2 2
farmwife67

Anyone Had Dh On The Scalp?

Rate this topic

Recommended Posts

Ads by Google:
Ads by Google:


i get DH at the hair line near my neck. i also get DH on my nose and chin.

Share this post


Link to post
Share on other sites

DH ON THE HEAD LOOK JUST LIKE THE SORE ON THE OTHER PARTS WHERE YOU GET IT. EXPECT THAT IT HURTS ALOT TO WASH AND BRUSH YOUR HEAD. JUST BE CAREFUL AND IT GOES AWAY BUT YOU HAVE TO LIVE A VERY STRICT gluten-free LIFE. EAT gluten-free AND ALL YOUR HYGINE PRODUCTS NEED TO BE gluten-free.... NO EXCEPTIONS!!! IT IS ALSO VERY IMPORTANT TO KEEP YOUR SCALP CLEAN I THINK THATS JUST MY OPINION.

Share this post


Link to post
Share on other sites

I agree with Daniel*s Amber. try to keep our head clean. Things seem to get owrse for me if I have any type of sweating at all. I also think that the sores on the scalp are the worst, Mine are horrible, they hurt all the time, its enough to drive me crazy--cept im already there. Trust me I have had the sores on my knees, elbows, fingers, feeet, glutial cleft--or the crack of my butt so to speak. under my arms--and teh ones on my head are by far the worst,

noel

  • Upvote 1

Share this post


Link to post
Share on other sites

I agree with Daniel*s Amber. try to keep our head clean. Things seem to get owrse for me if I have any type of sweating at all. I also think that the sores on the scalp are the worst, Mine are horrible, they hurt all the time, its enough to drive me crazy--cept im already there. Trust me I have had the sores on my knees, elbows, fingers, feeet, glutial cleft--or the crack of my butt so to speak. under my arms--and teh ones on my head are by far the worst,

noel

It's interesting that those are all places (except fingers) that I get psoriasis, and the psoriasis on my scalp drives me the craziest (unless my heels really flare up and I have real pain when walking) :o

Share this post


Link to post
Share on other sites
Ads by Google:


I have DH on my scalp only, so can't compare it to having it elsewhere, but it's extremely painful, and itchy; still, it was even itchier before I was gluten free. I can't really describe with words how bad it's been. It's been getting better on the whole, but it still flares up sometimes, and I'm doing everything I can do now to avoid gluten and casien like the plague.

It sure makes you crazy, and feel like you just can't take it any more, like you are being tortured almost

Share this post


Link to post
Share on other sites

I have DH on my scalp only, so can't compare it to having it elsewhere, but it's extremely painful, and itchy; still, it was even itchier before I was gluten free. I can't really describe with words how bad it's been. It's been getting better on the whole, but it still flares up sometimes, and I'm doing everything I can do now to avoid gluten and casien like the plague.

It sure makes you crazy, and feel like you just can't take it any more, like you are being tortured almost

I went thru this same thing over the summer. Turns out I was eating too much fruit--sugar--as soon as I cut the fruit and excess sugar, I felt like a new woman within 2 days!

Share this post


Link to post
Share on other sites

I have DH on my scalp only, so can't compare it to having it elsewhere, but it's extremely painful, and itchy; still, it was even itchier before I was gluten free. I can't really describe with words how bad it's been. It's been getting better on the whole, but it still flares up sometimes, and I'm doing everything I can do now to avoid gluten and casien like the plague.

It sure makes you crazy, and feel like you just can't take it any more, like you are being tortured almost

Hi,

Have you made sure your shampoo is gluten-free? Also, Iodine brings DH out. Good luck

Share this post


Link to post
Share on other sites

Thanks to everyone for your posts. I have had terrible GI symptoms, as yet undiagnosed, and misdiagnosed, and terrible scalp itch just like described as DH. I never thought the two problems, GI, and extremely itchy bumps/lesions on my scalp could be related to coeliac/gluten. I just found this blog today, and have never heard about such problems with gluten. Im extremely disappointed that my many GI doctors over the years never even talked to me about it. Hoping to get in to see my GI, calling him tomorrow. best luck to everyone getting back their health.

Share this post


Link to post
Share on other sites

I had been using a Redkin shampoo and conditioner. Every single time i used it, my head itched and itched and itched. I had to stop using it. When I said something to a person at a wholesaler (my husband is a hair stylist) She said "oh, are you gluten intolerant or Celiac? It has a HUGE amount of wheat filler in it!" I was like hmmmm...that's interesting....lol. I use Biologe now, and I don't seem to have a problem. Hair color is another one. My husband is Redkin certified, and Redkin uses a lot of wheat. The color dosen't bother me, but products and shampoo/conditoner do.

Share this post


Link to post
Share on other sites


Ads by Google:


I went thru this same thing over the summer. Turns out I was eating too much fruit--sugar--as soon as I cut the fruit and excess sugar, I felt like a new woman within 2 days!

This is the first I've heard of sugar making dh worse.

I'm willing to try anything, so hopefully this helps

thanks, although I love bananas.

Also, I only use gluten free soap for body care that I order in the mail.

Share this post


Link to post
Share on other sites

Hmmm, I get this crazy itchy scalp. Never really connected it to DH because I don't get the classic rash, and my scalp doesn't really have bumps, it's just itchy like crazy. It's much worse after an accidental glutening, but I am still suffering a bit with it on a strict gluten-free diet - still learning I guess

Share this post


Link to post
Share on other sites

I have had DH on my scalp for as long as I can remember, it was never even associated with a gluten intolerance until recently. Currently I only have it on my scalp, yet as a child I had it under my arms, in and around my ears, and on my belly button. It's downright horrible. Sometimes no matter what I do, how "clean" I keep my head, the flare ups are so bad that it's painful, and SO ITCHY!. I am never completely rid of it, though I am hoping now that I am on a gluten free diet I will have the DH under more control. For years I have been using Nuetrogena extra strength tar based shampoo, which works ok. The best I have found however (and finding it again has been difficult) is P&S Shampoo. For anyone who is experiencing DH on their scalp SINCE becoming gluten free, check your shampoo and make sure it contains no gluten. I recently switched to Shikai shampoos and conditioner (of course still using the Nuetrogena) and as far as I can tell they're great.

Share this post


Link to post
Share on other sites

I have had DH on my scalp for as long as I can remember, it was never even associated with a gluten intolerance until recently. Currently I only have it on my scalp, yet as a child I had it under my arms, in and around my ears, and on my belly button. It's downright horrible. Sometimes no matter what I do, how "clean" I keep my head, the flare ups are so bad that it's painful, and SO ITCHY!. I am never completely rid of it, though I am hoping now that I am on a gluten free diet I will have the DH under more control. For years I have been using Nuetrogena extra strength tar based shampoo, which works ok. The best I have found however (and finding it again has been difficult) is P&S Shampoo. For anyone who is experiencing DH on their scalp SINCE becoming gluten free, check your shampoo and make sure it contains no gluten. I recently switched to Shikai shampoos and conditioner (of course still using the Nuetrogena) and as far as I can tell they're great.

welcome to the board!

how long are you on the gluten-free diet now?

Share this post


Link to post
Share on other sites

welcome to the board!

how long are you on the gluten-free diet now?

Thanks! This forum has been a very helpful resource so far, I've been doing a lot of wandering around. I have been gluten free for 4 days, not very long. Yet I'm already seeing some magic-like changes :)Gluten intolerance runs in my family, and I have grown very familiar with it over the years.

Share this post


Link to post
Share on other sites

I went thru this same thing over the summer. Turns out I was eating too much fruit--sugar--as soon as I cut the fruit and excess sugar, I felt like a new woman within 2 days!

thanks SOOOOO much.

I'm @ 1 week w/ no fruit or sugar, and it does seem to be getting better. cut out the agave nectar in my tea, and my 2 bananas on an empty stomach in the AM. ( i do have an apple sliced up in a salad, but it's not too high in fructose?)

kinda sucks because bananas are my one convience food that i can just go into a store and eat, and don't have to worry about it being contaminated, ect...

i geuss i can get celery and carrots, and just eat them raw?

Share this post


Link to post
Share on other sites

Hi everyone.

I was diagnosed with celiac a year ago. I started experiencing stomach trouble 15 years ago. I had extreme stomach pains combined with non stop diarrhea, gas, the works. The Gynecologists I went to, after testing me via upper and lower endoscopy decided that "my problem is in my head." "Get a grip on your life" is exactly what the doctor told me. After about 10 years of stomach trouble, which eventually caused panic/anxiety attacks and almost caused me to quite my job and turn into a hermit, I developed a skin condition. The dermatologists could not figure out what I had. They would scratch their heads and say, "skin infection" with no medicine or solutions. The last skin doctor I went to about 1 1/2 years ago said I probably have skin lupus and that's when I went to a lupus/dermotology specialist in NYU & he is the one who diagnosed me as having celiac.

The skin condition consists of the following symptoms: Small bumps, whitish or skin color. The areas effected are my upper/outer arms, calves & thighs and buttox. Very rarely though, one or two will come out on my face and back/shoulders. Rarely, but it does occur. The itch is indescribable. There's no way I could control not scratching. In fact, scratching, stops the itch. Sometimes they bleed terribly and sometimes not, but always, the scratching eventually stops the itch. No cream works. Cold showers was the only thing that I discovered on my own calms it down somewhat. I later read about baking soda and taking a bath in it or just washing the area with it. This really helps. It helped me sleep at night whereas before I'd be up for hours in agony. Some of the bumps ooze when scratched, some don't and some remain a bump even after the itch is gone. The thing about it is that the bumps come out in the same spot on same parts of the body at the same time. For example, when I get a bump on my upper right arm above my elbow, I get one in the exact same spot on my left arm within the same time frame. I recently read on this site that someone described DH as being this way and now I know that this is just the nature of this condition, and not just my body being in sync :).

Anyway, I went immediately on a gluten-free diet a year ago, when the NYU specialist (God bless him!)diagnosed me with celiac & three months later my skin started easing up and my tummy was almost completely better. I was in heaven until I started eating gluten free oat bread and things started getting bad again. I only recently realized that it's probably the gluten free oat bread that's the culprit and so I'm starting from scratch again, but hopeful that I will heal in the near future. I'm really very careful now about cross contamination, and eat mostly what I cook myself and buy ingredients only from companies that have designated gluten-free equipment or kitchens.

I wanted to share this with all of you so that you can get a good idea of what DH looks like and feels like.

All the best to all of you.

Share this post


Link to post
Share on other sites

I have heard that some people also react to oats, gluten free or not. Maybe that is what happened.

Share this post


Link to post
Share on other sites

I have heard that some people also react to oats, gluten free or not. Maybe that is what happened.

I suspect so. Wish the information on the box would say this in a more obvious place or manner. It's sad that companies producing the products don't take extra care in how they market their stuff. I have to think they just don't realize how people suffer as a consequence of eating something they are not allowed to eat.

Share this post


Link to post
Share on other sites

I have it on the scalp too, but not anywhere else. Been gluten-free for only 2 months with occasional accidental glutening. When that happens my scalp gets hot and red and itchy and more hair falls out. Already have lost about 25/30% of my hair.

My dermatologist has just recommended a solution called Avixis. You put it on your scalp every night for 3 months and he says hair will stop falling out in 2 months and the follicles will be repaired.

Has anyone ever heard of this medicine? Know anything about it? I'm in Mexico and this medicine, I believe, comes from Germany.

TIA

Share this post


Link to post
Share on other sites


Ads by Google:


Thank you everyone who has posted about your DH. I have learned way more here than from several docs (including dermatologists) who have drawn a complete blank with my burning, itching, blistery, horrible rash. After reading all your posts I am totally sure that I have DH (I do have Celiac's).

I also want to share the one and only thing I have ever found that topically helps calm and heal the rash. (Besides eating COMPLETELY gluten free; for years I thought I was gluten-free but I was still licking envelopes, chewing gum, etc.) I have tried every prescription and OTC cream in the world for something that would calm the horrible itching and redness, and nothing has worked UNTIL... a friend told me about making a ginger compress! It is a miracle for my DH!

You get some fresh (organic) ginger root from the grocery/health food store. Ginger is a powerful anti-inflammatory plant. Grate it into a pot of water, a couple teaspoons of grated ginger in a saucepan of water, boil it, then soak washcloths in the hot water. Put a gingered washcloth on your worst spot of DH-- as hot as you can stand-- cover it with a towel and then a hot water bottle. Keep it on there for a while; I watch a TV show or something. It takes my bright red itchy blistery skin down to calm, normal color, normal feeling skin! Total miracle, and all natural and cheap! You can keep the gingery water in the pot and heat it up to use it again; I do it about twice a day. Tell me how it goes!

Share this post


Link to post
Share on other sites

Thank you everyone who has posted about your DH. I have learned way more here than from several docs (including dermatologists) who have drawn a complete blank with my burning, itching, blistery, horrible rash. After reading all your posts I am totally sure that I have DH (I do have Celiac's).

I also want to share the one and only thing I have ever found that topically helps calm and heal the rash. (Besides eating COMPLETELY gluten free; for years I thought I was gluten-free but I was still licking envelopes, chewing gum, etc.) I have tried every prescription and OTC cream in the world for something that would calm the horrible itching and redness, and nothing has worked UNTIL... a friend told me about making a ginger compress! It is a miracle for my DH!

You get some fresh (organic) ginger root from the grocery/health food store. Ginger is a powerful anti-inflammatory plant. Grate it into a pot of water, a couple teaspoons of grated ginger in a saucepan of water, boil it, then soak washcloths in the hot water. Put a gingered washcloth on your worst spot of DH-- as hot as you can stand-- cover it with a towel and then a hot water bottle. Keep it on there for a while; I watch a TV show or something. It takes my bright red itchy blistery skin down to calm, normal color, normal feeling skin! Total miracle, and all natural and cheap! You can keep the gingery water in the pot and heat it up to use it again; I do it about twice a day. Tell me how it goes!

OMG

i'm going to the store right now!

thank you so much!

Share this post


Link to post
Share on other sites

Holy cow! You people are all angels! I have been suffering unbearably with these hot, itchy, and painful bumps on my scalp for a year now. Two doctors had no idea what it was, so I was sent to see a "dermatologist." To my utter shock, he told me I WAS DIRTY! HE TOLD ME TO WASH MY HAIR EVERY DAY with a shampoo called Nizoral, that it would take the itch away. He also prescribed a Vaseline based salve with a steroid in it. Guess what? It did nothing nor did the shampoo, and the more I washed my hair, the worse it gets. It's like torture, and I just can't stop scratching holes into my scalp. Then they scab over, then itch again. I was almost ready to shave my head, until I found this forum. I knew nothing about celiac disease, sensitivity to gluten... I knew nothing. Just so happened that my daughter found a paper talking about celiac during her visit to her GI yesterday. She brought it home for me, and demanded that I read it!  WHAM- a light come on, and I said to her... That IS what I have. I am going to my GP tomorrow to demand that I be tested for ciliac. I am rather terrified, as I am already a type 1 diabetic and have been on insulin for 52 years! I was blaming my diabetes the whole time. I have had a lower left leg amputation, and the last thing I need is to start getting this ungodly rash on my stump!!!

Thank you everyone for all of the useful information you have provided in this blog. Maybe I'm not going to die after all! 😉

  • Like 1

Share this post


Link to post
Share on other sites
On 10/10/2010 at 3:36 AM, farmgirl12 said:

I agree with Daniel*s Amber. try to keep our head clean. Things seem to get owrse for me if I have any type of sweating at all. I also think that the sores on the scalp are the worst, Mine are horrible, they hurt all the time, its enough to drive me crazy--cept im already there. Trust me I have had the sores on my knees, elbows, fingers, feeet, glutial cleft--or the crack of my butt so to speak. under my arms--and teh ones on my head are by far the worst,

 

noel

I agree so much!!! I have been scratching my head since November and it’s February!!!!!

Share this post


Link to post
Share on other sites

Just to let you know. This thread is really old, it's from 2010. None of those people are still here.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
2 2

  • Who's Online   19 Members, 1 Anonymous, 971 Guests (See full list)

  • Top Posters +

  • Recent Articles

    Jefferson Adams
    Celiac.com 06/16/2018 - Summer is the time for chips and salsa. This fresh salsa recipe relies on cabbage, yes, cabbage, as a secret ingredient. The cabbage brings a delicious flavor and helps the salsa hold together nicely for scooping with your favorite chips. The result is a fresh, tasty salsa that goes great with guacamole.
    Ingredients:
    3 cups ripe fresh tomatoes, diced 1 cup shredded green cabbage ½ cup diced yellow onion ¼ cup chopped fresh cilantro 1 jalapeno, seeded 1 Serrano pepper, seeded 2 tablespoons lemon juice 2 tablespoons red wine vinegar 2 garlic cloves, minced salt to taste black pepper, to taste Directions:
    Purée all ingredients together in a blender.
    Cover and refrigerate for at least 1 hour. 
    Adjust seasoning with salt and pepper, as desired. 
    Serve is a bowl with tortilla chips and guacamole.

    Dr. Ron Hoggan, Ed.D.
    Celiac.com 06/15/2018 - There seems to be widespread agreement in the published medical research reports that stuttering is driven by abnormalities in the brain. Sometimes these are the result of brain injuries resulting from a stroke. Other types of brain injuries can also result in stuttering. Patients with Parkinson’s disease who were treated with stimulation of the subthalamic nucleus, an area of the brain that regulates some motor functions, experienced a return or worsening of stuttering that improved when the stimulation was turned off (1). Similarly, stroke has also been reported in association with acquired stuttering (2). While there are some reports of psychological mechanisms underlying stuttering, a majority of reports seem to favor altered brain morphology and/or function as the root of stuttering (3). Reports of structural differences between the brain hemispheres that are absent in those who do not stutter are also common (4). About 5% of children stutter, beginning sometime around age 3, during the phase of speech acquisition. However, about 75% of these cases resolve without intervention, before reaching their teens (5). Some cases of aphasia, a loss of speech production or understanding, have been reported in association with damage or changes to one or more of the language centers of the brain (6). Stuttering may sometimes arise from changes or damage to these same language centers (7). Thus, many stutterers have abnormalities in the same regions of the brain similar to those seen in aphasia.
    So how, you may ask, is all this related to gluten? As a starting point, one report from the medical literature identifies a patient who developed aphasia after admission for severe diarrhea. By the time celiac disease was diagnosed, he had completely lost his faculty of speech. However, his speech and normal bowel function gradually returned after beginning a gluten free diet (8). This finding was so controversial at the time of publication (1988) that the authors chose to remain anonymous. Nonetheless, it is a valuable clue that suggests gluten as a factor in compromised speech production. At about the same time (late 1980’s) reports of connections between untreated celiac disease and seizures/epilepsy were emerging in the medical literature (9).
    With the advent of the Internet a whole new field of anecdotal information was emerging, connecting a variety of neurological symptoms to celiac disease. While many medical practitioners and researchers were casting aspersions on these assertions, a select few chose to explore such claims using scientific research designs and methods. While connections between stuttering and gluten consumption seem to have been overlooked by the medical research community, there is a rich literature on the Internet that cries out for more structured investigation of this connection. Conversely, perhaps a publication bias of the peer review process excludes work that explores this connection.
    Whatever the reason that stuttering has not been reported in the medical literature in association with gluten ingestion, a number of personal disclosures and comments suggesting a connection between gluten and stuttering can be found on the Internet. Abid Hussain, in an article about food allergy and stuttering said: “The most common food allergy prevalent in stutterers is that of gluten which has been found to aggravate the stutter” (10). Similarly, Craig Forsythe posted an article that includes five cases of self-reporting individuals who believe that their stuttering is or was connected to gluten, one of whom also experiences stuttering from foods containing yeast (11). The same site contains one report of a stutterer who has had no relief despite following a gluten free diet for 20 years (11). Another stutterer, Jay88, reports the complete disappearance of her/his stammer on a gluten free diet (12). Doubtless there are many more such anecdotes to be found on the Internet* but we have to question them, exercising more skepticism than we might when reading similar claims in a peer reviewed scientific or medical journal.
    There are many reports in such journals connecting brain and neurological ailments with gluten, so it is not much of a stretch, on that basis alone, to suspect that stuttering may be a symptom of the gluten syndrome. Rodney Ford has even characterized celiac disease as an ailment that may begin through gluten-induced neurological damage (13) and Marios Hadjivassiliou and his group of neurologists and neurological investigators have devoted considerable time and effort to research that reveals gluten as an important factor in a majority of neurological diseases of unknown origin (14) which, as I have pointed out previously, includes most neurological ailments.
    My own experience with stuttering is limited. I stuttered as a child when I became nervous, upset, or self-conscious. Although I have been gluten free for many years, I haven’t noticed any impact on my inclination to stutter when upset. I don’t know if they are related, but I have also had challenges with speaking when distressed and I have noticed a substantial improvement in this area since removing gluten from my diet. Nonetheless, I have long wondered if there is a connection between gluten consumption and stuttering. Having done the research for this article, I would now encourage stutterers to try a gluten free diet for six months to see if it will reduce or eliminate their stutter. Meanwhile, I hope that some investigator out there will research this matter, publish her findings, and start the ball rolling toward getting some definitive answers to this question.
    Sources:
    1. Toft M, Dietrichs E. Aggravated stuttering following subthalamic deep brain stimulation in Parkinson’s disease--two cases. BMC Neurol. 2011 Apr 8;11:44.
    2. Tani T, Sakai Y. Stuttering after right cerebellar infarction: a case study. J Fluency Disord. 2010 Jun;35(2):141-5. Epub 2010 Mar 15.
    3. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    4. Jäncke L, Hänggi J, Steinmetz H. Morphological brain differences between adult stutterers and non-stutterers. BMC Neurol. 2004 Dec 10;4(1):23.
    5. Kell CA, Neumann K, von Kriegstein K, Posenenske C, von Gudenberg AW, Euler H, Giraud AL. How the brain repairs stuttering. Brain. 2009 Oct;132(Pt 10):2747-60. Epub 2009 Aug 26.
    6. Galantucci S, Tartaglia MC, Wilson SM, Henry ML, Filippi M, Agosta F, Dronkers NF, Henry RG, Ogar JM, Miller BL, Gorno-Tempini ML. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011 Jun 11.
    7. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    8. [No authors listed] Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 43-1988. A 52-year-old man with persistent watery diarrhea and aphasia. N Engl J Med. 1988 Oct 27;319(17):1139-48
    9. Molteni N, Bardella MT, Baldassarri AR, Bianchi PA. Celiac disease associated with epilepsy and intracranial calcifications: report of two patients. Am J Gastroenterol. 1988 Sep;83(9):992-4.
    10. http://ezinearticles.com/?Food-Allergy-and-Stuttering-Link&id=1235725 
    11. http://www.craig.copperleife.com/health/stuttering_allergies.htm 
    12. https://www.celiac.com/forums/topic/73362-any-help-is-appreciated/
    13. Ford RP. The gluten syndrome: a neurological disease. Med Hypotheses. 2009 Sep;73(3):438-40. Epub 2009 Apr 29.
    14. Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. 1996 Feb 10;347(8998):369-71.

    Jefferson Adams
    Celiac.com 06/14/2018 - Refractory celiac disease type II (RCDII) is a rare complication of celiac disease that has high death rates. To diagnose RCDII, doctors identify a clonal population of phenotypically aberrant intraepithelial lymphocytes (IELs). 
    However, researchers really don’t have much data regarding the frequency and significance of clonal T cell receptor (TCR) gene rearrangements (TCR-GRs) in small bowel (SB) biopsies of patients without RCDII. Such data could provide useful comparison information for patients with RCDII, among other things.
    To that end, a research team recently set out to try to get some information about the frequency and importance of clonal T cell receptor (TCR) gene rearrangements (TCR-GRs) in small bowel (SB) biopsies of patients without RCDII. The research team included Shafinaz Hussein, Tatyana Gindin, Stephen M Lagana, Carolina Arguelles-Grande, Suneeta Krishnareddy, Bachir Alobeid, Suzanne K Lewis, Mahesh M Mansukhani, Peter H R Green, and Govind Bhagat.
    They are variously affiliated with the Department of Pathology and Cell Biology, and the Department of Medicine at the Celiac Disease Center, New York Presbyterian Hospital/Columbia University Medical Center, New York, USA. Their team analyzed results of TCR-GR analyses performed on SB biopsies at our institution over a 3-year period, which were obtained from eight active celiac disease, 172 celiac disease on gluten-free diet, 33 RCDI, and three RCDII patients and 14 patients without celiac disease. 
    Clonal TCR-GRs are not infrequent in cases lacking features of RCDII, while PCPs are frequent in all disease phases. TCR-GR results should be assessed in conjunction with immunophenotypic, histological and clinical findings for appropriate diagnosis and classification of RCD.
    The team divided the TCR-GR patterns into clonal, polyclonal and prominent clonal peaks (PCPs), and correlated these patterns with clinical and pathological features. In all, they detected clonal TCR-GR products in biopsies from 67% of patients with RCDII, 17% of patients with RCDI and 6% of patients with gluten-free diet. They found PCPs in all disease phases, but saw no significant difference in the TCR-GR patterns between the non-RCDII disease categories (p=0.39). 
    They also noted a higher frequency of surface CD3(−) IELs in cases with clonal TCR-GR, but the PCP pattern showed no associations with any clinical or pathological feature. 
    Repeat biopsy showed that the clonal or PCP pattern persisted for up to 2 years with no evidence of RCDII. The study indicates that better understanding of clonal T cell receptor gene rearrangements may help researchers improve refractory celiac diagnosis. 
    Source:
    Journal of Clinical Pathologyhttp://dx.doi.org/10.1136/jclinpath-2018-205023

    Jefferson Adams
    Celiac.com 06/13/2018 - There have been numerous reports that olmesartan, aka Benicar, seems to trigger sprue‐like enteropathy in many patients, but so far, studies have produced mixed results, and there really hasn’t been a rigorous study of the issue. A team of researchers recently set out to assess whether olmesartan is associated with a higher rate of enteropathy compared with other angiotensin II receptor blockers (ARBs).
    The research team included Y.‐H. Dong; Y. Jin; TN Tsacogianis; M He; PH Hsieh; and JJ Gagne. They are variously affiliated with the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School in Boston, MA, USA; the Faculty of Pharmacy, School of Pharmaceutical Science at National Yang‐Ming University in Taipei, Taiwan; and the Department of Hepato‐Gastroenterology, Chi Mei Medical Center in Tainan, Taiwan.
    To get solid data on the issue, the team conducted a cohort study among ARB initiators in 5 US claims databases covering numerous health insurers. They used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for enteropathy‐related outcomes, including celiac disease, malabsorption, concomitant diagnoses of diarrhea and weight loss, and non‐infectious enteropathy. In all, they found nearly two million eligible patients. 
    They then assessed those patients and compared the results for olmesartan initiators to initiators of other ARBs after propensity score (PS) matching. They found unadjusted incidence rates of 0.82, 1.41, 1.66 and 29.20 per 1,000 person‐years for celiac disease, malabsorption, concomitant diagnoses of diarrhea and weight loss, and non‐infectious enteropathy respectively. 
    After PS matching comparing olmesartan to other ARBs, hazard ratios were 1.21 (95% CI, 1.05‐1.40), 1.00 (95% CI, 0.88‐1.13), 1.22 (95% CI, 1.10‐1.36) and 1.04 (95% CI, 1.01‐1.07) for each outcome. Patients aged 65 years and older showed greater hazard ratios for celiac disease, as did patients receiving treatment for more than 1 year, and patients receiving higher cumulative olmesartan doses.
    This is the first comprehensive multi‐database study to document a higher rate of enteropathy in olmesartan initiators as compared to initiators of other ARBs, though absolute rates were low for both groups.
    Source:
    Alimentary Pharmacology & Therapeutics

    Jefferson Adams
    Celiac.com 06/12/2018 - A life-long gluten-free diet is the only proven treatment for celiac disease. However, current methods for assessing gluten-free diet compliance are lack the sensitivity to detect occasional dietary transgressions that may cause gut mucosal damage. So, basically, there’s currently no good way to tell if celiac patients are suffering gut damage from low-level gluten contamination.
    A team of researchers recently set out to develop a method to determine gluten intake and monitor gluten-free dietary compliance in patients with celiac disease, and to determine its correlation with mucosal damage. The research team included ML Moreno, Á Cebolla, A Muñoz-Suano, C Carrillo-Carrion, I Comino, Á Pizarro, F León, A Rodríguez-Herrera, and C Sousa. They are variously affiliated with Facultad de Farmacia, Departamento de Microbiología y Parasitología, Universidad de Sevilla, Sevilla, Spain; Biomedal S.L., Sevilla, Spain; Unidad Clínica de Aparato Digestivo, Hospital Universitario Virgen del Rocío, Sevilla, Spain; Celimmune, Bethesda, Maryland, USA; and the Unidad de Gastroenterología y Nutrición, Instituto Hispalense de Pediatría, Sevilla, Spain.
    For their study, the team collected urine samples from 76 healthy subjects and 58 patients with celiac disease subjected to different gluten dietary conditions. To quantify gluten immunogenic peptides in solid-phase extracted urines, the team used a lateral flow test (LFT) with the highly sensitive and specific G12 monoclonal antibody for the most dominant GIPs and an LFT reader. 
    They detected GIPs in concentrated urines from healthy individuals previously subjected to gluten-free diet as early as 4-6 h after single gluten intake, and for 1-2 days afterward. The urine test showed gluten ingestion in about 50% of patients. Biopsy analysis showed that nearly 9 out of 10 celiac patients with no villous atrophy had no detectable GIP in urine, while all patients with quantifiable GIP in urine showed signs of gut damage.
    The ability to use GIP in urine to reveal gluten consumption will likely help lead to new and non-invasive methods for monitoring gluten-free diet compliance. The test is sensitive, specific and simple enough for clinical monitoring of celiac patients, as well as for basic and clinical research applications including drug development.
    Source:
    Gut. 2017 Feb;66(2):250-257.  doi: 10.1136/gutjnl-2015-310148.