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Showing results for tags 'arthritis'.
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Celiac.com 02/08/2023 - Arthritis is a common problem for many people with celiac disease. And patients with celiac disease get rheumatoid arthritis twice as much as non-celiacs. However, the connection between arthritis and celiac disease is not well understood. A number of studies have found connections between celiac disease and arthritis. The connections are still not well understood, but here are some of the main findings. Celiac Disease and Juvenile Idiopathic Arthritis A recent study shows that JIA is nearly three times more common among children with celiac disease than in the general population. Other studies support this finding. We also know that celiac disease can occur in JIA patients with no celiac symptoms. Celiac Disease and Rheumatoid Arthritis In adults with celiac disease, rheumatoid arthritis strikes nearly 9 per 10,000 person-years and about 5 per 10,000 person-years in matched factors over a follow-up of about nine years. Rheumatoid arthritis occurs nearly twice as often among adults with celiac disease. It's important for individuals with celiac disease to be aware of the possibility of developing rheumatoid arthritis and to inform their doctor if they have any joint symptoms. High rates of Celiac Disease Antibodies in Adult Rheumatology Patients We know that studies have shown high rates of celiac antibodies in adult rheumatology patients. A recent study showed celiac antibodies in 3% of adult rheumatology patients, which provides support for celiac screening in people with rheumatological issues might be good practice. Because of the extra risk, it is important for clinicians to watch closely for signs of arthritis in celiac patients with joint symptoms, as early arthritis detection and treatment leads to much better outcomes. Look for researchers to learn more about the connections between arthritis and celiac disease going forward. Stay tuned for more on this and other important stories about celiac disease. Read more on celiac disease and arthritis Could an Old Arthritis Drug Treat Celiac Disease and Allow Celiacs to Eat Gluten Again? Celiac Disease More Common in Patients With Juvenile Idiopathic Arthritis Celiac Disease Possible in Juvenile Idiopathic Arthritis Patients with no Celiac Symptoms
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Celiac.com 12/23/2022 - Compared with the general population, children with celiac disease are nearly three times as likely to develop juvenile idiopathic arthritis, while adults with celiac disease are nearly twice as likely to be diagnosed with rheumatoid arthritis. Celiac disease is tied to numerous immune-mediated conditions, but, so far, researchers haven't nailed down any solid epidemiological connection between celiac disease and juvenile idiopathic arthritis or rheumatoid arthritis. A new study changes that. Here's how. Population-based Cohort Study Using a population-based cohort, a team of researchers recently set out to determine the risk of juvenile idiopathic arthritis and rheumatoid arthritis in people with celiac disease. The research team included John B. Doyle, MD; Benjamin Lebwohl, MD, MS; Johan Askling, PhD; Anders Forss, MD; Peter H.R. Green MD; Bjorn Roelstraete, PhD; Jonas Söderling, PhD; Jans F. Ludvigsson, and Jonas MD, PhD. They are variously affiliated with the Celiac Disease Center, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA; the Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; the Department of Pediatrics, Orebro University Hospital, Orebro, Sweden. Celiac Disease Data Used to Spot Patients Using a national histopathology database in Sweden, the team identified patients diagnosed with biopsy-proven celiac disease between 2004 and 2017. They then matched each patient by age, sex, calendar year, and geographic region against people from the general population. They then used Cox proportional hazards models to calculate the incidence and estimated the relative risk of juvenile idiopathic arthritis in celiacs aged eighteen and under, and of rheumatoid arthritis in people with celiac disease aged eighteen and over. The team found just over 24,000 celiacs, whom they then matched to more than 117,000 people from the general population. Juvenile Idiopathic Arthritis Rates Triple for Celiac Youth & Rheumatoid Arthritis Rates Double for Adults Among people under 18 years old, the incidence rate of juvenile idiopathic arthritis was 5.9 per 10,000 person-years in patients with celiac disease and 2.2 per 10,000 person-years in the general population over a seven year follow-up. Among individuals 18 or over, the incidence of rheumatoid arthritis was 8.4 per 10,000 person-years in celiac disease and 5.1 per 10,000 person-years in matched comparators over a follow-up of 8.8 years. KIA is nearly three times more common among children with celiac disease than in the general population, while rheumatoid arthritis occurs nearly twice as often among adults with celiac disease. Based on their findings, the team advises clinicians caring for celiac patients with joint symptoms to be vigilant for signs of juvenile idiopathic arthritis or rheumatoid arthritis in those patients. Read more in the American Journal of Gastroenterology
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Celiac.com 05/30/2022 - A recent Italian study published in Pediatric Rheumatology indicates that juvenile idiopathic arthritis patients have higher rates of celiac disease, which suggests that celiac screening would be beneficial for IA sufferers, especially those with a family history of autoimmunity. Since many autoimmune disorders share similar immune triggers, mechanics and contributing factors, including genetics and environment, understanding the connections, along with the factors associated with an increased susceptibility, could help researchers and clinicians to design better case-finding strategies for certain at-risk populations. For their retrospective study, the team gathered information, including age at diagnosis, family history, other autoimmune disorders, juvenile idiopathic arthritis subtype, and medications, from a Southern Italian group of patients with juvenile idiopathic arthritis who were admitted to the Pediatric Rheumatology Unit between January 2001 and June 2019 who underwent celiac disease screening. Using the data, they were able to assess clinical features and disease course, along with associated risk factors when juvenile idiopathic arthritis and celiac disease happen together. The team evaluated juvenile idiopathic arthritis patients every 3 to 6 months and adjusted treatment in response to adverse events and disease effects. The team's analysis is limited in part by small sample size of patients with both juvenile idiopathic arthritis and celiac disease, and because patients with juvenile idiopathic arthritis and celiac disease had longer follow-up periods than patients with juvenile idiopathic arthritis alone. However, since most celiac disease diagnosis occurred within 12 months of juvenile idiopathic arthritis onset, the team believes this does not influence bias. The team concluded that: They also added that the "results highlight the importance of celiac disease screening in pediatric juvenile idiopathic arthritis patients." These results are also significant for juvenile idiopathic arthritis patients who also have celiac disease, as juvenile idiopathic arthritis looks to be more aggressive in those patients, who often need step-up therapy. They note that these patients might benefit from an early introduction of a biologic drug, but more study is needed to know for sure. They plan future studies to test whether first-line genetic testing followed by celiac disease-specific serological screening will produce better results than first-line serological screening. Stay tuned for more on this and related stories. Read more in Rheumatology Network
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Celiac.com 12/13/2021 - Celiac disease is potentially connected to juvenile idiopathic arthritis (JIA). A team of researchers recently set out to determine the serological incidence of celiac disease in patients with JIA. For their study, the team enrolled seventy-eight patients children under 16 years of age with JIA, who had not responded well to routine treatment, and who visited the pediatric centers of Tehran University of Medical Sciences between 2017 and 2019. The team also assessed the various manifestations of celiac disease, and measured celiac disease-related serological screening tests. Average subject age was about 8 years old, plus or minus about 4 years. years. Three patients with oligoarticular JIA had Anti-TTG-Ab levels above normal. None had celiac symptoms. Data showed no significant statistical differences in terms of growth disorders, sex distribution, and different subtypes of JIA between the sero-positive and sero-negative groups. The team confirmed one case of celiac disease by pathology, and recommended a gluten-free diet for the patient. Their main takeaway from the data is that celiac disease is still possible, even in JIA patients with no celiac symptoms. Read more in the Archives of Iranian Medicine. 2021 Oct 1;24(10):783-785. The research team included N Payman Sadeghi, Kobra Salari, Vahid Ziaee, Nima Rezaei, and Kambiz Eftekhari. They are variously affiliated with the Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran; the Pediatric Rheumatology Iranian Society; the Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; the Pediatric Gastroenterology and Hepatology Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran and the Department of Pediatrics, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
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To All, I have been busy with life issues lately.....so my forum time has been reduced lately. Recently there was a popular article on Reishi Mushrooms and could it help Celiacs. Here is the link to the article for those not familiar with the article. This caused me to do some digging to see if there is something in Mushrooms that might be helping Celiac's the doctor's might of have forgotten... And after a little research I hit on NAG....it is found in the Arthritis section of most Vitamins shops... Here is three studies of it on/in either IBS or Celiac's where it (NAG) has been shown to improve Celiac's conditions as a potential therapeutic.... But for whatever reason has been forgotten. Research them yourselves and see what you think. I would love to hear what the forum thinks. Here is the three best research articles I could find on N. Acetyl Glucosamine aka NAG as studied in GI patients. https://pubmed.ncbi.nlm.nih.gov/7877884/ https://pubmed.ncbi.nlm.nih.gov/2394351/ https://pubmed.ncbi.nlm.nih.gov/11121904/ We are finding potential therapeutics that are not drugs which is exciting to me. And some that have been forgotten for 30 years. As always I hope this is helpful but it is not medical advise. Posterboy,
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Celiac.com 08/17/2020 - The case of a man whose celiac disease went into remission after he took an off market drug for alopecia, even though he was eating gluten, is getting some attention from researchers. An alopecia patient at the University Hospitals Leuven, Belgium, tried to control his celiac disease by following a gluten-free diet. After some modest improvement in symptoms, the patient returned to a non-gluten-free diet, and the symptoms returned. The patient chose to continue eating gluten, and to keep an eye on the symptoms. At about that time, he began taking off-label Tofacitinib to treat his alopecia. Tofacitinib is a Janus kinase inhibitor approved for treatment of rheumatoid arthritis and bowel diseases. Tofacitinib inhibits enzymes associated with symptoms of rheumatoid arthritis, but it’s also used to treat alopecia and certain bowel diseases. To the surprise of his clinicians, a follow-up visit showed complete histologic and serologic remission of the man's celiac disease, despite his ongoing consumption of gluten. Blood tests for celiac antibodies all came back in the normal range. The result is intriguing, but is only a single case, and it will require a larger study to reveal whether this might also work in others with celiac disease. Since Tofacitinib has already been approved by the FDA as a safe and effective treatment for several non-celiac conditions, positive studies of it successfully treating celiac disease could mean that people with celiac disease may soon have a new drug option to manage their condition. Still, this case report is only one single patient, and much more research needs to be done before drawing any conclusions about whether this drug will work in others with celiac disease. The clinicians are encouraging further study of the relationship between Tofacitinib and celiac disease remission. At the same time, they advise caution, because Tofacitinib can have potentially serious side effects, and may not be suitable for long-term use. In fact, if Tofacitinib proves useful against celiac disease, it may be especially helpful for people with refractory celiac disease. Read more about the team's report in Annals of Internal Medicine
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Celiac.com 09/24/2019 - Currently, physicians do not routinely conduct celiac disease screening in patients with rheumatological diseases, as these people are not considered to have high risk for celiac disease. A team of researchers recently set out to determine rates of celiac disease serological markers in a group of patients with rheumatological issues. The research team included Giacomo Caio, Roberto De Giorgio, Francesco Ursini, Silvia Fanaro, and Umberto Volta. They are variously affiliated with the Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; the Mucosal Immunology and Biology Research Center, Massachusetts General Hospital – Harvard Medical School, Boston, Massachusetts, USA; the Department of Medical Sciences, University of Ferrara, Ferrara, Italy; the Department of Health Sciences, University of Catanzaro “Magna Graecia”; and the Centre of Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London. The team screened blood from 230 rheumatological patients for celiac disease by testing IgA antitransglutaminase (TTG IgA), IgG deamidated gliadin peptides (DGP IgG) and IgA antiendomysium (EMA) antibodies. Of the 230 total patients, the team found 67 patients with rheumatoid arthritis (RA), 52 with Sjögren’s syndrome (SjS), 42 with systemic sclerosis (SCL), 35 with systemic lupus erythematosus (SLE), 15 with mixed connective tissue disease, 11 with polymyositis and 10 with dermatomyositis. The results showed TTG IgA antibodies in a total of 7 out of 230 cases, or 3%. They also showed such antibodies in 3 of 42 SJS cases, 2 of 42 SCL cases, 1 of 67 RA cases, and 1 of 35 SLE sera. All seven samples were also positive for DGP IgG and EMA IgA. DGP IgG antibodies were the most common, showing up in 16 total samples. High rates of celiac disease antibodies in adult rheumatology patients suggest that celiac disease screening might be a good idea for people with rheumatological issues. Read more at Gastroenterology Hepatology Bed Bench. 2018 Summer; 11(3): 244–249.
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Celiac.com 03/16/2017 - When screening arthritis patients for celiac disease, should HLA be done before serology? During the past decades, an accumulating evidence shows a dramatic rise in the frequency of autoimmune diseases, including rheumatoid arthritis and gastrointestinal conditions, such as celiac disease. HLA genes have been shown to be strongly associated with numerous autoimmune diseases, including rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA) and celiac disease. A team of researchers recently set out to assess the performance of celiac disease associated serology in face of a rheumatologic patient, when gluten enteropaty is suspected. The research team included Hakim Rahmoune, Nada Boutrid, Mounira Amrane, and Belkacem Bioud. They are variously affiliated with the Pediatrics Department and the Biochemistry Department of Setif University Hospital at Setif-1 University in Algeria. The main question they sought to answer was: Should HLA be done prior to the serology? Could unnecessary serial serological celiac disease screening in such rheumatology patient be avoided by performing an HLA typing, as a long-life marker of genetically celiac disease-susceptible patients? Serogenetic screening without the requirement for follow-up small bowel biopsies provides a flexible, cost-effective methodology that could be widely applied to obtain accurate estimates of the prevalence of celiac disease in large group studies. Source: International Journal of Celiac Disease, 2017, Vol. 5, No. 1, xx. DOI:10.12691/ijceliac disease-5-1-2
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Arthritis may be an allergic response to materials in the food supply. Diet revision may be helpful in reducing the activity of inflammatory arthritis and in some instances may halt the progression of the disease. There are many patterns of arthritis. A group of related joint and connective disorders have been called rheumatic diseases. All these diseases are immune-mediated, and all are expressions of inflammation in connective tissues. Inflammation damages joints and surrounding tissues resulting in loss of function and deformities. Variations in the patterns of these diseases reflect the many possibilities for immune damage to disturb and distort structure and function. Severity ranges from mildly painful, chronic activity to drastic, disabling disease. Rheumatoid arthritis, often severe and disabling, is the dominant rheumatic disease that can attack all joints in the body. Rheumatoid arthritis is often considered to be an autoimmune disease. Our idea is that no disease is just internally generated and must involve outside contributions. Arthritis is often associated with inflammatory bowel disease. The mechanisms of food allergy link abnormal Gastrointestinal Tract (GIT) function with immune attacks on connective tissue. In all arthritic patients, normal GIT function should be rigorously sought by adaptive dietary adjustments. Simple allergic arthritis is a definite entity that is often not recognized as a food allergy. Typically, a dramatic, acute, and painful swelling develops in one or more joints asymmetrically. Eating a food, either an unusual food eaten for the first time or sometimes a regular food eaten in excess usually brings on the joint inflammation. This presentation is similar to and often confused with gout. Any food can cause allergic arthritis. Staple foods such as milk, eggs, and wheat (rye, oats, barley), coffee, beef, pork, and food additives are the most common food triggers. Carinini and Brostroff reviewed the concepts of and evidence for food-induced arthritis. They stated: Despite an increasing interest in food allergy and the conviction of innumerable patients with joint disease that certain foods exacerbate their symptoms, relatively little scientific attention has been paid to this relationship. Abnormalities of the gastrointestinal tract are commonly found in rheumatic disease...Support for an intestinal origin of antigens comes from studies of patients whose joint symptoms have improved on the avoidance of certain foods antigens, and become worse on consuming them. These have included patients with both intermittent symptoms, palindromic rheumatism and more chronic disease. In another study, 33 of 45 patients with rheumatoid arthritis improved significantly on a hypoallergenic diet. The authors concluded: Increasing numbers of scientific studies suggest that dietary manipulation may help at least some rheumatoid patients and perhaps the greatest need now is for more careful and well-designed research so that preconceptions may be put aside and role of diet, as a specific or even a nonspecific adjunctive therapy, may be determined. Unfortunately, dairy products, wheat and its close relatives, oats, barley, and rye, have proved to be a major problem in the diets of our patients. There are many possible reasons for cereal grains to become pathogenic. Hypersensitivity mechanisms triggered by grain proteins, collectively called Gluten, are the likely cause of the illnesses related to intake of cereal grains. Gluten is a mixture of individual proteins classified in two groups, the Prolamines and the Glutelins. The prolamine fraction of gluten concerns us the most when grain intolerance is suspected. The prolamine, Gliadin, seems to be a problem in celiac disease; gliadin antibodies are commonly found in the immune complexes associated with this disease. Recently marketed grains, spelt and kamut, are wheat variants (despite claims to the contrary) and are likely to cause problems similar to other wheat varieties. A wheat gluten mechanism has been studied in rheumatoid arthritis patients. The clinical observation is that wheat ingestion is followed within hours by increased joint swelling and pain. Little and his colleagues studied the mechanism, as it developed sequentially following gluten ingestion. Dr. Parke and colleagues concurred with this explanation of the gut-arthritis link in their report of three patients with celiac disease and rheumatoid arthritis. The mechanism involves several stages: GIT must be permeable to antigenic proteins or peptide fragments, derived from digested gluten. The food antigens appear in the blood stream and are bound by a specific antibody (probably of IgA or IgG, not IgE class), forming an antigen-antibody complex, a circulating immune complex (CIC). The antigen-antibody complex then activates the rest of the immune response, beginning with the release of mediators - serotonin is released from the blood platelets. Serotonin release causes symptoms as it circulates in the blood stream and enhances the deposition of CICs in joint tissues. Once in the joint, the immune complexes activate complement, which in turn damages cells and activates inflammation. More inflammation results in more pain, swelling, stiffness, and loss of mobility. Arthritis is usually treated with salicylates or related anti-inflammatory drugs generally referred to as NSAIDs. These drugs alleviate the terrible pain of active arthritis but do not favorably affect the outcome of the disease. All anti-arthritic medication can produce asthma or chronic rhinitis and a variety of allergic skin rashes. Gastrointestinal surface irritation, bleeding, and ulceration are routine problems of anti-arthritic medication. The first attack of joint swelling and pain should be treated as an urgent problem to be solved. Inflammation may damage joints. Often NSAIDs and physiotherapy are the only treatments prescribed and inflammation is given every opportunity to ravage tissues. We have seen countless patients, just treated with NSAIDs, who progressed rapidly to a severe disabling disease, often with poor pain control. In unlucky patients, severe deformities of joints accumulate in the first few months of a severe attack. There is a trend to recommend more aggressive treatments, using drugs that impair the immune response. The best drug is prednisone, but it is seldom used because it has long-term side effects which scare both physicians and patients. Prednisone is often a magic drug that relieves terrible pain and suffering often in the first 48 hours of therapy. Beyond prednisone, there is a grab bag of immune suppressant drugs to treat arthritis-chloroquine, penicillamine, gold and methotrexate have emerged as the favored drug therapies. All these drugs have impressive side effects and great potential for toxicity. Our preference is to try to stop the inflammatory activity as soon as possible with diet revision. All inflammation is likened to a fire. You get out the fire-extinguishers and go to work. No matter what pattern the immune attack assumes, our standard defense can be tried first. The Core Program method of diet revision is used. Food is replaced with an elemental nutrient formula, ENFood, for a clearing period of 10 to 20 days. Prednisone and/or NSAIDs are drug options during the clearing period and then the dosage is reduced after pain and swelling have subsided. Improvement is followed by slow food reintroduction (see Core Program). Each returning food is carefully screened for arthritis- triggering effects. You hope that food allergy caused the problem and that food control can be successful controlling the disease in the long- term. Nothing is lost by taking this approach and complete control of the disease can sometimes be obtained. If strict food control proves to be inadequate, then other drug treatments can be instituted. End Notes/Sources: Carinini C, Brostroff J. Gut and joint disease. Annals of Allergy 1985;55:624-625. Darlington et al. Lancet Feb 1 1986;236-238. Keiffer M et al. Wheat gliadin fractions and other cereal antigens reactive with antibodies in the sera of of celiac patients. Clin Exp Immunol 1982;50:651-60. Little C, Stewart AG, Fennesy MR. Platelet serotonin release in rheumatoid arthritis: a study in food intolerant patients. Lancet 1983;297-9. Parke AI et al. Celiac disease and rheumatoid arthritis. Annals of Rheum Dis 1984;43:378-380. Voorneveld CR, Rubin LA Disease-modifying antirheumatic drugs: early use is better. Medicine North Amer. Oct 1991 3177-3184.
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Celiac.com 02/24/2016 - Rosacea is a common inflammatory skin condition that shares the same genetic risk location as autoimmune diseases such as type 1 diabetes mellitus (T1DM) and celiac disease. Researchers have noted a clustering of autoimmune diseases in patients with rosacea. In fact, a recent genomewide association study found 90 genetic areas associated with T1DM, celiac disease, multiple sclerosis, and/or rheumatoid arthritis, but did not address a possible association with rosacea. A team of researchers recently set out to assess any connections between rosacea and T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively. The research team included Alexander Egeberg, MD, Peter Riis Hansen, MD, PhD, DMSci, Gunnar Hilmar Gislason, MD, PhD, Jacob Pontoppidan Thyssen, MD, PhD, DMSci, National Allergy Research Center, Department of Dermato-Allergology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark, Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. For their study, the team conducted a population-based case-control study in which a total of 6,759 patients with rosacea were matched with 33,795 control subjects on age, sex, and calendar time. They used conditional logistic regression to calculate crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs). After adjustment for smoking and socioeconomic status, patients with rosacea had significantly increased ORs for T1DM (OR 2.59, 95% CI 1.41-4.73), celiac disease (OR 2.03, 95% CI 1.35-3.07), multiple sclerosis (OR 1.65, 95% CI 1.20-2.28), and rheumatoid arthritis (OR 2.14, 95% CI 1.82-2.52). The connection was seen most commonly in women, while for men, only the rheumatoid arthritis connection was statistically significant. As a disclaimer, the researchers point out that they were unable to distinguish between the various sub-types and severities of rosacea. However, they did find that rosacea in general is associated with T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis in women, whereas the association in men was statistically significant only for rheumatoid arthritis. Source: Journal of the American Academy of Dermatology
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Celiac.com 06/08/2007 - In the first study, doctors Ibrahim S. Alghafeer, and Leonard H. Sigal conducted a routine gastroenterology follow-up of 200 adult celiac patients. Arthritis was present in 52 of 200 patients, or 26%. The arthritis was peripheral in 19 patients, Axial in 15 patients, and an overlap of the two in 18 patients. The doctors found that joint disease was much less common in those patients who were following a gluten-free diet (1). A related study by Usai, et al found that 63% of patients with celiac disease show axial joint inflammation (2). In that study, doctors conducted bone scintigraphy using 99m Tc methylene diphosphonate. 14 of these patients (65%) signs compatible with sacroiliitis. 11 of the 14 suffered from low back pain. In five of the 11 patients with low back pain, scintigraphy was negative. Sacroiliac radiographs were conducted on 4 of those 5 patients, and all of them were shown to have bilateral sacroiliitis. One patient had rheumatoid arthritis, but all patients in the studied showed negative HLA-B27 results. Rheumatoid Symptoms Less Common in Celiacs on Gluten-free Diet In patients with gluten enteropathy, symptoms of arthritis and other rheumatic complaints are common, and the associated clinical abnormalities routinely show improvement on a gluten-free diet. (3,4,5) In 9 of 74 patients with spondyloarthropathies, results show increased level of antigliadin antibodies, with 1 patient showing elevated antiendomysium antibodies and biopsy proven celiac disease (6). These results show that antiendomysial antibody testing is recommended as a screening tool in patients with suspected gluten enteropathy. Another study found that 3.3% of sprue patients had Sjogrens syndrome (7). 55 celiac patients who were tested for serial bone density showed osteoporosis in 50% of men and 47% of women. These findings confirm that celiac disease was an independent risk factor for osteoporosis (8). Bulletin on the Rheumatic Diseases, Volume 51, Number 2. Usai P. Adult celiac disease is frequently associated with sacroiliitis. Dig Dis Sci 1995;40:1906-8 Lubrano E, Ciacci C, Ames PR, et al. The arthritis of celiac disease: prevalence and pattern in 200 adult patients. Br J Rheumatol 1996;35:1314-8. Usai P. Adult celiac disease is frequently associated with sacroiliitis. Dig Dis Sci 1995;40:1906-8. Bagnato gluten-free, Quattrocchi E, Gulli S, et al. Unusual polyarthritis as a unique clinical manifestation of celiac disease. Rheumatol Int 2000;20:29-30. Borg AA, Dawes PT, Swan CH, Hothersall TE. Persistent monoarthritis and occult celiac disease. Postgrad Med J 1994;70:51-3. Collin P, Korpela M, Hallstrom O, et al. Rheumatic complaints as a presenting symptom in patients with celiac disease. Scan J Rheumatol 1992;21:20-3. Kallilorm R, Uibo O, Uibo R. Clin Rheumatol 2000;19:118-22. health writer who lives in San Francisco and is a frequent author of articles for Celiac.com.
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