rafrockabilly replied to Robix's topic in Celiac Disease - Related Disorders & ResearchMassive oral B12 doses did nothing for me. They'll do nothing if you have issues with intrinsic factor. Shots are the sure-fire way to go. I'm off my insurance so I just buy shots online and self-administer. My doctors were worthless anyway. I only caught this because I demanded tests. Then I told them I wanted shots and they gave me some BS about a B12 shot shortage - seriously?- I can just buy them online people. I was kind of afraid of doing it myself though so first I tried the massive oral doses - did nothing. Then I tried sublinguals- helped but my symptoms came back even while taking them regularly. So I did the shots and they work like a charm. It's a lot easier to do than I thought too.