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Celiac.com 02/27/2019 - Celiac disease is an autoimmune condition with numerous symptoms, and associated conditions. People with celiac disease often have gastrointestinal symptoms, including upset stomach, abdominal pain, gas, bloating, indigestion, and diarrhea. Some suffer from many of these on a regular basis. However, many people show few or no symptoms. No single set of signs or symptoms is typical for everyone with celiac disease. Signs and symptoms can vary greatly from person to person. Symptoms of Celiac Disease Fall Into 7 Major Categories Digestive symptoms such as abdominal pain, bloating, gas, diarrhea, constipation, nausea, vomiting, and steatorrhea (fatty stools); Non-digestive symptoms such as fatigue, weakness, anemia, weight loss, malnutrition, delayed growth, irritability, depression, anxiety, and cognitive impairment; Dermatological symptoms such as skin rash, itching, blistering, and dermatitis herpetiformis; Musculoskeletal symptoms such as joint pain, muscle pain, muscle cramps, and osteoporosis; Neurological symptoms such as headache, migraine, ataxia, neuropathy, seizures, and cognitive impairment; Reproductive symptoms such as infertility, menstrual irregularities, and recurrent miscarriage. No obvious symptoms or asymptomatic; Symptoms Can Vary Between Children and Adults The signs and symptoms of celiac disease can vary greatly and are different in children and adults. The most common signs for adults are diarrhea, fatigue and weight loss. Adults may also experience bloating and gas, abdominal pain, nausea, constipation, and vomiting. Many symptoms caused by celiac disease are the result of nutritional deficiencies caused by flattened villi and subsequent malabsorption. Symptoms in Children Children under 2 years old celiac symptoms often include vomiting, chronic diarrhea, failure to thrive, muscle wasting, poor appetite, and swollen belly. Older children may experience diarrhea, constipation, weight loss, irritability, short stature, delayed puberty, and neurological symptoms, including attention-deficit/hyperactivity disorder (ADHD), learning disabilities, headaches, lack of muscle coordination and seizures Vague Symptoms Can Delay Celiac Diagnosis It is not uncommon for symptoms of celiac disease to be vague or confusing. Vague or confusing symptoms can include dental enamel defects, bone disorders like osteoporosis, depression, irritability, joint pain, mouth sores, muscle cramps, skin rash, stomach discomfort, and even neuropathy, often experienced as tingling in the legs and feet. To make matters more challenging, celiac symptoms can also mimic symptoms of other diseases, such as anemia, Crohns disease, gastric ulcers, irritable bowel, parasitic infection, even various skin disorders or nervous conditions. Vague or confusing symptoms can delay celiac disease diagnosis. Signs and Symptoms of Celiac Disease Abdominal cramps, gas and bloating Acne Anemia Ataxia (gluten ataxia) Borborygmi—stomach rumbling Coetaneous bleeding Delayed puberty Dental enamel defects Diarrhea Dry skin Easy bruising Epistaxis—nose bleeds Eczema Failure to thrive or short stature Fatigue or general weakness Flatulence Fluid retention Folic acid deficiency Foul-smelling yellow or grayish stools that are often fatty or oily Gastrointestinal symptoms Gastrointestinal hemorrhage General malaise, feeling unwell Hematuria—red urine Hypocalcaemia/hypomagnesaemia Infertility, or recurrent miscarriage Iron deficiency anemia Joint Pain Lymphocytic gastritis Malabsorption Malnutrition Muscle weakness Muscle wasting Nausea Obesity/Overweight Osteoporosis Pallor—pale, unhealthy appearance Panic Attacks Peripheral neuropathy Psychiatric disorders such as anxiety and depression Skin Problems—acne, eczema, DH, dry skin Stunted growth in children Underweight Vertigo Vitamin A deficiency Vitamin B6 deficiency Vitamin B12 deficiency Vitamin D deficiency Vitamin K deficiency Vomiting Voracious appetite Weight loss/gain Zinc deficiency Conditions Associated with Celiac Disease People with one or more of these associated conditions are at higher risk for celiac disease: Addison's Disease Anemia Anorexia Nervosa, Bulimia Arthritis Asthma Ataxia, Nerve Disease, Neuropathy, Brain Damage Attention Deficit Disorder Autism Bacterial Overgrowth Cancer, Lymphoma Candida Albicans Canker Sores—Aphthous Stomatitis) Casein / Cows Milk Intolerance Chronic Fatigue Syndrome Cognitive Impairment Crohn's Disease Depression Dermatitis Herpetiformis Diabetes Down Syndrome Dyspepsia, Acid Reflux Eczema Epilepsy Eye Problems, Cataract Fertility, Pregnancy, Miscarriage Fibromyalgia Flatulence—Gas Gall Bladder Disease Gastrointestinal Bleeding Geographic Tongue—Glossitis Growth Hormone Deficiency Hashimoto’s Thyroiditis Heart Failure Infertility, Impotency Inflammatory Bowel Disease Intestinal Permeability Irritable Bowel Syndrome Kidney Disease Liver and biliary tract disorders (transaminitis, fatty liver, primary sclerosing cholangitis, etc.) Low bone density Lupus Malnutrition, Body Mass Index Migraine Headaches Multiple Sclerosis Myasthenia Gravis Celiac Disease Obesity, Overweight Osteopenia, osteoporosis, osteomalacia Psoriasis Refractory Celiac Disease & Collagenous Sprue Sarcoidosis Scleroderma Schizophrenia / Mental Problems Sepsis Sjogrens Syndrome Sleep Disorders Thrombocytopenic Purpura Thyroid & Pancreatic Disorders Tuberculosis Nutritional Deficiencies Associated with Celiac Disease and their Related Clinical Manifestations .divTable{ display: table; width: 100%; } .divTableRow { display: table-row; } .divTableHeading { background-color: #EEE; display: table-header-group; } .divTableCell, .divTableHead { border: 1px solid #999999; display: table-cell; padding: 3px 10px; min-width: 120px; } .divTableHeading { background-color: #EEE; display: table-header-group; font-weight: bold; } .divTableFoot { background-color: #EEE; display: table-footer-group; font-weight: bold; } .divTableBody { display: table-row-group; } Nutritional deficiency Most frequent signs and symptoms Iron Hypochromic, microcytic anemia, glossitis, koilonychia, fatigue, pallor, cognitive impairment Folate Megaloblastic anemia, glossitis, diarrhea, cognitive impairment Vitamin B12 Megaloblastic anemia, posterior columns syndrome, dementia, depression, psychosis Vitamin D Osteomalacia (deformity of bone, pathologic fractures), osteoporosis, cognitive impairment, secondary hyperparathyroidism Zinc Growth retardation, hypogonadism, infertility, dysgueusia, poor wound healing, diarrhea, dermatitis on the extremities and periorificial, glossitis, alopecia, corneal clouding Less frequently occurring Protein Edema, muscular atrophy Vitamin B1 (thiamine) Irritability, fatigue, headaches, peripheral neuropathy, wet Beriberi: congestive heart failure; Wernicke: nystagmus, ophtalmoplegia, ataxia; Korsakoff: hallucinations, impaired short-term memory and confabulation Vitamin B3 (niacin) Pellagra: diarrhea, dementia, pigmented dermatitis; Glossitis, stomatitis, vaginitis, vertigo, burning dysesthesias Vitamin B6 (pyridoxine) Stomatitis, angular cheilosis, glossitis, irritability, depression, confusion, normochromic normocytic anemia Vitamin A Follicular hyperkeratosis, night blindness, conjunctival xerosis, keratomalacia Vitamin E Hemolytic anemia, peripheral neuropathies, ophtalmoplegia, posterior columns syndrome Vitamin K Easy bleeding Top Scientific References on Celiac Symptoms University of Chicago Celiac Disease Center Mayo Clinic Celiac Disease Center Vitamin and Mineral Deficiencies Common in Newly Diagnosed Celiac Disease Patients Celiac Disease: Extraintestinal Manifestations and Associated Conditions

Celiac.com 03/21/2018 - Many people with celiac disease suffer from non-gastrointestinal symptoms. Here are 15 non-gastrointestinal symptoms that can make celiac disease difficult to diagnose. If the general public knows anything about celiac disease, it is likely that eating wheat can cause stomach problems in people with the condition. And that’s often true, classical celiac symptoms include abdominal bloating and pain, chronic diarrhea and/or constipation, and vomiting. Young children are more likely to show classic signs of celiac disease, including growth problems (failure to thrive, chronic diarrhea/constipation, recurring abdominal bloating and pain, fatigue, and irritability. Older children and adults tend to have symptoms that are not entirely gastrointestinal in nature. So, depending on age, and other factors, celiac disease affects different people differently. In fact, there are more than 200 signs and symptoms of celiac disease. Some patients have several, some just a few. Many report non-gastrointestinal symptoms. And many people with celiac disease never show any symptoms at all. Yet, both people with vague symptoms and those with no symptoms still face a higher risk of developing complications associated with celiac disease, as well as for celiac-associated conditions. Recent research has demonstrated that only a third of adult patients diagnosed with celiac disease experience diarrhea. Weight loss is also not a common sign. In fact, far more patients diagnosed these days are over weight. We’ve covered the most common physical complaints of people with celiac disease, but here is a list of fifteen common non-gastrointestinal symptoms that can make celiac disease hard to diagnose: 1) ANEMIA—The most common non-gastrointestinal problem faced by people with celiac disease is anemia. About one in three celiacs (34%) suffer from anemia. Anemia and Celiac Disease Is Celiac Disease Worse In People With Anemia? Celiac Disease and Iron Deficiency Linked in Caucasians, But Not Non-Caucasians 2) BLOATING—20% of celiacs complained of bloating prior to diagnosis. 3) DERMATITIS HERPETIFORMIS, PSORIASIS & other skin conditions—Many people with celiac disease suffer from dermatitis herpetiformis, psoriasis, or other skin conditions. Dermatitis Herpetiformis: Skin Condition Associated with Celiac Disease Skin Problems and Celiac Disease Five Common Skin Conditions Associated With Celiac Disease Psoriasis and Celiac Disease 4) ATAXIA, NERVE DISEASE, NEUROPATHY—Many people with celiac disease suffer from ataxia, nerve disease, or neuropathy, especially peripheral neuropathy. Peripheral Neuropathy 5) CRYPTOGENIC HYPERTRANSAMINASEMIA—nearly one-third (29%) of people with celiac disease, have what is called cryptogenic hypertransaminasemia, also known as celiac hepatitis. 6) THYROID DISEASE—Thyroid disorders are common in people with celiac disease. Thyroid & Pancreatic Disorders and Celiac Disease Should Patients with Autoimmune Thyroid Disease Be Screened for Celiac Disease? 7) JOINT PAIN—Joint pain is a common complaint of many people with celiac disease, possibly due to associated inflammation. 8) DENTAL ENAMEL DEFECTS—Researchers have recently linked dental enamel defects with celiac disease. In the future, dentists may play an important role in helping to diagnose celiac disease, especially in patients with non-classical or vague symptoms, by noting dental enamel defects common in people with celiac disease. Dental Enamel Defects Indicate Adult Celiac Disease Distinct Tooth Enamel Defects Can Help Reveal Celiac Disease 9) UNEXPLAINED INFERTILITY, RECURRENT MISCARRIAGE—Women who suffer from unexplained infertility an/or recurrent miscarriage have a much higher risk of celiac disease. 10) OSTEOPENIA/OSTEOPOROSIS—A full 52% of patients with celiac disease suffer from osteopenia/osteoporosis. Osteoporosis is a more serious bone density problem. Many people with celiac disease suffer from low bone density. Osteoporosis, Osteomalacia, Bone Density and Celiac Disease 11) PSORIASIS—Many people with celiac disease also have psoriasis. It’s also true that many people with psoriasis claim to find that a gluten-free diet can help their symptoms to improve. 12) PSYCHIATRIC DISORDERS—Many people with celiac disease suffer from psychiatric disorders such as anxiety and depression. In some cases, especially in those without classic symptoms, these psychiatric disorders can be among the few symptoms, and can make celiac disease difficult to diagnose. 13) CANKER SORES (Aphthous Stomatitis)—People with celiac disease have much higher rates of canker sores. In fact, nearly 20% of people with symptomatic celiac disease had canker sores as one of their symptoms. In many cases, these canker sores are recurrent, and can be one of the few or only signs of celiac disease. 14) FATIGUE—Many people with celiac disease report recurrent fatigue as one of their symptoms. Sometimes, fatigue can be one of the few or only symptoms, making celiac disease difficult to diagnose. 15) WEIGHT GAIN—Classic celiac disease patients commonly suffered weight loss or low body weight. That has changed. These days, it is much more common for people with celiac disease to be overweight. Screening Versus Symptoms: Does Detection Method Affect Body Mass For Celiacs on a Gluten-Free Diet? How can I be overweight with Celiac ? Sources: Celiac.com Cureceliacdisease.org

Celiac.com 09/25/2017 - There are currently several efforts underway to develop successful commercial enzyme treatments for celiac disease. Efforts include looking at the digestive enzymes in plants, such as the papaya and star fruits, including such predatory plants, such as the pitcher plant. One focus has been on developing enzymes that can break down gluten before it can trigger an immune reaction. This could prove helpful to many people with celiac disease. One such enzyme under development is Latiglutenase, formerly known as ALV003. Latiglutenase is a new name for an enzyme therapy designed to be taken with meals. The idea is that a person with celiac disease would take an enzyme tablet with a meal. If the meal had mild gluten contamination, the enzyme’s two recombinant proteins would break gluten into fragments that are not toxic to the immune system, thereby preventing exposure, and symptoms. But the stomach is a notoriously difficult environment to work in, so what seems like a simple idea quite a challenge from a science and biology perspective. Seeking to explore the ability of Latiglutinase to improve symptoms, a team of researchers recently set out to test latiglutenase on celiac patients who are seropositive despite following a gluten-free diet. The research team included Jack A. Syage, Joseph A. Murray, Peter H. R. Green and Chaitan Khosla. They are variously affiliated with the Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester USA, the Celiac Disease Center at Columbia University, New York, USA, the Departments of Chemical Engineering and Chemistry, Stanford University, USA, and with ImmunogenX, Newport Beach, USA. "Though the ALV003-1221 trial was inconclusive regarding histologic improvement from latiglutenase, the evidence for symptom benefit, which is more quickly achieved, is quite convincing and clinically relevant," Joseph Murray, MD, of the Mayo Clinic in Rochester, Minn., said in a press release. In these trials, patients with celiac disease who were seropositive despite following a gluten-free diet saw major improvement in symptoms when taking latiglutenase with meals, according to a post hoc analysis of the CeliAction study. The team was really hoping to see histological improvement, but they feel satisfied that this trial shows, says Dr. Murray, that a "therapy to help patients struggling with symptoms due to celiac disease is now within reach." Stay tuned for more on efforts to develop effective enzyme treatments for celiac disease. Read more: Dig Dis Sci. 2017 Doi:10.1007/s10620-017-4687-7.