Hi @herminia I am not sure reading your post if you are actually consuming gluten still, or are tempted to do so, but if the former, that's what is most likely causing your worsening pain. If you aren't consuming gluten, you may find that the Omeprazole is actually causing issues by causing low stomach acid as @knitty kitty suggests. You may well be able to gradually wean yourself off Omeprazole.   There are quite a few discussions on this and other forums on how to do this.  As you reduce your dosage, I would also recommend eating a reflux or gastritis diet,  so avoiding spicy food, caffeine, citrus, alcohol etc for a while, eating small regular meals, not eating or drinking for 2-3 hours before you go to bed, allowing your stomach to rest overnight properly, using a wedge pillow if you suffer from reflux.  Unless of course you have a medical condition, such as Barrett's Esophagus, for which I understand you do need to take PPIs long term. Cristiana

I had similar issues. My stomach was so bloated I was totally uncomfortable. I would wake up ok but first time I ate anything it was like I was 9 months pregnant. I felt tenderness everywhere in my abdomen and like you seemed to be always constipated. They did ultra sounds and said everything ok you are just constipated. I knew it had to be more. Took 2 years but after reading up on all my symptoms which got worse I decided to stop gluten. Within 2 weeks felt better. After 2 months if I mistakenly ate something with gluten I got violently ill. Finally got in to see good Gastrointerologist and although the test results were not 100 conclusive since I was gluten free 5 months already, he did other tests and endoscopy. Results Celiac. Has been 1 year gluten free and I realized last week I have had no bloating for last few weeks. Takes a while to get better for sure. I also hair loss (low iron), low sodium and bunch of other issues to work on from Celiac. I am still off dairy, oats even gluten free oats, and take Iron, B12 and Calcium which you have to stagger to not adversely impact iron absorption. However it is well worth it. GOOD LUCK and keep pushing the docs, it is your health.

@herminia, Welcome to the forum! Omeprazole is only supposed to be taken for a few weeks!  Omeprazole can cause villus  damage to the small intestine by itself.  Shame on your doctors for letting you be on it for years!  Shame on your doctors for not taking an interest in your worsening symptoms!  Omeprazole is a temporary fix, a bandaid, not a cure! Omeprazole is prescribed for Gerd, to lower stomach acid, but Gerd is a symptom of low stomach acid in the first place.  Taking Niacin and Thiamine and the other B vitamins will increase stomach acid normally.  Magnesium or calcium can be taken after meals to help, too. Omeprazole can affect vitamin and mineral absorption.  Thiamine, Vitamin B 1, can used to prevent nausea.  A combination of Thiamine, Cobalamine B12, and Pyridoxine B6 can be taken for pain without side effects. Have you been checked for nutritional deficiencies?  

@Sammy Web, PPI's like Omeprazole suppresses your ability to produce antibodies to gluten.  So if you had the tests done while you were taking Omeprazole, the tests won't be accurate.   Omeprazole will cause villus damage.  Not all the damage in Celiac is visible to the naked eye, especially in the early stages.  Damage to the intestines can be microscopic.  Were biopsies taken to look for microscopic changes?  You would be wise to stay off the Omeprazole, redo the gluten challenge and get tested again.   The Impact of Acid Suppression Medications and Non-steroidal Anti-Inflammatory Drugs on Clinical and Histologic Features in Celiac Disease https://pmc.ncbi.nlm.nih.gov/articles/PMC5511753/ "PPI/H2RA users comprised 12% of seropositive patients, compared to 55% of seronegative patients (p<0.01)." "PPI/H2RA use was associated with seronegative celiac disease."

herminia, Omeprazole may mask some of the symptoms of celiac disease but it will not prevent the damage being done to the villous lining of your small bowel that defines the disease. You seem not to be taking that very seriously.