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Showing results for tags 'ppis'.
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Proton Pump Inhibitors Increase Risk of Celiac Disease
Jefferson Adams posted an article in Latest Research
Celiac.com 12/26/2022 - Rates of celiac disease, and the use of medications that inhibit acid secretion, such as proton pump inhibitors, have both increased in recent decades. A team of researchers recently set out to explore potential connections between anti-secretory medication usage and risk for later development of celiac disease. Here's what they found. The research team included Benjamin Lebwohl, MD, MS, Stuart J. Spechler, MD, Timothy C. Wang, MD, Peter H.R. Green, MD, and Jonas F. Ludvigsson, MD, PhD. They are variously affiliated with the Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA; the Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; the Division of Gastroenterology, Department of Internal Medicine, VA North Texas Healthcare System and UT Southwestern Medical Center, Dallas, Texas; and the Department of Pediatrics, Örebro University Hospital, Sweden. Population-based case control study In their population-based case control study, the team identified patients diagnosed with celiac disease across all of Sweden's pathology departments from July 2005 through February 2008. The team then matched patients by age and gender with up to five control subjects. The team identified previous prescriptions for proton pump inhibitors and histamine-2 receptor antagonists in all study subjects. The team then used conditional logistic regression to measure the connection between these prescriptions and a later diagnosis for celiac disease. Proton pump inhibitor prescriptions strongly associated with celiac disease The data show that people with previous proton pump inhibitor prescriptions had a strong association with celiac disease. Patients prescribed both proton pump inhibitors and histamine-2 receptor antagonists had a higher risk of celiac disease than those prescribed proton pump inhibitors alone or histamine-2 receptor antagonists alone. Conclusions From their findings, the team concludes that exposure to anti-secretory medications, such as proton pump inhibitors, is strongly correlated with a later diagnosis of celiac disease. This association remained, even after the team excluded prescriptions in the year preceding the celiac disease diagnosis, which points to the medications as a causal connection. The idea that certain medications can influence rates of celiac disease is not new. The idea that medicines like proton pump inhibitors can influence celiac disease rates is both new and potentially powerful information that could change the way we use those medicines, and the way we understand celiac disease development. Stay tuned for more on this and related stories. Read more in Dig Liver Dis. 2014 Jan; 46(1): 36–40. doi: 10.1016/j.dld.2013.08.128- 20 comments
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To All, I am just trying to start this resource for others that shows how Low Stomach Acid can lead to a food allergy problem. Maybe someone will read it and it will make sense to them. Eva Untersmayr has done the most work on the topic. I will quote a couple research articles by her.....demonstrating that food allergies happen when we get low in Stomach Acid. Starting with this one entitled "The influence of gastric digestion on the development of food allergy" https://pubmed.ncbi.nlm.nih.gov/28616101/ And this one entiteld "The role of protein digestibility and antacids on food allergy outcomes" https://pubmed.ncbi.nlm.nih.gov/18539189/ Food allergies happen when are stomach acid is no longer strong enough to digest proteins into harmless peptides. See also this excellent article (recently found) that explains how Antacid use can trigger food allegies again by Eva Untersmayr. "New Study Shows that Antacid Use Leads to More Allergies: Q&A with Eva Untersmayr MD, PhD" https://asthmaallergieschildren.com/new-study-shows-that-antacid-use-leads-to-more-allergies-qa-with-eva-untersmayr-md-phd/ When I get a chance I will check back in......and see what others think about this new cutting edge research.....has Eva found the trigger for food allergies? What do you all think? I hope this is helpful but it is not medical advice. Posterboy by the grace of God, -
To All, I came across this great article where they are interviewing Eva Untersmayr the pioneering researcher that explains how food allergens develop and I thought it was a "Must Read" for anyone with food allergies. I hope you will read it ALL yourselfselves. It really a great overview of how these things happen.......and it IMHO confirms my hunch about how Low/NO Stomach Acid is the "Gate Keeper" for the Small Intestine and helps fight off food allergens.....or at least helps keep them out of the small intestine in the first place. I will quote select sections but the article is not too long.....that you shouldn't read it for yourself in it's entirety. Entitled "Protect Your Digestion, (or IE Stomach Acid the Gate Keeper) the First Line of Defense Against Food Allergies" https://asthmaallergieschildren.com/protect-your-digestion-the-first-line-of-defense-against-food-allergies/ I was STRUCK by how quickly this can happen when one takes PPIs (and recent research in children has also confirmed these connections etc.) quoting from the article "Eva: The change in the gastric milieu takes place very quickly. You are right that approximately 5-6 days of PPI intake elevates the gastric pH to around 5. But long-term use of anti-ulcer drugs seems to especially increase the risk for need of anti-allergy medication, which we could also prove in our current study." quoting again... "One mechanism, which we also highlight in our paper, could be the direct effect on the immune response as immune cells have H2 receptors, PPIs can induce mast cell activation and the aluminum-containing Sucralfate might act as an adjuvant. Moreover, anti-ulcer drugs have an enormous effect on microbiota, which is even more prominent than the effect of antibiotics when considering the entire population due to longtime intake of this medication. So there are different layers of mechanisms that might explain our results." This article only summarizes the earlier work......and I am fond of saying "Why isn't this on the front page of every newspaper in the country"..... It is summarizing this ground breaking research now almost 12 years old!!! Entitlted "Anti-acid medication as a risk factor for food allergy".....I would say this includes Low/NO stomach acid from STRESS in our lives as well! https://onlinelibrary.wiley.com/doi/full/10.1111/j.1398-9995.2010.02511.x But taking PPIs and H2 blockers just acclerates this process by which our bodies activates antibodies to food allergens including Wheat etc....because the way PPIs and H2 blockers change the way our Mast Cell's react to food.....see above article that explains this in much better/more detail.....it involved the use of Aluminum that perks "Ups the Ears" of our immune system and makes the food we were eating WHEN we were taking PPIs and H2 Blockers now a food enemy!!! where before it was a friendly food etc... I will quote the full abstract because It is instructive to us to know how this process works in the body.... "Abstract An important feature for oral allergens is their digestion-resistance during gastrointestinal transit. For some oral allergens, digestion stability is an innate feature, whereas digestion-labile antigens may only persist in times of impairment of the digestive system. In this review, we collect evidence from mouse and human studies that besides the inherent molecular characteristics of a food protein, the stomach function is decisive for the allergenic potential. Gastric acid levels determine the activation of gastric pepsin and also the release of pancreatic enzymes. When anti-ulcer drugs inhibit or neutralize gastric acid, they allow persistence of intact food allergens and protein-bound oral drugs with enhanced capacity to sensitize and elicit allergic reactions via the oral route. Mouse studies further suggest that maternal food allergy arising from co-application of a food protein with anti-acid drugs results in a Th2-biased immune response in the offspring. Especially, anti-ulcer drugs containing aluminum compounds act as Th2 adjuvants. Proton pump inhibitors act on proton secretion but also on expression of the morphogen Sonic hedgehog, which has been related to the development of atrophic gastritis. On the other hand, atrophic gastritis and resulting hypoacidity have previously been correlated with enhanced sensitization risk to food allergens in elderly patients. In summary, impairment of gastric function is a documented risk factor for sensitization against oral proteins and drugs." Eva has figured it out!.....but nobody want to follow her.....your enviroment (and things in it) are a trigger for food allergens via Low/NO Stomach acid! As always I hope this is helpful but it not medical advice. 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the Grace of God,
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To All, This work is by Eva Untersmayr that establishes your Stomach Acid as the "Gate Keeper" against food allergens. I quote the whole abstract because it is instructive to us. https://pubmed.ncbi.nlm.nih.gov/23160973/ Abstract "True food allergens are considered as digestion stable proteins, which are absorbed through the gastrointestinal epithelium in an intact form leading to sensitization and causing systemic symptoms. According to classifications, allergens, which are digestion-labile, cause local symptoms by their cross-reactivity towards inhalative allergens. Our recent studies revealed that digestion labile allergens can also have sensitizing capacity if gastric digestion is hindered. The increase of gastric pH via acid-suppression by proton pump inhibitors, sucralfate or antacids, interferes with protein digestion, and leads to sensitization and allergic reaction in mouse models as well as in human patients. Furthermore, the inhibition of digestion increases the risk for anaphylactic responses in sensitized individuals.Even though also other factors, such as sphingolipid metabolites, are associated with the development of food allergies, it is without any doubt that the stomach has an important gate keeping function against food allergies." This medical research was published 10 years ago and we still don't understand it is low stomach acid that is the trigger for food allergies in our diet! Even older research has been done testing Acid reducers and the onset of food allergens while using PPIs.....and yes their use triggered food allergies.....up to and including an allergy to Wheat......why isn't this research on the front page of every newspaper in America and/or the world! See this research 17+ years old entitled "Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients" https://pubmed.ncbi.nlm.nih.gov/15671152/ quoting "In an observational cohort study, we screened 152 adult patients from a gastroenterological outpatient clinic with negative case histories for atopy or allergy, who were medicated with H2-receptor blockers or proton pump inhibitors for 3 months. IgE reactivities to food allergens before and after 3 months of anti-acid treatment were compared serologically. Ten percent of the patients showed a boost of preexisting IgE antibodies and 15% de novo IgE formation toward numerous digestion-labile dietary compounds, like milk, potato, celery, carrots, apple, orange, wheat, and rye flour. If you consider the 10% who had already had a food allergy.....it more than doubled food allergens one had after only 3 months of PPIs or H2 receptor blockers use. Or totaled togther 1/4 of those taking a PPIs or H2 Blocker either had a worsened response or a new response to foods like milk, wheat (gluten) and rye etc. Pretty convincing evidence IMO that PPIs and H2 Blockers are a trigger for a NCGS and/or Celiac diagnsosis. And agrees with research reported on Celiac.com I am just trying to help those who have started taking them realize what harm they are doing to their bodies.....in hope they will find the courage to quit them for good! I hope this is helpful but it is not medical advice. Posterboy,
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Celiac.com 11/07/2022 - A team of researchers recently set out to investigate why certain at-risk individuals develop celiac disease. They especially wanted to look at the risk levels early on that might influence levels of celiac disease later on in childhood. The research team included Michael Boechler MD; Apryl Susi MS; Elizabeth Hisle-Gorman MSW PhD; Philip L. Rogers; and Cade M. Nylund MD. They are variously affiliated with the Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, and the Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD. For their retrospective cohort study, the team used the Military Healthcare System (MHS) database, the team found children born between October 1, 2001- September 30, 2013. The team examined the connections between patients who received either proton pump inhibitors (PPI), histamine-2 receptor antagonist (H2RA), or antibiotic prescriptions in the first six months of life, and who also had a celiac disease diagnosis in early childhood. They then searched outpatient prescription records for antibiotic, PPI, and H2RA prescriptions in the first 6 months of life. They used ICD-9 codes to identify children who made outpatient visits for celiac disease, and Cox proportional hazards regression to calculate the hazard ratio (HR) for the development of celiac disease based on medication exposure. Nearly one-million children met inclusion criteria, from which the researchers uncovered just over 1,700 cases of celiac disease. Average follow-up time for patients in this group was about 4.5 years. The data show that PPI’s, H2RA’s, and antibiotics were all associated with an increased hazard of celiac disease. Children who receive antibiotics, PPI’s and H2RA’s in the first 6 months of life face an increased risk for developing celiac disease. The data reinforce the notion that controllable factors, such as the use of drugs to treat conditions in infancy, could help to lower the childhood risk of celiac disease for many people worldwide. Read more in The Journal of Pediatrics -
To All, This shows IMHO opinion that long term use of PPI’s and/or acid reducers are the trigger for Celiac disease in children! I know Scott or Celiac.com will probably do a summary article on this topic soon…..but I wanted to get ahead of the pack/crowd and start a thread on this……to see what other’s thought about it? Is this this (Low/NO Stomach Acid) and/or acid reducers/suppressors really the environmental trigger for NCGS and/or Celiac disease in young children and infants? I think it makes a strong case for this arguement? What do others think of this new research? Here is the sumary link https://www.news-medical.net/news/20221020/Infancy-acid-suppression-and-antibiotic-use-are-associated-with-celiac-disease.aspx I have not had a chance to read the full blown research article yet.....but I think this person summarizes it well......so I am just going off their summary at this point. I hope this is helpful but it is not medical advice. Posterboy,
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02/17/2021 - Celiac disease rates in the US have increased in past decades, along with the use of proton pump inhibitors (PPIs), histamine-2-receptor antagonists (H2RAs), aspirin (ASA) and nonsteroidal anti-inflammatory drugs (NSAIDs). Is there any important connection between celiac rates and the use of these drugs? A team of researchers recently set out to measure the association between medication use and distribution of villous flattening among patients with newly diagnosed celiac disease. The research team included Robyn Jordan, Sarah Shannahan, Suzanne K Lewis, Suneeta Krishnareddy, Daniel A Leffler, Peter H R Green, and Benjamin Lebwohl. They are variously affiliated with the Icahn School of Medicine at Mount Sinai, United States; the Celiac Center, Beth Israel Deaconess Medical Center, United States; the Celiac Disease Center, Department of Medicine, Columbia University Medical Center, United States; the Celiac Disease Center, Department of Medicine, Columbia University Medical Center, United States; and the Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, United States. The research team conducted a cross-sectional study of newly-diagnosed adult celiac patients at two institutions. They gathered data on regular use of these medications, clinical presentation, celiac disease serologic status, and distribution of villous flattening. They then compared current ASA/NSAID users against non-users, and current PPI/H2RA users to non-users, with regard to these clinical characteristics. Of 148 patients with newly-diagnosed celiac disease, current users of ASA/NSAIDs and PPI/H2RAs were about 8 or 9 years older than non-users. Just 12% of seropositive patients used PPI/H2RAs, compared to 55% of seronegative patients. Users of PPI/H2RA or ASA/NSAID showed no differences in villous flattening in the bulb and distal duodenum. However, the data show that PPI/H2RA use was associated with seronegative celiac disease. The researches are calling for further assessment on the impact of these drugs on the development, presentation, and course of celiac disease. Read more in Digestive Liver Disease. 2017 Aug;49(8):883-886. -
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To All, This came up in another thread so as not to spam the other topic/thread. I have created another thread about it. How about it has other people had trouble with SSRIs, NSAIDS or PPIs that effect their GI tract. Or Losartan like me. Here is the threads that have been started previously about this topic. And here is a study about NSAIDs that show long term use can trigger GI inflammation. https://pubmed.ncbi.nlm.nih.gov/3780475/ (I know there might be current studies on NSAIDs) it was just the first one I could find. I hope this helps someone else but it is not medical advise. Posterboy,
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