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jsm

High IGA levels?

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Hi everyone, I just got results from my "Celiac Serology (IGA) with Reflex Testing" blood test, and I'm not sure how to interpret the results. Obviously I'll listen to my doctor, but given the holiday I don't expect to hear from her for a few days. 

The test I received has a normal IGA range of 70-400 mg/dL, and I got 433 mg/dL. Is this high normal, or a sign of mild celiac? The test I received doesn't appear to be the gliadin IGA test, so I haven't found much info on what my results actually mean. Any advice?

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On 12/24/2015 at 3:39 PM, jsm said:

Hi everyone, I just got results from my "Celiac Serology (IGA) with Reflex Testing" blood test, and I'm not sure how to interpret the results. Obviously I'll listen to my doctor, but given the holiday I don't expect to hear from her for a few days. 

The test I received has a normal IGA range of 70-400 mg/dL, and I got 433 mg/dL. Is this high normal, or a sign of mild celiac? The test I received doesn't appear to be the gliadin IGA test, so I haven't found much info on what my results actually mean. Any advice?

The testing that was done is for the Total Iga.....or so it would appear to me.  This needs to be included on the test panel because it measures how much IgA your body makes and if you have a below normal range, it can skew the IgA testing on a Celiac panel. Anyone who is IgA deficient, and this can happen, cannot use the blood panel for testing.  You cannot test what you don't make enough of.

This does not seem to be your problem, though.  My experience was that elevated total Iga levels can mean Celiac Disease.  Although this test is not diagnostic for the disease, mine was extremely high at around 800 when diagnosed and since going gluten-free nearly 11 years ago, my levels are always much lower......around the 200-300 mark. I think if you have actual Celiac, it is going to raise your antibody levels, which in turn drive up total IgA numbers.  Not something you see mentioned in literature but that was my experience.

They really need to do a full panel and that can be difficult to obtain, I know.

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