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I am new to this board as I have mostly been in the baking and cooking section. Quick intro...My Husband is diagnosed with celiac and has been gluten-free for 1 1/2 years. His brother, 2 sisters, 2 nieces and a nephew also have celiac. We have 5 children, 4 daughters ages 12,8,5,3 and a son who is 9 months. We have had all of the kids tested except for the baby and no one has had positive blood work. I question whether or not some of them have issues with gluten however because of specific behavioral symptoms that have been mentioned here. My 5 year old daughter gets severe headaches, is tiny for her age (33 lbs) and is a terror. I never realized the extent of it until she started kindergarten this year and when I was filling out a "get to know you" form the teacher sent home, I found that the only things I wrote about were how to deal with her mood swings, anger, lack of cooperation, etc. I had a really hard time thinking of positive things to write about her. It was really sad. As I read some of these threads today I am thinking that I will definitely try her on a gluten-free diet to see how it affects her moods. Anyway, I am actually concerned about my 12 year old. I was hoping someone would have some similar experiences and could help me. She has had issues with wetting the bed since she was about 5 years old. She went through a period of about 2 years when she was completely dry at night but then she started to wet the bed again. We have looked for physical issues (none), psychological issues(none) and have simply decided that it will hopefully be something she will eventually outgrow. Currently the longest period of time that she can go without being wet at night is 1 week. Her daytime dryness is fine and we have tried timers and alarms and all of those devices. She also gets frequent bladder infections. Sometimes as often as every 2-3 months. We think those are linked to constipation which is also an issue. In short, as I have been learning and reading about celiac, it occurred to me that maybe the constipation is a symptom of celiac and possibly if she went on a gluten-free diet it would clear up and that would help to eliminate the bedwetting. Am I stretching? Do I have celiac on the brain? Anybody else with experience with this? We have done all of the usual physical tests to ensure her bladder and kidneys are normal-they were all fine. The only thing that has given us a measure of success is waking her up in the middle of the night to try to retrain her bladder. This does not always work though. If anyone has any type of experience with this, please share! Thank you!

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I am new to this board as I have mostly been in the baking and cooking section. Quick intro...My Husband is diagnosed with celiac and has been gluten-free for 1 1/2 years. His brother, 2 sisters, 2 nieces and a nephew also have celiac. We have 5 children, 4 daughters ages 12,8,5,3 and a son who is 9 months. We have had all of the kids tested except for the baby and no one has had positive blood work. I question whether or not some of them have issues with gluten however because of specific behavioral symptoms that have been mentioned here. My 5 year old daughter gets severe headaches, is tiny for her age (33 lbs) and is a terror. I never realized the extent of it until she started kindergarten this year and when I was filling out a "get to know you" form the teacher sent home, I found that the only things I wrote about were how to deal with her mood swings, anger, lack of cooperation, etc. I had a really hard time thinking of positive things to write about her. It was really sad. As I read some of these threads today I am thinking that I will definitely try her on a gluten-free diet to see how it affects her moods. Anyway, I am actually concerned about my 12 year old. I was hoping someone would have some similar experiences and could help me. She has had issues with wetting the bed since she was about 5 years old. She went through a period of about 2 years when she was completely dry at night but then she started to wet the bed again. We have looked for physical issues (none), psychological issues(none) and have simply decided that it will hopefully be something she will eventually outgrow. Currently the longest period of time that she can go without being wet at night is 1 week. Her daytime dryness is fine and we have tried timers and alarms and all of those devices. She also gets frequent bladder infections. Sometimes as often as every 2-3 months. We think those are linked to constipation which is also an issue. In short, as I have been learning and reading about celiac, it occurred to me that maybe the constipation is a symptom of celiac and possibly if she went on a gluten-free diet it would clear up and that would help to eliminate the bedwetting. Am I stretching? Do I have celiac on the brain? Anybody else with experience with this? We have done all of the usual physical tests to ensure her bladder and kidneys are normal-they were all fine. The only thing that has given us a measure of success is waking her up in the middle of the night to try to retrain her bladder. This does not always work though. If anyone has any type of experience with this, please share! Thank you!

Wow, you have your hands full!

First off, frequent bladder infections can be and often are caused by a short uretha (sp). Some females are just born with it and it can be inherited. I was having frequent bladder infections to the point where my doctor gave me antibiotics to keep in the fridge (we live out of town). Then he came up with the idea that Vitamin C suppliments would help.

So, he started me on 1000 units, time release a day, after a couple of months I was pretty much free of infections and only had two the first year. I am now down to 500 units, time release a day and keep it pretty much under control. This would be a reason for bed wetting, as you get frequent bladder muscle spasms with an infection.

I hope your daughter is soon rid of the infections. They really are awful to deal with.

On the other children. You don't say where you are from, however some people in the US are getting Genetic testing done so see if they carry the Celiac genes. Sometimes the regular Celiac pannel is not accurate until the disease actually kicks in big time. But the symptoms you describe, including behaviour is certainly possible for Celiac. I don't think the genetic testing is available in Canada yet through the health system.

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my son wet his bed almost every night, we were told it was common in boys, he'd outgrow it ...blah blah.

Then he was diagnosed celiac at age 10 yrs and within weeks of going gluten free, he stopped bedwetting. I came to understand from other parents that celiac and bedwetting can go together...

there are other causes of bedwetting but this was our experience with it.

Sandy

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my son wet his bed almost every night, we were told it was common ion biys, he's outgrow...blah blah.

Then he was diagnosed celiac at age 10 yrs and within weeks of going gluten free, he stopped bedwetting. I came to understand from other parents that celiac and bedwetting can go together...

there are other cause of bedwetting but this was our experience with it.

Sandy

That would be a dream come true for my 10 year old daughter. She hates wetting the bed. I have been changing the sheets every night and reluctantly she agreed to go back to wearing Good Nites. I feel terrible for her and I'm affraid it's going to start to affect her self esteem. Here's our story...briefly...

Thomas (8) diagnosed w/ apthous stomatitis, lactose intolerance (hydrogen breath test), double DQ2, acid reflux, positve celiac bloodwork and currently on a gluten challenge to prepare for biopsy

Haley (10) diagnosed w/ Hypothyroid, joint pain, allergies, acid reflux but Celiac blood work was negative

Our GP reccommends scoping Haley for sure if Thomas' biopsy is positive regardless of her negative bloodwork. She would be estatic to get rid of the bedwetting. We are seeing Dr. Guandalini on January 31st at the Chicago Celiac Research Center. I am going to have her read this thread because sometimes she feels so alone and that no one else has this problem. I would love to hear if anyone else has had experience w/ going gluten free and getting rid of bed wetting.

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PS Our family practice doctor has Celiac himself and he said that just because the bloodwork is negative doesn't mean they don't for surely have it. From what I understand, you can catch it sooner when biopsied. Also, some biopsy proven Celiacs never had positive bloodwork because they were IGA deficient.

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I do live in the US, so the tests are available. I am of the school of thought that if the cure if the kids are positively diagnosed is the diet then why not at least try the diet to see if it helps before doing a biopsy or additional testing. We are also self employed so it wouldn't hurt to keep an official diagnoses off of the medical records either. I remembered as I was reading these responses that I had an outpatient surgery when I was in 2nd grade to stretch my urethra. I also used to get frequent bladder infections as a child but did not have a problem with bed wetting. I had almost forgotten about that surgery. I suggested to my daughter today that the whole family go on the diet and she was not very excited about the idea. Even if we just do it for a month, I need to see if it affects any of the issues we are dealing with. I'm glad there are others who feel there may be a link between celiac and bed wetting. My husband's family is actually involved in a celiac research study through the University of Utah and the University of California at Irvine. Everyone has had blood work done and some with positive blood work have also had biopsy done. Both my MIL and my FIL cary one of the celiac genes. I have not called the study people to get the gene info for our family but I guess I should. Thanks for everyones input.

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Hi!

Just a couple of thoughts - my daughter was never, ever dry at night and we figured that she was just taking her time although her twin brother was immediately dry at night even though he potty trained a little later. Camryn was also VERY constipated and never really presented with any other symptoms of celiac. Before she was diagnosed, the pediatrician suggested that the constipation could lead to lack of bladder control due to the amount of pressure on the bladder from the full bowels.

Anyway, as she became sicker and sicker with type 1 diabetes the bed wetting (and insatiable thirst) became progressively worse until we figured out what was wrong (that was only a matter of a couple of weeks). I am not even suggesting diabetes as that is not at all subtle and you would certainly notice other issues such as massive fatigue, weightloss and a painful, unquenchable thirst (if she does have any of those syptoms, get her to a dr. immediately). Once we got Camryn started on insulin and onto a gluten free diet the night wetting, and the constipation went away. I don't know what caused what but just thought I would pass it along.

I hope you find some answers - I too am of the school of thought that trying the diet can't hurt. I also understand about resistance, I am trying to convince my non-celiac son to go gluten free (at home) for the sake of his sister and it isn't going over well at all. Good luck!

B.

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You may not have heard of Elimination Communication/Natural Infant Hygeine/Infant Potty Training, but practicing this gentle method of early toilet learning was one of the things that tipped me off to my 11-mo.-old's gluten sensitivity. Basically, when she consumes gluten she wets her pants a lot and sometimes looks completely surprised when it occurs (even when she doesn't signal me that she has to go, there is usually a change in her posture, facial expression, activity, etc. whne she does). I know now that a gluten exposure means we go from 1-3 wet pants a day (our current range) to 5-12. From mothers on an EC list, I have heard that the same often happens with other food sensitivities. Someone theorized that if it's throwing off the gut, it may also affect muscles in the pelvic floor. Make sense? Anyway, I recommend investigating diet for any child that has incontinence issues--it's worked for us, and given us other benefits I hadn't expected!

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Your daughter sounds very like my daughter. One thing I think is important to realize is that there may never be an official diagnosis of Celiac. There are so many people that have gluten sensitivity or intolerance that will never be diagnoses. The only real way to see if you are affected negatively by gluten is to go on the diet. You have to be vigilant and go for a while. I would suggest a full month. I tried the diet on my daughter but gave up after 2 weeks. But I tried again and after 3 weeks there was significant impovement.

My daughter, like yours, has experience severe constipation from 2 years on. She is 8 now and a couple months ago lost almost all control over her bladder. The doctor says this is because having a bowel movement is so painful they refuse to release the bladder because that also relaxes the sphincter. They would rather just leak their urine than go. I have had my daughter on the gluten free diet since July. Her back pain went away almost immediately however the constipation has not relented. We even checked out Tetherd Cord Syndrome because constipation, back pain, and bladder control problems are typical of this. I am not trying lactose free, gluten free. I haven't been able to commit to such a strict diet for such a small girl but she's not getting better fast enough for me. If they are undiagnosed for a while I read that they may never be able to process dairy again.

My husband and my son are also gluten-sensitive. So my whole family is on the diet. I want to have another baby and its important to be gluten free during pregnancy and breastfeeding if gluten problems run in your family.

Don't give up. It's hard and frustrating and doctors think you are crazy. I have had to change pediatricians numerous times because they give up on my child. You are really her only advocate. And most medical doctors are not trained in nutrition and won't listen if they can't do a test.

Good Luck. If you find anything useful, let me know.

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my sister has been struggling with this same issue with her 6 year old son. she took him off all dairy and it went away within a day or so. her doctor completely said they are unrelated--but she found articles and it is obvious that it was dairy. just another idea if it doesnt go away after trying gluten-free.

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I am new to this board as I have mostly been in the baking and cooking section. Quick intro...My Husband is diagnosed with celiac and has been gluten-free for 1 1/2 years. His brother, 2 sisters, 2 nieces and a nephew also have celiac. We have 5 children, 4 daughters ages 12,8,5,3 and a son who is 9 months. We have had all of the kids tested except for the baby and no one has had positive blood work. I question whether or not some of them have issues with gluten however because of specific behavioral symptoms that have been mentioned here. My 5 year old daughter gets severe headaches, is tiny for her age (33 lbs) and is a terror. I never realized the extent of it until she started kindergarten this year and when I was filling out a "get to know you" form the teacher sent home, I found that the only things I wrote about were how to deal with her mood swings, anger, lack of cooperation, etc. I had a really hard time thinking of positive things to write about her. It was really sad. As I read some of these threads today I am thinking that I will definitely try her on a gluten-free diet to see how it affects her moods. Anyway, I am actually concerned about my 12 year old. I was hoping someone would have some similar experiences and could help me. She has had issues with wetting the bed since she was about 5 years old. She went through a period of about 2 years when she was completely dry at night but then she started to wet the bed again. We have looked for physical issues (none), psychological issues(none) and have simply decided that it will hopefully be something she will eventually outgrow. Currently the longest period of time that she can go without being wet at night is 1 week. Her daytime dryness is fine and we have tried timers and alarms and all of those devices. She also gets frequent bladder infections. Sometimes as often as every 2-3 months. We think those are linked to constipation which is also an issue. In short, as I have been learning and reading about celiac, it occurred to me that maybe the constipation is a symptom of celiac and possibly if she went on a gluten-free diet it would clear up and that would help to eliminate the bedwetting. Am I stretching? Do I have celiac on the brain? Anybody else with experience with this? We have done all of the usual physical tests to ensure her bladder and kidneys are normal-they were all fine. The only thing that has given us a measure of success is waking her up in the middle of the night to try to retrain her bladder. This does not always work though. If anyone has any type of experience with this, please share! Thank you!

I have a 12 year old also who has been bedwetting since 4 years old. He also has Eczema and has had alot of cavities compared to my other 4kids (who have had none). Researching Celiac disease for myself (I have a looong list of symptoms), mademe start thinking he may have it too and could it be the cause for all his symptoms? Nothing has worked for him either, not even medication.

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Considering the family history, it is likely that gluten is the culprit behind all that you've been experiencing with your children. Though they may not be thrilled with the prospect of going gluten-free, they may be surprised at how well they do on the diet. I'd definitely give it a shot.

As a side note, I would recommend also supplementing with D-Mannose for the child that is getting frequent bladder infections. It quite often stops the infection in its tracks. Generally it takes about 10 minutes to start working. http://www.associatedcontent.com/article/3461/dmannose_the_natural_cure_for_bladder.html

My daughter is sensitive to a lot of foods and chemicals/medications. The D-Mannose has been wonderful to have when we've dealt with bladder infections. Our doctor was seriously impressed that the bladder infection cleared up so quickly (the first infection we had him dx the infection and then went back in to make sure it was gone). And our daughter was just happy the pain went away almost immediately.

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    Jefferson Adams
    Celiac.com 06/18/2018 - Celiac disease has been mainly associated with Caucasian populations in Northern Europe, and their descendants in other countries, but new scientific evidence is beginning to challenge that view. Still, the exact global prevalence of celiac disease remains unknown.  To get better data on that issue, a team of researchers recently conducted a comprehensive review and meta-analysis to get a reasonably accurate estimate the global prevalence of celiac disease. 
    The research team included P Singh, A Arora, TA Strand, DA Leffler, C Catassi, PH Green, CP Kelly, V Ahuja, and GK Makharia. They are variously affiliated with the Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Lady Hardinge Medical College, New Delhi, India; Innlandet Hospital Trust, Lillehammer, Norway; Centre for International Health, University of Bergen, Bergen, Norway; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Gastroenterology Research and Development, Takeda Pharmaceuticals Inc, Cambridge, MA; Department of Pediatrics, Università Politecnica delle Marche, Ancona, Italy; Department of Medicine, Columbia University Medical Center, New York, New York; USA Celiac Disease Center, Columbia University Medical Center, New York, New York; and the Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.
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    Jefferson Adams
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    Dr. Ron Hoggan, Ed.D.
    Celiac.com 06/15/2018 - There seems to be widespread agreement in the published medical research reports that stuttering is driven by abnormalities in the brain. Sometimes these are the result of brain injuries resulting from a stroke. Other types of brain injuries can also result in stuttering. Patients with Parkinson’s disease who were treated with stimulation of the subthalamic nucleus, an area of the brain that regulates some motor functions, experienced a return or worsening of stuttering that improved when the stimulation was turned off (1). Similarly, stroke has also been reported in association with acquired stuttering (2). While there are some reports of psychological mechanisms underlying stuttering, a majority of reports seem to favor altered brain morphology and/or function as the root of stuttering (3). Reports of structural differences between the brain hemispheres that are absent in those who do not stutter are also common (4). About 5% of children stutter, beginning sometime around age 3, during the phase of speech acquisition. However, about 75% of these cases resolve without intervention, before reaching their teens (5). Some cases of aphasia, a loss of speech production or understanding, have been reported in association with damage or changes to one or more of the language centers of the brain (6). Stuttering may sometimes arise from changes or damage to these same language centers (7). Thus, many stutterers have abnormalities in the same regions of the brain similar to those seen in aphasia.
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    There are many reports in such journals connecting brain and neurological ailments with gluten, so it is not much of a stretch, on that basis alone, to suspect that stuttering may be a symptom of the gluten syndrome. Rodney Ford has even characterized celiac disease as an ailment that may begin through gluten-induced neurological damage (13) and Marios Hadjivassiliou and his group of neurologists and neurological investigators have devoted considerable time and effort to research that reveals gluten as an important factor in a majority of neurological diseases of unknown origin (14) which, as I have pointed out previously, includes most neurological ailments.
    My own experience with stuttering is limited. I stuttered as a child when I became nervous, upset, or self-conscious. Although I have been gluten free for many years, I haven’t noticed any impact on my inclination to stutter when upset. I don’t know if they are related, but I have also had challenges with speaking when distressed and I have noticed a substantial improvement in this area since removing gluten from my diet. Nonetheless, I have long wondered if there is a connection between gluten consumption and stuttering. Having done the research for this article, I would now encourage stutterers to try a gluten free diet for six months to see if it will reduce or eliminate their stutter. Meanwhile, I hope that some investigator out there will research this matter, publish her findings, and start the ball rolling toward getting some definitive answers to this question.
    Sources:
    1. Toft M, Dietrichs E. Aggravated stuttering following subthalamic deep brain stimulation in Parkinson’s disease--two cases. BMC Neurol. 2011 Apr 8;11:44.
    2. Tani T, Sakai Y. Stuttering after right cerebellar infarction: a case study. J Fluency Disord. 2010 Jun;35(2):141-5. Epub 2010 Mar 15.
    3. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    4. Jäncke L, Hänggi J, Steinmetz H. Morphological brain differences between adult stutterers and non-stutterers. BMC Neurol. 2004 Dec 10;4(1):23.
    5. Kell CA, Neumann K, von Kriegstein K, Posenenske C, von Gudenberg AW, Euler H, Giraud AL. How the brain repairs stuttering. Brain. 2009 Oct;132(Pt 10):2747-60. Epub 2009 Aug 26.
    6. Galantucci S, Tartaglia MC, Wilson SM, Henry ML, Filippi M, Agosta F, Dronkers NF, Henry RG, Ogar JM, Miller BL, Gorno-Tempini ML. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011 Jun 11.
    7. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    8. [No authors listed] Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 43-1988. A 52-year-old man with persistent watery diarrhea and aphasia. N Engl J Med. 1988 Oct 27;319(17):1139-48
    9. Molteni N, Bardella MT, Baldassarri AR, Bianchi PA. Celiac disease associated with epilepsy and intracranial calcifications: report of two patients. Am J Gastroenterol. 1988 Sep;83(9):992-4.
    10. http://ezinearticles.com/?Food-Allergy-and-Stuttering-Link&id=1235725 
    11. http://www.craig.copperleife.com/health/stuttering_allergies.htm 
    12. https://www.celiac.com/forums/topic/73362-any-help-is-appreciated/
    13. Ford RP. The gluten syndrome: a neurological disease. Med Hypotheses. 2009 Sep;73(3):438-40. Epub 2009 Apr 29.
    14. Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. 1996 Feb 10;347(8998):369-71.

    Jefferson Adams
    Celiac.com 06/14/2018 - Refractory celiac disease type II (RCDII) is a rare complication of celiac disease that has high death rates. To diagnose RCDII, doctors identify a clonal population of phenotypically aberrant intraepithelial lymphocytes (IELs). 
    However, researchers really don’t have much data regarding the frequency and significance of clonal T cell receptor (TCR) gene rearrangements (TCR-GRs) in small bowel (SB) biopsies of patients without RCDII. Such data could provide useful comparison information for patients with RCDII, among other things.
    To that end, a research team recently set out to try to get some information about the frequency and importance of clonal T cell receptor (TCR) gene rearrangements (TCR-GRs) in small bowel (SB) biopsies of patients without RCDII. The research team included Shafinaz Hussein, Tatyana Gindin, Stephen M Lagana, Carolina Arguelles-Grande, Suneeta Krishnareddy, Bachir Alobeid, Suzanne K Lewis, Mahesh M Mansukhani, Peter H R Green, and Govind Bhagat.
    They are variously affiliated with the Department of Pathology and Cell Biology, and the Department of Medicine at the Celiac Disease Center, New York Presbyterian Hospital/Columbia University Medical Center, New York, USA. Their team analyzed results of TCR-GR analyses performed on SB biopsies at our institution over a 3-year period, which were obtained from eight active celiac disease, 172 celiac disease on gluten-free diet, 33 RCDI, and three RCDII patients and 14 patients without celiac disease. 
    Clonal TCR-GRs are not infrequent in cases lacking features of RCDII, while PCPs are frequent in all disease phases. TCR-GR results should be assessed in conjunction with immunophenotypic, histological and clinical findings for appropriate diagnosis and classification of RCD.
    The team divided the TCR-GR patterns into clonal, polyclonal and prominent clonal peaks (PCPs), and correlated these patterns with clinical and pathological features. In all, they detected clonal TCR-GR products in biopsies from 67% of patients with RCDII, 17% of patients with RCDI and 6% of patients with gluten-free diet. They found PCPs in all disease phases, but saw no significant difference in the TCR-GR patterns between the non-RCDII disease categories (p=0.39). 
    They also noted a higher frequency of surface CD3(−) IELs in cases with clonal TCR-GR, but the PCP pattern showed no associations with any clinical or pathological feature. 
    Repeat biopsy showed that the clonal or PCP pattern persisted for up to 2 years with no evidence of RCDII. The study indicates that better understanding of clonal T cell receptor gene rearrangements may help researchers improve refractory celiac diagnosis. 
    Source:
    Journal of Clinical Pathologyhttp://dx.doi.org/10.1136/jclinpath-2018-205023

    Jefferson Adams
    Celiac.com 06/13/2018 - There have been numerous reports that olmesartan, aka Benicar, seems to trigger sprue‐like enteropathy in many patients, but so far, studies have produced mixed results, and there really hasn’t been a rigorous study of the issue. A team of researchers recently set out to assess whether olmesartan is associated with a higher rate of enteropathy compared with other angiotensin II receptor blockers (ARBs).
    The research team included Y.‐H. Dong; Y. Jin; TN Tsacogianis; M He; PH Hsieh; and JJ Gagne. They are variously affiliated with the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School in Boston, MA, USA; the Faculty of Pharmacy, School of Pharmaceutical Science at National Yang‐Ming University in Taipei, Taiwan; and the Department of Hepato‐Gastroenterology, Chi Mei Medical Center in Tainan, Taiwan.
    To get solid data on the issue, the team conducted a cohort study among ARB initiators in 5 US claims databases covering numerous health insurers. They used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for enteropathy‐related outcomes, including celiac disease, malabsorption, concomitant diagnoses of diarrhea and weight loss, and non‐infectious enteropathy. In all, they found nearly two million eligible patients. 
    They then assessed those patients and compared the results for olmesartan initiators to initiators of other ARBs after propensity score (PS) matching. They found unadjusted incidence rates of 0.82, 1.41, 1.66 and 29.20 per 1,000 person‐years for celiac disease, malabsorption, concomitant diagnoses of diarrhea and weight loss, and non‐infectious enteropathy respectively. 
    After PS matching comparing olmesartan to other ARBs, hazard ratios were 1.21 (95% CI, 1.05‐1.40), 1.00 (95% CI, 0.88‐1.13), 1.22 (95% CI, 1.10‐1.36) and 1.04 (95% CI, 1.01‐1.07) for each outcome. Patients aged 65 years and older showed greater hazard ratios for celiac disease, as did patients receiving treatment for more than 1 year, and patients receiving higher cumulative olmesartan doses.
    This is the first comprehensive multi‐database study to document a higher rate of enteropathy in olmesartan initiators as compared to initiators of other ARBs, though absolute rates were low for both groups.
    Source:
    Alimentary Pharmacology & Therapeutics