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- Aretaeus Cappadocia commented on Celiac.com Sponsored Post's article in Celiac.com Sponsors1Do You Know Your GlutenID?
This fascinates me, in part because I used to work for Illumina (the sequencing platform that this lab uses). The price has me tempted but I'm sitting on the fence for now. Fwiw, one thing this article does not mention is that the Company is offering a discount if you buy multiple tests: "GlutenIDTM Kits Quantity Discounts: Buy 3–4 → 10% o...- celiac disease
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- knitty kitty replied to xxnonamexx's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms6Gluten Free Sugar or Starch known to increase gas?
Even if you don't have Celiac Disease, you can still get SIBO. Glad to hear you're taking the vitamins and magnesium! Are you getting sufficient Omega Three oils like flaxseed, olive oil, or Sunflower seed oil? I didn't like coconut oil because it upset my digestive tract. How is your Vitamin D level? -
- xxnonamexx replied to xxnonamexx's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms6Gluten Free Sugar or Starch known to increase gas?
I was looking at SIBO but I don't think I fall into that category. Yes I eat meat. I don't think I'm celiac I think I am just gluten intolerant but I take multivitamin, Super B Complex, Benfo with Thiam, Thiamax, Neuromag that you suggested.- 1
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- Aretaeus Cappadocia replied to Lotte18's topic in Publications & Publicity17
Prospective CRISPR research
@Lotte18, thank you for providing this page from the research proposal. Some comments, if I may (apologies for what you already know): They start by saying that previous research has shown that it's possible to modify the HLA-DQA1 gene and have that new version expressed "in humans" (not sure if they mean intact humans or just cells in culture). This... -
- jenniber replied to jenniber's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms21Disaccharide deficient, confusing biopsy results, no blood test
thank you for that info too!! will keep this in mind if he ends up in the ER again!- 1
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By knitty kitty · Posted
Even if you don't have Celiac Disease, you can still get SIBO. Glad to hear you're taking the vitamins and magnesium! Are you getting sufficient Omega Three oils like flaxseed, olive oil, or Sunflower seed oil? I didn't like coconut oil because it upset my digestive tract. How is your Vitamin D level? -
By xxnonamexx · Posted
I was looking at SIBO but I don't think I fall into that category. Yes I eat meat. I don't think I'm celiac I think I am just gluten intolerant but I take multivitamin, Super B Complex, Benfo with Thiam, Thiamax, Neuromag that you suggested. -
By Aretaeus Cappadocia · Posted
@Lotte18, thank you for providing this page from the research proposal. Some comments, if I may (apologies for what you already know): They start by saying that previous research has shown that it's possible to modify the HLA-DQA1 gene and have that new version expressed "in humans" (not sure if they mean intact humans or just cells in culture). This is a standard form of scientific communication where you explain what is already known as it relates to what you want to do next. The HLA-DQA1 gene encodes 1/2 of a series of "locks" from my earlier metaphor. Two of the types of locks that can be made by variants of this gene are called DQ2.5 and DQ8 (either of which will confer susceptibility to celiac). DQ2.5, DQ8, and other DQ's are referred to as "heterodimers" - "dimer" means made up of exactly 2 pieces and "hetero" means that the pieces are not identical to one another (identical parts would be homodimer). HLA-DQA1 genes each make a protein that becomes one of the two parts of a series of heterodimers. Different forms of HLA-DQA1 are called "variants" or "alleles". Next they say that they propose to use the same technology in attempt to minimize/cure celiac. The idea is reasonable science and before considering all of the caveats it certainly has merit as something to consider. As a side note, I would challenge some of their language. DQ2.5 and not-2.5 are both "variants" or "alleles" - one is not "wildtype" nor the other "mutant". Their proposal is to "modify", not "correct" the gene. This might sound picky but I have a background in genetics and this is jarring to me. The last paragraph outlines more of the roadmap for their proposal using relatively mundane steps (apheresis) and relatively advanced steps (CAR-T). There is a logic to their approach but there are severe caveats. CAR-T is kind of a nuclear option. It has shown many miracle cures in certain kinds of cancer and it is being studied for some kinds of life-threatening autoimmune disease. It also has devastating side effects. If tomorrow someone offered me a fully validated CAR-T procedure for celiac along the lines of this proposal, based on my understanding of the risks I would turn them down. Separately, I would also have concerns about the "off target" risk of the CRISPR part of the procedure. In addition to funding issues, there may be significant ethical issues that would challenge their proposal. Human clinical trial proposals go through extensive review before they are approved and one of the significant considerations is whether the risks to the patient are warranted (relative to the benefit). If a procedure has really horrible side effects but it is the only available option for a dying patient, the review board is likely to approve. However, if there is a much less harmful treatment option that delivers enough of a benefit, then there is a higher chance that the trial would not be approved. For celiacs, the availability and relative effectiveness of gluten-free diet will raise the bar for trying risky therapies in the clinic. Science and medicine constantly progress, so it's entirely possible that someday there will be a safe and effective genetic "cure" for celiac. However not anytime soon and I believe it would only come after these CAR-T procedures have become routine in the treatment of a long list of other diseases. In a world of unlimited funding for scientific research I would definitely fund this proposal. In the world of tight competition for research funding that we live in I would need to know a lot more about their proposal and the greater context of how it fits in with other research before I would give them money at this time (not that anyone is asking me). -
thank you for that info too!! will keep this in mind if he ends up in the ER again!
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By knitty kitty · Posted
@Heavenly Flower and @lehum, How are you doing? My favorite book is The Paleo Approach by Dr. Sarah Ballantyne, a Celiac herself. This book explains the AutoImmune Protocol Diet (AIP diet) which is the diet I follow. Yes, it is very strict, just meat, veggies and some fruit. But it really works. You cut back to just meat and veggies to let your digestive system calms and starts healing. Then you add back foods slowly looking for intolerance symptoms. Supplementing with B Complex vitamins, Vitamin D and minerals like Magnesium ensures you're receiving sufficient nutrients needed to heal. Correcting any vitamin deficits is important in Celiac disease. Hope you're doing well!
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