Positive Deaminated Gliadin IGA & DQ2 but...

[heyitsmissa]

Hey guys. I have a lengthy history of autoimmune issues with official diagnoses of lupus, endometriosis, adenomyosis, and Reynauds. During the decade-long adventure of getting those labels, I also saw a GI on and off for relevant symptoms. 

I had labs drawn in 2012, early 2016 and mid-2016, and the results were always the same -- 

The entire panel was negative except for my Deaminated Gliadin IGA. The reference range was 0-19: negative, 20-30: weak positive, 31+:strong positive. My values were 61, 48, and 51. My DQ2 is also positive. Well here we are 7 years after those last tests were run and I have had a YEAR, yall. So much joint pain and inflammation. Intense, relentless fatigue. Bloating. Constipation sometimes, diarrhea other times. 

I am having these values tested again tomorrow, and that's fine and all, but I'm curious if these labs should've been monitored a bit more closely over time? I suppose we'll find out tomorrow. Hard to imagine those antibodies being strongly positive for no good reason. But I also know it's not the typical lab workup for a diagnosis. 

I suppose I don't have a question- just would like to know if anyone's had a similar history but gone on to have a confirmed diagnosis later on? 

[knitty kitty]

@heyitsmissa,

Did you ever get an endoscopy with several biopsy samples taken from the small intestine? 

Have you been eating gluten all this time???!!!???  

Why didn't they diagnose Celiac based on your previous tests? 

Are you taking any medications?

I'm thinking vitamin deficiencies.  

Vitamin D deficiency 

Vitamin D status in endometriosis: a systematic review and meta-analysis

"Conclusions: Women with endometriosis had lower vitamin D status when compared with controls, and a negative relationship between vitamin D levels and severity of endometriosis was observed. In addition, hypovitaminosis D was a potential risk factor for endometriosis."

https://pubmed.ncbi.nlm.nih.gov/32430755/

And...Celiacs often have the MTHFR mutation and need methylated forms of vitamins...

The frequency of Raynaud’s phenomenon in patients with methylenetetrahydrofolate reductase gene mutation and hyperhomocysteinemia

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018243/

And pain relief can be just a vitamin away....

Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review

https://pubmed.ncbi.nlm.nih.gov/35156556/

 

You should ask your doctor to check for vitamin and mineral deficiencies before starting supplementing.  

 

[Scott Adams]

More info about the blood tests are below, but you definitely could have celiac disease, and an endoscopy should have been done. At the very least it sounds like you have non-celiac gluten sensitivity, but more testing is needed to figure this out.