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Scientific Validation For Non-Celiac Gluten Sensitivity!

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University of Maryland School of Medicine Researchers Identify Key Pathogenic Differences Between Celiac Disease & Gluten Sensitivity

Thursday, March 10, 2011

http://somvweb.som.umaryland.edu/absolutenm/templates/?a=1474&z=5

Dr. Alessio Fasano directs the Center for Celiac Rsearch.

"Scientists at the University of Maryland School of Medicine’s Center for Celiac Research have proven that gluten sensitivity is different from celiac disease at the molecular level and in the response it elicits from the immune system. The research, published online in BMC Medicine, provides the first scientific evidence of a different mechanism leading to gluten sensitivity. It also demonstrates that gluten sensitivity and celiac disease are part of a spectrum of gluten-related disorders."

MARCH 15, 2011 Clues to Gluten Sensitivity

http://online.wsj.com/article/SB10001424052748704893604576200393522456636.html#articleTabs%3Darticle

"For the first time, we have scientific evidence that indeed, gluten sensitivity not only exists, but is very different from celiac disease," says lead author Alessio Fasano, medical director of the University of Maryland's Center for Celiac Research.

"There's a lot more that needs to be done for people with gluten sensitivity," she says. "But at least we now recognize that it's real and that these people aren't crazy."

Click the links for full stories... very interesting... most of it things we already knew... just nice to see the scientific medical community acknowledge these things! :)

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MsCurious, Excellent articles on Gluten Intolerance! The articles shows that the medical profession knows there is other gluten Intolerance in addition to Celiac Disease. I notice that one article said that the medical research for Gluten sensitivity is where medical research was for Celiac 30 years ago. That explains why there is no diagnosis and treatment for those negative to the blood tests and biopsy. I hope it doesn

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MsCurious, Excellent articles on Gluten Intolerance! The articles shows that the medical profession knows there is other gluten Intolerance in addition to Celiac Disease. I notice that one article said that the medical research for Gluten sensitivity is where medical research was for Celiac 30 years ago. That explains why there is no diagnosis and treatment for those negative to the blood tests and biopsy. I hope it doesn

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This almost makes me want to canel my drs appointment on Thursday!!! It explains why it seems my system can handle small amounts but when I load up I feel horrid. I may or may not get answers in the coming months but now at least I know that there is someone out there, exploring the fact that this could be a spectrum type disorder. I'm still going to go ahead with my plan to ask for genetic testing first but if it comes back negative for Celiac, I still have at least some medical validation for me to do what I know I should do, whether I have the scopes done or not! Thanks so much for sharing this!

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6% is a pretty large number of people. That should get some attention from researchers.

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6% is a pretty large number of people. That should get some attention from researchers.

LOL... Sorry for laughing but ... IMO the only money for research will come from gluten free food companies! :lol: The big pharmaceutical companies have zero interest in Gluten Intolerance and Celiac, because it is not treated with drugs, and people already know it can be successfully treated with diet. B)

University research, and independent research hospitals are the ones that have made attempts, but that has been limited, and certainly the findings are not reaching the general physican population. Sadly, that's the biggest gap right now... uneducated doctors. Hopefully, they will start taking more notice now! :)

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LOL... Sorry for laughing but ... IMO the only money for research will come from gluten free food companies! :lol: The big pharmaceutical companies have zero interest in Gluten Intolerance and Celiac, because it is not treated with drugs, and people already know it can be successfully treated with diet. B)

University research, and independent research hospitals are the ones that have made attempts, but that has been limited, and certainly the findings are not reaching the general physican population. Sadly, that's the biggest gap right now... uneducatd doctors. Hopefully, they will start taking more notice now! :)

Oh, well, that should get some attention in a perfect world. But you are right, we don't live in one of them.

Well, 6% is enough to form a good size voting block anyway. Viva the gluten-free party! :)

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No money in it for big pharma means research WILL be difficult to fund. When I think back ten years ago to the time I was so sick I could not function, it was a nightmare getting anyone to take me and my thyroid symptoms seriously.My labs, after all, were "normal". No one bothered to look at my thyroid antibodies because my hormone levels were "fine".

Thankfully a person can discover for themselves whether gluten is a problem by simply avoiding it. You don't need a doc to do tests or write a prescription.

I tell everyone I know who has intestinal problems and docs that brush them off, that they should try taking gluten out of their diet.

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I love this research article. Finally it tells everyone what we all knew! Hopefully they'll find some markers to help test those with sensitivity rather than celiac disease.

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6% is a pretty large number of people. That should get some attention from researchers.

The problem is that very few of the 6% have any clue that gluten might be the cause of their problems.

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Either they don't know, or they are like one of my sisters and don't want to know because they can't tolerate the thought of giving up their precious gluten :P

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FANTASTIC articles! I am passing these on to everyone I know. Good grief my friends are soooo sick of my Facebook updates about celiac disease, but I dont' care! These are just too good not to share. Thanks for posting them!

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I also was SO happy to read the study, since I don't have celiacs but I noticed a perhaps 80% improvement when I went off of gluten. (I tried going back on gluten a few times and those experiments utterly failed.)

The study also intrigued me because it appears that non-celiac gluten sensitive individuals had a different type of immune response, rather than just having a mini-form of celiacs. I'm no med student so I may have misunderstood the article, but something is messed up with the intestinal immune function.

I think this means that gluten sensitivity is just a manifestation of a deeper problem, especially as every non-celiac gluten sensitive person I met said they only felt about 80% better when they went off gluten. (I find it strange we all pick that number.) The interesting thing was that gluten sensitives had a lower Treg cell expression than the controls, and the celiacs didn't (with statistical significance). Couldn't this have implications for other types of immune responses, other than just to gluten?

I hope they continue with the research!

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I just read a book Healthier Without Wheat, and it says, that celiac is just one form of gluten intolerance, and not necessarily the most serious since some other froms can be very damaging to the body as well.

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I just read a book Healthier Without Wheat, and it says, that celiac is just one form of gluten intolerance, and not necessarily the most serious since some other froms can be very damaging to the body as well.

Yes, Gluten Ataxia can effect the brain and/or the nervous system, and DH a form of gluten intolerance can effect the skin. Celiac Disease generally effects the small intestines.

....And it's all gluten related.

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I just read a book Healthier Without Wheat, and it says, that celiac is just one form of gluten intolerance, and not necessarily the most serious since some other froms can be very damaging to the body as well.

I would like to clarify something: Celiac disease is a "form of gluten intolerance" yes, but it has some dire complications not found in NCGI.

And that is not at all what "that book says". The author differentiates these two conditions by discussing them at length.

Page 55

"In order to understand the various forms of gluten intolerance,

we first need to define celiac disease.

This will make it much easier to understand why celiac disease is not the same as gluten intolerance."

" In people with celiac disease, eating gluten leads to a very specific type of damage to the small intestine."

NCGI, which causes many horrid symptoms, does not affect the villi in the small intestine.

and DH ...IS the skin manifestation of celiac disease. Dr. Green states this unequivocally.

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Good article! This could explain why so many are mis-diagnosed! I like where it says, Agricultural changes to wheat production may have boosted the protein. Could be a conspiracy theory, but I love conspiracy theories! ;)

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That 6% of people with Gluten Sensitivity is way off. It's a whole lot higher. There are also tests available for "Gluten Sensitivity". Wheat IgG, Barley IgG, and Rye IgG. These are Allergy tests unlike the Celiac Panel which only tests for damage caused by Glaidin/Gluten. Even if you are already Gluten Free you will still get a positive. No scope or biopsy needed, just one simple blood test.

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