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Professor

Genes -- Are You Cd Positive?

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I was just reading the HLA types that are responsible for celiac disease, and then dug mine (printout of my genes) out of my file drawer (I have them because I was tested for a bone marrow transplant). They listed several HLA types on the site I was reading, and say that almost everyone with celiac disease has one of those in the first group, but the few that don't almost always have this other one. Be darned if I don't have both -- one in the first group, and also the one that is the "back-up!" :o Unbelievable, huh? Guess I was just bound to get celiac disease.

So I was wondering how many also have the gene that causes celiac disease, or if you were tested?

Patty

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If you're referring to the DQ2 and DQ8, mine were negative, though I am a Type 1 Diabetic. That was also the case for my family member, whose blood and biopsies at one time read positive for Celiac. And that is exactly why I've never bought into this, at least in her case.

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If you're referring to the DQ2 and DQ8 . . .

Well, I guess that must be an abbreviated description -- sorry I don't know it as such. The full typing assays, and my own molecular diagnostics reports list them fully:

"The majority of celiac disease patients carry the DRB1*0301- DQA1*0501- DQB1*0201 haplotype (the DR3, DQ2 haplotype) or are DRB1*11/12-DQA1*0505- DQB1*0301/ DRB1*07- DQA1*0201- DQB1*0202 heterozygotes (carry the DR5-DQ7/DR7-DQ2 haplotypes). Almost all the celiac patients who are DQA1*05 and DB1*02 negative bear the DRB1*04, DQA1*0301, DQB1*0302 haplotype (i.e., DR4-DQ8 )."

So, unfortunately I can only answer your question with another question: are we referring to the same thing? I think so. :unsure: But thanks for replying.

Patty

(Citation:

http://64.233.187.104/search?q=cache:nLsr8...&hl=en&ie=UTF-8 )

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:huh: Umm...well my blood test came back positive. So did my biopsy. <_< Is that what you mean? I'm really quite uneducated, when it comes to all the medical terms.

Cheers :)

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Excellent question, professor. I'll take another look into this. I know that there has been some confusion along the way in her case. Her medical reports detail testing for the DQ2 and DQ8, both of which were negative. I can say for certain that these tests also are defined in my medical history. I did research this at one time and the lab titles seemed to go along with what I was reading, but I will try to go back and take another look here at some point.

I must compliment you for the type of investigation you are attempting here. Great work.

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My Enterolab test results (back in 7/04) indicated that I "have a copy of one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQ3, subtype 8 (HLA-DQ8). This genotype also can predispose to microscopic colitis and other autoimmune syndromes".

BURDEE

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It can come from either parent or from both if you have two copies or one of each.

My daughter and I both have one copy of DQ2. My boys don't have either but are still gluten intolerant. They both have DQ3, subtype 7. DQ3, subtype 8 is the one referred to as DQ8. I am still wondering if they have missed the fact that other subtypes of DQ3 can cause problems with gluten. I have all of the children on the gluten-free diet, since they all responded so well to the diet. Almost all of their health problems went away and their growth has been amazing.

God bless,

Mariann

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Thanks:) If I have 2 copies of the gene that would mean it came from both parents correct?

Also, when I was tested for the gene would they have told me if there was more than one copy of the gene in the results?

We are trying to figure out which side it came frome it seems both sides of the family think it is the other side that has the gene and they aren't being to easy about getting tested <_<

Thank you all for your help :D

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Also, when I was tested for the gene would they have told me if there was more than one copy of the gene in the results?

They would not necessarily tell you if you had more than one copy. They would only be required to tell you if you were positive for the gene or not. It would be a good idea for your parents to be tested, regardless of if there are two copies of the gene, or if they have symptoms. But I do understand about them not being easy about getting tested. My husband won't be tested, and my father is convinced that it isn't an issue. I have 6 siblings and only one has tried to be tested, and her doctor is clueless as to what tests to order. My sister decided to let it go for now, since she doesn't plan on following the gluten-free diet anyhow!

God bless,

Mariann

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gf4life-Thank you so much. That info definately helps out so much. My parents have both been tested. Digestive problems run in the family on both sides and we suspect possibly some cousins ,grandma, and others that may have celiac. They aren't necessarily convinced either and it's hard because we can only tell them so much and give them so much info. I guess when their symptoms get bad enough they will be tested. Again thanks and God bless! :D

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