Celiac.com Sponsor (A1):


Join eNewsletter


Celiac.com Sponsor (A1-m):



Join eNewsletter

Archived

This topic is now archived and is closed to further replies.

DrMom

New Rx Drug For Celiac

Recommended Posts

Enzyme Could Help Celiac Disease Patients Tolerate Gluten

Barley-based compound may prevent allergic inflammation, researchers say

WEDNESDAY, June 28 (HealthDay News) -- Patients with celiac disease have to carefully monitor their diet to avoid consuming gluten, a ubiquitous protein found in whole grains.

Now, researchers say a newly discovered enzyme may prevent an allergic reaction in celiac patients who have accidentally consumed gluten.

Gluten causes an inflammatory reaction that can lead to significant intestinal damage in people suffering from celiac disease. The damage prevents the intestine from properly absorbing nutrients from food. Avoiding gluten in the diet prevents this damage, but the risk of accidentally ingesting gluten remains high.

However, researchers at Stanford University say they've identified an enzyme called EP-B2 that successfully digested gluten in an acidic environment similar to that of a human stomach. The enzyme even broke down the elements of the protein associated with causing the inflammatory reactions in celiac patients.

"Non-dietary therapies that allow celiac patients to safely incorporate low-to-moderate levels of gluten into their daily diet would be of considerable benefit," study author Dr. Chaitan Khosla, of Stanford University and the Celiac Sprue Research Foundation, said in a prepared statement. "Having demonstrated earlier that certain types of enzymes can detoxify gluten, our laboratory set out to devise an optimal oral enzyme therapy for celiac sprue by borrowing from nature," Khosla said.

"In germinating barley seed, gluten serves as a nutritious storage protein that is efficiently digested by enzymes. One enzyme, EP-B2, plays a crucial role in this process by breaking gluten proteins after glutamine residues, which comprise one-third of all amino acid residues in gluten," Khosla added.

Khosla's team used a combination of EP-B2 and PEP, another enzyme known to digest gluten. The two enzymes together broke down and detoxified gluten within 10 minutes. Neither was effective when used alone.

"Our results suggest that recombinant EP-B2 should be effective as supportive therapy to help celiacs cope with the 'hidden' gluten in everyday life, and that a two-enzyme cocktail containing PEP and EP-B2 may even allow celiacs to resume a more normal diet in the future," concluded Khosla.

Results from the study are reported in the June issue of Chemistry and Biology.


Dx celiac sprue 06-06-06

Prometheus Labs in California, blood work

AGA IgG=negative AGA IgA=negative

TTG IgA=positive EMA IgA=positive

Endoscopy shows moderate to severe villa blunting

severe asthma, COPD

right Bundle Branch Block (heart conduction)

short PR interval (heart)

Arnold Chiari Malformation

Irritable Bowel Syndrome

Fibromyalgia, Myofascial pain syndrome

GERD

Osteoporosis, osteoarthritis

Severe claustrophobia

Gallbladder removed

When someone you love becomes a memory,

that memory becomes a treasure.

Share this post


Link to post
Share on other sites

Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8):


I would love to have some of that!


Celiac Sprue

Multiple Food Allergies

Diagnosed June 2006

Stopped Eating June 2007

IV Nutrition: 6/27/07 - Present

Share this post


Link to post
Share on other sites

I sure hope that's true. Not that I'd go back to full fledged gluten eating, but if it would protect against the accidental glutenings I would be thrilled!


gluten-free since Oct 1996

Share this post


Link to post
Share on other sites

And that is what it is designed to do, use it after accidentally being glutened.


Dx celiac sprue 06-06-06

Prometheus Labs in California, blood work

AGA IgG=negative AGA IgA=negative

TTG IgA=positive EMA IgA=positive

Endoscopy shows moderate to severe villa blunting

severe asthma, COPD

right Bundle Branch Block (heart conduction)

short PR interval (heart)

Arnold Chiari Malformation

Irritable Bowel Syndrome

Fibromyalgia, Myofascial pain syndrome

GERD

Osteoporosis, osteoarthritis

Severe claustrophobia

Gallbladder removed

When someone you love becomes a memory,

that memory becomes a treasure.

Share this post


Link to post
Share on other sites

It would be good if you could take it every day as a preventative measure.


Celiac Sprue

Multiple Food Allergies

Diagnosed June 2006

Stopped Eating June 2007

IV Nutrition: 6/27/07 - Present

Share this post


Link to post
Share on other sites