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Celiac Disease & Gluten-Free Diet Blogs

  • kareng's Blog
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  • An Unmistakeable Journey
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  • The Patient Celiac
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  • Trials and Tribulations
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  • Cee Cee's Blog
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  • Research on South African Celiac Tours
  • lindylynn's Blog
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  • shelly184's Blog
  • Melissa.77's Blog
  • Keating's Not-so-Glutenfree life
  • AmandasMommy's Blog
  • Coeliac, or just plain unlucky?
  • bandanamama's Blog
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  • Ellenor Whitty's Blog
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  • Scott's Celiac Blog
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  • Angie Baker
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  • Silly Yak 08's Blog
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  • NotMollyRingwald's Blog
  • Searchin for a Primary Care Dr. In Redlands That is Knowledgeable about Celiac disease
  • num1habsfan's Blog
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  • Celiac-Positive
  • Jason's Mommy's Blog
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  • Lauren Johnson's Celiac Blog
  • I love my plant Cactus <3
  • Chele's Blog
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  • Blues Boulevard
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  • Cindy Neshe's Blog
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  • What I've Learned
  • Da Rant Sheet
  • Michael Fowler's Blog
  • Living in Japan with Ceoliac Disease
  • mkmaren's Blog
  • MJ
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  • x1x_Stargirl_x1x's Blog
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  • Joe pilk
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  • My Blog
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  • GlutenFreeLexi's Blog
  • drewsant's Blog
  • SadAndSick's Blog
  • HONG KONG GLUTEN, WHEAT FREE PRODUCTS
  • Guth 101's Blog
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  • Gail Marie's Blog
  • Healthy Food Healthy You
  • SydneyT1D - Diabetic and Celiac YouTuber!
  • GFGF's Blog
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  • SMAS: www.celiac.com
  • gardener1's Blog
  • Naezer's Blog
  • JordanBattenSymons' Blog
  • JillianC
  • Sugar's Blog
  • Blanche22's Blog
  • Jason's Blog
  • Gluten-Free Sisters :)
  • Eab12's Celiac Blog
  • ohiodad's Blog
  • Newly Self Diagnosed?
  • misscorpiothing's Blog
  • anshika_0204's Blog
  • Petroguy
  • abqrock's Blog
  • WhoKnew?'s Blog
  • Soap Opera Central
  • nurcan's Blog
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  • Daughter_of_TheLight's Blog
  • nopastanopizza's Blog
  • w8in4dave's Blog
  • Mr J's Blog
  • Rachel Keating's Blog
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  • krisb's Blog
  • deetee's Blog
  • CAC's Blog
  • EmilyLinn7's Blog
  • Teri Kiefer's Blog
  • happyasabeewithceliac's Blog
  • quietmorning01's Blog
  • jaimekochan's Blog
  • Cheryl
  • Seosamh's Blog
  • donna mae's Blog
  • Colleen's blog
  • DawnJ's Blog
  • Gluten Challenge
  • twins2's Blog
  • just trying to feel better's Blog
  • Celiac Teen
  • MNBelle blog
  • Gabe351's Blog
  • moosemalibu's Blog
  • Coeliac Disease or Coeliac Sprue or Non Tropical Sprue
  • karalto's Blog
  • deacon11's Blog
  • Nyxie's Blog
  • Swpocket's Blog
  • threeringfilly's Blog
  • Madison Papers: Living Gluten-Free in a Gluten-Full World
  • babinsky's Blog
  • prettycat's Blog
  • Celiac Diagnosis at Age 24 months in 1939
  • Sandy R's Blog
  • mary m's Blog
  • Jkrupp's Blog
  • Oreo1964's Blog
  • keyboard
  • Louisa's Blog
  • Guts & Brains
  • Gluten Free Betty
  • Jesse'sGirl's Blog
  • NewMom's Blog
  • Connie C.'s Blog
  • garden girl's Blog
  • april anne's Blog
  • 4xmom's Blog
  • benalexander60's Blog
  • missmyrtle's Blog
  • Jersey Shore wheat no more's Blog
  • swezzan's Blog
  • aheartsj's Blog
  • MeltheBrit's Blog
  • glutenfreecosmeticcounter
  • Reasons Why Tummy tuck is considered best to remove unwanted belly fat?
  • alfgarrie's Blog
  • SmidginMama's Blog
  • lws' Blog
  • KMBC2014's Blog
  • Musings and Lessons Learned
  • txwildflower65's Blog
  • Uncertain
  • jess4736's Blog
  • deedo's Blog
  • persistent~Tami's Blog
  • Posterboy's Blog
  • jferguson
  • tiffjake's Blog
  • KCG91's Blog
  • Yolo's Herbs & Other Healing Strategies
  • scrockwell's Blog
  • Sandra45's Blog
  • Theresa Marie's Blog
  • Skylark's Blog
  • JessicaB's Blog
  • Anna'sMommy's Blog
  • Skylark's Oops
  • Jehovah witnesses
  • Celiac in Seattle's Blog
  • March On
  • honeybeez's Blog
  • The Liberated Kitchen, redux
  • onceandagain's Blog
  • JoyfulM's Blog
  • keepingmybabysafe's Blog
  • To beer, with love...
  • nana b's Blog
  • kookooto's Blog
  • SunnyJ's Blog
  • Mia'smommy's Blog
  • Amanda's Blog
  • jldurrani's Blog
  • Why choosing Medical bracelets for women online is the true possible?
  • Carriefaith's Blog
  • acook's Blog
  • REAGS' Blog
  • gfreegirl0125's Blog
  • Gluten Free Recipes - Blog
  • avlocken's Blog
  • Thiamine Thiamine Thiamine
  • wilbragirl's Blog
  • Gluten and Maize-Free (gluten-free-MF)
  • Elimination Diet Challenge
  • DJ 14150
  • mnsny's Blog
  • Linda03's Blog
  • GFinDC's Blog
  • Kim UPST NY's Blog
  • cmc's Blog
  • blog comppergastta1986
  • JesikaBeth's Blog
  • Melissa
  • G-Free's Blog
  • miloandotis' Blog
  • Confessions of a Celiac
  • Know the significance of clean engine oil
  • bobhayes1's Blog
  • Robinbird's Blog
  • skurtz's Blog
  • Olivia's Blog
  • Jazzdncr222's Blog
  • Lemonade's Blog
  • k8k's Blog
  • celiaccoach&triathlete's Blog
  • Gluten Free Goodies
  • cherbourgbakes.blogspot.com
  • snow dogs' Blog
  • Rikki Tikki's Blog
  • lthurman1979's Blog
  • Sprue that :)'s Blog
  • twinkletoes' Blog
  • Ranking the best gluten free pizzas
  • Gluten Free Product
  • Wildcat Golfer's Blog
  • Becci's Blog
  • sillyker0nian's Blog
  • txplowgirl's Blog
  • Gluten Free Bread Blog
  • babygoose78's Blog
  • G-freegal12's Blog
  • kelcat's Blog
  • Heavy duty 0verhead crane
  • beckyk's Blog
  • pchick's Blog
  • NOT-IN-2gluten's Blog
  • PeachPie's Blog
  • Johny
  • Breezy32600's Blog
  • Edgymama's Gluten Free Journey
  • Geoff
  • audra's Blog
  • mfrklr's Blog
  • 2 chicks
  • I Need Help With Bread
  • the strong one has returned!
  • sabrina_B_Celiac's Blog
  • Gluten Free Pioneer's Blog
  • Theanine.
  • The Search of Hay
  • Vanessa
  • racecar16's Blog
  • JCH13's Blog
  • b&kmom's Blog
  • Gluten Free Foodies
  • NanaRobin's Blog
  • mdrumr8030's Blog
  • Sharon LaCouture's Blog
  • Zinc, Magnesium, and Selenium
  • sao155's Blog
  • Tabasco's Blog
  • Amanda Smith
  • mmc's Blog
  • xphile1121's Blog
  • golden exch
  • kerrih's Blog
  • jleb's Blog
  • RUGR8FUL's Blog
  • Brynja's Grain Free Kitchen
  • schneides123's Blog
  • Greenville, SC Gluten-Free Blog
  • ramiaha's Blog
  • Kathy P's Blogs
  • rock on!'s Blog
  • Carri Ninja's Blog
  • jerseygirl221's Blog
  • Pkhaselton's Blog
  • Hyperceliac Blog
  • abbiekir's Blog
  • Lasister's Thoughts
  • bashalove's Blog
  • Steph1's Blog
  • Etboces
  • Rantings of Tiffany
  • GlutenWrangler's Blog
  • kalie's Blog
  • Mommy Of A Gluten Free Child
  • ready2go's Blog
  • Maureen
  • Floridian's Blog
  • Bobbie41972's Blog
  • Everyday Victories
  • Intolerance issue? Helpppp!
  • Feisty
  • In the Beginning...
  • Cheri46's Blog
  • Acne after going gluten free
  • sissSTL's Blog
  • Elizabeth19's Blog
  • LindseyR's Blog
  • sue wiesbrook's Blog
  • I'm Hungry's Blog
  • badcasper's Blog
  • M L Graham's Blog
  • Wolicki's Blog
  • katiesalmons' Blog
  • CBC and celiac
  • Kaycee's Blog
  • wheatisbad's Blog
  • beamishmom's Blog
  • Celiac Ninja's Blog
  • scarlett54's Blog
  • GloriaZ's Blog
  • Holly F's Blog
  • Jackie's Blog
  • lbradley's Blog
  • TheSandWitch's Blog
  • Ginger Sturm's Blog
  • The Struggle is Real
  • whataboutmary's Blog
  • JABBER's Blog
  • morningstar38's Blog
  • Musings of a Celiac
  • Celiacchef's Blog
  • healthygirl's Blog
  • allybaby's Blog
  • MGrinter's Blog
  • LookingforAnswers15's Blog
  • Lis
  • Alilbratty's Blog
  • 3sisters' Blog
  • MGrinter's Blog
  • Amanda
  • felise's Blog
  • rochesterlynn's Blog
  • mle_ii's Blog
  • GlamourGetaways' Blog
  • greendog's Blog
  • Tabz's Blog
  • Smiller's Blog
  • my vent
  • newby to celiac?'s Blog
  • siren's Blog
  • myraljo's Blog
  • Relieved and confused
  • carb bingeing
  • scottish's Blog
  • maggiemay832's Blog
  • Cristina Barbara
  • ~~~AnnaBelle~~~'s Blog
  • nikky's Blog
  • Suzy-Q's Blog
  • mfarrell's Blog
  • Kat-Kat's Blog
  • Kelcie's Blog
  • cyoshimit's Blog
  • pasqualeb's Blog
  • My girlfriend has celiacs and she refuses to see a doctor
  • Ki-Ki29's Blog
  • mailmanrol's Blog
  • Sal Gal
  • WildBillCODY's Blog
  • Ann Messenger
  • aprilz's Blog
  • the gluten-free guy
  • gluten-free-wifey's Blog
  • Lynda MEADOWS's Blog
  • mellajane's Blog
  • Jaded's Celiac adventures in a non-celiac world.
  • booboobelly18's Blog
  • Dope show
  • Classic Celiac Blog
  • Keishalei's Blog
  • Bada
  • Sherry's blurbs
  • addict697's Blog
  • MIchael530btr's Blog
  • Shawn C
  • antono's Blog
  • Undiagnosed
  • little_d's Blog
  • Gluten, dairy, pineapple
  • The Fat (Celiac) Lady Sings
  • Periomike
  • Sue Mc's Blog
  • BloatusMaximus' Blog
  • It's just one cookie!
  • Kimmy
  • jacobsmom44's Blog
  • mjhere's Blog
  • tlipasek's Blog
  • You're Prescribing Me WHAT!?!
  • Kimmy
  • nybbles's Blog
  • Karla T.'s Blog
  • Young and dealing with celiacs
  • Celiac.com Podcast Edition
  • LCcrisp's Blog
  • ghfphd's allergy blog
  • https://www.bendglutenfree.com/
  • Costume's and GF Life
  • mjhere69's Blog
  • dedeadge's Blog
  • CeliacChoplin
  • Ravenworks' Blog
  • ahubbard83's Blog
  • celiac<3'sme!'s Blog
  • William Parsons
  • Gluten Free Breeze (formerly Brendygirl) Blog
  • Ivanna44's Blog
  • Daily Life and Compromising
  • Vonnie Mostat
  • Aly'smom's Blog
  • ar8's Blog
  • farid's Blog
  • Sandra Lee's Blog
  • Demertitis hepaformis no Celac
  • Vonnie Mostat, R.N.
  • beetle's Blog
  • Sandra Lee's Blog
  • carlyng4's Blog
  • totalallergyman's Blog
  • Kim
  • Vhips
  • twinsmom's Blog
  • Newbyliz's Blog
  • collgwg's Blog
  • Living in the Gluten Free World
  • lisajs38's Blog
  • Mary07's Blog
  • Treg immune celsl, short chain fatty acids, gut bacteria etc.
  • questions
  • A Blog by Yvonne (Vonnie) Mostat, RN
  • ROBIN
  • covsooze's Blog
  • HeartMagic's Blog
  • electromobileplace's Blog
  • Adventures of a Gluten Free Mom
  • Fiona S
  • bluff wallace's Blog
  • sweetbroadway's Blog
  • happybingf's Blog
  • Carla
  • jaru24's Blog
  • AngelaMH's Blog
  • collgwg's Blog
  • blueangel68's Blog
  • SimplyGF Blog
  • Jim L Christie
  • Debbie65's Blog
  • Alcohol, jaundice, and celiac
  • kmh6leh's Blog
  • Gluten Free Mastery
  • james
  • danandbetty1's Blog
  • Feline's Blog
  • Linda Atkinson
  • Auntie Lur: The Blog of a Young Girl
  • KathyNapoleone's Blog
  • Gluten Free and Specialty Diet Recipes
  • Why are people ignoring Celiac Disease, and not understanding how serious it actually is?
  • miasuziegirl's Blog
  • KikiUSA's Blog
  • Amyy's Blog
  • Pete Dixon
  • abigail's Blog
  • CHA's Blog
  • Eczema or Celiac Mom?'s Blog
  • Thoughts
  • International Conference on Gastroenterology
  • Deedle's Blog
  • krackers' Blog
  • cliniclfortin's Blog
  • Mike Menkes' Blog
  • Juanita's Blog
  • BARB OTTUM
  • holman's Blog
  • It's EVERYWHERE!
  • life's Blog
  • writer ann's Blog
  • Ally7's Blog
  • Gluten Busters: Gluten-Free Product Alerts by Celiac.com
  • K Espinoza
  • klc's Blog
  • Pizza&beer's Blog
  • CDiseaseMom's Blog
  • sidinator's Blog
  • Dr Rodney Ford's Blog
  • How and where is it safe to buy cryptocurrency?
  • lucedith's Blog
  • Random Thoughts
  • Kate
  • twin#1's Blog
  • myadrienne's Blog
  • Nampa-Boise Idaho
  • Ursa Major's Blog
  • bakingbarb's Blog
  • Does Celiac Cause Sensitivites To Rx's?
  • delana6303's Blog
  • psychologygrl25's Blog
  • Alcohol and Celiac Disease
  • How do we get it???
  • cooliactic_BOOM's Blog
  • GREAT GF eating in Toronto
  • Gluten-free Food Recommendations!
  • YAY! READ THIS!!
  • BROW-FREE DIET BLOG
  • carib168's Blog
  • A Healing Kitchen
  • Shawn s
  • AZ Gal's Blog
  • mom1's Blog
  • The Beginning - The Diagnosis
  • PeweeValleyKY's Blog
  • solange's Blog
  • Cate K's Blog
  • Layered Vegetable Baked Pasta (gluten-free Vegetarian Lasagna)
  • Gluten Free Teen by Ava
  • mtdawber's Blog
  • sweeet_pea's Blog
  • DCE's Blog
  • Infertility and Celiac Disease
  • What to do in the Mekong Delta in 1 Day?
  • glutenfreenew's Blog
  • Living in the Garden of Eden
  • toddzgrrl02's Blog
  • redface's Blog
  • Gluten Free High Protein
  • Ari
  • Great Harvest Chattanooga's Blog
  • CeliBelli's Blog
  • Aboluk's Blog
  • redface's Blog
  • Being in Control of Your Gluten-Free Diet on a Cruise Ship
  • jayshunee's Blog
  • lilactorgirl's Blog
  • Yummy or Yucky Gluten-Free Foods
  • Electra's Blog
  • Cocerned husband's Blog
  • lilactorgirl's Blog
  • A Little History - My Celiac Disease Diagnosis
  • How to line my stomach
  • sewfunky's Blog
  • Oscar's Blog
  • Chey's Blog
  • The Fun of Gluten-free Breastfeeding
  • Dawnie's Blog
  • Sneaky gluten free goodness!
  • Chicago cubs shirts- A perfect way of showing love towards the baseball team!
  • Granny Garbonzo's Blog
  • GFzinks09's Blog
  • How do I get the Celiac.com podcast on my mp3 player?
  • quantumsugar's Blog
  • Littlebit's Blog
  • Kimberly's Blog
  • Dayz's Blog
  • Swimming Breadcrumbs and Other Issues
  • Helen Burdass
  • celiacsupportnancy's Blog
  • Life of an Aggie Celiac
  • kyleandjra.jacobson's Blog
  • Hey! I'm Not "Allergic" to Wheat!
  • FoOdFaNaTic's Blog
  • Wendy Cohan, RN's Gluten-Free and Dairy-Free Cooking Classes
  • Lora Derry
  • Dr. Joel Goldman's Blog
  • The Ultimate Irony
  • Lora Derry
  • ACK514's Blog
  • katinagj's Blog
  • What Goes On, Goes In (Gluten in Skin Care Products)
  • What’s new in hydraulic fittings?
  • cannona3's Blog
  • citykatmm's Blog
  • Adventures in Gluten-Free Toddling
  • tahenderson67's Blog
  • The Dinner Party Drama—Two Guidelines to Assure a Pleasant Gluten-Free Experience
  • What’s new in hydraulic fittings?
  • sparkybear's Blog
  • justbikeit77's Blog
  • To "App" or Not to "App": The Use of Gluten Free Product List Computer Applications
  • Onangwatgo
  • Raine's Blog
  • lalla's Blog
  • To die for Cookie Crumb Gluten-Free Pie Crust
  • DeeTee33's Blog
  • http://glutenfreegroove.com/blog/
  • David2055's Blog
  • Gluten-Free at the Fancy Food Show in San Francisco
  • Kup wysokiej jakości paszporty, prawa jazdy, dowody osobiste
  • Janie's Blog
  • Managing Hives & Gluten Allergies
  • Bogaert's Blog
  • Janie's Blog
  • RaeD's Blog
  • Dizzying Disclaimers!
  • Dream Catcher's Blog
  • PinkZebra's Blog
  • Hibachi Food and Hidden Gluten Hazards (How to Celebrate Gluten-Free)
  • jktenner's Blog
  • OhSoTired's Blog
  • PinkZebra's Blog
  • gluten-free Lover's Blog
  • Gluen Free Health Australia
  • Melissamb21's Blog
  • Andy C's Blog
  • halabackgirl9129's Blog
  • Liam Edwards' Blog
  • Celiac Disease in Africa?
  • Suz's Blog
  • Gluten-Free Fast Food
  • mis_chiff's Blog
  • gatakat's Blog
  • macocha's Blog
  • Newly Diagnosed Celiacs Needed for Study in Chicago
  • Poor Baby's Blog
  • the loonie celiac's Blog
  • jenlex's Blog
  • Sex Drive/Testosterone can be Depleted by Certain Foods
  • samantha79's Blog
  • 21 Months into the Gluten-free Diet
  • WashingtonLady's Blog-a-log
  • James S. Reid's Blog
  • Living with a Gluten-Free Husband
  • runner girl's Blog
  • kp3972's Blog
  • ellie_lynn's Blog
  • trayne91's Blog
  • Gluten-free Lipstick!
  • Nonna2's Blog
  • Schar Chocolate Hazelnut Bar (Gluten-Free)
  • pnltbox27's Blog
  • Live2BWell's Blog
  • melissajohnson's Blog
  • nvsmom's Blog
  • Diagnosed with Celiac Disease and Still Sick
  • snowcoveredheart's Blog
  • Gluten Free Nurse
  • Gluten-Free Frustration!
  • Melody A's Blog
  • novelgutfeeling's Blog
  • Trouble Eating Out Gluten-Free...Good or Bad?!
  • dilsmom's Blog
  • theceliachusband's Blog
  • amanda2610's Blog
  • Pancreas and Celiac Disease Link?
  • epiphany's Blog
  • Patty55's Blog
  • The Latest Gluten-Free Food Recalls
  • kenzie's blog
  • CVRupp's Blog
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  1. Hi! I recently had a bunch of blood tests done and the only one that was elevated was the TTG-A. My level was 12.6, with negative listed as 0-4 and positive as >15. I asked my doctor about it and she said if I was Celiac my level would have been much higher, and that there wasn’t much research supporting just a gluten sensitivity. That being said, I had been suffering from the following symptoms for YEARS: GERD, indigestion, chronic migraines, extreme fatigue and brain fog, joint pain, and bloating. I’d never considered that gluten was the issue, but I decided to try going gluten-free just to see what happened and I could literally cry by how much better I feel. I feel like I’m alive again. Going forward, is it possible that I am celiac or should I just assume it’s some kind of gluten sensitivity? Do I even need to push for an official diagnosis or should I just continue a strict gluten-free diet and call it good?
  2. Hi everyone, I am new to this site and hoping people may have a bit of advice for me. We’ve recently started trying to conceive, but unfortunately have had two miscarriages with a growth of under 6 weeks each. I’ve never had an official diagnosis, but myself/my doctor suspected I had gluten sensitivity around eight years ago when I was also being diagnosed with endometriosis. As I didn’t have any pain/bloating that was particularly bad, I continued with my normal diet including gluten. Not until my second miscarriage did anyone mention a link between eating gluten and miscarriages. I’m now on a strict gluten diet - but the wait time for testing to see how bad the damage is isn’t for another nine months, which seems like a really long time to just have the test done, let alone wait for results and know if I’m on the right track. I want to do as much as possible to limit the chances of another miscarriage, while knowing this might not be the only cause of the problems (e.g endometriosis). can people advise on how long I should be gluten free before I even consider trying again, and what vitamins etc I should be taking in the meantime to try and boost my chances?

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  4. Celiac.com 03/09/2023 - After nearly a year on a gluten-free diet, I now look back at my recovery to evaluate its success—the severe joint pain, muscle weakness, bone pain, fatigue, abdominal bloating, steatorrhea, and weight loss plagued me until my treatment commenced in earnest. Much of the extra-intestinal symptoms resolved within the first few months. However, the intestinal and stomach symptoms have taken much longer, and my weight loss recovery is ongoing. The road to recovery has been long and arduous. Many of us experience an array of residual and persistent symptoms even with the complete removal of gluten from our diets. Intestinal Absorption Traditionally, response to a gluten-free diet has been assessed by blood antibody tests and biopsies. It has long been known that the intestinal villi, seen in biopsy samples, do not always revert back to normal even after a prolonged gluten-free diet (1) . A recent study by Cummins et al. found that area of the villi improved significantly by three months on a gluten-free diet, but improved only slightly more during the six to 24 month period (2) . After two years on a gluten-free diet, the villi area increased to about four times that at diagnosis of CD, but was still only about half of normal. Similarly, Wahab et al. found that at two years of follow-up on a gluten-free diet, 37% of the celiac patients still had varying degrees of villous atrophy (3) . After five years, 12% of the adult patients had villous atrophy, of which half still had total villous atrophy. All children in the study recovered completely and recovered faster than the adults in long term follow-up. Besides intestinal biopsy, assessment of serum IgA class endomysial antibody (EmA) has been evaluated as a predictor of intestinal mucosal recovery4 . However, EmA conversion from positive to negative status was not found to be a reliable predictor of complete mucosal recovery. Intestinal mucosal recovery was incomplete in 47% of patients who had become EmA negative after 12 months on a gluten-free diet, and EmA sensivitivity for total villous atrophy and partial villous atrophy was only 33% and 9%, respectively. Likewise, Cummins et al. found that even after two years on a gluten-free diet, patients who tested positive or negative for anti-endomysial antibodies showed no difference in villous atrophy (2). Another assessment of recovery is disaccharidase activity, which can be deficient secondarily to mucosal injury from celiac disease. Disaccharides are sugars (such as lactose, sucrose, and maltose) which must be split by disaccharidases (enzymes produced by villi in the small intestine) to be absorbed properly as monosaccharides and utilized by the body. Disaccharides such as lactose and sucrose are likely to be malabsorbed in patients with villous atrophy2 . Cummins et al. found that lactase activity increased by more than double after two years on a gluten-free diet, but this was still only about 55% of normal. Similar two-year recovery patterns were seen for activity levels of sucrase (83% of normal) and maltase (79%), yet, because disaccharidase activities improve despite incomplete recovery of the surface lining, they are thought to be the main reason why clinical symptom relief comes early on in treatment. (1) Gastrointestinal Symptoms Fine et al. found that celiac patients initially experienced chronic diarrhea (79%), excessive flatulence (74%), abdominal bloating (68%), nausea (36%), vomiting (19%), and constipation (6%)5 . After one year on a gluten-free diet these gastrointestinal symptoms completely resolved with the exception of chronic diarrhea, although 17% of celiac patients had chronic diarrhea to a lesser extent than before starting the diet. Anemia Celiac patients’ anemia-related symptoms receded and resolved as normalization of hemoglobin levels correlated with intestinal mucosal improvement on a gluten-free diet, even without oral iron supplementation (6) . This finding suggested that iron absorption was inefficient due to villous atrophy, and that oral iron therapy may not be effective during the first six months of treatment. After six months on a gluten-free diet, 78% of adult celiac patients recovered from iron deficiency anemia based on an assessment of their hemoglobin levels, and only 28% were no longer iron deficient based on serum ferritin levels. From 12 to 24 months of treatment, 94% of the patients were no longer anemic; however, only 55% of the patients reversed from iron deficiency (i.e., iron absorption was greater than iron loss) after 24 months of treatment. Bone Osteoporosis and osteopenia are common findings in newly diagnosed and untreated celiac patients. The deficiency of serum vitamin D which results in secondary calcium malabsorption is associated with low bone mineral density at diagnosis. A five year study follow-up with of adult celiac patients on a gluten-free diet found that bone mineral density improves or may normalize over the long-term, but that nearly all of the improvement occurs in the first year (7) . Blood 25(OH) vitamin D, the active form of vitamin D, increased 14% in the first year of a gluten-free diet, and increased another 80% by the fifth year. A slight (7%) but significant increase in blood calcium was seen after the first year with a further slight increase by the fifth year. Villous atrophy changes and the adherence to a gluten-free diet did not correlate with bone mineral density improvement. Patients’ weight gain in the study was associated with an increase in their bone mineral density. In a separate one-year study, bone mineral density and bone metabolism markers significantly improved in 43 percent of CD patients despite incomplete mucosal recovery (8) . These markers improved even in postmenopausal women and patients with low serum vitamin D levels. These studies confirm that recovery can take a long time and can often be incomplete in adults. Cummins et al. studied patients for villous atrophy up to 15 years after diagnosis, while most of the studies followed patients from one to five years after diagnosis. Indeed, more follow-up studies need to be performed to address the length of time it takes to achieve complete recovery in all aspects. To the extent that recovery is still incomplete, future studies need to identify and explain the reasons why.
  5. Hi all! I am about a month into my gluten free diet, I was feeling better initially, now, I have been having some sinus problems, headaches and fatigue. It almost feels like I’m constantly coming down with a cold, but, it never actually happens. Has anyone experienced this in the initial stages of their healing journey? Currently taking: l-glutamine, multi-vitamin, magnesium, b complex, vitamin D+C, probiotics. THANK YOU. Meg.
  6. Celiac.com 09/13/2021 - Gut damage is slow to heal in many patients with celiac disease. There has been some indication that budesonide together with a gluten-free diet can speed small bowel healing and improve symptoms improvement in patients with newly diagnosed celiac disease. A team of researchers recently set out to assess the effects of effervescent budesonide in conjunction with a gluten-free diet on Marsh grading and quantitative duodenal morphometry in newly diagnosed celiac patients. Basically, they wanted to see if the budesonide would improve the healing, compared to the gluten-free diet alone. The research team included Evan D. Newnham; Daniel Clayton-Chubb; Meena Nagarethinam; Patrick Hosking; and Peter R. Gibson. They are variously affiliated with the Departments of Pathology, Gastroenterology and Hepatology at Eastern Health in Melbourne, Victoria, Australia; Pathology, Eastern Health, Box Hill, Vic., Australia; and the Department of Gastroenterology, Alfred Health, Melbourne, Vic., Australia. The team crafted a randomized, double-blind trial that measured the effects on Marsh grading and quantitative duodenal morphometry of 10 weeks' effervescent budesonide or placebo in newly diagnosed celiac patients. They then assessed the patients' progress across numerous clinical factors at 2 months and 1 year. The study followed nineteen newly diagnosed celiac patients who randomly received budesonide, along with a control group of eighteen, who received a placebo. The team saw no differences in mucosal response (Marsh 0 or 1) between the budesonide vs placebo groups in terms of week-8 remission (Marsh 0), week-52 response, and week-52 remission. Likewise the two groups showed no difference in improvement from baseline of villous-height-to-crypt-depth ratio, nor any statistically significant differences in clinical measures or adverse events. They saw no negative effects associated with corticosteroids. Overall, they noted that Marsh 3C was present at the diagnostic biopsy in 1 of 9 achieving mucosal remission at 8 weeks compared with 18 of 23 who did not achieve it; and mean villous-height : crypt-depth ratio was 1.06 (SD: 0.73) versus 0.46 (0.38) (P = 0.005). In this study, budesonide showed no significant effect on mucosal healing in celiac patients on a gluten-free diet. Mucosal remission at 8 weeks occurred in approximately one in four patients, regardless, and was associated with less severe histological lesions at the time the patient was diagnosed. Read more in Alimentary Pharmacology & Therapeutics

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  8. Celiac.com 10/28/2020 - Eating that Thanksgiving turkey and taking probiotics may promote gut healing and improve gluten-free diet response in people with celiac disease. A research team at Canada's McMaster University has found that tryptophan, an amino acid found in high concentrations in turkey meat, along with some probiotics, may help celiacs heal faster, and respond better to a gluten-free diet. The researchers included Bruno Lamas, Leticia Hernandez-Galan, Heather J. Galipeau, Marco Constante, Alexandra Clarizio, Jennifer Jury, Natalia M. Breyner, Alberto Caminero, Gaston Rueda, Christina L. Hayes, Justin L. McCarville, Miriam Bermudez Brito, Julien Planchais, Nathalie Rolhion, Joseph A. Murray, Philippe Langella, Linda M. P. Loonen, Jerry M. Wells, Premysl Bercik, Harry Sokol, and Elena F. Verdu. For their study, the team set out to see if the breakdown of tryptophan by gut bacteria was different in celiac disease, and whether this difference could be targeted as a potential therapy. The team studied three groups: patients with active celiac disease, patients two years after a gluten-free diet, and healthy people. Their findings suggest targeting tryptophan metabolism in the guts of people with celiac disease might help to control symptoms and accelerate intestinal healing. "The only treatment for celiac disease is a strict adherence to a gluten-free diet, which is difficult to follow, and doesn't always lead to complete recovery of the gut or symptom resolution," says Elena Verdu, lead researcher of the study and a professor of medicine at McMaster's Farncombe Family Digestive Health Research Institute. She also holds the Canada Research Chair in Nutrition, Inflammation and Microbiota. Tryptophan is an essential amino acid that is necessary for numerous functions within the body, but which cannot be produced by the body, and instead must be consumed via foods like poultry, chocolate, bananas, and cruciferous vegetables, like broccoli, cabbage and cauliflower. Once consumed, tryptophan is broken down by gut bacteria to produce bioactive molecules (called "metabolites") that interact with receptors in the gut lining that control inflammation. One of these receptors is the aryl hydrocarbon receptor, or AhR, and suboptimal activation of this receptor has been implicated in chronic intestinal inflammation, including inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Celiacs showed evidence of reduced bacterial metabolism of tryptophan, and their gut microbiota did not appropriately stimulate the AhR pathway, which controls inflammation and protects the gut barrier. These changes improved a bit in patients after two years of a gluten-free diet. Using mice that express the genes for celiac disease, the authors showed that two strains of lactobacilli, bacteria known to breakdown tryptophan, activated AhR and reduced gluten-triggered inflammation. The study findings highlight the potential therapeutic value of targeting tryptophan metabolism in the gut in celiac disease to better control symptoms. Hopefully, we will get studies that look into therapeutic strategies, such as tryptophan supplementation in combination with specific probiotics, that produce AhR ligands from the diet, in celiac patients who do not respond to the gluten-free diet. Read more in Science Translational Medicine The researchers are variously affiliated with the Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada; the Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France; the Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hospital Saint Antoine, Service de Gastroenterologie, Paris, France; the Division of Gastroenterology and Hepatology, Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA; and the Host-Microbe Interactomics, Animal Sciences Group, Wageningen University, Wageningen, Netherlands.
  9. Celiac.com 10/01/2020 - People with celiac disease, even those on a long-term gluten-free diet, with healed mucosa and no obvious gut damage, still show signs of ongoing disease at the molecular level, and may not be "healthy," according to the results of a new study. In these people, a gluten challenge will trigger hyperactive Wnt-signaling, and leave a clear, secretory cell type signature. This makes gluten challenge studies important for uncovering the mechanisms that drive celiac disease. A team of researchers recently set out to reveal early gluten-induced transcriptomic changes in duodenal biopsies and to find tools clinics can use to measure the level of intestinal injury to celiac patients. Molecular histomorphometry might be one such tool. The research team included Valeriia Dotsenko, Mikko Oittinen, Juha Taavela, Alina Popp, Markku Peräaho, Synnöve Staff, Jani Sarin, Francisco Leon, Jorma Isola, Markku Mäki, and Keijo Viiri. For their study, the team collected duodenal biopsies from 15 celiac disease patients on a strict long-term gluten-free diet (GFD) prior to and post gluten challenge (PGC) and from 6 healthy control individuals (DC). They conducted morphometric analysis on each biopsy, and put biopsy RNA through genomewide 3’ RNA-Sequencing. They used the sequencing data to find differences among the three groups, and to compare against sequencing data from the public sources. The team's gluten challenge trial gave them a way to study the transition from good health to celiac disease. When the team compared the gluten-free group with the healthy control group, they found 167 differentially expressed genes, 117 of which were upregulated. A comparison of the prior-post-gluten challenge vs. gluten-free groups showed 417 differentially expressed genes, with 195 genes downregulated and 222 genes upregulated. Their results show that even gluten-free, seemingly healthy celiac patients reveal patterns of ongoing disease on the molecular level. Meaning that even seemingly healthy celiacs on a gluten-free diet were not “healthy”. What the results of this small study mean for the ongoing treatment and management of celiac disease remains unclear, as do the health implications for celiacs. Certainly, the idea that molecular damage may be ongoing in healthy, gluten-free celiacs is a bit concerning, at the very least. Further follow-up of people with celiac disease might be warranted, to assess any ongoing damage. Also, is this molecular damage related to ongoing, even low-level, gluten-exposure? The data invite many questions. Further study will help to shed some important light on this subject. Stay tuned for more on the ongoing health and wellness challenges faced by people with celiac disease. Read more in Cell Mol Gastroenterol Hepatol 2020 The researchers are variously affiliated with the Faculty of Medicine and Health Technology, Tampere University Hospital, Tampere University Tampere, Finland; the Department of Internal Medicine, Central Finland Central Hospital, Jyväskylä, Finland; the Carol Davila University of Medicine and Pharmacy; the Alessandrescu-Rusescu National Institute for Mother and Child Health, Bucharest, Romania; the Department of Obstetrics and Gynecology and Tays Cancer Centre, Faculty of Medicine and Health Technology, Tampere University Hospital, Tampere University, Tampere, Finland; the Laboratory of Cancer Biology, Faculty of Medicine and Health Technology, Tampere University in Tampere, Finland; Jilab Inc, in Tampere, Finland; and Celimmune LLC, Bethesda, Maryland.
  10. Celiac.com 06/19/2020 (Revised 06/24/2020) - It is not uncommon to have received blood testing from your doctor to see if you have celiac disease, and it comes back negative, when in fact your body is actually having a problem and you are on the celiac spectrum. The tests most doctors use to determine whether or not someone has celiac disease are very accurate for end stage celiac disease-after you have total villous atrophy, but not earlier stages of the disease (1). In those earlier situations, these tests often come back negative, even though you truly have a problem and are reacting to wheat moving towards total villous atrophy (1, 2, 3, 4, 5). It’s the wrong test. If you have an earlier stage in terms of the amount of damage incurred, the standard blood tests can be wrong over 70% of the time giving false negatives Standard blood tests for celiac disease have been extremely accurate and dependable if a person has total villous atrophy celiac disease. However, the accuracy of the blood test results for the two accepted blood markers (Endomysium and Tissue Transglutaminase) with anything less than total villous atrophy drops tremendously (to as low as being wrong 7 out of 10 times) (8,9). The reason these tests are often wrong in some people is that the research to validate the test used subjects who all had been diagnosed with celiac disease which by definition was total villous atrophy (Marsh IIIa,b,c). The earlier stages, Marsh 1 and 2 by most are considered ‘potential celiac disease’. So, when researchers were looking to validate if their blood tests were accurate in diagnosing celiac disease, they tested the blood of people diagnosed with celiac disease (total villous atrophy). And in that scenario, endomysium and tissue transglutaminase are highly accurate. from Lerner A, Jeremias P, Neidhöfer S, Matthias T (2017) Comparison of the Reliability of 17 Celiac Disease Associated Bio-Markers to Reflect Intestinal Damage. J Clin Cell Immunol 8: 486. from Lerner A, Jeremias P, Neidhöfer S, Matthias T (2017) Comparison of the Reliability of 17 Celiac Disease Associated Bio-Markers to Reflect Intestinal Damage. J Clin Cell Immunol 8: 486. Why? Celiac disease is defined as total villous atrophy. However, you don’t just magically go to sleep one night fine and wake up the next morning with total villous atrophy celiac disease. This disease, like all diseases, needs to be looked at more as a spectrum. That’s why Prof. Michael Marsh identified the spectrum of celiac disease development (Marsh I, II, III a, b, c). Bottom line? The test for total villous atrophy celiac disease (Marsh III a, b, c) are not the tests to rely on for earlier phases of the spectrum (Marsh I, II). The end result is many people have been told they do not have celiac disease and wheat is not a problem continue eating this food that is leading them further down the path of autoimmune disease. And of course, the tests for celiac disease are NOT the tests for the spectrum of Wheat Related Disorders (9). Predictive autoimmunity can tell you what areas of your body are under attack. Identifying an autoimmune mechanism early in the spectrum of development gives an opportunity to address it before there is so much tissue damage, now you have an autoimmune disease. Autoimmunity is the number 3 cause of death and highly preventable. If you could peek inside and determine what is going on before it does irreparable damage, it gives you a window of opportunity to address the problem early on and change the course of your health. This is called Predictive Autoimmunity (30). Identifying that you are on the celiac spectrum at Marsh I, gives you the opportunity to take action (gluten-free diet) and prevent progressing to Marsh III total villous atrophy. So the tests that are highly accurate for Marsh III are the wrong tests for Marsh I and II. They may be helpful and they may be misleading Gluten, Autoimmunity, and Your Gut Dr. Alessio Fasano is the chair of pediatric gastroenterology at Mass. General Hospital, Harvard, and director of Mucosal Immunology and Biology Research Center at Mass General Hospital for Children. He has done extensive research in the area of mucosal lining of the gut. He discovered, in the early 2000’s, a trilogy present in the development of autoimmunity: genetics, triggers, and intestinal permeability. (10) With celiac, we all know this – DQ2/DQ8, gluten, leaky gut = vulnerability to developing celiac disease. In the last 15 years, research has continued to expand to include two more features - thus a total of 5 components in the development of autoimmune diseases. In addition to genetics, environmental triggers and intestinal permeability, we now know that a dysbiotic microbiome and a systemic inflammatory immune response are involved. (11) This is important in our understanding of treatment. You can arrest the development of autoimmunity by healing the gut and addressing intestinal permeability. The majority of people with leaky gut do not show symptoms in the gut. A leaky gut spews out macromolecules into the blood stream that travel throughout your body that are considered foreign objects that your immune system will protect you from. And the resulting systemic inflammation from a leaky gut can affect any area of your body. And what are the most common triggers that will trigger a leaky gut? Gluten and small intestinalal bacteria overload. (11) Dangers of a Gluten-Free Diet Now this is a ‘Big Picture’ concept, but when you read the science it is clear that no one can fully digest the proteins in wheat (11, 12, 13, 14). It is indigestible to all humans, and in every single person causes a transient state of intestinal permeability (12, 13). Having said that, not everything about wheat is bad. Wheat (78%) and barley (3%) account for 78 - 81% of total prebiotics in the Western diet (14, 15, 16). When you remove wheat from your diet, a large percentage of the good bacteria will likely starve. This may be a contributing factor to the jaw-dropping statistic from the largest study ever done on mortality and celiac disease, that being diagnosed with celiac disease is associated with an 86% increased risk of mortality from a cardiovascular incident within 1 year (18). Just by being diagnosed. As far as I know, no one has pursued further research on this fact. What is different after diagnosis? People go on a gluten-free diet. What else? For most people, nothing else-they just stat eating gluten-free foods. You MUST be conscious of replacing the loss of prebiotics in your diet. Replacing wheat-based products with gluten-free products is a landmine. The vast majority of gluten-free products do not have prebiotic fibre, are not enriched, and are just tasty white paste. There’s nothing wrong with a gluten-free blueberry muffin once in a while, or gluten-free pasta on occasion. But these products are not healthy for you and can NOT be the cornerstone of your new diet. Be mindful of this at the onset of starting your gluten-free diet, so that you replenish your body with the necessary prebiotic nutrients your microbiome needs to increase diversity and balance. (14) So many people make the same newbie mistakes of just shopping in the gluten-free aisle and walk away with gluten-free cookies and snacks. I’m sorry to say that those are pretty much just as unhealthy, or worse, than the gluten versions. They just lack the antigen gluten. You need to look towards the produce aisle, vary your food choices from day to day, eat a wide variety in colour and types of organic fruits and vegetables, eat fermented foods rich in probiotics, and feed that good bacteria in your gut with foods that are prebiotics (root vegetables daily). I highly recommend finding a Certified Gluten-free Practitioner (CGP) who has received extensive training in celiac disease, gluten sensitivities, wheat-related disorders and autoimmunity. That is the most comprehensive training out there in this area. Find a CGP in your area-they’re all over the world, and most do on-line private consults. Addressing the intestinal permeability that has been developing with every exposure to wheat (12), within 5 minutes of wheat coming out of the stomach into the small intestine (20), is a game-changer in your overall health. There are over 300 autoimmune conditions. With the ‘Gateway’ in the development of autoimmune diseases being intestinal permeability, addressing this, and focusing on healing the gut can bring big rewards. Heal the Gut Identify and eliminate your triggers. Reduce inflammation. Reduce stress. The following supplements all have many studies showing their value in addressing intestinal permeability: Glutamine (21), Fish oils (22), Vitamin D (23), Colostrum (24), Turmeric (25), Pre (26) and Probiotics (27). Each of these basic nutrients modulates (has their hands on the steering wheel) of genes to reduce inflammation achieving a similar end goal, but they each work in different ways. Using a pleiotropic approach ensures success (great scrabble word-pleiotropic-means ‘all roads lead to Rome’. When you have a gluten-related disorder, the treatment is a strict gluten-free diet - without exception. Don’t let the treatment be the trigger for more problems. I’m known for the saying “You can’t be a little pregnant, you can’t have a little gluten” (if your immune system is activated fighting any of the peptides of wheat). Cheating once-per-month increases your risk of early death 6-fold! (19) Take measures to protect yourself against nutritional and vitamin deficiencies associated with a gluten-free diet. The benefits of a ‘Coach’ to learn the correct basics through this transition cannot be overemphasized (28, 29). A CGP, Nutritionist, trained Registered Dietician, Health Coach, … are invaluable in you learning the basics of this transition into a new way of eating. Eat different colors of the rainbow at every meal, every day. It will help restore balance to your gut health and rebalance your immune system. If you’re going to do this alone, avoid wheat (gluten), dairy, and added sugar for a month. Eat nutrient dense organic foods, such as quinoa, amaranth, vegetables, and quality meats. Gauge how you feel. Is your weight better managed? Do your hands and feet no longer feel cold? Are you able to think more clearly? If so, continue to eliminate those offending foods and eat a varied diet rich in nutrients. If you reintroduce and notice a problem, now you know those were foods that are inflammatory to you. And be careful of your tricky mind. Humans are the only species on the planet that finds something that works, and they stop doing it! References: Lerner A, Jeremias P, Neidhöfer S, Matthias T (2017) Comparison of the Reliability of 17 Celiac Disease Associated Bio-Markers to Reflect Intestinal Damage. J Clin Cell Immunol 8: 486 Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac disease. Salmi TT, Collin P, Järvinen O, Haimila K, Partanen J, Laurila K, Korponay-Szabo IR, Huhtala H, Reunala T, Mäki M, Kaukinen K.Aliment Pharmacol Ther. 2006 Aug 1;24(3):541-52 Lack of correlation of degree of villous atrophy with severity of clinical presentation of coeliac disease. Brar P, Kwon GY, Egbuna II, Holleran S, Ramakrishnan R, Bhagat G, Green PH.Dig Liver Dis. 2007 Jan;39(1):26-9 Seronegative celiac disease: increased prevalence with lesser degrees of villous atrophy. Abrams JA, Diamond B, Rotterdam H, Green PH.Dig Dis Sci. 2004 Apr;49(4):546-50 Utility in clinical practice of immunoglobulin a anti-tissue transglutaminase antibody for the diagnosis of celiac disease. Abrams JA, Brar P, Diamond B, Rotterdam H, Green PH.Clin Gastroenterol Hepatol. 2006 Jun;4(6):726-30 Tests for Serum Transglutaminase and Endomysial Antibodies Do Not Detect Most Patients With Celiac Disease and Persistent Villous Atrophy on Gluten-free Diets: a Meta-analysis. Silvester JA, Kurada S, Szwajcer A, Kelly CP, Leffler DA, Duerksen DR.Gastroenterology. 2017 Sep;153(3):689-701 Screening for celiac disease.Lebwohl B, Green PH.N Engl J Med. 2003 Oct 23;349 (17):1673-4 Joint BAPEN and British Society of Gastroenterology Symposium on 'Coeliac disease: basics and controversies'. Coeliac disease in the twenty-first century. Dickey W. Proc Nutr Soc. 2009 Aug;68(3):234-41. Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Fasano A, Shea-Donohue T. Nat Clin Pract Gastroenterol Hepatol. 2005 Sep;2(9):416-22. Fasano A. All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases. F1000Res. 2020;9:F1000 Faculty Rev-69. Published 2020 Jan 31. doi:10.12688/f1000research.20510.1. Celiac Disease and Nonceliac Gluten Sensitivity: A Review. Leonard MM, Sapone A, Catassi C, Fasano A. JAMA. 2017 Aug 15;318(7):647-656. Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Hollon J, Puppa EL, Greenwald B, Goldberg E, Guerrerio A, Fasano A.Nutrients. 2015 Feb 27;7(3):1565-76. Lerner A, O'Bryan T, Matthias T. Navigating the Gluten-Free Boom: The Dark Side of Gluten Free Diet. Front Pediatr. 2019;7:414. Published 2019 Oct 15. Effects of a gluten-free diet on gut microbiota and immune function in healthy adult Human subjects - comment by Jackson. Jackson FW. Br J Nutr. 2010 Sep;104(5):773. On the presence of Inulin and Oligofructose as natural ingredients in the western diet Jan Van Loo , Paul Coussement , Leen De Leenheer , Hubert Hoebregs & Georges Smits Critical Reviews in Food Science and Nutrition, Volume 35, 1995 - Issue 6. Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice. Neyrinck AM, Possemiers S, Druart C, Van de Wiele T, De Backer F, Cani PD, Larondelle Y, Delzenne NM. PLoS One. 2011;6(6):e20944. Small-intestinal histopathology and mortality risk in celiac disease. Ludvigsson JF, Montgomery SM, Ekbom A, Brandt L, Granath F., JAMA. 2009 Sep 16;302(11):1171-8. Mortality in patients with coeliac disease and their relatives: a cohort study. Corrao G, Corazza GR, Bagnardi V, Brusco G, Ciacci C, Cottone M, Sategna Guidetti C, Usai P, Cesari P, Pelli MA, Loperfido S, Volta U, Calabró A, Certo M; Club del Tenue Study Group.Lancet. 2001 Aug 4;358(9279):356-61. Confocal endomicroscopy shows food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome. Fritscher-Ravens A, Schuppan D, Ellrichmann M, Schoch S, Röcken C, Brasch J, Bethge J, Böttner M, Klose J, Milla. PJ.Gastroenterology. 2014 Nov;147(5):1012-20. Glutamine and the regulation of intestinal permeability: from bench to bedside. Achamrah N, Déchelotte P, Coëffier M.Curr Opin Clin Nutr Metab Care. 2017. Jan;20(1):86-91 Potential of Omega-3 Polyunsaturated Fatty Acids in Managing Chemotherapy- or Radiotherapy-Related Intestinal Microbial Dysbiosis. Zhang Y, Zhang B, Dong L, Chang P.Adv Nutr. 2019 Jan 1;10(1):133-147. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Kong J, Zhang Z, Musch MW, Ning G, Sun J, Hart J, Bissonnette M, Li YC.Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G208-16. Peptide Immunotherapy: Colostrum, A Physician's Reference Guide Hardcover, Keech A., AKS Publishing; 1St Edition edition (2009) ISBN-10: 0692002421. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Aggarwal BB, Harikumar KB.Int J Biochem Cell Biol. 2009 Jan;41(1):40-59. Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Delzenne NM, Neyrinck AM, Cani PD.Microb Cell Fact. 2011 Aug 30;10 Suppl 1(Suppl 1):S10 Gut Microbiota in Celiac Disease: Is There Any Role for Probiotics? Pecora F, Persico F, Gismondi P, Fornaroli F, Iuliano S, de'Angelis GL, Esposito S.Front Immunol. 2020 May 15;11:957. Factors that influence adherence to a gluten-free diet in adults with celiac disease. Leffler DA, Edwards-George J, Dennis M, Schuppan D, Cook F, Franko DL, Blom-Hoffman J, Kelly CP.Dig Dis Sci. 2008 Jun;53(6):1573-81. Gluten-free diet: the medical and nutrition management of celiac disease. See J, Murray JA.Nutr Clin Pract. 2006 Feb;21(1):1-15. Predicting and preventing autoimmunity, myth or reality? Harel M, Shoenfeld Y.Ann N Y Acad Sci. 2006 Jun;1069:322-45.
  11. Celiac.com 05/08/2020 - Can someone with celiac disease really heal? This is sort of how I see the villi of someone with Celiac disease - flattened with big gaps between. I missed this one, but in November 2019, there were some results from the Nexvax study involving endoscopic biopsies. It confirms what we already knew - blood tests and biopsy results are unrelated and celiac patients are sicker that they should be. The study lists that 93 patients underwent endoscopic biopsies as part of their participation in the Nexvax2 clinical trial. Only SIX patients had Marsh 0 or 1 damage. Marsh 0 or 1 damage is considered normal. Thirty had Marsh 2 damage and fifty-six were Marsh 3a or 3b. The good news is that some people had complete healing. But out of 93 patients, 86 people had enough damage to warrant a celiac diagnosis. More specifically, seventy-eight patients were on a gluten free diet for greater than two years and seronegative (had negative blood tests). 72 out of 78 patients have Marsh 2 or higher damage. Fourty -five or 58% of those tested still had Marsh 3 or higher damage. Typically, Marsh 3 or higher damage is required for celiac diagnosis. So, even after two years of a gluten free diet and clean blood tests, these patients are just as damaged as someone who is just diagnosed with celiac disease. That is disheartening. Now, we always knew there was a chance that people with celiac may never heal. We also know that blood tests and damage are not correlated and this proves that again. How do we know the damage is ongoing without endoscopic biopsies? We don't at this point. Look, I can go off on this and talk about how frustrating it is. How we really need some way to know what is going on in our bodies. How we need something to help us because this diet alone isn't working and these results prove it. But we just have to be patient. I know scientists are working on it. I know volunteers are volunteering to participate in trials. I'm just ready! Here is the study.
  12. Celiac.com 02/24/2015 - I've posted recipes for chicken and beef broth lately, and now it's time for what may be the healthiest of all broths, fish broth. Naturally gluten-free fish broth offers a delicious way to promote gut health, and recovery from illness. Ideally, fish broth is made from the bones of sole or turbot. Unfortunately, it's hard to get whole sole fish in America. However, you can make a great broth using any non-oily fish, such as snapper, rock fish, or lingcod. Ask your fish merchant to save the carcasses for you. Avoid using oily fish such as salmon for making broth, mainly because oily fish will make the broth turn rancid during the long cooking process. Be sure to use the heads as well as the bodies, as the heads are especially rich in iodine and fat-soluble vitamins. Use the broth any time you make seafood-based stews, soups, or chowders. Ingredients: 3 or 5 whole carcasses, including heads, of non-oily fish such as sole, turbot, rockfish or snapper about 3 quarts cold filtered water 2 or 3 sprigs fresh thyme 2 or 3 sprigs parsley 2 onions, coarsely chopped ¼ cup dry sake, white wine or vermouth ⅓ cup vinegar Sea salt to taste Directions: Melt butter in a large stainless steel pot. Add the vegetables and cook very gently, about 30 minutes, until they are soft. Add wine and bring to a boil. Add the fish carcasses and cover with cold, filtered water. Add vinegar. Bring to a boil and skim off the scum and impurities as they rise to the top. Tie herbs together and add to the pot. Reduce heat, cover and simmer for at least 4 hours or as long as 24 hours. I usually cook it for about 12-24 hours. Remove carcasses with tongs or a slotted spoon and strain the liquid into pint-sized storage containers for refrigerator or freezer. Chill well in the refrigerator and remove any congealed fat before transferring to the freezer for long-term storage.
  13. Celiac.com 02/17/2015 - Homemade bone broth is a great foundation for a healthy diet, and helps to promote gut healing, and overall health. Simmering animal bones and marrow, feet, tendons, and ligaments in water for one or two days turns collagen into gelatin, and produces a rich complex soup of amino acids and highly absorbable minerals like calcium, magnesium, sulfur, silicon, phosphorus, along with trace minerals. For best results use organic pasture raised, or free-range chickens. Many commercially-raised chickens produce stock that does not gel properly. Ingredients: 1 whole free-range chicken or 2 to 3 pounds of bony chicken parts, such as backs, breastbones, necks and wings 2-4 chicken feet gizzards from one chicken 4 quarts cold water 2 tablespoons vinegar 1 large onion, coarsely chopped 2 carrots, peeled and coarsely chopped 3 celery stalks, with leaves, coarsely chopped 1 bunch flat parsley Directions: If you are using a whole chicken, cut off the wings and remove the neck, and the gizzards from the cavity. Cut chicken parts, including neck and wings, into several pieces. Place chicken or chicken pieces in a large stock pot with water, vinegar and all vegetables, except parsley. Let stand 30 minutes to 1 hour. Bring to a boil, and skim away any froth that rises to the top. Reduce heat, cover and simmer for at least 6 to 8 hours, and up to 24 hours. Longer simmering time makes richer and more flavorful broth. About 10 minutes before finishing the stock, add parsley. This is important, as is adds ionized minerals to the broth. Remove chicken carcass and any meat and bones with a slotted spoon. If using a whole chicken, let it cool and then strip the meat away. Keep the meat to use in other meals, such as chicken salad, casseroles, enchiladas. You can also add it to any soup you might make with the broth later on. Strain the stock into a large bowl and refrigerate until the fat rises to the top and hardens. Skim off fat and store the stock in covered containers in your refrigerator or freezer. Use broth liberally whenever a recipe calls for broth.
  14. Celiac.com 02/11/2015 - Broth is the new black. Read the food magazines and blogs and you will inevitably come upon an article about the benefits of broth. But, unlike so many health foods, broth is not an overhyped fad food. Broth can be digested by every body, and broth is healthy for everyone. For people with celiac disease or gluten-intolerance, broth can be part of a diet that promotes healing and wellness of the gut, the immune system, the bones and more. From baby to granny and from sickest to healthiest, broth has something for everyone. Ingredients: 4 pounds beef marrow and knuckle bones 3 pounds meaty rib or neck bones 4 or more quarts cold filtered water ½ cup cider vinegar 3 onions, coarsely chopped 3 carrots, coarsely chopped 3 celery stalks, coarsely chopped several sprigs of fresh thyme, tied together 1 teaspoon dried peppercorns, crushed l bunch flat parsley, chopped Directions: Place the knuckle and marrow bones into a very large pot with vinegar and cover with water. Let sit for one hour. Meanwhile, place the meaty bones in a roasting pan and brown at 350 degrees in the oven. When well browned, add to the pot along with the vegetables. Pour the fat out of the roasting pan, add cold water to the pan, set over a high flame and bring to a boil, stirring with a wooden spoon to loosen up coagulated juices. Add this liquid to the pot. Top with water, if needed, just enough to cover the bones. **NOTE: Remember to keep the liquid no higher than one inch below the rim of the pot, as the volume expands slightly during cooking. Bring pot to a boil. A large amount of frothy scum will rise to the top, and it is important to remove this with a spoon or mesh skimmer. After you have skimmed, reduce heat and add the thyme and crushed peppercorns. Simmer stock for at least 12 and as long as 72 hours. Just before finishing, add the parsley and simmer another 10 minutes. At this point, the broth will look more like a scary brown liquid with globs of gelatinous and fatty material. It won’t even smell very good. However, all you need to do is to strain it properly to get a delicious and nourishing clear broth that you can use for myriad soups and stews and other dishes. So, remove bones with tongs or a slotted spoon, and strain the stock through a sieve or mesh strainer and into a large bowl. Refrigerate the bowl and, once it’s cold, remove the hardened fat from the top. Transfer to smaller containers, and freeze for long-term storage.
  15. I have been gluten free for about 2 months, been knowingly glutened once. I am also dairy-free, and grain-free (except for rice) mainly because I also react to corn similarly to wheat. I am feeling much better, some 50-70% of my brain fog (which is the most prominent symptom) already vanished. However, it's not all sunshine and rainbows. For quite a while now (a few weeks) I've been having digestive issues that I didn't even have before I went gluten-free. For the first few days gluten free, I had unreal appetite for food, like I-can't-stop-eating-and-now-I'm-too-full kind of appetite. That all changed now. My stomach is fine, the problem is in my small intestine. I have visible bloating, general discomfort, and I always feel like the food is stuck there sitting for days and not being digested or absorbed with nonrelieving belching and sounds. It's really hard to describe; I feel like my intestines are constantly and persistently full of garbage and undigested rotting food that bloats me up, and feels like it would take 10 years of belching and passing gas on a water fast to finally clean out and flush. What I want right now is for something to run through my gut and push every molecule of food and liquid out of my body so that I can be finally relieved. That's what it is. From what I understand I might be having difficulty digesting food and/or having gut bacteria issues, so I am trying to limit my fat/fiber intake and eat simpler foods; however that doesn't seem to be making that much of a change. I cannot take digestive enzymes to help because they're unavoidably derived from pigs (as far as I know) and my religion prohibits that. I am getting adequate hydration, it helps a bit but doesn't tackle the issue. I want to ask if someone has experienced something similar, how long it takes to go away, and what I can do to help with it. Due to this issue I am losing weight due to the mere inability to eat sometimes. I am afraid of going downhill on a diet that's supposed to make me feel better. I almost said screw it and started eating gluten again; because some points during this journey have been pure misery. I don't get it: I'm supposed to be healing, right?
  16. Celiac.com 06/20/2019 (originally published 07/12/2010) - Autoimmune diseases taken together are the third leading cause of death in the US. The list of autoimmune diseases is long and varied—M.S., type 1 diabetes, lupus, Hashimoto’s thyroiditis, rheumatoid arthritis, Sjogren’s, and fibromyalgia to name just a few. But the autoimmune disease celiac, unlike all the others, has a unique feature—it’s the only autoimmune disease where the exact trigger is known. Gluten is the trigger for celiac disease and when that trigger is removed the body stops destroying its own small intestine. Why is this profound? Two reasons: There is no other autoimmune disease where the exact trigger is known. Gluten and the damage it causes to the small intestine may very well be the root cause of other autoimmune diseases! We have appreciated the interesting phenomenon where people “develop” gluten intolerance at different ages. It used to be perplexing because it was assumed that if the problem was genetically driven, as soon as the body received its first gluten “insult” damage should begin to occur. When patients stated that they felt perfectly fine until a certain age, it was thought that the damage had probably begun far earlier but the patient had just not noticed. What we have come to realize is that a genetic propensity plus the presence of gluten in the diet are only two of the three necessary constituents of the puzzle—the third is damage to the small intestine. A completely healthy, intact small intestine seems to be quite able to defend itself against gluten. But once damage has occurred, the gut becomes “leaky” and not only can digestive complaints result but symptoms arise in other body systems. There has been proof for many years that the intestine is not the only tissue targeted by the immune reaction to gluten. The prime example of this is a disease called dermatitis herpetiformis where the gluten sensitivity manifests primarily in skin, with only mild or no intestinal involvement. Now, more recent research reveals that perhaps a vast number of autoimmune diseases may also involve an immune response to dietary gluten as well as its consequent autoimmune reaction to tissue transglutaminase. This may be the main immunologic cause. [Note: Although we typically think of tissue transglutaminase as an enzyme in the gut, it is, in fact, an enzyme found throughout the body. This is perhaps another reason why gluten has such far-reaching effects in other systems of the body.] The substance that dictates the permeability between the barrier cells that line the small intestine is called zonulin. Increased zonulin causes the intestine to become leaky, thereby allowing substances to leave the intestine that normally shouldn’t. Research has shown that in patients with celiac disease, gliadin activates zonulin signaling, leading to increased intestinal permeability. But how does this extend to other autoimmune diseases? Dr. Alessio Fasano performed a brilliant study on rats that were genetically predisposed to develop type 1 diabetes. The premise was that if the gut was not affected negatively by zonulin and remained intact and healthy, then perhaps the auto-antibodies made against specific cells of the pancreas that create diabetes would be prevented from leaving the gut and thereby stopped from causing damage to the pancreas. Sure enough 2/3 of these rats who were highly predisposed to develop diabetes did not! This study was the first time that an autoimmune disease was prevented by blocking intestinal permeability. It further puts a new face on the entire concept of how and why autoimmune disease develops. We’ve always thought that the genetic predisposition was an overriding characteristic of autoimmune diseases that overshadowed any effort to sublimate it. This study opens a new field of investigation into the relationship between the health of the intestine and the basis of many diseases. Imagine if the “unknown trigger” of autoimmune disease turns out to be gluten and its effect of creating a leaky gut! It is for this reason that I am so passionate about early diagnosis of gluten intolerance. Whether it be celiac disease or gluten sensitivity, the effect that gluten imposes on the integrity of the small intestine has far-reaching implications. I see it clinically in my patients on a daily basis, but the above research puts a point on it that we must consider seriously. A study from Italy showed that the longer gluten sensitive people eat gluten, the more likely they are to develop autoimmune diseases. They found that in childhood celiacs, the prevalence of autoimmune disease rose from a baseline of 5% at age 2 to almost 35% by age 20. Imagine if screening of all children for gluten intolerance resulted in reductions of future autoimmune diseases! I am currently working on a program with my patients who are gluten intolerant to restore their small intestines to the healthiest possible condition. This is important from the obvious viewpoint that optimal digestion and absorption is critical to good health. But it is also vital from the perspective of understanding and managing zonulin and its long-term effects on health. I would recommend that you take the following steps to ensure that you are doing everything you can to restore your small intestine to optimal functioning. Have a comprehensive stool analysis performed to ensure that no pathogenic organisms (bacteria, amoeba, parasites, etc) are present. Such a test should also measure the effect of your body’s enzymes to see how effectively your food is being broken down and absorbed. It should also assess the health of your intestinal bacteria or probiotics. Eliminate dairy foods from your diet. There is considerable evidence to suggest that consuming milk from other mammals is not conducive to good health, especially in our digestive tracts. The inflammation that dairy can cause could well be contributing to a leaky gut, despite the elimination of gluten. Once you have taken the above steps, see how you’re feeling. Some patients require supplements such as glutamine, quercitin, reduced glutathione, N-acetylcysteine, omega 3 fatty acids, and vitamins A, E, B and zinc to help the intestinal lining heal fully. Once the above have been done, have a lab test performed for leaky gut. It’s called a lactulose/mannitol test and will show whether large molecules are crossing the intestinal barrier. This is a non-invasive, non-drug test. Just to reiterate: encourage parents you know to have their children evaluated for gluten intolerance. The more we can affect an early diagnosis, the healthier our future generations will be. Last but not least, show your doctor this data. There is still too much ignorance in our profession about gluten and its broad reaching negative effects. I hope you find this information helpful. Many of the steps mentioned above are best administered with the help of a clinician so let me know if I can assist you to find someone in your area who can help. References: Scandinavian Journal of Gastroenterology. 2006 Apr;41(4):408-19. Annals N Y Academy Science. 2009 May;1165:195-205. “Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms.” Clinical Gastroenterology & Hepatology. 2005 Apr;3(4):335-41. “Permeability, zonulin production, and enteropathy in dermatitis herpetiformis.” Gut. 2003 Feb;52(2):218-23. “Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function.”
  17. Celiac.com 01/09/2019 - People with celiac disease who eat a gluten-free diet generally see an improvement in gut health over the next months and years. That’s true, but many people with celiac disease who eat a gluten-free diet still have gut damage many months later. What exactly is the connection between gut health and a gluten-free diet in people with celiac disease? To try to answer that question, a team of researchers recently set out to analyze the relationships between pre-diagnosis celiac serology, duodenal histopathology, primary presenting symptoms, celiac-related comorbidity and response to treatment in a modern cohort with new diagnosis of celiac disease. The research team included Oliver Cronin, Emma Flanagan, and Damian Dowling. They are variously affiliated with the Department of Gastroenterology, University Hospital Geelong, in Geelong, Australia, and the Department of Gastroenterology at St Vincent’s Hospital in Fitzroy, Australia. The team’s retrospective cohort study included 99 participants diagnosed with celiac disease between 1999 and 2013. For each patient, the team recorded baseline characteristics, celiac serology, and small bowel histopathology. Several patients underwent a repeat small bowel biopsy. The team used logistic regression to determine independent associations. Patients ranged from 30 to 53 years old, and averaged 43 years at diagnosis. Women made up nearly seventy percent of the group. The researchers used standard Marsh-Oberhuber Score (MS) to rate damage to intestinal villi. At diagnosis, nearly half of the patients showed total villous blunting (MS 3c), while twelve patients showed subtotal villous blunting (MS 3b), and 29 patients showed partial villous blunting (MS 3a). The extent of villous blunting was independent of symptom prevalence prior to diagnosis. A total of 87 patients received repeat small bowel biopsy at an average of 7 months after their initial biopsy. Meanwhile, a total of 34 patients had biopsy results at or above MS 3a, compared to 90 patients at the initial biopsy. 24 of the 34 patients reported following a strict a gluten free diet (GFD). Persistent MS at or above grade 3a at repeat biopsy was not associated with symptoms (P = 0.358) or persistent positive celiac serology. This study shows that the severity of the small bowel mucosal lesion at celiac disease diagnosis is independent of both symptoms and serology, and that neither are good predictors of mucosal health. While numerous patients do see histological improvement on a gluten-free diet, many newly diagnosed celiac patients show ongoing mucosal damage after many months on a gluten-free diet. An absence of celiac disease antibodies did not preclude ongoing mucosal damage. Basically, not all celiac patients see rapid gut healing, even on a strict gluten-free diet. Also, people with celiac disease can still have mucosal damage, even if they test negative for celiac disease antibodies. Source: World J Gastrointest Pharmacol Therv.9(6); 2018
  18. Celiac.com 12/03/2018 - Biomarkers in blood samples are not effective indicators for diagnosis or monitoring of celiac disease. A team of researchers recently set out to assess biomarkers of celiac disease derived from neoepitopes of deamidated gliadin peptides (DGP) and tTG fragments, and to assess their usefulness in identifying patients with celiac disease with mucosal healing. The research team included RS Choung, SK Rostamkolaei, JM Ju, EV Marietta, CT Van Dyke, JJ Rajasekaran, V Jayaraman, T Wang, K Bei, KE Rajasekaran, K Krishna, HK Krishnamurthy, and JA Murray. They are variously affiliated with the Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA; Vibrant Sciences LLC, San Carlos, CA, USA; and with the Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. The team began by analyzing serum samples from 90 patients with biopsy-proven celiac disease, along with 79 healthy control subjects for immune reactivity against the tTG-DGP complex. They used a fluorescent peptide microarray platform to estimate the antibody binding intensity of each synthesized tTG-DGP epitope. They validated results in 82 patients with newly diagnosed celiac disease, and in 217 control subjects. They assessed the ability of the peptide panel to spot patients with mucosal healing based on histologic results and using serum samples from 85 patients with treated and healed celiac disease; 81 patients with treated but unhealed celiac disease who showed villous atrophy despite adhering to a gluten-free diet; 82 patients with untreated celiac disease; 27 disease control subjects who showed villous atrophy without celiac disease; and 217 healthy control subjects. To assess their data, they relied on principal component analysis followed by machine learning and support vector machine modeling. In all, the team found 172 immunogenic epitopes of the tTG-DGP complex. Compared with control subjects, celiac patients showed substantially higher immune reactivity against these epitopes. In the test group, neoepitopes derived from the tTG-DGP complex identified people with celiac disease with a remarkable 99% sensitivity and 100% specificity. Blood samples from untreated celiac patients showed the greatest average antibody-binding intensity against the tTG-DGP complex. Blood from patients with treated but unhealed CeD mucosa (15.1 ± 7.5) showed significantly higher average antibody-binding intensity than blood from patients with treated and healed CeD mucosa (5.5±3.4) (P<.001). The test spotted celiac patients with healing mucosa with 84% sensitivity and 95% specificity. The research team discovered immunogenic epitopes of the tTG-DGP complex, and found that a test that measures immune response to epitopes accurately identified both celiac patients and patients with mucosal healing. From this study, the team concludes that the biomarker method for celiac testing could be useful in both the detection and monitoring of celiac disease. Read more at: Gastroenterology.
  19. So my son (age 20) was diagnosed with celiac early Feb 2018. He had symptoms since November so was a fairly quick diagnosis. Around December he started developing a swallowing difficulty which has progressed a lot in the last few weeks. He found swallowing liquids hard but now food is getting harder. During the few months before diagnosis he lost about 15lbs and probably another 10lbs since. I’m really concerned he isn’t getting enough calories and nutrients. He has seen every specialist from gastro to ENT to allergist plus ct scans barium swallow X-rays you name it and everything for swallowing comes back normal. Anyone else had this issue related to their celiac? If so what helped. He is also going for counselling because it is causing him so much anxiety. So number one any ideas in the swallowing and number two after nearly 5 months gluten free how can I get him to gain weight. Thanks worried mum.
  20. Celiac.com 10/13/2017 - Tissue transglutaminase (tTG) immunoglobulin A (IgA) testing is a sensitive adjunct to the diagnosis of coeliac disease. The threshold for positivity was developed for diagnosis, with negative results reported as below the reference value (<4 U/mL). A team of researchers recently set out to investigate if an undetectable tissue transglutaminase IgA antibodies (tTG IgA<1.2 U/mL) is more predictive of healing compared to patients with negative but detectable serology (1.2-3.9 U/mL). The research team included H. Fang, K. S. King, J. J. Larson, M. R. Snyder, T. T. Wu, M. J. Gandhi, and J. A. Murray. They are variously affiliated with the Department of Medicine, the Division of Gastroenterology and Hepatology, the Division of Anatomic Pathology, the Division of Clinical Biochemistry and Immunology, the Division of Biomedical Statistics and Informatics, and the Division of Transfusion Medicine at the Mayo Clinic, Rochester, MN, USA. The research team conducted a retrospective study of 402 treated coeliac disease patients seen at the Mayo Clinic with negative tTG IgA values drawn within 1 month of duodenal biopsy between January 2009 and December 2015. The team used Corazza-Villanacci scores to assess mucosal healing, and logistic regression to assess the relationship of clinical variables with a normal biopsy. They also noted the presence of gastrointestinal symptoms. Their results showed that patients with undetectable test levels more frequently had normal duodenal histology, as compared with patients with detectable tTG IgA levels. Asymptomatic patients more often showed normal duodenal histology as compared to symptomatic patients. Patients with undetectable blood levels, and who followed a gluten-free diet for ≥2 years were more likely to have no villous atrophy, as compared to patients with detectable blood levels. Follow-up biopsies revealed that people recovering from celiac disease with negative tTG IgA serology showed that undetectable test levels are associated with normal histology. Source: AP&T
  21. Well, since my last post things have really turned around in a good way. My mom is now on my side fully with going gluten-free. I feel so much better, though I am now having huge flare-ups of new and typical allergies, and also now having loose stool and gastro pain. I think it's my daily pills... I'm having issues with lactose still, gluten (of course), my tea tree organic castile soap (Dr. Bronner's Tea Tree Bar Soap), any shampoo (currently am using Mane and Tail), an organic body wash called 100% Pure White Peach Hydrating Body Wash which I used to be able to use to wash my face and now it causes an awful full-faced itchy, burning rash, and I'm sure other things which I can't think of at the moment. I take 40mg Lexapro daily for depression and anxiety. I have for about 10 years. Well all of a sudden on Thursday when I took all my pills in the afternoon I began having this awful panic attack - but it wasn't the kind where my brain is panicking - like "THE SKY IS FALLING" no, it's a body-only thing where my body gets super hot in the core and upper arms/legs and my hands and feet get freezing cold! and It's like there is a fire burning inside my torso. It's freaky and awful and I hate it! I eventually got over it mostly Thursday night and was finally able to fall asleep at about 4am. Then Friday afternoon I took only 2 Lexapro and no other medications. Same reaction, though not as severe. So I googled it and it seems it may be seretonin toxicity. Hmm. My gut may be healing - so it's absorbing more of the Lexapro - which makes my brain more saturated or whatever. So today I will only take 1 Lexapro (20mg) which is half dose. I'll see how I do tonight. I think I will take my blood pressure pill though. I do need that one. So, yeah, my body is freaking out severely and I have no idea why. Allergies, pain, rashes, panic attacks. I'm a walking mystery at this point. But hopefully I can get over these problems. *shrugs* I do see my allergist March 21st - this coming Friday. I will tell him everything that is going on and hopefully he can help me figure this out.
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