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Confusing Biopsy Results

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Hello everyone,

My mom was diagnosed w/celiac disease, so I had the blood tests to see if I have the disease. I have not had any diarrhea or other intestinal symptoms over the course of my life (I'm in my early 40s), but just wanted to be sure.

My blood test results came back positive (I don't know the numbers, but had the endomysial and gliadin antibody tests, and I think one more). I then had an endoscopy/biopsy, with the following results: "slight villous blunting, focal intraepithelial lymphocytes, and lamina propriaa plasma cell proliferation. The findings are non specific and might be associate with mild duodenitis. However, the possibility of an early celiac or treated celiac disease cannot be excluded."

Since I am in my early 40;s, the doctor said that early celiac disease doesn't make sense, but he still recommended a gluten-free diet. I've been on the diet for a year, and don't feel any different. My doc said that if I want, I can slowly reintroduce gluten, see how I feel, and then have another blood test if I still feel OK.

Two questions: what do you think of my biopsy report? Should I try eating gluten again? I'm not sure on what basis to make my decision, and am very confused. Thanks for any help you can provide.

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Celiac.com Sponsor (A8):

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;) i wouldnt eat gluten if i was you, but that is up to you--your doctor is wrong though---40 is not too early to have celiacs--celiacs knows no age level--babies are born with celiacs, you are born with the gene for celiacs and it can be triggered at any point inyour life--read all the post in here and you will find lots of useful info--deb


Long Island, NY

Double DQ1, subtype 6

We urge all doctors to take time to listen to your patients.. don't "isolate" symptoms but look at the whole spectrum. If a patient tells you s/he feels as if s/he's falling apart and "nothing seems to be working properly", chances are s/he's right!

"The calm river of your life approaches the rocky chute of the rapids - flow on through. You are the same water. The rocks cannot hurt you. Remember, now and then, that you are the water and not the boat. Flow on!

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40 is how old I am now, and I was just diagnosed. I have had mild symptoms on and off all my life, just no one ever knew what was the actual cause. You have positive bloodwork, and the blunting to me is a positive biopsy. No conflict.


The Lord bless you and keep you; the Lord make His face shine upon you and be gracious to you." Numbers 6:24-25

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Perhaps you have celiac--perhaps you have another condition such as a skin condition called dermatitis herptiformis(DH)-both are related to Gluten sensitivity. Or you could just have a wheat allergy. Gluten sensitivity can display at any age for those carrying the gene and in several diferent but related ways. I am 39 and just diagnosed with DH. perhaps my gut might show the same type of results as yours should I ever chose to get a biopsy. I've a neice that was diagnosed 20 years ago with celiac sprue due to her failure to thrive as a child leading her parents to seek out a real answer and not jut take a doctors pat answer that she was just slow to mature. And yes it is true that you should remain gluten free to avoid potential nutritional problems but it is a choice you have to make. But be sure to watch that your diet does contain enough vitamins and minerals. Many of the gluten free items that are on the market or in speciality stores do not contain enough viamins and minerals to make up for what you are not getting in foods that contained gluten. Routinely follow up with your doctor and learn all you can about what to watch for concerning gluten related diseases. Study up on allergies, they do not always demontrate the same symptoms every time you are exposed to the offending agent. That is why this disease is so hard for doctors to spot until it has progressed quite far for many who are affected by it.

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