Jump to content
  • Join Our Community!

    Do you have questions about celiac disease or the gluten-free diet?

luciddream928

Gene Results - Questions Re: Dqb1

Rate this topic

Recommended Posts

You have the trans form of DQ2 (DQ5 and DQ7) see other postings on that and go to wikipedia and read on DQ DR, (and DQ2 and DQ7 and DQ5)

We have not seen any patients reporting on any labs telling them they have this trans for of DQ2. This is neither new, alternative or debatable. (that DQ5 and DQ7 make up DQ2 in trans)

nora

Share this post


Link to post
Share on other sites

Also, if your total IgA is low, or youi have IgA deficiency (about 10% of the normal population have that), the antibody tests at enterolab will be negative. You need a total IgA test from somewhere. Even if it is low within range, the results of the antibody tests may be negative.

In that case you need the ordinary celiac blod tests, ttg and antigliadin, but the IgG versions of these tests.

I think your fat malabsorption test was very very high, sound abnormal to me.

nora

Share this post


Link to post
Share on other sites
You have the trans form of DQ2 (DQ5 and DQ7) see other postings on that and go to wikipedia and read on DQ DR, (and DQ2 and DQ7 and DQ5)

We have not seen any patients reporting on any labs telling them they have this trans for of DQ2. This is neither new, alternative or debatable. (that DQ5 and DQ7 make up DQ2 in trans)

nora

Hi Nora,

Thank you for sharing the info - I'm not sure what it means but I will look up all that you suggested. When you say that you have not seen any patients reporting on labs telling them they have this trans form of DQ2, do you mean on this forum or do you work in a healthcare setting? (You sound professional : ) )

Share this post


Link to post
Share on other sites

I have been reading around on these forums for some time, and the question about DQ5 plus DQ7 has been discussed here several times. Some have had all the symptoms, had DQ5 plus DQ7 and been told they were negative for celiac genes. So, when you look it up, it si most likey the trans form of DQ2 8depending on wether one has the 05* thing in the alpha chain, but this is the most common thing to have with these genes)

I am just researching this thing, as they told me I was negative for DQ2 and 8. So if they do not tell patients they have DQ2 when they have DQ2 but the trans form, I wonder.....and DQ8 can be mistyped since the test methods do not pick it up very well.

(my daughter is diagnosed celiac, so I think there are good chances that I am either mistyped, or DQ1 which sometimes are very sensitive to gluten, and they have then antigliadin antibodies in the brain)

nora

Share this post


Link to post
Share on other sites

There are several variations of each gene. You are DQ7 and DQ5. The numbers 0301 and and 0502 tell you the variations. There is a chart on wikipedia with the major variations listed. So you are DQ7(that is 0301) and DQ5(that is the 0502).

DQ7 can cause celiac or gluten intolerance on it's own but very rarely.

Have you had any blood work done? A total IGA test would tell you your IGA levels. If they are low then enterolab can not be accurate. Most celiac blood tests do test for total IGA levels.

good luck

Share this post


Link to post
Share on other sites

Hello.

My daughter and I both have the same genes as you (Enterolab: Serologic equivalent DQ 1,3) We ALSO carry the more rare Celiac gene on the alpha chain. We found that out through Kimball Genetics. We are both very symptomatic and have been diagnosed as Celiac.

I agree with Nora, have your ability to produce IgA antibodies checked because some can't produce enough, so your IgA scores could be falsely low.

I'm new at this too. We were diagnosed in August, but I'd be happy to answer any questions you have if I can. I've done a lot of research on this. There's so much to learn, huh?

Best,

Sonya

Share this post


Link to post
Share on other sites
Hello.

My daughter and I both have the same genes as you (Enterolab: Serologic equivalent DQ 1,3) We ALSO carry the more rare Celiac gene on the alpha chain. We found that out through Kimball Genetics. We are both very symptomatic and have been diagnosed as Celiac.

I agree with Nora, have your ability to produce IgA antibodies checked because some can't produce enough, so your IgA scores could be falsely low.

I'm new at this too. We were diagnosed in August, but I'd be happy to answer any questions you have if I can. I've done a lot of research on this. There's so much to learn, huh?

Best,

Sonya

Hi Sonya. Yes it is overwhelming. In fact, I came home from work after 2 days of not feeling all that great, and realized I ate fries the other day and after some research I found they are not gluten free as I thought. On my way home I just burst into tears. I'm going home for the holidays, and I see my family once a year. We are Italian and the whole culture revolves around food. I never realized how much it means to feel a part of things with family and eating, but it's so true. It's so upsetting to not be able to share the same things and eat the traditional food anymore.

I thought managing the diet was hard, but the genotype discussions blow my mind. I'm a graduate student but not in medicine : ) I'm still unclear as to whether or not the gluten sensitivity does the same damage as true celiac disease. I understand it as a spectrum, but my lab results imply that having this genotype is just like having the disease. My experience is that going gluten free for the most part seems to lessen the symptoms when I do get "glutened" but there seems to be a real emotional component to this. I just burst into tears and get angry for no apperent reason, or at the slightest provocation.

'tis a journey for sure......

More to read about, I guess... but wikipedia is over my head.

Share this post


Link to post
Share on other sites

But sonya, if you are DQ5 and DQ7, you are the trans form of DQ2 (most likely).

Really confirms that labs do not report that those are in fact DQ2.

One thing is the genes, they do an electrophoresis test, the other thing is the gene expression on the surface of the white blood cell, that is what matters. DQ2 is DQ2 either from the cis form , or the trans form. (also, from half the gene).

There is also serotyping, this is done by antibody testing and tests for the genes too. It does not test the gene product either, so they also miss the trans form I think (from what we have read here, what people report)

nora

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


  • Top Posters +

  • Upcoming Events

    • May 29, 2019 04:00 PM Until 08:00 AM
      0  
       
       
       
      Celiac Emotional Healing Support Group
       
       
       
      Again you are invited to join Johnny Patout, LCSW for Baton Rouge's first emotional healing support group meeting to assist those living with celiac disease manage the emotional challenges so many of us face. Most often the emotional disturbances include depression, disinterest in normal activities, insomnia, grief, mood changes, anxiety, inability to concentrate, extreme concern about managing a gluten-free lifestyle and other emotional and behavioral challenges.
       
      The professionals at Jamestown Avenue Counseling Center created the emotional healing support group to give us a safe place to begin to process our emotions and support each other as we heal emotionally while managing celiac disease and the resulting autoimmune disorders.
       
      The emotional healing support group meets every Thursday, 6:00-7:00pm, at the Jamestown Avenue Counseling Center of Baton Rouge. Jamestown Avenue Counseling Center is located at 4637 Jamestown Avenue, Baton Rouge, Suite B-1. Suite B-1 is upstairs.
       
      The support group is free and open everyone managing celiac disease. For more information: emotionalhealingforceliacs@hotmail.com
    • June 01, 2019 Until June 02, 2019
      0  
      Nourished Festival is a family-friendly event with 10 locations across the US. Attendees will be able to sample food, health and beauty products, meet with companies, learn about the most current food lifestyles, receive coupons and attend educational sessions with industry experts. 
      Nourished Festival, managed by The Nourished Group and presented by Enjoy Life Foods, is the largest gluten-free, allergy-friendly and specialty diet event in the US, with 10 locations including.
      ABOUT THE NOURISHED FESTIVALS
      Managed by The Nourished Group, formerly The Gluten Free Media Group, The Nourished Festivals are the largest and fastest growing special diet consumer events in the United States. Started in 2007, the events have expanded from one to ten cities throughout the country. The festivals cater to anyone looking to lead a healthier lifestyle or those who follow a specialty diet due to autoimmune conditions, food sensitivities, allergies or intolerances. Offerings including Paleo, Keto, Plant-Based, Gluten-Free, Allergen-Friendly and Nut-Free products. The events provide the opportunity for attendees to sample and purchase new products, receive coupons, meet with brand ambassadors and attend educational classes with industry experts. For more information, visit http://www.nourishedfestival.com 
       
    • July 07, 2019 Until August 03, 2019
      0  
      For more information, visit www.kefss.com or call (407) 255-6550. info@kefss.com 

      KEF USA Summer Camps Announces the New KEF Gluten-Free Camp in Orlando, Florida for Youths with Celiac Disease.

      [Orlando, FL February 6, 2019]-KEF USA is excited to announce that we will offer a new 100% gluten-free camp program to give kids and teens with Celiac Disease a safe, exciting and healthy summer. KEF USA programs offer fun and unique experiences that can only be found in Orlando, Florida. Campers explore the theme parks and local attractions, make new friends, discover new interests and create memories that last a lifetime.


×
×
  • Create New...