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Celiac Disease & Gluten-Free Diet Blogs

  • kareng's Blog
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  • Research on South African Celiac Tours
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  • Keating's Not-so-Glutenfree life
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  • Searchin for a Primary Care Dr. In Redlands That is Knowledgeable about Celiac disease
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  • Living in Japan with Ceoliac Disease
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  • HONG KONG GLUTEN, WHEAT FREE PRODUCTS
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  • JillianC
  • Sugar's Blog
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  • Gluten-Free Sisters :)
  • Eab12's Celiac Blog
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  • Newly Self Diagnosed?
  • misscorpiothing's Blog
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  • Petroguy
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  • Soap Opera Central
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  • Mr J's Blog
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  • CAC's Blog
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  • Teri Kiefer's Blog
  • happyasabeewithceliac's Blog
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  • Cheryl
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  • Colleen's blog
  • DawnJ's Blog
  • Gluten Challenge
  • twins2's Blog
  • just trying to feel better's Blog
  • Celiac Teen
  • MNBelle blog
  • Gabe351's Blog
  • moosemalibu's Blog
  • Coeliac Disease or Coeliac Sprue or Non Tropical Sprue
  • karalto's Blog
  • deacon11's Blog
  • Nyxie's Blog
  • Swpocket's Blog
  • threeringfilly's Blog
  • Madison Papers: Living Gluten-Free in a Gluten-Full World
  • babinsky's Blog
  • prettycat's Blog
  • Celiac Diagnosis at Age 24 months in 1939
  • Sandy R's Blog
  • mary m's Blog
  • Jkrupp's Blog
  • Oreo1964's Blog
  • keyboard
  • Louisa's Blog
  • Guts & Brains
  • Gluten Free Betty
  • Jesse'sGirl's Blog
  • NewMom's Blog
  • Connie C.'s Blog
  • garden girl's Blog
  • april anne's Blog
  • 4xmom's Blog
  • benalexander60's Blog
  • missmyrtle's Blog
  • Jersey Shore wheat no more's Blog
  • swezzan's Blog
  • aheartsj's Blog
  • MeltheBrit's Blog
  • glutenfreecosmeticcounter
  • Reasons Why Tummy tuck is considered best to remove unwanted belly fat?
  • alfgarrie's Blog
  • SmidginMama's Blog
  • lws' Blog
  • KMBC2014's Blog
  • Musings and Lessons Learned
  • txwildflower65's Blog
  • Uncertain
  • jess4736's Blog
  • deedo's Blog
  • persistent~Tami's Blog
  • Posterboy's Blog
  • jferguson
  • tiffjake's Blog
  • KCG91's Blog
  • Yolo's Herbs & Other Healing Strategies
  • scrockwell's Blog
  • Sandra45's Blog
  • Theresa Marie's Blog
  • Skylark's Blog
  • JessicaB's Blog
  • Anna'sMommy's Blog
  • Skylark's Oops
  • Jehovah witnesses
  • Celiac in Seattle's Blog
  • March On
  • honeybeez's Blog
  • The Liberated Kitchen, redux
  • onceandagain's Blog
  • JoyfulM's Blog
  • keepingmybabysafe's Blog
  • To beer, with love...
  • nana b's Blog
  • kookooto's Blog
  • SunnyJ's Blog
  • Mia'smommy's Blog
  • Amanda's Blog
  • jldurrani's Blog
  • Why choosing Medical bracelets for women online is the true possible?
  • Carriefaith's Blog
  • acook's Blog
  • REAGS' Blog
  • gfreegirl0125's Blog
  • Gluten Free Recipes - Blog
  • avlocken's Blog
  • Thiamine Thiamine Thiamine
  • wilbragirl's Blog
  • Gluten and Maize-Free (gluten-free-MF)
  • Elimination Diet Challenge
  • DJ 14150
  • mnsny's Blog
  • Linda03's Blog
  • GFinDC's Blog
  • Kim UPST NY's Blog
  • cmc's Blog
  • blog comppergastta1986
  • JesikaBeth's Blog
  • Melissa
  • G-Free's Blog
  • miloandotis' Blog
  • Confessions of a Celiac
  • Know the significance of clean engine oil
  • bobhayes1's Blog
  • Robinbird's Blog
  • skurtz's Blog
  • Olivia's Blog
  • Jazzdncr222's Blog
  • Lemonade's Blog
  • k8k's Blog
  • celiaccoach&triathlete's Blog
  • Gluten Free Goodies
  • cherbourgbakes.blogspot.com
  • snow dogs' Blog
  • Rikki Tikki's Blog
  • lthurman1979's Blog
  • Sprue that :)'s Blog
  • twinkletoes' Blog
  • Ranking the best gluten free pizzas
  • Gluten Free Product
  • Wildcat Golfer's Blog
  • Becci's Blog
  • sillyker0nian's Blog
  • txplowgirl's Blog
  • Gluten Free Bread Blog
  • babygoose78's Blog
  • G-freegal12's Blog
  • kelcat's Blog
  • Heavy duty 0verhead crane
  • beckyk's Blog
  • pchick's Blog
  • NOT-IN-2gluten's Blog
  • PeachPie's Blog
  • Johny
  • Breezy32600's Blog
  • Edgymama's Gluten Free Journey
  • Geoff
  • audra's Blog
  • mfrklr's Blog
  • 2 chicks
  • I Need Help With Bread
  • the strong one has returned!
  • sabrina_B_Celiac's Blog
  • Gluten Free Pioneer's Blog
  • Theanine.
  • The Search of Hay
  • Vanessa
  • racecar16's Blog
  • JCH13's Blog
  • b&kmom's Blog
  • Gluten Free Foodies
  • NanaRobin's Blog
  • mdrumr8030's Blog
  • Sharon LaCouture's Blog
  • Zinc, Magnesium, and Selenium
  • sao155's Blog
  • Tabasco's Blog
  • Amanda Smith
  • mmc's Blog
  • xphile1121's Blog
  • golden exch
  • kerrih's Blog
  • jleb's Blog
  • RUGR8FUL's Blog
  • Brynja's Grain Free Kitchen
  • schneides123's Blog
  • Greenville, SC Gluten-Free Blog
  • ramiaha's Blog
  • Kathy P's Blogs
  • rock on!'s Blog
  • Carri Ninja's Blog
  • jerseygirl221's Blog
  • Pkhaselton's Blog
  • Hyperceliac Blog
  • abbiekir's Blog
  • Lasister's Thoughts
  • bashalove's Blog
  • Steph1's Blog
  • Etboces
  • Rantings of Tiffany
  • GlutenWrangler's Blog
  • kalie's Blog
  • Mommy Of A Gluten Free Child
  • ready2go's Blog
  • Maureen
  • Floridian's Blog
  • Bobbie41972's Blog
  • Everyday Victories
  • Intolerance issue? Helpppp!
  • Feisty
  • In the Beginning...
  • Cheri46's Blog
  • Acne after going gluten free
  • sissSTL's Blog
  • Elizabeth19's Blog
  • LindseyR's Blog
  • sue wiesbrook's Blog
  • I'm Hungry's Blog
  • badcasper's Blog
  • M L Graham's Blog
  • Wolicki's Blog
  • katiesalmons' Blog
  • CBC and celiac
  • Kaycee's Blog
  • wheatisbad's Blog
  • beamishmom's Blog
  • Celiac Ninja's Blog
  • scarlett54's Blog
  • GloriaZ's Blog
  • Holly F's Blog
  • Jackie's Blog
  • lbradley's Blog
  • TheSandWitch's Blog
  • Ginger Sturm's Blog
  • The Struggle is Real
  • whataboutmary's Blog
  • JABBER's Blog
  • morningstar38's Blog
  • Musings of a Celiac
  • Celiacchef's Blog
  • healthygirl's Blog
  • allybaby's Blog
  • MGrinter's Blog
  • LookingforAnswers15's Blog
  • Lis
  • Alilbratty's Blog
  • 3sisters' Blog
  • MGrinter's Blog
  • Amanda
  • felise's Blog
  • rochesterlynn's Blog
  • mle_ii's Blog
  • GlamourGetaways' Blog
  • greendog's Blog
  • Tabz's Blog
  • Smiller's Blog
  • my vent
  • newby to celiac?'s Blog
  • siren's Blog
  • myraljo's Blog
  • Relieved and confused
  • carb bingeing
  • scottish's Blog
  • maggiemay832's Blog
  • Cristina Barbara
  • ~~~AnnaBelle~~~'s Blog
  • nikky's Blog
  • Suzy-Q's Blog
  • mfarrell's Blog
  • Kat-Kat's Blog
  • Kelcie's Blog
  • cyoshimit's Blog
  • pasqualeb's Blog
  • My girlfriend has celiacs and she refuses to see a doctor
  • Ki-Ki29's Blog
  • mailmanrol's Blog
  • Sal Gal
  • WildBillCODY's Blog
  • Ann Messenger
  • aprilz's Blog
  • the gluten-free guy
  • gluten-free-wifey's Blog
  • Lynda MEADOWS's Blog
  • mellajane's Blog
  • Jaded's Celiac adventures in a non-celiac world.
  • booboobelly18's Blog
  • Dope show
  • Classic Celiac Blog
  • Keishalei's Blog
  • Bada
  • Sherry's blurbs
  • addict697's Blog
  • MIchael530btr's Blog
  • Shawn C
  • antono's Blog
  • Undiagnosed
  • little_d's Blog
  • Gluten, dairy, pineapple
  • The Fat (Celiac) Lady Sings
  • Periomike
  • Sue Mc's Blog
  • BloatusMaximus' Blog
  • It's just one cookie!
  • Kimmy
  • jacobsmom44's Blog
  • mjhere's Blog
  • tlipasek's Blog
  • You're Prescribing Me WHAT!?!
  • Kimmy
  • nybbles's Blog
  • Karla T.'s Blog
  • Young and dealing with celiacs
  • Celiac.com Podcast Edition
  • LCcrisp's Blog
  • ghfphd's allergy blog
  • https://www.bendglutenfree.com/
  • Costume's and GF Life
  • mjhere69's Blog
  • dedeadge's Blog
  • CeliacChoplin
  • Ravenworks' Blog
  • ahubbard83's Blog
  • celiac<3'sme!'s Blog
  • William Parsons
  • Gluten Free Breeze (formerly Brendygirl) Blog
  • Ivanna44's Blog
  • Daily Life and Compromising
  • Vonnie Mostat
  • Aly'smom's Blog
  • ar8's Blog
  • farid's Blog
  • Sandra Lee's Blog
  • Demertitis hepaformis no Celac
  • Vonnie Mostat, R.N.
  • beetle's Blog
  • Sandra Lee's Blog
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  • totalallergyman's Blog
  • Kim
  • Vhips
  • twinsmom's Blog
  • Newbyliz's Blog
  • collgwg's Blog
  • Living in the Gluten Free World
  • lisajs38's Blog
  • Mary07's Blog
  • Treg immune celsl, short chain fatty acids, gut bacteria etc.
  • questions
  • A Blog by Yvonne (Vonnie) Mostat, RN
  • ROBIN
  • covsooze's Blog
  • HeartMagic's Blog
  • electromobileplace's Blog
  • Adventures of a Gluten Free Mom
  • Fiona S
  • bluff wallace's Blog
  • sweetbroadway's Blog
  • happybingf's Blog
  • Carla
  • jaru24's Blog
  • AngelaMH's Blog
  • collgwg's Blog
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  • SimplyGF Blog
  • Jim L Christie
  • Debbie65's Blog
  • Alcohol, jaundice, and celiac
  • kmh6leh's Blog
  • Gluten Free Mastery
  • james
  • danandbetty1's Blog
  • Feline's Blog
  • Linda Atkinson
  • Auntie Lur: The Blog of a Young Girl
  • KathyNapoleone's Blog
  • Gluten Free and Specialty Diet Recipes
  • Why are people ignoring Celiac Disease, and not understanding how serious it actually is?
  • miasuziegirl's Blog
  • KikiUSA's Blog
  • Amyy's Blog
  • Pete Dixon
  • abigail's Blog
  • CHA's Blog
  • Eczema or Celiac Mom?'s Blog
  • Thoughts
  • International Conference on Gastroenterology
  • Deedle's Blog
  • krackers' Blog
  • cliniclfortin's Blog
  • Mike Menkes' Blog
  • Juanita's Blog
  • BARB OTTUM
  • holman's Blog
  • It's EVERYWHERE!
  • life's Blog
  • writer ann's Blog
  • Ally7's Blog
  • Gluten Busters: Gluten-Free Product Alerts by Celiac.com
  • K Espinoza
  • klc's Blog
  • Pizza&beer's Blog
  • CDiseaseMom's Blog
  • sidinator's Blog
  • Dr Rodney Ford's Blog
  • How and where is it safe to buy cryptocurrency?
  • lucedith's Blog
  • Random Thoughts
  • Kate
  • twin#1's Blog
  • myadrienne's Blog
  • Nampa-Boise Idaho
  • Ursa Major's Blog
  • bakingbarb's Blog
  • Does Celiac Cause Sensitivites To Rx's?
  • delana6303's Blog
  • psychologygrl25's Blog
  • Alcohol and Celiac Disease
  • How do we get it???
  • cooliactic_BOOM's Blog
  • GREAT GF eating in Toronto
  • Gluten-free Food Recommendations!
  • YAY! READ THIS!!
  • BROW-FREE DIET BLOG
  • carib168's Blog
  • A Healing Kitchen
  • Shawn s
  • AZ Gal's Blog
  • mom1's Blog
  • The Beginning - The Diagnosis
  • PeweeValleyKY's Blog
  • solange's Blog
  • Cate K's Blog
  • Layered Vegetable Baked Pasta (gluten-free Vegetarian Lasagna)
  • Gluten Free Teen by Ava
  • mtdawber's Blog
  • sweeet_pea's Blog
  • DCE's Blog
  • Infertility and Celiac Disease
  • What to do in the Mekong Delta in 1 Day?
  • glutenfreenew's Blog
  • Living in the Garden of Eden
  • toddzgrrl02's Blog
  • redface's Blog
  • Gluten Free High Protein
  • Ari
  • Great Harvest Chattanooga's Blog
  • CeliBelli's Blog
  • Aboluk's Blog
  • redface's Blog
  • Being in Control of Your Gluten-Free Diet on a Cruise Ship
  • jayshunee's Blog
  • lilactorgirl's Blog
  • Yummy or Yucky Gluten-Free Foods
  • Electra's Blog
  • Cocerned husband's Blog
  • lilactorgirl's Blog
  • A Little History - My Celiac Disease Diagnosis
  • How to line my stomach
  • sewfunky's Blog
  • Oscar's Blog
  • Chey's Blog
  • The Fun of Gluten-free Breastfeeding
  • Dawnie's Blog
  • Sneaky gluten free goodness!
  • Chicago cubs shirts- A perfect way of showing love towards the baseball team!
  • Granny Garbonzo's Blog
  • GFzinks09's Blog
  • How do I get the Celiac.com podcast on my mp3 player?
  • quantumsugar's Blog
  • Littlebit's Blog
  • Kimberly's Blog
  • Dayz's Blog
  • Swimming Breadcrumbs and Other Issues
  • Helen Burdass
  • celiacsupportnancy's Blog
  • Life of an Aggie Celiac
  • kyleandjra.jacobson's Blog
  • Hey! I'm Not "Allergic" to Wheat!
  • FoOdFaNaTic's Blog
  • Wendy Cohan, RN's Gluten-Free and Dairy-Free Cooking Classes
  • Lora Derry
  • Dr. Joel Goldman's Blog
  • The Ultimate Irony
  • Lora Derry
  • ACK514's Blog
  • katinagj's Blog
  • What Goes On, Goes In (Gluten in Skin Care Products)
  • What’s new in hydraulic fittings?
  • cannona3's Blog
  • citykatmm's Blog
  • Adventures in Gluten-Free Toddling
  • tahenderson67's Blog
  • The Dinner Party Drama—Two Guidelines to Assure a Pleasant Gluten-Free Experience
  • What’s new in hydraulic fittings?
  • sparkybear's Blog
  • justbikeit77's Blog
  • To "App" or Not to "App": The Use of Gluten Free Product List Computer Applications
  • Onangwatgo
  • Raine's Blog
  • lalla's Blog
  • To die for Cookie Crumb Gluten-Free Pie Crust
  • DeeTee33's Blog
  • http://glutenfreegroove.com/blog/
  • David2055's Blog
  • Gluten-Free at the Fancy Food Show in San Francisco
  • Kup wysokiej jakości paszporty, prawa jazdy, dowody osobiste
  • Janie's Blog
  • Managing Hives & Gluten Allergies
  • User Is it safe to use GB WhatsApp pro in 2024?
  • Bogaert's Blog
  • Janie's Blog
  • RaeD's Blog
  • Dizzying Disclaimers!
  • Dream Catcher's Blog
  • PinkZebra's Blog
  • Hibachi Food and Hidden Gluten Hazards (How to Celebrate Gluten-Free)
  • jktenner's Blog
  • OhSoTired's Blog
  • PinkZebra's Blog
  • gluten-free Lover's Blog
  • Gluen Free Health Australia
  • Melissamb21's Blog
  • Andy C's Blog
  • halabackgirl9129's Blog
  • Liam Edwards' Blog
  • Celiac Disease in Africa?
  • Suz's Blog
  • Gluten-Free Fast Food
  • mis_chiff's Blog
  • gatakat's Blog
  • macocha's Blog
  • Newly Diagnosed Celiacs Needed for Study in Chicago
  • Poor Baby's Blog
  • the loonie celiac's Blog
  • jenlex's Blog
  • Sex Drive/Testosterone can be Depleted by Certain Foods
  • samantha79's Blog
  • 21 Months into the Gluten-free Diet
  • WashingtonLady's Blog-a-log
  • James S. Reid's Blog
  • Living with a Gluten-Free Husband
  • runner girl's Blog
  • kp3972's Blog
  • ellie_lynn's Blog
  • trayne91's Blog
  • Gluten-free Lipstick!
  • Nonna2's Blog
  • Schar Chocolate Hazelnut Bar (Gluten-Free)
  • pnltbox27's Blog
  • Live2BWell's Blog
  • melissajohnson's Blog
  • nvsmom's Blog
  • Diagnosed with Celiac Disease and Still Sick
  • snowcoveredheart's Blog
  • Gluten Free Nurse
  • Gluten-Free Frustration!
  • Melody A's Blog
  • novelgutfeeling's Blog
  • Trouble Eating Out Gluten-Free...Good or Bad?!
  • dilsmom's Blog
  • theceliachusband's Blog
  • amanda2610's Blog
  • Pancreas and Celiac Disease Link?
  • epiphany's Blog
  • Patty55's Blog
  • The Latest Gluten-Free Food Recalls
  • kenzie's blog
  • CVRupp's Blog
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  1. Celiac.com 01/20/2024 - The tissue transglutaminase IgA antibodies (tTG-IgA) test is a crucial diagnostic tool for celiac disease. In individuals with celiac disease, the ingestion of gluten triggers an immune response, leading to the production of antibodies, including tTG-IgA. These antibodies target the tissues of the small intestine, causing damage and inflammation. The tTG-IgA test measures the levels of these specific antibodies in the blood. Elevated tTG-IgA levels are indicative of an active immune response to gluten and suggest the presence of celiac disease. This blood test is an essential component of the diagnostic process, helping healthcare providers identify individuals who may require further evaluation, such as genetic testing and an endoscopic biopsy, to confirm the diagnosis of celiac disease. Elevated tissue transglutaminase IgA antibodies (tTG-IgA) are primarily associated with celiac disease, but they can also be elevated in some other conditions. It's important to note that the presence of elevated antibodies alone doesn't diagnose a specific condition, and further clinical evaluation is needed. Conditions and factors that may lead to elevated tTG-IgA antibodies may include the following: Non-Celiac Gluten Sensitivity (NCGS) Wheat Allergy Inflammatory Bowel Diseases (IBD) Type 1 Diabetes Autoimmune Liver Diseases Rheumatoid Arthritis Thyroid Disorders Genetic Conditions Casein/Cow's Milk Intolerance Non-Celiac Gluten Sensitivity (NCGS) Although it doesn't involve the autoimmune response seen in celiac disease, NCGS can lead to symptoms similar to those of celiac disease and may be associated with elevated tTG-IgA. NCGS is characterized by gluten-related symptoms without the autoimmune response and intestinal damage seen in celiac disease. The exact mechanisms leading to elevated tTG-IgA in NCGS are not fully understood, but it's believed that gluten sensitivity in NCGS may still induce an immune response, even though it differs from the autoimmune process seen in celiac disease. The presence of elevated tTG-IgA in NCGS underscores the complexity of gluten-related disorders and highlights the need for further research to elucidate the underlying immune responses and mechanisms associated with different gluten-related conditions. Wheat Allergy Individuals with a wheat allergy may produce antibodies, including tTG-IgA, as part of the allergic response. Individuals with a wheat allergy may also exhibit increased tTG-IgA levels. Wheat allergy is an immune-mediated response to proteins in wheat, distinct from the autoimmune nature of celiac disease. The presence of elevated tTG-IgA in individuals with a wheat allergy is somewhat perplexing, as tTG is an enzyme involved in the pathology of celiac disease, and its elevation is not commonly associated with allergies. One possible explanation is that the immune response triggered by a wheat allergy might lead to some cross-reactivity or shared epitopes with components involved in celiac disease, causing an increase in tTG-IgA. However, the exact mechanisms behind this phenomenon are not well-elucidated, and more research is needed to understand the connections between wheat allergy and the elevation of tTG-IgA. It emphasizes the intricate interplay between the immune system and various wheat-related disorders, requiring further exploration to unravel the complexities of immune responses in these conditions. Inflammatory Bowel Diseases (IBD) Conditions such as Crohn's disease and ulcerative colitis can cause gastrointestinal inflammation, and elevated tTG-IgA levels have been reported in some individuals with IBD. Elevated tissue transglutaminase IgA antibodies (tTG-IgA) can also be observed in individuals with Inflammatory Bowel Diseases (IBD). IBD, which includes conditions like Crohn's disease and ulcerative colitis, involves chronic inflammation of the gastrointestinal tract. The link between IBD and elevated tTG-IgA is not as straightforward as in celiac disease, and the reasons behind this elevation in some IBD patients remain a subject of research. One hypothesis suggests that the chronic inflammation and alterations in the intestinal mucosa associated with IBD may lead to increased permeability of the gut barrier. This heightened permeability might allow gluten proteins to interact with the immune system in a way that triggers the production of tTG-IgA. The intricate relationship between IBD and tTG-IgA elevation underscores the complex interplay between autoimmune responses and gastrointestinal disorders, requiring further investigation to uncover the underlying mechanisms and clinical implications. Type 1 Diabetes Some individuals with type 1 diabetes may have elevated tTG-IgA antibodies, and there is an increased risk of celiac disease in individuals with diabetes. Elevated tissue transglutaminase IgA antibodies (tTG-IgA) can be found in individuals with Type 1 Diabetes (T1D), establishing a connection between these two autoimmune conditions. Both celiac disease and Type 1 Diabetes involve an autoimmune response, where the body's immune system mistakenly targets its own tissues. In the case of celiac disease, the immune system reacts to gluten, while in Type 1 Diabetes, it attacks the insulin-producing cells in the pancreas. The shared genetic susceptibility to autoimmune disorders could explain the co-occurrence of celiac disease and Type 1 Diabetes. The presence of certain genetic markers might predispose individuals to develop multiple autoimmune conditions. Additionally, environmental factors and common triggers in the immune response pathways could contribute to the simultaneous development of these disorders. Clinicians often monitor individuals with Type 1 Diabetes for celiac disease-related antibodies, including tTG-IgA, to identify and manage celiac disease early, highlighting the importance of understanding these interconnected autoimmune processes for comprehensive patient care. Thyroid Disorders Conditions such as autoimmune thyroiditis (Hashimoto's thyroiditis) and Graves' disease may be associated with elevated tTG-IgA antibodies. Elevated tissue transglutaminase IgA antibodies (tTG-IgA) can be associated with thyroid disorders, particularly autoimmune thyroid conditions such as Hashimoto's thyroiditis. Hashimoto's thyroiditis is an autoimmune disease where the immune system attacks the thyroid gland, leading to inflammation and potential impairment of thyroid function. The link between celiac disease and autoimmune thyroid disorders has been observed, suggesting a shared genetic predisposition for autoimmune conditions. Individuals with celiac disease may have an increased risk of developing autoimmune thyroid disorders, and vice versa. The interconnected nature of autoimmune diseases suggests that the immune system's response to gluten in celiac disease might trigger or exacerbate autoimmune reactions in other organs, including the thyroid. Monitoring thyroid function and related antibodies, such as tTG-IgA, is crucial in individuals with celiac disease to identify and manage potential thyroid complications early. Understanding these complex interactions between autoimmune disorders is essential for comprehensive patient care and effective management of associated health conditions. Autoimmune Liver Diseases Certain autoimmune liver diseases, such as autoimmune hepatitis and primary biliary cirrhosis, may be associated with elevated tTG-IgA antibodies. Elevated tissue transglutaminase IgA antibodies (tTG-IgA) may be detected in individuals with autoimmune liver diseases, particularly autoimmune hepatitis (AIH). Autoimmune hepatitis is a chronic inflammatory condition where the body's immune system erroneously attacks liver cells, leading to liver inflammation and potential damage. The connection between celiac disease and autoimmune liver diseases, although not fully understood, suggests shared autoimmune mechanisms. In some cases, individuals with celiac disease may experience immune system dysregulation that extends beyond the small intestine, leading to autoimmune reactions in other organs such as the liver. The presence of elevated tTG-IgA in individuals with autoimmune liver diseases underscores the complex interplay between various autoimmune conditions. Monitoring liver function and related antibodies is essential for comprehensive healthcare in individuals with celiac disease, as the autoimmune cascade can impact multiple organs. Understanding these connections aids in early detection, proper management, and improved overall outcomes for individuals with autoimmune liver diseases and concurrent celiac disease. Genetic Conditions Some genetic conditions, such as Down syndrome, may be associated with an increased prevalence of celiac disease and elevated tTG-IgA. Elevated tissue transglutaminase IgA antibodies (tTG-IgA) in individuals with genetic conditions such as Down syndrome can be attributed to the increased prevalence of autoimmune disorders in this population. Down syndrome, characterized by the presence of an extra copy of chromosome 21, is associated with a higher susceptibility to autoimmune conditions, including celiac disease. The genetic link between Down syndrome and celiac disease suggests a shared vulnerability to immune dysregulation. Individuals with Down syndrome may exhibit an elevated risk of developing autoimmune disorders due to alterations in immune system function associated with the genetic anomaly. The complex relationship between genetics and autoimmune responses underscores the importance of monitoring individuals with Down syndrome for various health conditions, including celiac disease. Early detection and management of celiac disease in individuals with Down syndrome are crucial for optimizing their overall health and well-being, considering the potential impact of untreated celiac disease on nutrient absorption and long-term health outcomes. Rheumatoid Arthritis Elevated tTG-IgA levels have been reported in some individuals with rheumatoid arthritis. The presence of elevated tissue transglutaminase IgA antibodies (tTG-IgA) in individuals with rheumatoid arthritis (RA) can be linked to the complex interplay between autoimmune disorders. Rheumatoid arthritis is a chronic inflammatory condition primarily affecting the joints, but it is increasingly recognized that individuals with RA may have an elevated risk of coexisting autoimmune diseases, including celiac disease. The shared genetic predisposition and immune dysregulation mechanisms contribute to the observed association between RA and elevated tTG-IgA. In the context of rheumatoid arthritis, the immune system mistakenly attacks the joints, leading to inflammation and joint damage. This dysregulated immune response may extend beyond the joints and manifest as an increased susceptibility to other autoimmune conditions, such as celiac disease. The identification of elevated tTG-IgA in individuals with RA underscores the importance of comprehensive health assessments in autoimmune disorders, as coexisting conditions may impact the overall management and prognosis of these individuals. Regular monitoring and collaboration between healthcare providers specializing in different autoimmune diseases are crucial for a holistic approach to patient care. Casein/Cow's Milk Intolerance Recent studies have shown that elevated tTG-IgA levels have been reported in some individuals with casein/cow's milk intolerance. Conclusion While it's true that elevated tissue transglutaminase IgA antibodies (tTG-IgA) can be associated with various conditions beyond celiac disease, including autoimmune disorders and genetic conditions, the tTG-IgA test remains a valuable tool in the diagnosis of celiac disease. In individuals with celiac disease, there is a specific immune response triggered by the ingestion of gluten, a protein found in wheat, barley, and rye. People with celiac disease often have higher levels of tTG-IgA in their blood due to the immune system's reaction to gluten. When gluten is ingested, individuals with celiac disease produce antibodies, including tTG-IgA, which target and attack the tissues of the small intestine. The elevated tTG-IgA levels are indicative of this immune response and the damage occurring in the intestinal lining. However, it's important to note that the interpretation of tTG-IgA levels should be done in the context of the individual's overall health, medical history, and the possibility of other conditions. A definitive diagnosis of celiac disease typically involves a combination of blood tests, genetic testing (HLA-DQ2 and HLA-DQ8), and, in some cases, an endoscopic biopsy of the small intestine. In summary, while elevated tTG-IgA levels are a common feature in celiac disease, the diagnosis involves a comprehensive assessment, and healthcare providers consider various factors to ensure accurate identification of the condition. It's crucial to interpret antibody test results in the context of the individual's clinical symptoms, medical history, and additional diagnostic tests. If tTG-IgA antibodies are elevated, further evaluation by a healthcare professional, typically including endoscopic procedures and biopsies, is often necessary to confirm or rule out celiac disease.
  2. Hello everyone. Brand new to the Celiac scene personally and this is my first post here. I just recently had my tTg-IgA drawn and it came back at 11 U/mL. Standard range 0-3, weak positive 4-10 and 11 or greater positive. A little background: My grandfather was diagnosed late in life (in his 70's) with Dermatitis Herpetiformis via skin biopsy. His physician put him on Dapsone and told him to try to avoid gluten. My grandfather wasn't ever told he had to be strictly gluten free for life. He tried to avoid gluten for a period of time, along with the Dapsone and his DH got better. It sounds like things had calmed down and he was "avoiding" gluten so his doctor took him off Dapsone. Turns out my grandfather didn't realize how important it was for him to be strictly gluten free because he was never educated properly. According to my grandmother, (which is where I got all of this information) he was told he did not have Celiac disease but he was just allergic to wheat. After this, my grandfather decided it was too difficult to avoid gluten in his diet and the doctor agreed to just put him back on Dapsone so he could consume gluten without having all of the DH flare-ups. Eventually this downward spiral led to him having emergency surgical exploration ending up with small-bowel resection due to complications with his small intestines (I'm speculating this is Celiac related but not 100% positive). Throughout the next several years his health continued to rapidly deteriorate to the point he became extremely frail and was using a walker. Fast forward to the day before he passed away. He had fallen and sustained a fractured hip. He had surgical repair that night which eventually led to him being admitted to the ICU due to inability to keep his blood pressure stable. That night, despite all of the ICU IV blood pressure support medications they had him on he passed away. Since it was such a sudden and unexplained death they offered my grandmother an autopsy and she agreed. In the report, according to my grandmother, they put that he had a chronic adrenal gland issue which ended up causing his death. I investigated this some online and I found there was a link between Addison's Disease and Celiac Disease. From what it sounds like to me he went into an Addisonian crisis and led to his death. I started with that story because I am utterly shocked at how little education my grandfather received regarding his diagnosis of DH and to be told he just has a wheat allergy and needs to avoid gluten if possible. I found this website after I tested on the positive scale for tTg-IgA and started reading post after post absorbing as much information as possible. I came to be tested after my younger brother mentioned to me he had been tested for Celiac disease and had a "weak positive" test result on tTg-IgA and was told to go gluten free immediately after that test. He was not given a diagnosis or recommended GI consultation for EGD biopsy. (I have since shared the information I have learned but he already went gluten free and had resolution to most of his symptoms and is not interested in EGD with biopsy or going back on gluten for that matter!). I started to put the pieces together after he told me about his "weak positive" result and started thinking about all of the weird symptoms I had experienced off and on throughout my 33 years of life. As a child I oftentimes would throw up for no reason after eating breakfast or have diarrhea before school. My mom always attributed it to nerves about going to school. She also told me that I threw up at school a lot early on and would be sent to the nurses office but again it was attributed to nerves and apparently I would say things like "I'm afraid my parents won't pick me up after school." I had a lot of childhood anxieties and worries that other children didn't have and my parents thought I was just a sensitive child. Eventually, all of the gastric concerns triggered a pediatric GI consultation. I had an EGD and some form of barium study (as I remember the distinct white poo it produced later). I was just a small child at the time this was happening and now that I'm older I asked my mom if she remembers what they were looking for or what they told her and she can't remember any of the test results. She said they thought it was just stress related. As a child I also developed this strange rash on my hands that presented as small, clear blister-like bumps with a tiny dot in the middle of them and would be on my palms and in between my fingers. The inside of the finger bumps I remember would get kind of raw, itchy and would crust over and the bumps on my palms would just itch a lot. Eventually it just went away and would come and go randomly up until early adulthood. I remember distinctly the last time I had this rash on my hands. I was in California at the beach in my early 20's and I picked up a large bull kelp seaweed and was swinging it around. Later that night I had that rash randomly appear after not having that rash on my hands for years and years. In my early adult life I had 4 different occasions of kidney stones. I know this is a very common thing to happen to people but also found information that said Celiac individuals have a higher incidence of these due to malabsorption issues (correct me if I'm wrong). The biggest symptoms I have been experiencing since 2017, after I just finished up a year long divorce. I started having the most intense anal irritation....I mean this was bad. It was itchy, raw, burning and there was blood whenever I would wipe. This went on for a year until 2018 when I started having other symptoms. I went to my primary doctor and told him I am completely wiped out and feeling fatigued to the point it was very noticeable to me (told me it was stress from going through divorce). I had this "fuzzy" feeling like I was walking around kind of dazed all the time. I also reported having joint pain in my thumb, hip, knee and ankle. They weren't all painful at the same time and the pain would sometimes be there and sometimes be fine. I reported that I had developed a red, bumpy and very itchy rash on my arm that eventually went away and then went to my back. After my back rash went away it moved to my abdomen where it stayed for months and was present at the time of my appointment. I also told him about the severe anal discomfort. He said I had anal fissures and gave me some steroid suppositories. He checked labs for rheumatoid arthritis and lupus which were both negative. He also tested my testosterone which was slightly elevated and checked my leutinizing hormone and follicle stimulating hormone, which were both high. Nothing ever came of these symptoms or tests and I kind of just internalized everything and thought this must just be how I am and I am getting a little bit older now. I continued to have these symptoms off and on until the present time just thinking this is the way I was built. I also always wondered what those bright white areas on four of my teeth were (enamel defects!). My last primary care check up (May 2022) I told the doctor I was feeling really weird and that I felt like the normal everyday things that didn't stress me out before are now stressing me out a lot and getting me down. I told him I was very irritable all of the time for no reason at all. I could have all kinds of great things happening in my life and I was just irritated and moody all of the time (to the point my new wife was noticing a change in character for me and mentioned it). He asked if I wanted to be put on some meds and I told him I didn't want them. I have also been having almost daily minor, annoying headaches almost every single day for several months now. Fast forward to September 2022 and this is the point I put the pieces together and asked my doctor to be screened for Celiac disease. I was given a formal GI referral after my positive test and I am set to go to that appointment today at 3:00 pm. I am seeing a nurse practitioner for the consult due to long wait time to see a doctor. I was assured the NP will be able to order the EGD and will take my history, etc. I'm very apprehensive about the coming EGD because I'm worried they won't be able to see what they need to see or won't biopsy enough sites to give an actual diagnosis. I guess I'm so worried about that because my tTg-IgA was only an 11 U/mL and was just on the cusp of being positive but still considered positive. If my result was much higher I would be less apprehensive I guess. Technically my tTg-IgA is close to 4 times the upper normal level for my lab. I only had my tTg-IgA drawn and didn't know at the time I asked for testing about all of the other things I should have asked for. Should I ask for more celiac tests i.e DGP IGA/IGG, total IGA at my GI consultation today or is the tTg-IgA enough since it was positive? Should I ask to be screened for vitamin deficiencies and what are the most important ones to ask for? Is it rude to ask them how many biopsies they take and is it okay to be pushy and tell them I want 4-6 biopsies?? Thank you for allowing me to tell my story! Sorry it ended up being so long and I would greatly appreciate any feedback, recommendations, etc. if you have time to get through to the end of my novel!! Take care.

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  4. Celiac.com 08/15/2022 - In a significant finding, a celiac disease registry at University of Alabama reveals significant issues in accurately testing Black people for celiac disease using the TTG antibody test. The new registry of celiac disease patients at the University of Alabama at Birmingham is the work gastroenterologist Dr. Amanda Cartee, MD, and fellow colleagues at UAB. Among the most important findings, the registry reveals that Black people with biopsy confirmed celiac disease are exponentially more likely than non-Hispanic whites to show negative results on the most common diagnostic celiac disease blood test. For people with celiac disease, a positive TTG antibody test is the most common path to an endoscopy and biopsy to confirm or negate celiac disease. For most people with celiac disease, especially non-Hispanic whites, a positive TTG test is highly predictive of celiac disease, hence the routine endoscopy and biopsy to follow-up a positive test. In fact, less than ten percent of non-Hispanic whites with biopsy-proven celiac disease have a "negative" TTG test. However, according to the registry data, high percentages of Black people with celiac disease are testing negative for TTG antibodies, and so being denied a swift and properly diagnosis, simply because they never meet themes common threshold for biopsy. It's the TTG threshold currently used to determine the definition of positive and negative TTG that might just be at the heart of the problem. That's because the numbers are nearly reversed for Black people. While less than ten percent of non-Hispanic whites with celiac disease show negative TTG results, the registry data shows that a whopping eighty percent of Black people with biopsy-proven celiac disease have a "negative" TTG test. The means that these folks were unlikely to have gotten a biopsy as quickly as someone with a positive TTG test. It also means they may have had to suffer longer, and/or self diagnose. And those facts are also borne out by the registry data, which point to longer times to diagnosis and less biopsy-driven diagnoses for Black celiac patients. Black patients were also much less likely to have received genetic testing for celiac-associated genes. There is limited data on celiac disease and Black people, said Dr. Cartee, noting that only a single study with the primary goal of investigating the clinical characteristics of celiac disease and Black people has been done. While the registry revealed differences in TTG test results and BMI, it showed similarities in celiac disease diagnosis for non-Hispanic white and Black patients. These included symptoms as the primary cause for testing, length of time to diagnosis, and a diagnosis that did not include recommended blood tests and a biopsy. Basically, the data show that TTG tests will be negative in the vast majority of Black patients with biopsy-proven celiac disease. That means further study is needed to determine whether the TTG test is useful for Black patients, and more research needs to be done to figure out how to make sure they can get quickly and properly diagnosed. Stat tuned for more on this and related stories regarding celiac disease testing, screening, and diagnosis in Black people, and in other ethnic populations. Read more about the celiac registry data and findings presented by UAB gastroenterologist Dr. Amanda Cartee, MD, at Digestive Disease Week.
  5. Hello I was diagnosed years ago with celiac disease, With positive blood test and positive biopsy. Recently had to have an endoscopy for h pylori and ulcers. The doctor noted that normal mucosa was seen at the entrance to the duodenum. No villi atrophy seen, even under the microscope. So Dr ordered anti tissue transglutaminase antibody blood test (ttg). It came back 15 U/ml. So i think only slightly positive. So a weak positive ttg test a negative biopsy test. So she ordered an Endomysial (EMA) test. It came back negative. How can i be diagnosed years ago as positive, +ttg and + biopsy. Now only weak positve ttg? So confusing. Could it be another autoimmune disease?
  6. I had an endoscopy last Monday that yielded some biopsies, one of which the dr said was consistent with celiac (Marsh 3b). They had me come in for a blood test to confirm, but now they haven’t called back to talk to me about it. These are the labs that show in my portal. This and the positive biopsies seems pretty positive to me but now I am paranoid that we haven’t actually found the issue. What is your take on it? https://imgur.com/a/ikQBC2q
  7. Hello! I was hoping someone would be able to explain a little more to me about the recent blood results I have received. Long story short, I am a female in my mid twenties, I lost 30 pounds in the span of three months with no explanation (5'6" 128lbs in February of 2020, down to 98lbs in April of 2020). I have since gained a few pounds over the last year, but not much, I now rest around 101/102lbs. I was tiny before, and now I am extremely underweight. I am eating normally and have been, no changes in exercise, no explanation. I noticed I started having typical GI issues related to Celiac, went to four different doctors who kept telling me I had an eating disorder (which I am eating the exact same as I always have and have not changed any exercise patterns) which was very frustrating because I knew something was wrong, but no one was taking me seriously. Finally one doctor decided to test me for Celiac and we got a positive result back on one of the tests and I now have to get an EGD and colonoscopy done (they want to look for multiple things at the same time for a biopsy from what I understand). However, no one has really explained anything to me so I have been trying to do my own research. (They tested me for other things such as diabetes, thyroid, etc. and nothing was positive except the celiac panel). These were the tests run and the results (picture of test and result numbers listed below): Antigliadin Abs, IgA; Antigliadin Abs, IgG; t-Transglutaminase (tTG) IgA; t-Transglutaminase (tTG) IgG; Immunoglobulin A, Qn, Serum The only thing that came back positive was the t-Transglutaminase (tTG) IgG at a score of (7) which is scored as a weak positive. What does this mean? Is this also affected also by the amount of gluten that is consumed (I do not eat much to begin with because I picked up that it was gluten that was giving me issues and I have been reading that you have to eat a good amount of gluten to be able to get a solid positive test). What does it mean that the TTG-IGG came back positive, but the TTG-IGA came back negative? And that none of the other ones came back positive? I've also been reading about sensitivities and specificities of the blood tests, but don't entirely understand what that means if someone can help explain that as well. Thank you all so much ahead of time, I really appreciate your help to help me understand the beginning of this journey!

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  9. Celiac.com 05/04/2021 - Immunoglobulin A tissue transglutaminase gives doctors a noninvasive way to spot celiac disease, but new research suggests that its sensitivity may be lower than estimated, making it a poor screening test, at least in asymptomatic patients. The reason comes down to verification bias, wherein a technique appears to have higher sensitivity and lower specificity than it actually does, because individuals who screen positive are more likely to have their disease confirmed by a follow-up small-bowel biopsy, while those who screen negative are unlikely to have a follow-up biopsy that could reveal missed celiac disease. That matters because the disparity could lead to missed celiac diagnoses, because some of those in the negative group could actually have celiac disease. "What you're missing from when you're calculating sensitivity is, what about the ones that are negative on the index test? Would they have been positive on that reference test? That's not even coming into your calculation because they're not getting that reference test," said Marisa Stahl, MD, a physician and researcher at the Children's Hospital Colorado Center of Celiac Disease in Aurora. Stahl was not involved in the meta-analysis, but commented on it in an interview. To determine whether the studies used by USPSTF may have overestimated sensitivity due to verification bias, Isabel Hujoel, MD, of the Mayo Clinic, Rochester, Minn., and colleagues conducted a meta-analysis, in which they reviewed those same nine studies to see the potential impact of verification bias. They then rated each study as being high, low, or unclear for possible verification bias. In all, they found five studies to be high risk. The only way to fully correct the bias is to run both IgA tissue transglutaminase (tTG) testing and small bowel biopsy on a complete or random sample of patients, and compare the sensitivity and specificity of IgA tTG with the preferred method small-bowel biopsy. But this is almost never done. Instead, when the U.S. Preventive Services Task Force concluded that evidence was insufficient for IgA tTG testing for celiac disease, it relied on a 2016 comparative effectiveness review of nine studies that estimated sensitivity at 92.6% and specificity at 97.6%. USPSTF remained noncommittal because of inadequate evidence surrounding the balance of benefit and harms of screening for celiac disease in asymptomatic individuals. Dr. Stahl was a bit shocked to see that the sensitivity was so much lower than has been traditionally accepted. The data clearly shows that "...the sensitivity is probably lower than what we oftentimes reference, and we should think more about the population of patients that could potentially screen negative and still have celiac disease," she said. Stahl suggests that the problem may be more common in adults, who have a higher incidence of seronegative Celiac disease, though there is no good data on that point, right now. Clearly reduced sensitivity of IgA tissue transglutaminase (tTG) testing is a big deal, and we're likely to hear more on this, so stay tuned. Read the full report in the Journal of Clinical Gastroenterology and the abstract pubmed.ncbi.nlm.nih.gov
  10. Celiac.com 10/31/2020 - Since this article was originally published in 2008, the tTG test has become the standard for celiac disease screening, while a newer test called "Deamidated Gliadin Peptide (DGP)" is now considered the best for CD, and the company 2G Pharma is unfortunately no longer in business. Do you know someone who might benefit from a celiac blood test? Maybe they are too shy to assert themselves. Or maybe they’ve been turned down flat by a physician who is not current with the medical literature on celiac disease. As many of us know, asking for celiac testing is sometimes like hitting a brick wall. Stories abound of incorrect diagnoses, cavalier indifference, dismissal, denial, frustration, illness, often leading to a pervasive sense of futility. Each of these stories is punctuated by pain, illness, heartache, and sometimes, death. For the lucky ones, a health care professional who is well versed in celiac disease sometimes furnished the answer. Others found their own way to a gluten free diet. Until now, most have not been so lucky. However, the brick wall is starting to crumble. A powerful force is poised to bring new hope to that unlucky, unhappy, unhealthy majority of untreated, undiagnosed group with celiac disease. 2G Pharma Inc. is now offering an at-home test for IgA tissue transglutaminase antibodies (tTG) called the Biocard celiac test. Although currently only available in Canada, it can be ordered over the Internet for only $50. Although not yet approved by Health Canada, the newer version also tests for IgA deficiency, and will thus be more accurate than the celiac testing offered by many conventional laboratories (because they often fail to consider IgA deficiency). Few physicians would deny the extreme likelihood of celiac disease in the context of positive tTG test results. If the test shows IgA deficiency (when approved) although it is not as reliable an indicator of celiac disease, it would also be well accepted as indicating the need for further investigation for celiac disease. So this new test is offering something very special, and for a very small price. Those of us who are familiar with celiac disease know that if it goes untreated it can pose a wide range of challenges. Untreated celiacs can appear healthy. Or they can manifest just a single sign or symptom such as isolated iron deficiency or osteoporosis, or rheumatoid arthritis or cancer or thyroid disease or a brain disorder or a fertility problem. On the other hand, untreated celiacs can also show a confusing array of signs, symptoms, and associated autoimmune disease. Still others will report concerns and symptoms that seem more like psychological complaints than physical manifestations of a diet-driven autoimmune disease. For instance, we now know that there are more overweight and obese individuals with untreated celiac disease than there are underweight celiacs. That is what they mean when researchers talk about the protean manifestations of celiac disease. Whatever the symptom, sign, or ailment, it can stand alone as the sole indicator, or it can be one of a constellation of problems that are due to, or associated with, an underlying case of undiagnosed celiac disease. Yet few physicians will make the connection. Until now, most cases of celiac disease will never be diagnosed because medical professionals are taught to look for a consistent complex of signs and symptoms. Most believe that untreated celiac patients are gaunt, wasted, sickly, and have protruding bellies. While this may have been true in the past we now know that celiac disease is difficult, often impossible, to identify on the basis of symptoms. Objective testing is often the only way that celiac disease can be diagnosed. Thus, this new test will identify the vast majority of untreated celiac patients. And the test is easily defended against those who might look askance at home testing. Korponay-Szabo et. al. report in Alimentary Pharmacology and Therapeutics that this test is 97% specific and 97% sensitive (1). Test sensitivity is determined by how many celiacs are identified by a positive test. Only 3% of those with celiac disease failed to be identified by this test. However, the one celiac patient that was missed in this research project suffered from IgA deficiency, which is much more common in the context of celiac disease than in the general population. Further, because the newer form of this test would have identified this deficiency, it is very likely that the patient would be further investigated for celiac disease. Thus, the test could be argued to have been 100% sensitive in their study. The same group reported that the test is 97% specific. That means that the test will show positive in cases of celiac disease as well as in 3% of patients who do not have celiac diseae. Several other groups of researchers report that many of those who test positive for tTG often go on to develop celiac disease within a few months or years. Crovella et. al., report in Digestive and Liver Disease, similar results but with one important exception. When this test was used among a group of impoverished individuals who were infected with filariasis its specificity weakened substantially. People who were infected with this parasite showed positive tTG test results despite the absence of celiac disease. Thus, despite 100% specificity among Brazilian urbanites, the test was only 76% specific when used to screen impoverished suburban Brazilians. Thus, although this test is less than ideal in some third world settings among those with filariasis infections, it is clearly a powerful tool for identifying celiac disease in the industrialized world. Closer to home, 2G Pharma Inc. is rolling out this new test in Canada, as I write this column. I suggested to Janet Monk that there might be a little cross-border shopping. Her company has chosen to take the high road and avoid the risk of contravening U.S. import/export laws. Sadly, many crooks and charlatans feel perfectly happy to send drugs and other dangerous substances into the US. Yet this young company, offering a simple (but powerful) blood test that could save the US medical system billions of dollars annually, is forced to await appropriate approvals before sending their product into the US. Bear in mind that it is not a drug. It is an at-home test for a dangerous disease that goes undiagnosed in 97% of cases in the U.S. (3) and because of all the associated ailments, takes an enormous toll on at least three million Americans (4). I would love to see this product available in the U.S., if only to stem the enormous risk of illness and lurking cancers that have been shown to reduce on a gluten free diet among those with celiac disease. If you live in Canada, you can order or encourage others to order the test. If you live elsewhere, perhaps there is something you can do to make this test available in the U.S. If nothing else, you can order and make use of the test when you visit Canada. In the meantime, this grand new test is poised and ready help diagnose the millions of Americans who will otherwise go untested and undiagnosed. I am confident that some alternative can be implemented to harness this test and get it working for Americans and Canadians alike. Sources: Korponay-Szabó IR, Raivio T, Laurila K, Opre J, Király R, Kovács JB, Kaukinen K, Fésüs L, Mäki M.Coeliac disease case finding and diet monitoring by point-of-care testing. Aliment Pharmacol Ther. 2005 Oct 15;22(8):729-37. Crovella S, Brandao L, Guimaraes R, Filho JL, Arraes LC, Ventura A, Not T.Speeding up coeliac disease diagnosis in the developing countries. Dig Liver Dis. 2007 Oct;39(10):900-2. Epub 2007 Aug 13. Green PH.Where are all those patients with Celiac disease? Am J Gastroenterol. 2007 Jul;102(7):1461-3. Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, Elitsur Y, Green PH, Guandalini S, Hill ID, Pietzak M, Ventura A, Thorpe M, Kryszak D, Fornaroli F, Wasserman SS, Murray JA, Horvath K. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003 Feb 10;163(3):286-92.
  11. Celiac.com 08/12/2020 - The interaction between celiac disease and the liver is complex and not well understood. In some cases, isolated hypertransaminasemia is the only clear sign of celiac disease, while in other cases, liver diseases can occur with isolated tissue transglutaminase antibodies IgA (tTG IgA), but without the histologic markers that would indicate celiac disease. A team of researchers recently set out to assess the results of tTG IgA testing for chronic liver disease (CLD) or cytolysis, and to seek out biopsy-confirmed celiac disease in patients with existing liver disease. The research team included Lena Cvetkovic, Gabriel Bernard, Nathanaelle Galette, Pierre-Olivier Hétu, Catherine Vincent, Mickael Bouin, and Amelie Therrien. They are variously affiliated with the Department of Medicine - Division of Gastroenterology, Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada; the Department of Biochemistry, Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada; and the Department of Medicine, Division of Hepatology, Centre de recherche du Centre Hospitalier de l'Université de Montréal in Montréal, Québec, Canada. Their retrospective study used two groups. The first included 444 consecutive patients with no known celiac disease, for whom liver specialists had ordered tTG IgA testing. In this group, the team assessed the incidence of positive tTG and biopsy-confirmed celiac disease. The second group included 212 consecutive individuals with positive tTG IgA and subsequent duodenal biopsies. In this group, the team assessed the frequency and clinical features of patients without biopsy-confirmed celiac disease, both with and without liver disease. Tests conducted on the first patient group by a liver specialist turned up nine first time positive tTG IgA results. However, only six of these patients had biopsy-confirmed celiac disease. The second group included 33 individuals who also had liver disease, though nearly 43% showed no biopsy-confirmed celiac disease, compared with the 16% of patients who did not have liver disease. Nearly two-thirds of the patients without biopsy-confirmed celiac disease showed an increase below three times the upper limit of normal of tTG IgA. Cases of chronic liver disease without elevated transaminase levels showed no association with celiac disease. Testing liver disease patients for celiac disease can be helpful, but large numbers of patients may show positive celiac tests without any histological signs celiac disease. Read more at J Can Assoc Gastroenterol. 2020 Aug;3(4):185-193.
  12. Iron: 17 mcg/dL (Low) November 11, 2016 Ferritin: 1.8 ng/mL (Low) November 11, 2016 RBC: 4.05x10^6/uL (Low) November 11, 2016 Hemoglobin: 8.5 gm/dL (Low) November 11, 2016 Vitamin D: 25.7 ng/mL (Low) February 22, 2017 ANA Profile : February 27, 2017 FANA: Positive FANA Titer: 1:640 FANA Pattern: Homogenous Gliadin IgA: 2 units June 29, 2017 Gliadin IgG: 3 units June 29,2017 TTG Ab IgA: <1 units/mL June 29, 2017 TTG Ab IgG: <1 units/mL June 29, 2017 Immunoglobulin A: 59.1 mg/Dl (Low) July 10, 2017 Immunoglobulin M: 44.2 mg/Dl (Low) July 10,2017 Immunoglobulin G: 1010.0 mg/Dl (Normal?) July 10, 2017 Immunoglobulin E: 5 KU/L July 10,2017 My RBC and Hemoglobin have come up and are normal. My iron levels will get high (too high) when I take 65 mg elemental iron twice a day for several weeks but my ferritin has never gotten over 42 ng/mL. When I stop taking my iron supplement my iron and ferritin plummet in just a matter of weeks. My hair is falling out, I get rapid heartbeat when I get too low on iron and if I get my iron too high. My whole body hurts especially my finger joints, back , knees and really all of my joints. Going to the bathroom at least 2 times day and sometimes up to 5 times a day. Extreme fatigue, Brain fog, extremely emotional and irritable. I just went gluten free July 1, 2017 and am starting to feel better. Joints feel better, I can sleep better, my mood is better. Celiac or maybe just gluten sensitive? Any thoughts? What do my labs say about me?
  13. Hey I was diagnosed celiac in November 2017 with ttg levels above 200 and started on a strict gluten free diet. After 6 months it came down to 100 and I got it checked 3 months back and it was down to 25 but I checked again this week and they were rocket high to 100. What could be the cause of this ? I don’t understand why my levels won’t go down I’m on the most strict gluten free diet I think anybody could be on. I don’t even eat chicken unless it says gluten free on it
  14. Hi. I received my first batch of results and it shows ttg iga negative ttg igg negative dga iga positive (above 140) dga igg negative Could that point to a celiac diagnosis? Thank you for your help!!!
  15. Celiac.com 02/19/2019 - Microbial transglutaminase, aka ‘meat glue,’ is an enzyme commonly used in the meat industry to “glue” together smaller pieces of meat, fish, or meat to make a single larger piece. The result is a large chunk of virtually intact piece of meat or fish that looks like a single chunk. Transglutaminase is usually unlabeled and largely invisible to consumers. For people with celiac disease or gluten-intolerance, meat glue could be dangerous. Meat Glue Can Trigger Celiac Reactions Because it is functionally similar to the tissue transglutaminase (tTg), microbial transglutaminase acts like glue, binding gliadin peptides together to form neo-complexes that trigger an immune response, and may also trigger an adverse response in people with celiac disease. A recent study by a team of German and Israeli researchers found that “Even when it lacks sequence identity, microbial transglutaminase functionally mimics endogenous tissue transglutaminase,” which researchers know to be an autoantigen of celiac disease, as well as a key player in the development and progression of celiac disease. Confirmation of the team’s findings could lead to changes in product labeling, processed food additive policies and consumer health education. If it’s true that “microbial transglutaminase functionally mimics endogenous tissue transglutaminase,” even in small pieces, and could trigger celiac disease, or celiac symptoms, then people with celiac disease need to know about it, and avoid it in foods. Talk with Your Butcher to Avoid Meat Glue Until labeling is required, and standards are set, talking with your local butcher is likely the best strategy for avoiding meat glue. Your butcher will be able to guide you to meat, poultry, fish and other products that have not been processed with meat glue. Read more at: Frontiers in Pediatrics Sciencedirect.com
  16. Hello, What does my results mean? Am I allergic to gluten? tTg-IgG 8.62 tTg-IgA 3.02 Anti Gliadin IgA 93.24 And what’s the normal range for each? Thank you!
  17. Hi Im new here. I've been suffering from GERD and IBS for past two years. I have done several courses of different medicines including PPIs to no avail. I have been researching on celiac desease and gluten sensitivity for past few weeks and out of curiosity I took the tTG and DGP antibodies test. My results are as follows, tTG-igA: 8.29 U/ml tTG-igG: 20.0 U/ml normal: values less than 12 U/ml equivocal: values between 12 -18 U/ml positive: values greater than than 18 U/ml ------------------------------------------------------------------------------------------ DGP-igA: 21.7 AU/ml DGP-igG: 14.75 AU/ml normal: values less than 15 AU/ml equivocal: values between 15-30 AU/ml positive: values greater than than 30 AU/ml ------------------------------------------------------------------------------------------ so basically my tTG-igG is positive and DGP-igA is equivocal. how would this result be interpreted?
  18. Both of my sons (7 and 8) were diagnosed three and a half years ago. We removed gluten completely from our home, including remodeling the kitchen, dining room, and living room. Replaced all dishes, pans, etc... We test things from time to time to makes sure no CC happens. Husband and I even eat gluten free outside the home so we don't bring home any crumbs. Sons have not eaten out in over three years. Youngest has all bloodwork come back to normal/safe ranges. Oldest still has never had Transglutaminase IgA get below 20. Had another endoscopy done in March and intestines/villi all healed. He had complete atrophy at time of diagnosis. GI says he's not getting glutened, but no explanation for his high TTG. We went the alternative medicine route for the last year, eliminated quite a bit, including gluten free oats, hoping for a reset for his body. It didn't help bring down his numbers. Only buy products, food and supplements, that are made in gluten free facilities, or have safe practices to prevent CC. Very little processed food in general. His March bloodwork showed his TTG IgA was at 43.3. At time of diagnosis it was >235.10. He has been tested every 3-6 months since diagnosis. Has done T4, free twice, first in 2016 - 1.1, second this past March - 1.4. TSH in 2016 - 2.273, March - 1.826. No deficiencies except Vitamin D, so he is back on a supplement. Random glucose test in good range - 86mg So my question is... what could be causing his IgA to not come down? I've read on here people suggest thyroid and diabetes issues, but he gets tested for that as you see above.
  19. Hi there, I am new to this and have a couple questions, my 14 yr old daughter has tested positive for celiacs via blood test, her TTG IgA is 234.7( apparently 15 or less is normal?) endomysial antibodies is also positive and IgA 1.4 g/L does this confirm celiacs? Is there a chance she may not have it? She has been referred for a biopsy but that could be months away. What are the chances the biopsy could be negative? really feeling for my girl at the moment, thanks
  20. As I wait (impatiently) for my biopsy results, I've been doing a lot of research about my conflicting test results (positive TTG at 11, where positive is anything over 4, and negative EMA). Everything I've been reading has said that TTG has a positive predictive value of about 90% and that EMA has a negative predictive value of 100%. So according to that, I have a 90% chance of a positive biopsy, but also a 100% chance of a negative biopsy. I also was reading a study where a positive TTG and negative EMA combo resulted in very low positive biopsy results in the study group. Thoughts? Yes, I'm going crazy waiting for my results, LOL.
  21. Suggestions please, I have been gluten free for 6 years and feel fairly confident about cross contamination, hidden gluten, my medications, toothpaste, lipstick, salad dressing, etc. I rarely eat out and when I do, it is at a restaurant that can be trusted to be thorough (well, as much as that is possible). And yet, I feel so tired, migraines, aching joints, brain fog, and words not coming out right when I talk. My GI ran many blood tests which came out normal except for low magnesium level and the presence of tTg in higher levels. When the assistant called, she began the conversation with a condescending lecture about cheating on the gluten free diet. I about lost it, but didn't. I let her know that I do not cheat and am diligent about what goes in and on my body. A follow up appointment has been made for 12 weeks out along with another intestinal biopsy. In the meantime, I am going through everything to find any hidden sources of gluten I may not be aware of. I am supposed to hear from a dietician but haven't yet. (I met with one early on in my diagnosis.) Salad dressings - any really good certified gluten-free ones? Are the vinegars used in them okay or no? I have changed my coffee and coffee maker out. I use Coffee Mate sweet Italian creamer. It states it is gluten free, but, has anyone else had problems? I have checked and rechecked my Rx pills as well as any OTC meds and supplements. I WAS eating Quaker Oats chocolate rice cakes (gluten free is stated on the packing but not certified) and suspect them; however, I stopped a couple of weeks ago and do not feel much better. (Migraine and brain fog yesterday along with joint pain). Has anyone else gone through this? What do you suggest I do? I would like to reeducate the nurse/assistant at my GI on her assumption that everyone must "cheat" and her lecture (I put in a call to my GI but was told by the nurse that she doesn't talk to patients outside of appointments ???) In all the blood work I have had done, my tTg levels are high. Am I non responsive to the diet? Ultra sensitive? Thanks for feedback.
  22. Hello! This is my first post. My big question is about Gliadin IgG. I was tested in 2004 and had a high positive at 64 (24 being positive). My Dr at the time told me I should cut back on gluten and diagnosed me with Sjogrens Syndrome (even though I was B12 deficient, anemic, and having such bad acid reflux that I would get sores all over the back of my throat). Recently I was diagnosed with Lupus (SLE) and asked to be tested for Celiacs. My Gliadin tests came back negative, but TtG IgG was 6 (6-9 weak positive). TtG IgA was 1.4. Tomorrow I get the endoscopy and biopsy. I'm so confused as to why I tested so high for Gliadin IgG and now it is negative. I am not gluten free. The Dr said she has no idea and they are just trying to figure it out. Ive read Celiacs does not go into remission unless you are gluten free. Does anyone know how I could have been positive 12 yrs ago and now be negative?
  23. Clin Chem Lab Med. 2004;42(10):1092-7 Celiac.com 01/22/2005 - A study by Italian researchers has found that anti-tissue transglutaminase (tTG) antibodies, once considered to be identical to anti-endomysial antibodies (EMA) in celiac disease, can also be found in patients with inflammatory bowel disease. The researchers looked at serum and intestinal tTG levels in 49 patients with Crohns disease, 29 patients with ulcerative colitis, 45 patients with celiac disease, 85 autoimmune patients as disease controls, and 58 volunteers as healthy controls. Additionally, Immunoglobulin A (IgA) anti-recombinant human tissue transglutaminase and anti-endomysial antibody detection in sera and fecal supernatants, along with adsorption of positive sera with recombinant human tissue transglutaminase, were performed on all patients. The researchers detected an increase in tTG concentration in all patients with celiac disease, and also low positive values in those with Crohns disease and ulcerative colitis, however the EMA were only detected in those with celiac disease. According to the researchers, the "Data highlight that both circulating and intestinal anti-tissue transglutaminases are detectable in inflammatory bowel disease, and that they are related to disease activity. These features underline that, in addition to anti-tissue transglutaminase, an anti-endomysial antibody test is necessary in the diagnostic work-up of celiac sprue, especially in patients with known inflammatory bowel disease." This study supports others that have found that the sole use of tTG to diagnose celiac disease may lead to misdiagnoses, and EMA testing must be performed to make an accurate celiac disease diagnosis.
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