Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Do we have some data on serum marker correlation with symptoms?


heyitsme

Recommended Posts

heyitsme Apprentice

Personally for example TTG IgA has zero correlation with my symptoms. It's been negative for a long time (even despite eating tiny amounts of gluten, which I know isin't the case for everyone) yet I have still persisting, debilitating symptom (specifically brain fog - and let's just assume it's because of celiac. I'm tired of people suggesting alternative explanations when I'm not even asking for it). We also know that a lot of people need to take "gluten challenge" for their antibodies to be elevated. I guess vast majority actually from what I read. So TTG IgA need proper amount of gluten, but occurence of symptoms does not. The correlation is weak, if any. So I wonder about other serum markers, specifically anti DGP gliadin IgG, which seems to still be positive in my case. Or others. Is there any research on that? Do you have any experiences?


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



Scott Adams Grand Master

Currently this is in the research phase, but zonulin levels may one day be a way to measure a gluten reaction:

 

Scott Adams Grand Master

Another marker in the research stage is cytokine levels.

 

 

heyitsme Apprentice

@Scott Adams Yes, I recently found some article on that: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697360/

There is nice table with all of the markers and cytokines are also there. I found the lab that checks some cytokines, IL8 and IL1b among others which apparently might be useful with celiacs. Will be doing the test next week.

Scott Adams Grand Master

Before doing the test you may want to ask the lab whether or not you need to eat gluten before the test is done. I'm not sure what the protocol would be for such a test.

knitty kitty Grand Master

@heyitsme,

Anemia, diabetes and Thiamine deficiency will cause poor production of tTg IgA antibodies.  

Have you had a Total IgA test done?

DGP IgG antibodies are still produced with these conditions.  

Some of us are seronegative.  

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      127,962
    • Most Online (within 30 mins)
      7,748

    Tiannuo
    Newest Member
    Tiannuo
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121k
    • Total Posts
      70.5k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • Pasballard
      I have Celiacs and want you to be aware of the amount of weight you can potentially put on if you rely on gluten free snacks, bread etc.,they  are high in carbs.  I put on 25 lbs in a short amount of time.  Whole Foods are the best way to go but I struggle with this.  The cost of gluten free is also a problem.  I love black licorice but most have gluten.  My favorite chili seasoning as well.  The list is endless.  I take  Advil liquid gels and had no idea until I read this.  I hope you do better than I have done.  I feel I am destined to suffer daily no matter what.  My aunt didn’t take care of herself and died from complications.  I hope you can get on a good routine.
    • growlinhard1
      Thank you, I appreciate the response. I'm going to begin the gluten free diet and wait for the biopsy results. I feel fairly certain that it's the right thing for my well being. I will keep you posted.
    • Scott Adams
      The flu vaccine is indeed not 100% effective every year, as its effectiveness varies depending on how well the vaccine strains match the circulating flu viruses. However, even in years when the match is less than perfect, the flu vaccine still provides significant benefits. Studies consistently show that vaccinated individuals who contract the flu often experience milder symptoms, a lower risk of complications, and a reduced likelihood of hospitalization or death compared to those who are unvaccinated. For high-risk groups, such as the elderly, young children, and individuals with chronic health conditions, the flu vaccine remains a critical tool for reducing severe outcomes. Regarding the mention of risks associated with vaccines, it’s important to note that the flu vaccine is generally very safe for most people. Serious side effects are extremely rare, and the benefits of vaccination far outweigh the risks for the vast majority of individuals. If someone has specific concerns about vaccine safety due to medical conditions or allergies, they should consult their healthcare provider to discuss their options. As for alternative measures like a D Lamp (ultraviolet light disinfection), while these can be useful for reducing pathogens in the environment, they are not a substitute for vaccination. The flu virus spreads primarily through respiratory droplets, and personal protection measures like hand hygiene, masking, and improving indoor ventilation can complement vaccination but cannot replace its targeted immune protection.
    • trents
      Because you have already had the "gold standard" test done, and because you have some experiential evidence that removing gluten from your diet causes you to feel better, it would make sense to begin the gluten-free diet as you wait for biopsy results.
    • growlinhard1
      I wasn't given any blood tests. I think I should try the gluten free diet because when I cut it out a few weeks ago for just a couple of days, I know I started feeling better. The difference was actually pretty dramatic. When I learned gluten free eating may cause false negative biopsy results, I went back to gluten full force and feel like you know what × 10. Do you feel it would be okay since the gold standard for diagnosis is behind me or should I wait for biopsy results? In your opinion, of course. I know you can't offer me medical advice.
×
×
  • Create New...