Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Celiac.com!
    eNewsletter
    Donate

celiac disease Associated Autoantibodies In Dh Published 4/12

squirmingitch

Recommended Posts

squirmingitch Veteran
squirmingitch
Posted

I know this is some really important info. for us & may give those of us with dh a better chance for testing & dx. I'm not that great at understanding EXACTLY how much hope this gives us though. Some of you have a better grasp of medical techno lingo &/or may be able to access the entire article. Would like comments on this.

Open Original Shared Link

Novel assay for detecting celiac disease-associated autoantibodies in dermatitis herpetiformis using deamidated gliadin-analogous fusion peptides.

Open Original Shared Link, [url=Open Original Shared Link
Link to comment
Share on other sites
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


pricklypear1971 Community Regular
pricklypear1971
Posted

I can't being anything intelligent to the discussion but what is the GAF3x?

Link to comment
Share on other sites
squirmingitch Veteran
squirmingitch
  • Author
Posted

I think it's this:

deamidated gliadin-analogous fusion

peptides

(GAF3X)

see:

https://www.celiac.com/articles/21901/1/Antibodies-to-Deamidated-Gliadin-as-a-Tool-in-Diagnosing-Childhood-Celiac-Disease/Page1.html

Link to comment
Share on other sites
pricklypear1971 Community Regular
pricklypear1971
Posted

Hmm. I looked on the LabCorp site and don't see it - or don't think I see it. I wonder which labs offer it.

Link to comment
Share on other sites
squirmingitch Veteran
squirmingitch
  • Author
Posted

This is also what they say is better for detecting celiac in children.

Open Original Shared Link

Link to comment
Share on other sites
pricklypear1971 Community Regular
pricklypear1971
Posted

Yes, but how do you GET it?

Link to comment
Share on other sites
squirmingitch Veteran
squirmingitch
  • Author
Posted

I haven't the foggiest notion. I did a search too for Labs who do it & couldn't get anywhere --- just kept coming up with the article abstract.

Ask doctors?

Link to comment
Share on other sites
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


ciamarie Rookie
ciamarie
Posted

Dunno. But it does look promising, as far as a tool for detecting DH / celiac without biopsy!

Link to comment
Share on other sites
itchy Rookie
itchy
Posted

I took it to mean that in tests (done correctly) the false negative level will be 30%. Or possibly the false positive rate. In any case it appears that the tests will be slightly better and there are at least eight researchers working on improving them. THat's good news to me.

Link to comment
Share on other sites

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      121,043
    • Most Online (within 30 mins)
      7,748
    Gluten Freends
    Newest Member
    Gluten Freends
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.3k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • cristiana
      Finding out I’m coeliac whilst pregnant

      By cristiana · Posted

      @Katiec123 Welcome to the forum. I started to have symptoms related to coeliac disease (mouth ulcers, aura migraines etc) but no gastric symptoms during my first pregnancy.  That went to term, in fact, I was 10 days over and had to be induced.  But my second baby, born 21 months later, arrived at 33 weeks.  He's now doing well, and taller than all of us - it was just an earlier than expected arrival! I think if you can, you should ask for an urgent referral to the gastroenterologist from your GP.   See if that works. By the way you spell 'coeliac' I'm guessing you are posting from the UK?  If that is the case, the NHS may rush things along for you, I suspect they will.  If it appears that they cannot refer you urgently, if you have the money for a private consultation it might be well worth it, as there is a trend here in the UK (I'm British) to diagnose coeliacs without the need for an endoscopy if the blood test results are compelling. Sounds like this is the case for you.  If you can see a consultant gastroenterologist privately s/he might be able to diagnose you without going any further.  Once you get a formal diagnosis, there is a lot of support for coeliacs through the NHS, with nutritionist support, annual reviews and blood tests to check for diet compliance and health related issues, DEXA scans to check bone density, extra vaccinations where indicated and in some areas, certain gluten free food available on prescription. I hope all goes well with your appointment, let us know how you get on.
    • Shireen32
      Still testing positive after being gluten free for one year ?!!

      By Shireen32 · Posted

      Hi , since being gluten free I am still having bad stomach problems . Such as constant gas in my stomach 24/7 ,burning, constant bubbling noises coming from my stomach and gurgling sounds that never stop .Pain under the left side of my rib cage when ever I eat and just always there’s pain there  .  My symptoms have not improved at all since being gluten free.  Could this be refractory coeliac disease ?? How is that even diagnosed or confirmed  ?  I had tests recently and this is what they say :Endomysial abs (IgA) -Positive  TTG abs (IgA)U/ml : My result is : 0.9 U/ml The Range:0 - 10 U/ml What does this mean pls ??? How can I still test positive for Endomysial abs when I am gluten free and am very careful about cross contamination? Do I even have coeliac disease I’m convinced some other digestive disorder is causing these symptoms .   I also have not had a endoscopy and now the gastroenterologist calls me after one year ( I’m from the uk and have free healthcare which has been such a nightmare with all this and never help me  )  so as I am gluten free the gastroenterologist advised me to start eating gluten again to be referred for a biopsy .. Is a biopsy even worth me doing ? The only proof I have is when I was eating gluten I could never get my ferretin , vitamin d and folate levels up . And since being gluten free these have gone up a little bit  . But that doesn’t always mean coeliac as I know gluten stops absorption in even normal people  . Pls can anyone shed some light it’s much needed ! And share some advice or answer my questions above . I have no idea with this whole coeliac stuff and am very much struggling .Much Appreciated .  
    • knitty kitty
      Joint swelling when ill even on gluten-free diet

      By knitty kitty · Posted

      Vitamin D deficiency.  Not enough Omega Threes. Another autoimmune disease like arthritis, maybe.    
    • Eldene
      Oats gluten free?

      By Eldene · Posted

      Any Naturopaths on this site?
    • Katiec123
      Finding out I’m coeliac whilst pregnant

      By Katiec123 · Posted

      @RMJ it makes sense as it’s something I’ve experienced more than once. Currently 24 weeks and baby is doing well! Will be seeking more medical advice today 
×
×
  • Create New...