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Zonulin *might Have Spelled That Wrong*

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So, what's you're take on the research into the role zonulin plays in creating autoimmunity? I have a very low grasp on the issue and am looking for *hope* and information. Is the research into zonulin a good starting point towards a cure??? It sounds good to me, but I'm not well versed yet. Looking for insight from those who "get it" better than I do right now.

I'm not really sure I understand how it's going to be that helpful. It's supposed to keep the "junctions" between cells in the gut "tight" so that molecules don't get through to the bloodstream that shouldn't. That means gluten and gluten antibodies won't get into the blood stream - which is good, of course - but it doesn't mean that the reaction that damages the villi won't occur. It doesn't seem to be the big deal people seem to be making out of it for celiac (possibly for t1 diabetes, though), but I may be misinformed on something about it.

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I have wondered the same thing, if I've been missing something. Maybe we aren't!

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I don't fully understand it either, but the drug that is being worked on by Alba Therapeutics w/Dr. Fassano is related to zonulin....so it must be important! I would be interested in more info, also.

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And don't we "cure" the leaky gut by going gluten free? I know my son's dullness subsided 100% 4days gluten free. I thought going gluten free closed up the gaps?

From what I recall, celiacs and t1 diabetics generally produce too much zonulin in general, but it would primarily be, it seems, for instances when you accidentally get gluten, so that it doesn't further increase zonulin production and get out into the bloodstream. That's what I recall anyway. Hopefully the press releases on the studies will be a bit more descriptive in the future.

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