Celiac.com Sponsor (A1):


Join eNewsletter


Celiac.com Sponsor (A1-m):



Join eNewsletter

Archived

This topic is now archived and is closed to further replies.

JennyC

I Found A Great Article Regarding The Molecular Mechanisms Of Celiac Disease

Recommended Posts

While doing some online research I found a great article about the molecular pathogenesis of celiac disease. As a molecular biology fanatic, it really bothered me that I couldn't get a clear picture of the molecular steps to this disease. This article really helped. It goes into GREAT DETAIL about all components of the disease. (Although it must have been written before the work on zonulin was published.) If the scientific jargon gets to be too much, then click on figure 5 and it will give you a nice and to the point summary of the disease. :)

http://www.pubmedcentral.nih.gov/articlere...i?artid=1716218


Jenny

Son 6 yrs old, Positive blood work, Outstanding dietary response, no biopsy.

Household mostly gluten free since 3/07

Me: HLA-DQ 02 & 0302 (DQ 08), which I ran & analyzed myself!Currently gluten lite, negative tTG, asymptomatic

Share this post


Link to post
Share on other sites

Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8):


Thanks for posting this. Lots of detail that I've never seen.

Nancy


The person who says it cannot be done should not interrupt the person who is doing it.

~Chinese Proverb

Share this post


Link to post
Share on other sites

Great article. Thanks. I also found the genetic tree of the grains interesting. It's interesting that rice is a shorter genetic distance to wheat (not sure whether tree is linear or logarithmic) than maize yet it seems that more people react corn than rice. It would be interesting treeing gliadin.

Share this post


Link to post
Share on other sites

jc,

My thanks also. This is very informative (not that I understand all of it). Different presentation than I've seen previously, I like it very much.

best regards, lm


gluten-free 12-18-06

colonoscopy, upper GI
blood, urine, stool tests, prometheus panel
positive endoscopy/positive duodenal biopsies (severe villous atrophy, high intraepithelial lympocytes)
diagnosed celiac disease by Gastroenterologist Andrew R. Gottesman, 12-18-06

"Sobriety sucks. That's why they invented booze in the first place." Denis Leary - Rescue Me

Beware the chocolate of Chiapa

Share this post


Link to post
Share on other sites
While doing some online research I found a great article about the molecular pathogenesis of celiac disease. As a molecular biology fanatic, it really bothered me that I couldn't get a clear picture of the molecular steps to this disease. This article really helped. It goes into GREAT DETAIL about all components of the disease. (Although it must have been written before the work on zonulin was published.) If the scientific jargon gets to be too much, then click on figure 5 and it will give you a nice and to the point summary of the disease. :)

http://www.pubmedcentral.nih.gov/articlere...i?artid=1716218

Thanks also, I need to understand in detail also.

mm&j (Susie)

Share this post


Link to post
Share on other sites