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Can Everyone Post Their Genes

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Double DQ1


McDougall diet (low fat vegan) since 6/00

Gluten free since 1/6/07

Soy free and completely casein and egg free since 2/15/07

Yeast free, on and off, since 3/1/07 -- I can't notice any difference one way or the other

Enterolab results -- 2/15/07

Fecal Antigliladin IgA 140 (Normal Range <10 units)

Fecal Antitissue Transglutaminase IgA 50 (Normal Range <10 units)

Quantitative Microscopic Fecal Fat Score 517 (Normal Range <300 units)

Fecal anti-casein (cow's milk) IgA antibody 127 (Normal Range <10 units)

HLA-DQB1 Molecular analysis, Allele 1 0501

HLA-DQB1 Molecular analysis, Allele 2 06xx

Serologic equivalent: HLA-DQ 1,1 (subtype 5,6)

Fecal anti-ovalbumin (chicken egg) IgA antibody 11 (Normal range <10 units)

Fecal Anti-Saccharomyces cerevisiae (dietary yeast) IgA 11 (Normal range <10 units)

Fecal Anti-Soy IgA 119 (Normal Range < 10 units)

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Got my diagnosis through a Biopsy so now my you have peaked my interest. How do you find out what Genes you carry? Is it a blood test?

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I found out my genes by sending swabs from the inside of my cheeks to Enterolab.


McDougall diet (low fat vegan) since 6/00

Gluten free since 1/6/07

Soy free and completely casein and egg free since 2/15/07

Yeast free, on and off, since 3/1/07 -- I can't notice any difference one way or the other

Enterolab results -- 2/15/07

Fecal Antigliladin IgA 140 (Normal Range <10 units)

Fecal Antitissue Transglutaminase IgA 50 (Normal Range <10 units)

Quantitative Microscopic Fecal Fat Score 517 (Normal Range <300 units)

Fecal anti-casein (cow's milk) IgA antibody 127 (Normal Range <10 units)

HLA-DQB1 Molecular analysis, Allele 1 0501

HLA-DQB1 Molecular analysis, Allele 2 06xx

Serologic equivalent: HLA-DQ 1,1 (subtype 5,6)

Fecal anti-ovalbumin (chicken egg) IgA antibody 11 (Normal range <10 units)

Fecal Anti-Saccharomyces cerevisiae (dietary yeast) IgA 11 (Normal range <10 units)

Fecal Anti-Soy IgA 119 (Normal Range < 10 units)

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I would really appreciate someone helping me understand these results.These are for my 6 year old son.

HLA-DQB1 Molecular analysis, Allele 1 0302

HLA-DQB1 Molecular analysis, Allele 2 0302

Serologic equivalent: HLA-DQ 3,3 (Subtype 8,8)

Interpretation Of HLA-DQ Testing: HLA gene analysis reveals that you have two copies of the main genes that predispose to gluten sensitivity and celiac sprue, HLA-DQ2 or HLA-DQ8. Having two copies of a gluten sensitive or celiac gene means that each of your parents, and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.

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I would really appreciate someone helping me understand these results.These are for my 6 year old son.

HLA-DQB1 Molecular analysis, Allele 1 0302

HLA-DQB1 Molecular analysis, Allele 2 0302

Serologic equivalent: HLA-DQ 3,3 (Subtype 8,8)

He's doubld DQ8. That means he got a DQ8 from you and your husband. If he's had a reaction to gluten then he is either on his way to becoming celiac (with diagnosable damage via biopsy) or he is celiac. My family all tested low through enterolab (between 10 and 15) but with the celiac genes we just figured it was early celiac. Enterolab can't tell you whether you have celiac, just whether you are mounting an IgA response to gluten.


Andrea

Enterolab positive results only June 06:
Me HLA-DQB1 Molecular analysis, Allele 1 0201; HLA-DQB1 Molecular analysis, Allele 2 0301; Serologic equivalent: HLA-DQ 2,3 (subtype 2, 7)
Husband HLA-DQB1 Molecular analysis, Allele 1 0201; HLA-DQB1 Molecular analysis, Allele 2 0302; Serologic equivalent: HLA-DQ 2,3 (subtype 2,8)



The whole family has been soy free since February, gluten free since June 2006.

The whole family went back to a gluten diet October 2011.  We never had official testing done and I decided to give gluten a go again.  At this point I've decided to work on making some gluten free things again, though healthwise everyone seems to be fine.  The decision to add gluten back in was also made based on other things I'd read about the 2nd sequence of genes.  It is my belief that we had a gluten intolerance, but thanks to things I've learned here, I know more what to keep an eye on.  If you have a confirmed case of celiac, please don't go back to gluten, it's a lifelong lifestyle change.

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Myself:

HLA-DQB1 Molecular analysis, Allele 1 0201

HLA-DQB1 Molecular analysis, Allele 2 0301

Serologic equivalent: HLA-DQ 2,3 (Subtype 2,7)

Husband:

HLA-DQB1 Molecular analysis, Allele 1 0302

HLA-DQB1 Molecular analysis, Allele 2 06xx

Serologic equivalent: HLA-DQ 3,1 (Subtype 8,6)

Son:

LA-DQB1 Molecular analysis, Allele 1 0201

HLA-DQB1 Molecular analysis, Allele 2 0302

Serologic equivalent: HLA-DQ 2,3 (Subtype 2,8)


Nan

-Anti Gliadin Ab IgG 39 Spring 2006, positive improvement to gluten-free diet, past possible symptoms of thyroid, miscariges, heart palpitations

-Enterolab results Anti-gliadin 8, Tissue transglut 5, Genes 2,7

-husband genes 8,6

-Son age 11 postive enterolab results, high Gliadin AB IgG. Encopresis (soiling) Genes 2,8

-Daughter age 3 Chronic Constipation, eczema, clears up on gluten-free.

-Three children no symptoms, not tested

-Mother positive in Tissue Transglut Antibody, IgA Fall 2006

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He's doubld DQ8. That means he got a DQ8 from you and your husband. If he's had a reaction to gluten then he is either on his way to becoming celiac (with diagnosable damage via biopsy) or he is celiac. My family all tested low through enterolab (between 10 and 15) but with the celiac genes we just figured it was early celiac. Enterolab can't tell you whether you have celiac, just whether you are mounting an IgA response to gluten.

my results from enterolab on the IgA response were 9, i talked to enterolab as i have DQ8,5 and she said that im on my way to testing positive if i continue to consume gluten in a year from now i probably would, since i am having a great responce to the diet the nurse told me to keep on it and never go back.


Nadine

mom of 4 great kids - 2 diagnosed with autism and 2 typical kids (thank goodness)

all this started after my hysterectomy in March of 2006

G.F. since Feb 2007

Soy free since April 2007

Blood work was negatvie (after 2 weeks of being on the gluten-free diet)

entrolab results:

Antigliadin 9 (normal <10)

HLA-DQB1 Allele 1 - 0302

HLA-DQB2 Allele 2 - 0502

HLA-DQ 3,1 (subtype 8,5)

carrying one celiac gene and one gluten intolerant gene

nurse at entrolab figures i caught this early and dont eat gluten anymore

life is like a box of chocolates;sometimes you get stuck with the yukky coconut fillet one

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Got my diagnosis through a Biopsy so now my you have peaked my interest. How do you find out what Genes you carry? Is it a blood test?

It's a genetic panel test. You can ask your doctor about it. But I would be concerned with which lab they chose to send it to, some are more reputable than others.

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Having two copies of a gluten sensitive or celiac gene means that each of your parents, and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.

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