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fisherl6

High Igg Levels/negative Everything Else

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i have just started reading this board and it has been very helpful so far. I just got some labwork back, my gliadin IGG level was 48, where >30 is a strong positve, my IgA levels were negative as well as TTG. I saw some post saying that a elevated IgG level could be related to other things, can anyone elaborate on that.?

My history is I am 24, I have been feeling fatigued/moody/brain foggy for the last few years, after seeing a few different doctors, i finally got a thryoid panel and found out I have a Hashimatos disease (autoimmune thyroid problem causing hypothyroidism). They medicine has made me feel a lot better with the moodiness and constant weight gain, but I still have pretty bad bouts of fatigue (at least for someone who used to be very active). Also I have always had a "bad stomach" (bouts of diarehhia, cramping constant bloating, soreness in my lower abdomen), so I finally went to see a GI doctor, after deciding I probably just had mild IBS, i asked him to get an autoimmune panel since I have heard people with one autoimmune problem tend to have others. Anyway, I just got the labs back, I am not sure what all of the test performed are (Endomysial AB, Transglutaminase IGA, and Gliadin Antibodies) but the only high value is the Gliadin IgG. The other thing is I have a kind of low wheat intake already, maybe a piece of bread a day, but mostly protein and veggies and I have noticed that makes me feel better.

Sorry for the long posting, just wondering if anyone had any similar experiences and maybe someone could explain the IGG better. Thanks

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My only non-negative test was anti-reticulin IgG. I too have heard that elevated IgG's can be related to "other things" but have still never found any actual "things" that it is related to. (I've looked... nothing...) The low gluten consumption could affect your test results, and unless you plan to get a biopsy, I can only suggest going completely off gluten for a while, and - if you're feeling brave - do a dietary challenge (have some pasta - not bread since it has other things you could react to) and see how it goes.

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I have the same problem. My gliadin IgG is 52.0 (ref 0-10) but everything else is normal. I have terrible GI symptoms as well as fatigue and moodiness. Plus there's a family history of celiac disease. I can't find any other condition linked to levels like these either. I have an appointment with my doctor in two days, so if I find anything further, I'll update, but I read a study that said about 20% of celiac disease cases are shown to be IgA deficient, so we could just be a part of that lucky percentage.

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I also was diagnosed by IgG and positive response to the diet. I later found out I had one of the genes as well (HLA DQ8).

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