god send; as I have been home sick this week with severe tiredness, I think due to Iron deficiency (awaitng results from full blood test).

 

As for moving around the site and the forum bit, it is a bit confusing, but they say there will be a revamp of the site soon.

 

On another note Juvela sent me two loaves of bread.  Again that was a total surprise. :D

 

Off to the Coeliac Food Fair in Salisbury today B) (I'll added the details if that is ok?) :)

 

The South Wiltshire Food Fair is taking place on Saturday 29 June from 10.30am to 3pm at:

Southern Counties Auction Rooms
Salisbury Livestock Market
Salisbury Road
Netherhampton
Salisbury
SP2 8RH

For more information on this and other Local Group events, visit http://bit.ly/cukevents or email the Local Group at southwilts@coeliac.org.uk.

Share this post


Link to post
Share on other sites

Hi

I'm on coeliac uk too. Directory would be useful if I was able to eat processed food! I think coeliac UK is really behind on up to date information although obviously it's better than nothing. I'm like CM and see my membership as more of a donation/ support. I never really use the website much unless its UK food related.

Share this post


Link to post
Share on other sites

I must say I was not impressed with the Food Fair.  It was all cakes, biscuits and cereals.

 

One stall asked me to sample their bread, but did not know what was in it (dried milk powder, when I checked)  it had Country Life butter on it.  Being Lactose Intolerant, I thought I would give it a miss. :rolleyes:

 

And on top of that; the restaurant did not have gluten-free sandwiches or soya milk so I couldn't even have a cup of tea :( .

 

The one and only time I stupidly thought I could eat out and be safe...stupid, stupid, stupid (bangs head against wall).

Share this post


Link to post
Share on other sites

I must say I was not impressed with the Food Fair.  It was all cakes, biscuits and cereals.

 

One stall asked me to sample their bread, but did not know what was in it (dried milk powder, when I checked)  it had Country Life butter on it.  Being Lactose Intolerant, I thought I would give it a miss. :rolleyes:

 

And on top of that; the restaurant did not have gluten-free sandwiches or soya milk so I couldn't even have a cup of tea :( .

 

The one and only time I stupidly thought I could eat out and be safe...stupid, stupid, stupid (bangs head against wall).

 hi , 

i havent been to the site for a while, may have a look later on.the fair doesnt sound good - if you cant get gluten free at a celiac fair where can you get it?? i cant do dairy either or potato-which is in  nearly all gluten free goods.its plain wholefoods for me .

Share this post


Link to post
Share on other sites

 hi , 

i havent been to the site for a while, may have a look later on.the fair doesnt sound good - if you cant get gluten free at a celiac fair where can you get it?? i cant do dairy either or potato-which is in  nearly all gluten free goods.its plain wholefoods for me .

lol,  yes starch for me too.   I registered with Juvela, they have sent me a couple of loaves of bread and today I received a starter pack.  Which I think is really nice, I know they are promoting their products, but I still think it's nice.

Share this post


Link to post
Share on other sites

Hi I joined - I'm in Yorkshire in the UK  :)

 

I was diagnosed 8 months ago whilst I was away in NZ.  I also can't eat dairy or soya which is giving me a bit of trouble finding things.  I've just come back from being overseas so getting used to the UK supermarket choices (I ate gluten-containing foods before).  Shame about the food fair - how silly for them not to have allergen free foods in the coffee shop!!

 

Heather

Share this post


Link to post
Share on other sites

Hi heather.....welcome!

I'm from yorkshire (sheffield) and nearly 8 months into it too. Ive let my membership lapse on coeliac uk, its ok but this site has been far more valuable to me since diagnosis but I may join it again at some point. Yes I'm the same, and had to cut out dairy and soya, but there is alternatives but its finding out what works best for you. All the best . Helen

Share this post


Link to post
Share on other sites

I just had their latest magazine, and they are shortly launching an app version of their book listing gluten-free products. I quite like that idea, and it means it will be kept up to date, hopefully.

If only we could pesuade them to break it down to avoid dairy and soy, we'd be sorted :)

Share this post


Link to post
Share on other sites

Yes definately cmw! To be honest, I've got their food directory but have never used it...what do you think to it? I've 'liked' their facebook page but they recently gave questionable info about what they class as gluten free beer and my dietician said they were promoting kelloggs rice krispies as gluten-free but as far as I can tell they're not suitable ?!? Maybe I should read it and see for myself lol

Share this post


Link to post
Share on other sites


Ads by Google:


 hi , 

i havent been to the site for a while, may have a look later on.the fair doesnt sound good - if you cant get gluten free at a celiac fair where can you get it?? i cant do dairy either or potato-which is in  nearly all gluten free goods.its plain wholefoods for me .

 

The situation for those of us with fewer allergies is perhaps worse. Our most common options are packed with sugar and starch, which lead happy consumers down the path to diabetes.

Share this post


Link to post
Share on other sites

This thread is also old but I would like to contribute and corroborate the fact that coeliac uk are very behind with their information- and often inaccurate with respect to foods one can use which in other parts of world are taken to be dangerous for celiacs. They've launched their new website , but I haven't had a chance to study it in detail yet, I hope it has improved.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
0

  • Who's Online   18 Members, 0 Anonymous, 1,065 Guests (See full list)

  • Top Posters +

  • Recent Articles

    Jefferson Adams
    Celiac.com 06/18/2018 - Celiac disease has been mainly associated with Caucasian populations in Northern Europe, and their descendants in other countries, but new scientific evidence is beginning to challenge that view. Still, the exact global prevalence of celiac disease remains unknown.  To get better data on that issue, a team of researchers recently conducted a comprehensive review and meta-analysis to get a reasonably accurate estimate the global prevalence of celiac disease. 
    The research team included P Singh, A Arora, TA Strand, DA Leffler, C Catassi, PH Green, CP Kelly, V Ahuja, and GK Makharia. They are variously affiliated with the Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Lady Hardinge Medical College, New Delhi, India; Innlandet Hospital Trust, Lillehammer, Norway; Centre for International Health, University of Bergen, Bergen, Norway; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Gastroenterology Research and Development, Takeda Pharmaceuticals Inc, Cambridge, MA; Department of Pediatrics, Università Politecnica delle Marche, Ancona, Italy; Department of Medicine, Columbia University Medical Center, New York, New York; USA Celiac Disease Center, Columbia University Medical Center, New York, New York; and the Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.
    For their review, the team searched Medline, PubMed, and EMBASE for the keywords ‘celiac disease,’ ‘celiac,’ ‘tissue transglutaminase antibody,’ ‘anti-endomysium antibody,’ ‘endomysial antibody,’ and ‘prevalence’ for studies published from January 1991 through March 2016. 
    The team cross-referenced each article with the words ‘Asia,’ ‘Europe,’ ‘Africa,’ ‘South America,’ ‘North America,’ and ‘Australia.’ They defined celiac diagnosis based on European Society of Pediatric Gastroenterology, Hepatology, and Nutrition guidelines. The team used 96 articles of 3,843 articles in their final analysis.
    Overall global prevalence of celiac disease was 1.4% in 275,818 individuals, based on positive blood tests for anti-tissue transglutaminase and/or anti-endomysial antibodies. The pooled global prevalence of biopsy-confirmed celiac disease was 0.7% in 138,792 individuals. That means that numerous people with celiac disease potentially remain undiagnosed.
    Rates of celiac disease were 0.4% in South America, 0.5% in Africa and North America, 0.6% in Asia, and 0.8% in Europe and Oceania; the prevalence was 0.6% in female vs 0.4% males. Celiac disease was significantly more common in children than adults.
    This systematic review and meta-analysis showed celiac disease to be reported worldwide. Blood test data shows celiac disease rate of 1.4%, while biopsy data shows 0.7%. The prevalence of celiac disease varies with sex, age, and location. 
    This review demonstrates a need for more comprehensive population-based studies of celiac disease in numerous countries.  The 1.4% rate indicates that there are 91.2 million people worldwide with celiac disease, and 3.9 million are in the U.S.A.
    Source:
    Clin Gastroenterol Hepatol. 2018 Jun;16(6):823-836.e2. doi: 10.1016/j.cgh.2017.06.037.

    Jefferson Adams
    Celiac.com 06/16/2018 - Summer is the time for chips and salsa. This fresh salsa recipe relies on cabbage, yes, cabbage, as a secret ingredient. The cabbage brings a delicious flavor and helps the salsa hold together nicely for scooping with your favorite chips. The result is a fresh, tasty salsa that goes great with guacamole.
    Ingredients:
    3 cups ripe fresh tomatoes, diced 1 cup shredded green cabbage ½ cup diced yellow onion ¼ cup chopped fresh cilantro 1 jalapeno, seeded 1 Serrano pepper, seeded 2 tablespoons lemon juice 2 tablespoons red wine vinegar 2 garlic cloves, minced salt to taste black pepper, to taste Directions:
    Purée all ingredients together in a blender.
    Cover and refrigerate for at least 1 hour. 
    Adjust seasoning with salt and pepper, as desired. 
    Serve is a bowl with tortilla chips and guacamole.

    Dr. Ron Hoggan, Ed.D.
    Celiac.com 06/15/2018 - There seems to be widespread agreement in the published medical research reports that stuttering is driven by abnormalities in the brain. Sometimes these are the result of brain injuries resulting from a stroke. Other types of brain injuries can also result in stuttering. Patients with Parkinson’s disease who were treated with stimulation of the subthalamic nucleus, an area of the brain that regulates some motor functions, experienced a return or worsening of stuttering that improved when the stimulation was turned off (1). Similarly, stroke has also been reported in association with acquired stuttering (2). While there are some reports of psychological mechanisms underlying stuttering, a majority of reports seem to favor altered brain morphology and/or function as the root of stuttering (3). Reports of structural differences between the brain hemispheres that are absent in those who do not stutter are also common (4). About 5% of children stutter, beginning sometime around age 3, during the phase of speech acquisition. However, about 75% of these cases resolve without intervention, before reaching their teens (5). Some cases of aphasia, a loss of speech production or understanding, have been reported in association with damage or changes to one or more of the language centers of the brain (6). Stuttering may sometimes arise from changes or damage to these same language centers (7). Thus, many stutterers have abnormalities in the same regions of the brain similar to those seen in aphasia.
    So how, you may ask, is all this related to gluten? As a starting point, one report from the medical literature identifies a patient who developed aphasia after admission for severe diarrhea. By the time celiac disease was diagnosed, he had completely lost his faculty of speech. However, his speech and normal bowel function gradually returned after beginning a gluten free diet (8). This finding was so controversial at the time of publication (1988) that the authors chose to remain anonymous. Nonetheless, it is a valuable clue that suggests gluten as a factor in compromised speech production. At about the same time (late 1980’s) reports of connections between untreated celiac disease and seizures/epilepsy were emerging in the medical literature (9).
    With the advent of the Internet a whole new field of anecdotal information was emerging, connecting a variety of neurological symptoms to celiac disease. While many medical practitioners and researchers were casting aspersions on these assertions, a select few chose to explore such claims using scientific research designs and methods. While connections between stuttering and gluten consumption seem to have been overlooked by the medical research community, there is a rich literature on the Internet that cries out for more structured investigation of this connection. Conversely, perhaps a publication bias of the peer review process excludes work that explores this connection.
    Whatever the reason that stuttering has not been reported in the medical literature in association with gluten ingestion, a number of personal disclosures and comments suggesting a connection between gluten and stuttering can be found on the Internet. Abid Hussain, in an article about food allergy and stuttering said: “The most common food allergy prevalent in stutterers is that of gluten which has been found to aggravate the stutter” (10). Similarly, Craig Forsythe posted an article that includes five cases of self-reporting individuals who believe that their stuttering is or was connected to gluten, one of whom also experiences stuttering from foods containing yeast (11). The same site contains one report of a stutterer who has had no relief despite following a gluten free diet for 20 years (11). Another stutterer, Jay88, reports the complete disappearance of her/his stammer on a gluten free diet (12). Doubtless there are many more such anecdotes to be found on the Internet* but we have to question them, exercising more skepticism than we might when reading similar claims in a peer reviewed scientific or medical journal.
    There are many reports in such journals connecting brain and neurological ailments with gluten, so it is not much of a stretch, on that basis alone, to suspect that stuttering may be a symptom of the gluten syndrome. Rodney Ford has even characterized celiac disease as an ailment that may begin through gluten-induced neurological damage (13) and Marios Hadjivassiliou and his group of neurologists and neurological investigators have devoted considerable time and effort to research that reveals gluten as an important factor in a majority of neurological diseases of unknown origin (14) which, as I have pointed out previously, includes most neurological ailments.
    My own experience with stuttering is limited. I stuttered as a child when I became nervous, upset, or self-conscious. Although I have been gluten free for many years, I haven’t noticed any impact on my inclination to stutter when upset. I don’t know if they are related, but I have also had challenges with speaking when distressed and I have noticed a substantial improvement in this area since removing gluten from my diet. Nonetheless, I have long wondered if there is a connection between gluten consumption and stuttering. Having done the research for this article, I would now encourage stutterers to try a gluten free diet for six months to see if it will reduce or eliminate their stutter. Meanwhile, I hope that some investigator out there will research this matter, publish her findings, and start the ball rolling toward getting some definitive answers to this question.
    Sources:
    1. Toft M, Dietrichs E. Aggravated stuttering following subthalamic deep brain stimulation in Parkinson’s disease--two cases. BMC Neurol. 2011 Apr 8;11:44.
    2. Tani T, Sakai Y. Stuttering after right cerebellar infarction: a case study. J Fluency Disord. 2010 Jun;35(2):141-5. Epub 2010 Mar 15.
    3. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    4. Jäncke L, Hänggi J, Steinmetz H. Morphological brain differences between adult stutterers and non-stutterers. BMC Neurol. 2004 Dec 10;4(1):23.
    5. Kell CA, Neumann K, von Kriegstein K, Posenenske C, von Gudenberg AW, Euler H, Giraud AL. How the brain repairs stuttering. Brain. 2009 Oct;132(Pt 10):2747-60. Epub 2009 Aug 26.
    6. Galantucci S, Tartaglia MC, Wilson SM, Henry ML, Filippi M, Agosta F, Dronkers NF, Henry RG, Ogar JM, Miller BL, Gorno-Tempini ML. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011 Jun 11.
    7. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    8. [No authors listed] Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 43-1988. A 52-year-old man with persistent watery diarrhea and aphasia. N Engl J Med. 1988 Oct 27;319(17):1139-48
    9. Molteni N, Bardella MT, Baldassarri AR, Bianchi PA. Celiac disease associated with epilepsy and intracranial calcifications: report of two patients. Am J Gastroenterol. 1988 Sep;83(9):992-4.
    10. http://ezinearticles.com/?Food-Allergy-and-Stuttering-Link&id=1235725 
    11. http://www.craig.copperleife.com/health/stuttering_allergies.htm 
    12. https://www.celiac.com/forums/topic/73362-any-help-is-appreciated/
    13. Ford RP. The gluten syndrome: a neurological disease. Med Hypotheses. 2009 Sep;73(3):438-40. Epub 2009 Apr 29.
    14. Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. 1996 Feb 10;347(8998):369-71.

    Jefferson Adams
    Celiac.com 06/14/2018 - Refractory celiac disease type II (RCDII) is a rare complication of celiac disease that has high death rates. To diagnose RCDII, doctors identify a clonal population of phenotypically aberrant intraepithelial lymphocytes (IELs). 
    However, researchers really don’t have much data regarding the frequency and significance of clonal T cell receptor (TCR) gene rearrangements (TCR-GRs) in small bowel (SB) biopsies of patients without RCDII. Such data could provide useful comparison information for patients with RCDII, among other things.
    To that end, a research team recently set out to try to get some information about the frequency and importance of clonal T cell receptor (TCR) gene rearrangements (TCR-GRs) in small bowel (SB) biopsies of patients without RCDII. The research team included Shafinaz Hussein, Tatyana Gindin, Stephen M Lagana, Carolina Arguelles-Grande, Suneeta Krishnareddy, Bachir Alobeid, Suzanne K Lewis, Mahesh M Mansukhani, Peter H R Green, and Govind Bhagat.
    They are variously affiliated with the Department of Pathology and Cell Biology, and the Department of Medicine at the Celiac Disease Center, New York Presbyterian Hospital/Columbia University Medical Center, New York, USA. Their team analyzed results of TCR-GR analyses performed on SB biopsies at our institution over a 3-year period, which were obtained from eight active celiac disease, 172 celiac disease on gluten-free diet, 33 RCDI, and three RCDII patients and 14 patients without celiac disease. 
    Clonal TCR-GRs are not infrequent in cases lacking features of RCDII, while PCPs are frequent in all disease phases. TCR-GR results should be assessed in conjunction with immunophenotypic, histological and clinical findings for appropriate diagnosis and classification of RCD.
    The team divided the TCR-GR patterns into clonal, polyclonal and prominent clonal peaks (PCPs), and correlated these patterns with clinical and pathological features. In all, they detected clonal TCR-GR products in biopsies from 67% of patients with RCDII, 17% of patients with RCDI and 6% of patients with gluten-free diet. They found PCPs in all disease phases, but saw no significant difference in the TCR-GR patterns between the non-RCDII disease categories (p=0.39). 
    They also noted a higher frequency of surface CD3(−) IELs in cases with clonal TCR-GR, but the PCP pattern showed no associations with any clinical or pathological feature. 
    Repeat biopsy showed that the clonal or PCP pattern persisted for up to 2 years with no evidence of RCDII. The study indicates that better understanding of clonal T cell receptor gene rearrangements may help researchers improve refractory celiac diagnosis. 
    Source:
    Journal of Clinical Pathologyhttp://dx.doi.org/10.1136/jclinpath-2018-205023

    Jefferson Adams
    Celiac.com 06/13/2018 - There have been numerous reports that olmesartan, aka Benicar, seems to trigger sprue‐like enteropathy in many patients, but so far, studies have produced mixed results, and there really hasn’t been a rigorous study of the issue. A team of researchers recently set out to assess whether olmesartan is associated with a higher rate of enteropathy compared with other angiotensin II receptor blockers (ARBs).
    The research team included Y.‐H. Dong; Y. Jin; TN Tsacogianis; M He; PH Hsieh; and JJ Gagne. They are variously affiliated with the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School in Boston, MA, USA; the Faculty of Pharmacy, School of Pharmaceutical Science at National Yang‐Ming University in Taipei, Taiwan; and the Department of Hepato‐Gastroenterology, Chi Mei Medical Center in Tainan, Taiwan.
    To get solid data on the issue, the team conducted a cohort study among ARB initiators in 5 US claims databases covering numerous health insurers. They used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for enteropathy‐related outcomes, including celiac disease, malabsorption, concomitant diagnoses of diarrhea and weight loss, and non‐infectious enteropathy. In all, they found nearly two million eligible patients. 
    They then assessed those patients and compared the results for olmesartan initiators to initiators of other ARBs after propensity score (PS) matching. They found unadjusted incidence rates of 0.82, 1.41, 1.66 and 29.20 per 1,000 person‐years for celiac disease, malabsorption, concomitant diagnoses of diarrhea and weight loss, and non‐infectious enteropathy respectively. 
    After PS matching comparing olmesartan to other ARBs, hazard ratios were 1.21 (95% CI, 1.05‐1.40), 1.00 (95% CI, 0.88‐1.13), 1.22 (95% CI, 1.10‐1.36) and 1.04 (95% CI, 1.01‐1.07) for each outcome. Patients aged 65 years and older showed greater hazard ratios for celiac disease, as did patients receiving treatment for more than 1 year, and patients receiving higher cumulative olmesartan doses.
    This is the first comprehensive multi‐database study to document a higher rate of enteropathy in olmesartan initiators as compared to initiators of other ARBs, though absolute rates were low for both groups.
    Source:
    Alimentary Pharmacology & Therapeutics