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MsCurious

Scientific Validation For Non-Celiac Gluten Sensitivity!

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University of Maryland School of Medicine Researchers Identify Key Pathogenic Differences Between Celiac Disease & Gluten Sensitivity

Thursday, March 10, 2011

http://somvweb.som.umaryland.edu/absolutenm/templates/?a=1474&z=5

Dr. Alessio Fasano directs the Center for Celiac Rsearch.

"Scientists at the University of Maryland School of Medicine’s Center for Celiac Research have proven that gluten sensitivity is different from celiac disease at the molecular level and in the response it elicits from the immune system. The research, published online in BMC Medicine, provides the first scientific evidence of a different mechanism leading to gluten sensitivity. It also demonstrates that gluten sensitivity and celiac disease are part of a spectrum of gluten-related disorders."

MARCH 15, 2011 Clues to Gluten Sensitivity

http://online.wsj.com/article/SB10001424052748704893604576200393522456636.html#articleTabs%3Darticle

"For the first time, we have scientific evidence that indeed, gluten sensitivity not only exists, but is very different from celiac disease," says lead author Alessio Fasano, medical director of the University of Maryland's Center for Celiac Research.

"There's a lot more that needs to be done for people with gluten sensitivity," she says. "But at least we now recognize that it's real and that these people aren't crazy."

Click the links for full stories... very interesting... most of it things we already knew... just nice to see the scientific medical community acknowledge these things! :)


~ MsCurious ~

"If you keep doing what you're doing... You'll keep getting what you're getting!"

tTg IgA IgG borderline 1/25/11 rolleyes.gif

HLA DQ2.5 Positive 2/11/11

Biopsy 4/11/11

100% Lactose/Dairy Free 4/11/11

Gluten Free 4/14/11

Life is SO MUCH better gluten-free!

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MsCurious, Excellent articles on Gluten Intolerance! The articles shows that the medical profession knows there is other gluten Intolerance in addition to Celiac Disease. I notice that one article said that the medical research for Gluten sensitivity is where medical research was for Celiac 30 years ago. That explains why there is no diagnosis and treatment for those negative to the blood tests and biopsy. I hope it doesn

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MsCurious, Excellent articles on Gluten Intolerance! The articles shows that the medical profession knows there is other gluten Intolerance in addition to Celiac Disease. I notice that one article said that the medical research for Gluten sensitivity is where medical research was for Celiac 30 years ago. That explains why there is no diagnosis and treatment for those negative to the blood tests and biopsy. I hope it doesn


~ MsCurious ~

"If you keep doing what you're doing... You'll keep getting what you're getting!"

tTg IgA IgG borderline 1/25/11 rolleyes.gif

HLA DQ2.5 Positive 2/11/11

Biopsy 4/11/11

100% Lactose/Dairy Free 4/11/11

Gluten Free 4/14/11

Life is SO MUCH better gluten-free!

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This almost makes me want to canel my drs appointment on Thursday!!! It explains why it seems my system can handle small amounts but when I load up I feel horrid. I may or may not get answers in the coming months but now at least I know that there is someone out there, exploring the fact that this could be a spectrum type disorder. I'm still going to go ahead with my plan to ask for genetic testing first but if it comes back negative for Celiac, I still have at least some medical validation for me to do what I know I should do, whether I have the scopes done or not! Thanks so much for sharing this!

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I was very excited to read these articles!!


Proud breastfeeding, toddlerwearing, part time cosleeping, stay at home mom. Positive for two copies of DQ8, negative celiac panel after 3 month gluten challenge; biopsy showed gastritis, inflammation in the esophagus, and hiatial hernia but no signs of celiac. Possible DH. Gluten free as of 3/11/2011

ODD 3 1/2, positive for DQ8 and DQ6, negative celiac panel after 3 month gluten challenge. Gluten free as of 3/10/2011

YDD 2, no testing. Positive for DQ8 and DQ6. Possible DH. Gluten free as of 3/10/2011

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6% is a pretty large number of people. That should get some attention from researchers.


Proverbs 25:16 "Hast thou found honey? eat so much as is sufficient for thee, lest thou be filled therewith, and vomit it."

Job 30:27 My bowels boiled, and rested not: the days of affliction prevented me.

Thyroid cyst and nodules, Lactose / casein intolerant. Diet positive, gene test pos, symptoms confirmed by Dr-head. My current bad list is: gluten, dairy, sulfites, coffee (the devil's brew), tea, Bug's Bunnies carrots, garbanzo beans of pain, soy- no joy, terrible turnips, tomatoes, peppers, potatoes, eggplant, celery, strawberries, pistachios, and hard work. Have a good day! 🙂 Paul

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6% is a pretty large number of people. That should get some attention from researchers.

LOL... Sorry for laughing but ... IMO the only money for research will come from gluten free food companies! :lol: The big pharmaceutical companies have zero interest in Gluten Intolerance and Celiac, because it is not treated with drugs, and people already know it can be successfully treated with diet. B)

University research, and independent research hospitals are the ones that have made attempts, but that has been limited, and certainly the findings are not reaching the general physican population. Sadly, that's the biggest gap right now... uneducated doctors. Hopefully, they will start taking more notice now! :)


~ MsCurious ~

"If you keep doing what you're doing... You'll keep getting what you're getting!"

tTg IgA IgG borderline 1/25/11 rolleyes.gif

HLA DQ2.5 Positive 2/11/11

Biopsy 4/11/11

100% Lactose/Dairy Free 4/11/11

Gluten Free 4/14/11

Life is SO MUCH better gluten-free!

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LOL... Sorry for laughing but ... IMO the only money for research will come from gluten free food companies! :lol: The big pharmaceutical companies have zero interest in Gluten Intolerance and Celiac, because it is not treated with drugs, and people already know it can be successfully treated with diet. B)

University research, and independent research hospitals are the ones that have made attempts, but that has been limited, and certainly the findings are not reaching the general physican population. Sadly, that's the biggest gap right now... uneducatd doctors. Hopefully, they will start taking more notice now! :)

Oh, well, that should get some attention in a perfect world. But you are right, we don't live in one of them.

Well, 6% is enough to form a good size voting block anyway. Viva the gluten-free party! :)


Proverbs 25:16 "Hast thou found honey? eat so much as is sufficient for thee, lest thou be filled therewith, and vomit it."

Job 30:27 My bowels boiled, and rested not: the days of affliction prevented me.

Thyroid cyst and nodules, Lactose / casein intolerant. Diet positive, gene test pos, symptoms confirmed by Dr-head. My current bad list is: gluten, dairy, sulfites, coffee (the devil's brew), tea, Bug's Bunnies carrots, garbanzo beans of pain, soy- no joy, terrible turnips, tomatoes, peppers, potatoes, eggplant, celery, strawberries, pistachios, and hard work. Have a good day! 🙂 Paul

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No money in it for big pharma means research WILL be difficult to fund. When I think back ten years ago to the time I was so sick I could not function, it was a nightmare getting anyone to take me and my thyroid symptoms seriously.My labs, after all, were "normal". No one bothered to look at my thyroid antibodies because my hormone levels were "fine".

Thankfully a person can discover for themselves whether gluten is a problem by simply avoiding it. You don't need a doc to do tests or write a prescription.

I tell everyone I know who has intestinal problems and docs that brush them off, that they should try taking gluten out of their diet.


1999 - Hypothyroid

2003 - Hashimoto's Disease

2008 - Diverticulitis

2009 - Significant Vit D Deficiency

2011 - Diverticulitis again

2011 - HLA-DQ2.2

2012 - TtG IgG positive... I am now, finally, Gluten Free - 5/16/2012

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6% is a pretty large number of people. That should get some attention from researchers.

The problem is that very few of the 6% have any clue that gluten might be the cause of their problems.

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Either they don't know, or they are like one of my sisters and don't want to know because they can't tolerate the thought of giving up their precious gluten :P


Neroli

"Everything that can be counted does not necessarily count; everything that counts cannot necessarily be counted." - Albert Einstein

"Life is not weathering the storm; it is learning to dance in the rain"

"Whatever the question, the answer is always chocolate." Nigella Lawson

------------

Caffeine free 1973

Lactose free 1990

(Mis)diagnosed IBS, fibromyalgia '80's and '90's

Diagnosed psoriatic arthritis 2004

Self-diagnosed gluten intolerant, gluten-free Nov. 2007

Soy free March 2008

Nightshade free Feb 2009

Citric acid free June 2009

Potato starch free July 2009

(Totally) corn free Nov. 2009

Legume free March 2010

Now tolerant of lactose

Celiac.com - Celiac Disease Board Moderator

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FANTASTIC articles! I am passing these on to everyone I know. Good grief my friends are soooo sick of my Facebook updates about celiac disease, but I dont' care! These are just too good not to share. Thanks for posting them!

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I also was SO happy to read the study, since I don't have celiacs but I noticed a perhaps 80% improvement when I went off of gluten. (I tried going back on gluten a few times and those experiments utterly failed.)

The study also intrigued me because it appears that non-celiac gluten sensitive individuals had a different type of immune response, rather than just having a mini-form of celiacs. I'm no med student so I may have misunderstood the article, but something is messed up with the intestinal immune function.

I think this means that gluten sensitivity is just a manifestation of a deeper problem, especially as every non-celiac gluten sensitive person I met said they only felt about 80% better when they went off gluten. (I find it strange we all pick that number.) The interesting thing was that gluten sensitives had a lower Treg cell expression than the controls, and the celiacs didn't (with statistical significance). Couldn't this have implications for other types of immune responses, other than just to gluten?

I hope they continue with the research!

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I just read a book Healthier Without Wheat, and it says, that celiac is just one form of gluten intolerance, and not necessarily the most serious since some other froms can be very damaging to the body as well.

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I just read a book Healthier Without Wheat, and it says, that celiac is just one form of gluten intolerance, and not necessarily the most serious since some other froms can be very damaging to the body as well.

Yes, Gluten Ataxia can effect the brain and/or the nervous system, and DH a form of gluten intolerance can effect the skin. Celiac Disease generally effects the small intestines.

....And it's all gluten related.


Lisa

Gluten Free - August 15, 2004

"Not all who wander are lost" - JRR Tolkien

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I just read a book Healthier Without Wheat, and it says, that celiac is just one form of gluten intolerance, and not necessarily the most serious since some other froms can be very damaging to the body as well.

I would like to clarify something: Celiac disease is a "form of gluten intolerance" yes, but it has some dire complications not found in NCGI.

And that is not at all what "that book says". The author differentiates these two conditions by discussing them at length.

Page 55

"In order to understand the various forms of gluten intolerance,

we first need to define celiac disease.

This will make it much easier to understand why celiac disease is not the same as gluten intolerance."

" In people with celiac disease, eating gluten leads to a very specific type of damage to the small intestine."

NCGI, which causes many horrid symptoms, does not affect the villi in the small intestine.

and DH ...IS the skin manifestation of celiac disease. Dr. Green states this unequivocally.


"Life is not the way it's supposed to be. It's the way it is. The way we cope with it makes the difference." Virginia Satir

"The strongest of all warriors are these two - time and patience." Leo Tolstoy

"If you want to lift yourself up, lift up someone else" Booker T. Washington

“If idiots could fly, the sky would be like an airport.”― Laura Davenport 

"Do or do not. There is no try. "-  Yoda.

"LTES"  Gem 2014

 

Misdiagnosed for 25+ years; Finally Diagnosed with Celiac  11/01/10.  Double DQ2 genes. This thing tried to kill me. I view Celiac as a fire breathing dragon --and I have run my sword right through his throat.
I. Win. bliss-smiley-emoticon.gif

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That 6% of people with Gluten Sensitivity is way off. It's a whole lot higher. There are also tests available for "Gluten Sensitivity". Wheat IgG, Barley IgG, and Rye IgG. These are Allergy tests unlike the Celiac Panel which only tests for damage caused by Glaidin/Gluten. Even if you are already Gluten Free you will still get a positive. No scope or biopsy needed, just one simple blood test.


Diagnosed with Wheat, Barley, Rye Allergies Dec. 2011

Gluten Free since Dec. 2011

No more Arthritis, Acid Reflux, Acne, Hyperlipidemia, Hypertension, and countless other minor health problems. Also lost 50 lbs. & avoiding future health problems

Added Bananas, Lettuce, Strawberries, Pork, & Goat Milk to my diagnosed Food Allergy list Oct. 2012

Still a long way to go on discovering all my Food Allergies

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