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hard2handle

Another Newbie Needs Test Intepretation Help Pls!

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Background: finished treatment recently for lung cancer (44yo non-smoker) and am working with an integrative medicine dr on nutritional and supplement approaches to reduce inflammation in my body and repair damage from disease and treatment. He ran a large number of tests and I received the results of the HLA-DQ yesterday morning. I'm actually not sure that these results matter so much as I already have a serious malignancy and am committed to going gluten-free to improve my overall health. I had trouble mapping these into the table (DQ2.2???) and am hoping this is enough for one of the board experts to read. I'm thinking my questions to him were too general, hence a very short reply.

<note I sent him last night>

The results from this test were not back when we met on Monday. I noticed also that a comment was added to all of my results stating that the celiac gene was present and to avoid gluten. Could you help me understand these results, and in conjunction with my other labs (i.e. Gliadin). I looked at the tables at http://en.wikipedia.org/wiki/HLA-DQ but still not sure what they mean (DQ2 and DQ5?). Thanks.

<test results>

Component Your Value Standard Range Units Flag

DQ ALPHA 1 01:01,02:01

DQ BETA 1 02:02,05:01

ELIAC GENE PAIRS PRESENT? INDETERMINATE

CELIAC ASSOC HLA INTERPRETATION Heterozygous only, while lacks genes only in celiac disease, there are rare

exceptions in which celiac disease can occur with only one half of the gene

pair(1% of celiacs)

<his reply this morning>

Yes, the gene tests shows you have one of the two gene pairs plus you have all of these tests showing damage

<other test results>

GLIADIN AB, IGA: 6

GLIADIN AB, IGG: 7

MAGNESIUM: 2.2

CALCIUM: 9.1

VITAMIN D: 30.9

PTH INTACT: 24.0

LDL CHOLESTEROL, CALCULATED: 121 (H)

NON-HDL CHOLESTEROL (CHOL-HDL): 133 (H)

TSH, HIGH-SENSITIVITY: 2.421

IRON: 46 (L)

IRON SATURATION: 14 (L

C-REACTIVE PROTEIN: 14.10 (H)

SEDIMENTATION RATE AUTOMATED: 30 (H)

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On the "other" test results you posted at the bottom, are there ranges given, as it was a 6 and a 7 on a scale of ?????

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You have DQ5 (the 0101-0501 part)

and DQ2,2 (the 0201-0202 )

Now before, they could not discern between DQ2,5 and DQ2,2, and the DQ2,2 people were considered celiac prone too.

now they can discern, so first they said DQ2,2 was not a celiac gene, but then they said some do have DQ2,2.

Anyway, there have been several DQ2,2 with celiac symptoms here, and some with diagnosis.

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I'm a DQ2.2, like you. I test negative on Celiac blood tests, but had completely flattened villi/ulceration in the duodenum when scoped. I was DXed with Celiac because of the damage.

I've had several Dr.s say DQ2.2 isn't Celiac, but it seems like they need to keep a more open mind? If all of the Dr.s are dismissing those with symptoms, but don't have DQ2 and Dq8 a lot of us are being mis-diagnosed!

There are several studies underway to sort out "other" Celiac/gluten intolerant genes.

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